|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
CA2359244C
(en)
|
1999-01-13 |
2013-10-08 |
Bayer Healthcare Llc |
.omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
|
|
US7351834B1
(en)
|
1999-01-13 |
2008-04-01 |
Bayer Pharmaceuticals Corporation |
ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
US20030216396A1
(en)
|
2002-02-11 |
2003-11-20 |
Bayer Corporation |
Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
|
|
EP2324825A1
(en)
|
2002-02-11 |
2011-05-25 |
Bayer Healthcare LLC |
Aryl ureas with angiogenesis inhibiting activity
|
|
ATE447404T1
(de)
*
|
2002-03-29 |
2009-11-15 |
Novartis Vaccines & Diagnostic |
Substituierte benzazole und ihre verwendung als raf-kinase-hemmer
|
|
UY28213A1
(es)
|
2003-02-28 |
2004-09-30 |
Bayer Pharmaceuticals Corp |
Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
|
|
US7902192B2
(en)
|
2003-05-15 |
2011-03-08 |
Arqule, Inc. |
Inhibitors of P38 and methods of using the same
|
|
DE602004007382T2
(de)
|
2003-05-20 |
2008-04-17 |
Bayer Pharmaceuticals Corp., West Haven |
Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
|
|
DK1663978T3
(da)
|
2003-07-23 |
2008-04-07 |
Bayer Pharmaceuticals Corp |
Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser
|
|
JP4755991B2
(ja)
*
|
2003-10-16 |
2011-08-24 |
ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド |
Ｒａｆキナーゼインヒビターとしての置換ベンゾアゾールおよびその使用
|
|
WO2006010082A1
(en)
*
|
2004-07-08 |
2006-01-26 |
Arqule, Inc. |
1,4-disubstituted naphtalenes as inhibitors of p38 map kinase
|
|
EP2258704A1
(en)
*
|
2004-10-19 |
2010-12-08 |
ArQule, Inc. |
Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
|
|
WO2006078907A1
(en)
*
|
2005-01-20 |
2006-07-27 |
Amgen Inc. |
2-substituted benzimidazole derivatives as vanilloid receptor ligands and their use in treatments
|
|
TWI370820B
(en)
*
|
2005-04-27 |
2012-08-21 |
Takeda Pharmaceutical |
Fused heterocyclic compounds
|
|
TW200804345A
(en)
*
|
2005-08-30 |
2008-01-16 |
Novartis Ag |
Substituted benzimidazoles and methods of preparation
|
|
WO2007047397A2
(en)
*
|
2005-10-13 |
2007-04-26 |
Smithkline Beecham Corporation |
Phenol ethers as modulators of the opioid receptors
|
|
AU2007215247B2
(en)
*
|
2006-02-10 |
2012-12-13 |
Transtech Pharma, Llc |
Benzazole derivatives, compositions, and methods of use as Aurora kinase inhibitors
|
|
DK2010528T3
(en)
|
2006-04-19 |
2018-01-15 |
Novartis Ag |
6-O-Substituted Benzoxazole and Benzothiazole Compounds and Methods for Inhibiting CSF-1R Signaling
|
|
KR20090033904A
(ko)
|
2006-07-21 |
2009-04-06 |
노파르티스 아게 |
벤즈이미다졸릴 피리딜 에테르의 제제
|
|
PE20130814A1
(es)
*
|
2006-08-30 |
2013-08-08 |
Novartis Ag |
Sales de benzimidazolil piridil eteres y formulaciones que las contienen
|
|
BRPI0809643A2
(pt)
*
|
2007-04-05 |
2014-11-11 |
Daiichi Sankyo Co Ltd |
Derivados de heteroarila bicíclica fundida
|
|
CL2008001626A1
(es)
|
2007-06-05 |
2009-06-05 |
Takeda Pharmaceuticals Co |
Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer.
|
|
JP5270553B2
(ja)
|
2007-08-23 |
2013-08-21 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
JP5350247B2
(ja)
*
|
2007-08-29 |
2013-11-27 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
UA101166C2
(ru)
|
2007-09-21 |
2013-03-11 |
Аррей Биофарма Инк. |
Производные пиридин-2-иламино-1,2,4-тиадиазола как активаторы глюкокиназы для лечения сахарного диабета
|
|
US20100261679A1
(en)
*
|
2007-10-18 |
2010-10-14 |
James Sutton |
CSF-1R, Inhibitors, Compositions, and Methods of Use
|
|
US8697874B2
(en)
*
|
2008-12-01 |
2014-04-15 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound and use thereof
|
|
JO3101B1
(ar)
|
2008-12-02 |
2017-09-20 |
Takeda Pharmaceuticals Co |
مشتقات بنزوثيازول كعوامل مضادة للسرطان
|
|
BRPI0921862A2
(pt)
*
|
2008-12-05 |
2015-12-29 |
Arqule Inc |
inibidores de raf e seus usos
|
|
BRPI1006113A2
(pt)
|
2009-03-05 |
2016-02-16 |
Daiichi Sankyo Co Ltd |
"derivado de piridina".
|
|
AU2011265254B2
(en)
|
2010-06-11 |
2016-05-19 |
Smith & Nephew, Inc. |
Patient-matched instruments
|
|
JP2013531687A
(ja)
|
2010-07-16 |
2013-08-08 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
ナトリウムチャネル遮断剤としてのピリジン化合物
|
|
EP2616441B1
(en)
|
2010-09-17 |
2019-08-07 |
Purdue Pharma L.P. |
Pyridine compounds and the uses thereof
|
|
CN102276482A
(zh)
*
|
2011-04-11 |
2011-12-14 |
常州大学 |
2-甲氧基-5-溴苯胺的制备方法
|
|
US9408885B2
(en)
|
2011-12-01 |
2016-08-09 |
Vib Vzw |
Combinations of therapeutic agents for treating melanoma
|
|
AU2013203824A1
(en)
|
2012-03-16 |
2013-10-03 |
Purdue Pharma L.P. |
Substituted pyridines and pryimidines as sodium channel blockers
|
|
WO2014096941A1
(en)
|
2012-12-20 |
2014-06-26 |
Purdue Pharma L.P. |
Cyclic sulfonamides as sodium channel blockers
|
|
US9242969B2
(en)
|
2013-03-14 |
2016-01-26 |
Novartis Ag |
Biaryl amide compounds as kinase inhibitors
|
|
CN103435554A
(zh)
*
|
2013-09-06 |
2013-12-11 |
中国药科大学 |
2-苯氨基苯并咪唑类化合物及其用途
|
|
WO2015041534A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
P90rsk in combination with raf/erk/mek
|
|
EP3046557A1
(en)
|
2013-09-20 |
2016-07-27 |
Stichting Het Nederlands Kanker Instituut |
Rock in combination with mapk-pathway
|
|
US10730866B2
(en)
|
2014-04-07 |
2020-08-04 |
Purdue Pharma L.P. |
Indole derivatives and use thereof
|
|
US20170027940A1
(en)
|
2014-04-10 |
2017-02-02 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
|
WO2015178770A1
(en)
|
2014-05-19 |
2015-11-26 |
Stichting Het Nederlands Kanker Instituut |
Compositions for cancer treatment
|
|
UY36294A
(es)
|
2014-09-12 |
2016-04-29 |
Novartis Ag |
Compuestos y composiciones como inhibidores de quinasa
|
|
EP3623371A1
(en)
|
2014-12-16 |
2020-03-18 |
Axovant Sciences GmbH |
Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
|
|
CN105949178B
(zh)
*
|
2015-03-09 |
2020-05-26 |
西格莱(苏州)生物医药有限公司 |
一种苯并咪唑类化合物、其制备方法、中间体及应用
|
|
CA2988968A1
(en)
|
2015-06-10 |
2016-12-15 |
Forum Pharmaceuticals, Inc. |
Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors
|
|
WO2017027600A1
(en)
|
2015-08-12 |
2017-02-16 |
Forum Pharmaceuticals, Inc. |
GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS
|
|
KR101770310B1
(ko)
|
2015-08-24 |
2017-08-24 |
이화여자대학교 산학협력단 |
2-(페닐아미노)벤조[d]옥사졸-5-올 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 또는 치료용 약학적 조성물
|
|
EP3383852A4
(en)
*
|
2015-11-30 |
2019-08-28 |
Children's Medical Center Corporation |
COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
|
|
EP3515446B1
(en)
|
2016-09-19 |
2023-12-20 |
Novartis AG |
Therapeutic combinations comprising a raf inhibitor and a erk inhibitor
|
|
CN106674264A
(zh)
*
|
2016-12-20 |
2017-05-17 |
苏州汉德创宏生化科技有限公司 |
(2,2,2‑三氟乙氧基)苯硼酸类化合物的合成方法
|
|
US11471538B2
(en)
|
2017-02-10 |
2022-10-18 |
INSERM (Institut National de la Santéet de la Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway
|
|
JP7094942B2
(ja)
|
2017-03-15 |
2022-07-04 |
住友ファーマ株式会社 |
ベンズイミダゾール誘導体の製造方法
|
|
US11266653B2
(en)
|
2017-05-02 |
2022-03-08 |
Novartis Ag |
Combination therapy
|
|
EP3652165B1
(en)
*
|
2017-07-12 |
2021-08-25 |
Bristol-Myers Squibb Company |
Five membered-aminoheterocyclic and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
|
|
CA3079786A1
(en)
|
2017-10-24 |
2019-05-02 |
The Broad Institute, Inc. |
4h-pyrrolo[3,2-c]pyridin-4-one derivatives
|
|
EP3732285A1
(en)
|
2017-12-28 |
2020-11-04 |
Tract Pharmaceuticals, Inc. |
Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
|
|
CN111788183B
(zh)
*
|
2018-02-07 |
2024-02-23 |
韩国化学硏究院 |
用于抑制tnik的杂环融合苯基化合物及其医疗用途
|
|
JP2022500385A
(ja)
|
2018-09-10 |
2022-01-04 |
ミラティ セラピューティクス， インコーポレイテッド |
組み合わせ療法
|
|
EP3876939A4
(en)
|
2018-11-07 |
2022-08-10 |
Dana-Farber Cancer Institute, Inc. |
Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
|
|
EP3876930A4
(en)
|
2018-11-07 |
2022-07-20 |
Dana-Farber Cancer Institute, Inc. |
BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
|
|
WO2020097400A1
(en)
|
2018-11-07 |
2020-05-14 |
Dana-Farber Cancer Institute, Inc. |
Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof
|
|
GEP20247648B
(en)
|
2019-04-24 |
2024-07-25 |
Bayer Ag |
4h-pyrrolo[3,2-c]pyridin-4-one compounds
|
|
US20240307362A1
(en)
|
2019-04-24 |
2024-09-19 |
Bayer Aktiengesellschaft |
4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS
|
|
EP3958865B1
(en)
|
2019-04-24 |
2025-12-10 |
Bayer Aktiengesellschaft |
4h-pyrrolo[3,2-c]pyridin-4-one derivatives
|
|
ES3025633T3
(en)
|
2019-05-13 |
2025-06-09 |
Novartis Ag |
New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
|
|
WO2021198020A1
(en)
|
2020-03-31 |
2021-10-07 |
Bayer Aktiengesellschaft |
3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer
|
|
BR112022022409A2
(pt)
*
|
2020-05-06 |
2023-02-07 |
Ajax Therapeutics Inc |
6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2
|
|
WO2022133098A2
(en)
*
|
2020-12-16 |
2022-06-23 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
WO2022140527A1
(en)
|
2020-12-23 |
2022-06-30 |
Ajax Therapeutics, Inc. |
6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
|
|
WO2023009708A1
(en)
*
|
2021-07-29 |
2023-02-02 |
Ajax Therapeutics, Inc. |
Heteroaryloxy triazolo- and imidazo-azines as jak2 inhibitors
|
|
WO2023086320A1
(en)
|
2021-11-09 |
2023-05-19 |
Ajax Therapeutics, Inc. |
Forms and compositions of inhibitors of jak2
|
|
CA3234638A1
(en)
|
2021-11-09 |
2023-05-19 |
Ajax Therapeutics, Inc. |
6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
|