JP2013516393A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013516393A5 JP2013516393A5 JP2012546344A JP2012546344A JP2013516393A5 JP 2013516393 A5 JP2013516393 A5 JP 2013516393A5 JP 2012546344 A JP2012546344 A JP 2012546344A JP 2012546344 A JP2012546344 A JP 2012546344A JP 2013516393 A5 JP2013516393 A5 JP 2013516393A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- lower alkyl
- optionally substituted
- pharmaceutically acceptable
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 29
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229940041181 antineoplastic drug Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 53
- 125000005843 halogen group Chemical group 0.000 description 42
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 37
- 125000003545 alkoxy group Chemical group 0.000 description 36
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 32
- 125000000623 heterocyclic group Chemical group 0.000 description 18
- -1 cyan Chemical group 0.000 description 16
- 125000001072 heteroaryl group Chemical group 0.000 description 14
- 229910052739 hydrogen Inorganic materials 0.000 description 14
- 239000001257 hydrogen Substances 0.000 description 14
- 125000003118 aryl group Chemical group 0.000 description 11
- 125000000753 cycloalkyl group Chemical group 0.000 description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 125000003342 alkenyl group Chemical group 0.000 description 7
- 125000000304 alkynyl group Chemical group 0.000 description 7
- 150000002431 hydrogen Chemical class 0.000 description 7
- 238000000034 method Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 125000005553 heteroaryloxy group Chemical group 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 description 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 1
- XUIRHRWOJCYEDJ-UHFFFAOYSA-N 7-fluoroquinoline Chemical compound C1=CC=NC2=CC(F)=CC=C21 XUIRHRWOJCYEDJ-UHFFFAOYSA-N 0.000 description 1
- 125000000000 cycloalkoxy group Chemical group 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 description 1
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 description 1
- 125000004499 isoxazol-5-yl group Chemical group O1N=CC=C1* 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2009/076321 | 2009-12-31 | ||
| CN2009076321 | 2009-12-31 | ||
| PCT/CN2010/080499 WO2011079804A1 (en) | 2009-12-31 | 2010-12-30 | Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013122502A Division JP2013209418A (ja) | 2009-12-31 | 2013-06-11 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516393A JP2013516393A (ja) | 2013-05-13 |
| JP2013516393A5 true JP2013516393A5 (OSRAM) | 2013-08-01 |
| JP5337313B2 JP5337313B2 (ja) | 2013-11-06 |
Family
ID=44226181
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546344A Active JP5337313B2 (ja) | 2009-12-31 | 2010-12-30 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
| JP2013122502A Pending JP2013209418A (ja) | 2009-12-31 | 2013-06-11 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
| JP2016074893A Active JP6194046B2 (ja) | 2009-12-31 | 2016-04-04 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
| JP2017155493A Active JP6486999B2 (ja) | 2009-12-31 | 2017-08-10 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
| JP2019028197A Active JP6647434B2 (ja) | 2009-12-31 | 2019-02-20 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013122502A Pending JP2013209418A (ja) | 2009-12-31 | 2013-06-11 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
| JP2016074893A Active JP6194046B2 (ja) | 2009-12-31 | 2016-04-04 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
| JP2017155493A Active JP6486999B2 (ja) | 2009-12-31 | 2017-08-10 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
| JP2019028197A Active JP6647434B2 (ja) | 2009-12-31 | 2019-02-20 | 特定のトリアゾロピリジンおよびトリアゾロピラジン、それらの組成物並びにそれらの使用方法 |
Country Status (38)
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2719699T3 (pl) | 2009-12-31 | 2016-01-29 | Hutchison Medipharma Ltd | Pewne triazolopirazyny, ich kompozycje i sposoby ich stosowania |
| EP2571878B1 (en) * | 2010-05-17 | 2018-10-17 | Incozen Therapeutics Pvt. Ltd. | Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of protein kinases |
| CN103030654A (zh) * | 2011-10-09 | 2013-04-10 | 济南赛文医药技术有限公司 | 一种小分子c-Met蛋白激酶抑制剂 |
| CN102516046A (zh) * | 2011-11-22 | 2012-06-27 | 太仓市运通化工厂 | 一种2-溴丙醛的合成方法 |
| KR20140144726A (ko) * | 2012-03-30 | 2014-12-19 | 리젠 파마슈티컬스 소시에떼 아노님 | C-met 단백질 키나제의 조절제로서의 신규한 3,5-디치환-3h-이미다조[4,5-b]피리딘 및 3,5- 디치환 -3h-[1,2,3]트리아졸로[4,5-b] 피리딘 화합물 |
| CA2776178A1 (en) | 2012-04-05 | 2013-10-05 | Hydro-Quebec | Ionic compounds |
| KR101745741B1 (ko) | 2012-08-13 | 2017-06-12 | 한국화학연구원 | 신규한 트리아졸로 피라진 유도체 및 그의 용도 |
| JP6114313B2 (ja) | 2013-01-11 | 2017-05-24 | 富士フイルム株式会社 | 含窒素複素環化合物またはその塩 |
| SI2964638T1 (sl) | 2013-03-06 | 2017-11-30 | Astrazeneca Ab | Kinazolinski inhibitorji aktiviranja mutantnih oblik receptorja epidermalnega rastnega faktorja |
| CN103265468A (zh) * | 2013-06-17 | 2013-08-28 | 连云港盛和生物科技有限公司 | 一种2,4-二甲基-3-吡咯甲酸乙酯的合成方法 |
| EP2818471A1 (en) * | 2013-06-27 | 2014-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5 |
| US9403831B2 (en) | 2013-09-30 | 2016-08-02 | Korea Research Institute Of Chemical Technology | Triazolopyrazine derivative and use thereof |
| JP2017500362A (ja) * | 2013-12-26 | 2017-01-05 | イグナイタ インコーポレイテッド | ピラゾロ［１，５−ａ］ピリジン誘導体およびその使用方法 |
| JP2016048495A (ja) * | 2014-08-28 | 2016-04-07 | 京セラ株式会社 | 携帯端末、レコメンドプログラム、レコメンドシステムおよびレコメンド方法 |
| EP3340983B1 (en) | 2015-08-26 | 2023-10-04 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
| WO2017035405A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amino compounds for treatment of immune and inflammatory disorders |
| EP3398951B1 (en) * | 2015-12-31 | 2021-04-07 | Shanghai Pharmaceuticals Holding Co., Ltd. | Salt of quinolone compound, polymorphs thereof, preparation method therefor, composition, and applications |
| GB201616116D0 (en) | 2016-09-22 | 2016-11-09 | Astrazeneca Ab | Use of c-Met inhibitors to treat cancers harbouring MET mutations |
| KR20180092096A (ko) | 2017-02-08 | 2018-08-17 | 에이비온 주식회사 | 트리아졸로 피라진 유도체의 신규한 다형체 및 이의 제조 방법 |
| AU2018227849B2 (en) | 2017-03-01 | 2022-04-28 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders |
| EP3589287B1 (en) | 2017-03-01 | 2022-09-14 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for treatment of medical disorders |
| WO2018160891A1 (en) | 2017-03-01 | 2018-09-07 | Achillion Pharmaceutical, Inc. | Pharmaceutical compounds for treatment of medical disorders |
| CN108570053A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元并六元杂环化合物、制备方法、中间体、组合和应用 |
| KR101924801B1 (ko) | 2017-08-16 | 2018-12-04 | 한국원자력의학원 | 트리아졸로피리딘계 유도체를 유효성분으로 함유하는 암 예방 또는 치료용 조성물 |
| HU231333B1 (hu) | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
| HU231414B1 (hu) | 2018-07-13 | 2023-08-28 | Richter Gedeon Nyrt. | Tiadiazin származékok |
| EP3847174A4 (en) | 2018-09-06 | 2022-06-15 | Achillion Pharmaceuticals, Inc. | MORPHIC FORMS OF COMPLEMENT D FACTOR INHIBITORS |
| JP7443375B2 (ja) | 2018-09-06 | 2024-03-05 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 医学的障害の治療のための大環状化合物 |
| CA3110762A1 (en) * | 2018-09-11 | 2020-03-19 | Astrazeneca Ab | Improved method for the manufacture of 3-[(1s)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine and polymorphic forms thereof |
| US11807627B2 (en) | 2018-09-25 | 2023-11-07 | Achillon Pharmaceuticals, Inc. | Morphic forms of complement factor D inhibitors |
| KR20210097124A (ko) * | 2018-10-30 | 2021-08-06 | 리페어 세라퓨틱스 인크. | 화합물, 약제 조성물, 및 화합물 제조 방법 및 atr 키나제 억제제로서의 이것들의 사용 방법 |
| CA3122575A1 (en) | 2018-12-14 | 2020-06-18 | Beta Pharma, Inc. | Organophosphorus-substituted compounds as c-met inhibitors and therapeutic uses thereof |
| CA3123583A1 (en) | 2018-12-17 | 2020-06-25 | Achillion Pharmaceuticals, Inc. | Targeted dosing for the treatment of complement mediated disorders |
| AU2020245434A1 (en) | 2019-03-22 | 2021-09-30 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
| UA129807C2 (uk) * | 2019-07-22 | 2025-08-06 | Ріпеа Терапьютикс Інк. | Похідні заміщеного 2-морфолінопіридину як інгібітори atr-кінази |
| JP2023515073A (ja) * | 2020-02-20 | 2023-04-12 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 補体因子ｄ媒介障害の処置用のヘテロアリール化合物 |
| WO2021229605A1 (en) * | 2020-05-14 | 2021-11-18 | Dr. Reddy's Laboratories Limited | Process for preparation of savolitinib and its intermediates |
| IL301146A (en) * | 2020-09-28 | 2023-05-01 | Codexis Inc | Engineered biocatalysts and methods for synthesizing chiral amines |
| US20240076285A1 (en) * | 2020-12-16 | 2024-03-07 | Shankar Venkatraman | Compounds and compositions for treating conditions associated with sting activity |
| KR102659095B1 (ko) | 2021-01-08 | 2024-04-19 | 에이비온 주식회사 | 트리아졸로피라진 유도체 화합물을 유효성분으로 하는 약학적 조성물의 태블릿정의 제조방법 |
| CN113278019A (zh) * | 2021-05-31 | 2021-08-20 | 河南偶联生物科技有限公司 | 一种咪唑并[1,2-a]吡啶类化合物的合成方法 |
| AU2023258030A1 (en) * | 2022-04-20 | 2024-10-17 | Engrail Therapeutics, Inc. | Gabaa receptor modulator salts, particles, and uses thereof |
| CA3261476A1 (en) | 2022-07-08 | 2024-01-11 | Astrazeneca Ab | Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Combination with HGF Receptor Inhibitors for the Treatment of Cancer |
| CA3264745A1 (en) * | 2022-07-29 | 2024-02-01 | Baylor College Of Medicine | NEUROTROPHIC TYROSINE KINASE RECEPTOR (NTRK) INHIBITORS AND ASSOCIATED METHODS |
| CN115611802B (zh) * | 2022-12-02 | 2023-03-14 | 北京迪泰医药科技有限公司 | 一种3-乙酰基-2-氯吡啶的合成方法 |
| WO2024148089A1 (en) * | 2023-01-04 | 2024-07-11 | Blueprint Medicines Corporation | Cdk2 inhibitors |
| GB202300923D0 (en) | 2023-01-20 | 2023-03-08 | Macfarlan Smith Ltd | Novel polymorphic forms of savolitinib |
| WO2024263860A1 (en) * | 2023-06-22 | 2024-12-26 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4444762A (en) | 1980-04-04 | 1984-04-24 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclopentan-2-ones |
| US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| CA2333040A1 (en) * | 1998-05-26 | 1999-12-02 | Merck & Co., Inc. | Imidazopyridine thrombin inhibitors |
| JP2000119250A (ja) * | 1998-08-11 | 2000-04-25 | Takeda Chem Ind Ltd | 環状アミド化合物、その製造法、中間体及び除草剤 |
| WO2004092177A1 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| JP2007516180A (ja) * | 2003-07-02 | 2007-06-21 | スゲン，インコーポレイティド | ｃ−Ｍｅｔ阻害薬としてのアリールメチルトリアゾロおよびイミダゾピラジン類 |
| US7122548B2 (en) | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| EP1675858A2 (en) | 2003-09-03 | 2006-07-05 | Neurogen Corporation | 5-aryl-pyrazolo [4,3-d] pyrimidines, pyridines, and pyrazines and related compounds |
| MX2007001127A (es) | 2004-07-27 | 2007-07-11 | Sgx Pharmaceuticals Inc | Moduladores de pirrolo-piridina cinasa. |
| BRPI0514327A (pt) | 2004-08-18 | 2008-06-10 | Pharmacia & Upjohn Co Llc | compostos triazolopiridina |
| CN101119996A (zh) * | 2005-02-16 | 2008-02-06 | 阿斯利康(瑞典)有限公司 | 化学化合物 |
| AU2006215394B2 (en) | 2005-02-16 | 2009-10-08 | Astrazeneca Ab | Chemical compounds |
| NZ568666A (en) | 2005-11-30 | 2011-09-30 | Vertex Pharma | [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole derivative as inhibitors of c-Met |
| ME02736B (me) * | 2005-12-21 | 2017-10-20 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
| NL2000613C2 (nl) * | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| EP2032578A2 (en) | 2006-05-30 | 2009-03-11 | Pfizer Products Incorporated | Triazolopyridazine derivatives |
| PE20121506A1 (es) * | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| JP2010500365A (ja) | 2006-08-07 | 2010-01-07 | インサイト・コーポレイション | キナーゼ阻害剤としてのトリアゾロトリアジン |
| EP2066676A1 (en) | 2006-09-18 | 2009-06-10 | Vertex Pharmaceuticals, Inc. | HETEROCYCLIC INHIBITORS OF c-MET AND USES THEREOF |
| ES2393132T3 (es) * | 2006-10-23 | 2012-12-18 | Sgx Pharmaceuticals, Inc. | Moduoladores de proteína quinasa de triazolopiridazina |
| NZ575336A (en) | 2006-10-23 | 2012-04-27 | Sgx Pharmaceuticals Inc | Bicyclic triazoles as protein kinase modulators |
| BRPI0719333A2 (pt) | 2006-11-22 | 2014-02-04 | Incyte Corp | Midazotriazinas e imidazopirimidinas como inbidores de cinase |
| JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| MX2009010984A (es) | 2007-04-10 | 2010-01-15 | Sgx Pharmaceuticals Inc | Moduladores de heterociclo cinasa de anillo fusionado. |
| US8148369B2 (en) | 2007-05-10 | 2012-04-03 | Janssen Pharmaceutica Nv | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| PA8792501A1 (es) | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| US8673970B2 (en) * | 2008-02-21 | 2014-03-18 | Sequoia Pharmaceuticals, Inc. | HIV protease inhibitor and cytochrome p450 inhibitor combinations |
| WO2009106577A1 (en) | 2008-02-28 | 2009-09-03 | Novartis Ag | Imidazo [1,2-b] pyridazine derivatives for the treatment of c-met tyrosine kinase mediated disease |
| EP2310389B1 (en) | 2008-05-22 | 2012-01-04 | Amgen Inc. | Heterocycles as protein kinase inhibitors |
| DE102008037790A1 (de) | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| EA201200260A1 (ru) * | 2009-08-12 | 2012-09-28 | Новартис Аг | Гетероциклические гидразоны и их применение для лечения рака и воспаления |
| IN2012DN01453A (OSRAM) * | 2009-08-20 | 2015-06-05 | Novartis Ag | |
| PL2719699T3 (pl) * | 2009-12-31 | 2016-01-29 | Hutchison Medipharma Ltd | Pewne triazolopirazyny, ich kompozycje i sposoby ich stosowania |
| EP2571878B1 (en) | 2010-05-17 | 2018-10-17 | Incozen Therapeutics Pvt. Ltd. | Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of protein kinases |
-
2010
- 2010-12-30 PL PL13198224T patent/PL2719699T3/pl unknown
- 2010-12-30 EA EA201691461A patent/EA030141B1/ru not_active IP Right Cessation
- 2010-12-30 US US13/501,222 patent/US8987269B2/en active Active
- 2010-12-30 CN CN201610437304.3A patent/CN106117248B/zh active Active
- 2010-12-30 PE PE2020001800A patent/PE20211094A1/es unknown
- 2010-12-30 AU AU2010338712A patent/AU2010338712B2/en active Active
- 2010-12-30 SM SM20220371T patent/SMT202200371T1/it unknown
- 2010-12-30 HU HUE20199091A patent/HUE059696T2/hu unknown
- 2010-12-30 CU CU20120101A patent/CU24167B1/es active IP Right Grant
- 2010-12-30 SI SI201031021T patent/SI2719699T1/sl unknown
- 2010-12-30 SI SI201032046T patent/SI3511330T1/sl unknown
- 2010-12-30 ES ES13198224.1T patent/ES2546635T3/es active Active
- 2010-12-30 MX MX2012007756A patent/MX336996B/es active IP Right Grant
- 2010-12-30 HR HRP20221090TT patent/HRP20221090T1/hr unknown
- 2010-12-30 ES ES15170608T patent/ES2726152T3/es active Active
- 2010-12-30 HU HUE13198224A patent/HUE025504T2/en unknown
- 2010-12-30 PH PH1/2012/501355A patent/PH12012501355A1/en unknown
- 2010-12-30 JP JP2012546344A patent/JP5337313B2/ja active Active
- 2010-12-30 UA UAA201208929A patent/UA107822C2/ru unknown
- 2010-12-30 KR KR1020147010967A patent/KR101771299B1/ko active Active
- 2010-12-30 EP EP10840591.1A patent/EP2519524A4/en not_active Withdrawn
- 2010-12-30 ES ES19151824T patent/ES2840454T3/es active Active
- 2010-12-30 WO PCT/CN2010/080499 patent/WO2011079804A1/en not_active Ceased
- 2010-12-30 EP EP20199091.8A patent/EP3795573B1/en active Active
- 2010-12-30 PT PT191518240T patent/PT3511330T/pt unknown
- 2010-12-30 PL PL20199091.8T patent/PL3795573T3/pl unknown
- 2010-12-30 KR KR1020127019509A patent/KR101434766B1/ko active Active
- 2010-12-30 DK DK20199091.8T patent/DK3795573T3/da active
- 2010-12-30 HU HUE19151824A patent/HUE052828T2/hu unknown
- 2010-12-30 SG SG2012044830A patent/SG181781A1/en unknown
- 2010-12-30 PT PT131982241T patent/PT2719699E/pt unknown
- 2010-12-30 CN CN201080065014.1A patent/CN102906092B/zh active Active
- 2010-12-30 EA EA201200951A patent/EA025466B1/ru not_active IP Right Cessation
- 2010-12-30 ES ES20199091T patent/ES2927146T3/es active Active
- 2010-12-30 EP EP13198224.1A patent/EP2719699B1/en active Active
- 2010-12-30 LT LTEP20199091.8T patent/LT3795573T/lt unknown
- 2010-12-30 SM SM20200693T patent/SMT202000693T1/it unknown
- 2010-12-30 NZ NZ601128A patent/NZ601128A/en unknown
- 2010-12-30 PT PT201990918T patent/PT3795573T/pt unknown
- 2010-12-30 RS RS20150584A patent/RS54217B1/sr unknown
- 2010-12-30 CN CN201610432059.7A patent/CN106432225B/zh active Active
- 2010-12-30 RS RS20220854A patent/RS63612B1/sr unknown
- 2010-12-30 MX MX2016001733A patent/MX386852B/es unknown
- 2010-12-30 DK DK13198224.1T patent/DK2719699T3/en active
- 2010-12-30 BR BR112012016129-6A patent/BR112012016129B1/pt active IP Right Grant
- 2010-12-30 MY MYPI2012002974A patent/MY179933A/en unknown
- 2010-12-30 EP EP19151824.0A patent/EP3511330B1/en active Active
- 2010-12-30 PL PL19151824T patent/PL3511330T3/pl unknown
- 2010-12-30 PE PE2012000903A patent/PE20130375A1/es not_active Application Discontinuation
- 2010-12-30 DK DK19151824.0T patent/DK3511330T3/da active
- 2010-12-30 CA CA2785749A patent/CA2785749C/en active Active
- 2010-12-30 PE PE2016000292A patent/PE20160588A1/es unknown
- 2010-12-30 EP EP15170608.2A patent/EP2966075B1/en active Active
- 2010-12-30 RS RS20201567A patent/RS61281B1/sr unknown
- 2010-12-30 ME MEP-2015-150A patent/ME02211B/me unknown
- 2010-12-30 KR KR1020177022937A patent/KR101905350B1/ko active Active
-
2012
- 2012-04-10 US US13/501,224 patent/US8507487B2/en active Active
- 2012-06-14 IL IL220433A patent/IL220433B/en active IP Right Grant
- 2012-06-26 CL CL2012001752A patent/CL2012001752A1/es unknown
- 2012-06-28 GT GT201200220A patent/GT201200220A/es unknown
- 2012-06-29 NI NI201200118A patent/NI201200118A/es unknown
- 2012-06-29 EC EC2012012011A patent/ECSP12012011A/es unknown
- 2012-06-29 DO DO2012000188A patent/DOP2012000188A/es unknown
- 2012-06-29 CO CO12109937A patent/CO6612235A2/es not_active Application Discontinuation
- 2012-07-30 ZA ZA2012/05730A patent/ZA201205730B/en unknown
-
2013
- 2013-06-11 JP JP2013122502A patent/JP2013209418A/ja active Pending
-
2015
- 2015-01-21 US US14/601,674 patent/US20150368271A1/en not_active Abandoned
- 2015-06-23 AU AU2015203480A patent/AU2015203480B2/en active Active
- 2015-07-16 IL IL239997A patent/IL239997A/en active IP Right Grant
- 2015-09-08 HR HRP20150952TT patent/HRP20150952T1/hr unknown
- 2015-09-09 SM SM201500213T patent/SMT201500213B/xx unknown
- 2015-09-17 CY CY20151100816T patent/CY1118250T1/el unknown
-
2016
- 2016-04-04 JP JP2016074893A patent/JP6194046B2/ja active Active
- 2016-10-14 US US15/293,722 patent/US9956218B2/en active Active
-
2017
- 2017-08-10 JP JP2017155493A patent/JP6486999B2/ja active Active
-
2018
- 2018-04-04 US US15/945,324 patent/US10512645B2/en active Active
-
2019
- 2019-02-20 JP JP2019028197A patent/JP6647434B2/ja active Active
- 2019-11-08 US US16/678,091 patent/US10946014B2/en active Active
-
2020
- 2020-12-17 HR HRP20202017TT patent/HRP20202017T1/hr unknown
- 2020-12-21 CY CY20201101206T patent/CY1123777T1/el unknown
-
2021
- 2021-02-03 US US17/248,688 patent/US11896592B2/en active Active
-
2023
- 2023-12-13 US US18/538,151 patent/US20240139182A1/en not_active Abandoned
-
2024
- 2024-05-28 US US18/676,172 patent/US20250099462A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013516393A5 (OSRAM) | ||
| JP6873145B2 (ja) | ５−置換２−（モルホリン−４−イル）−１，７−ナフチリジン | |
| JP2012506381A5 (OSRAM) | ||
| JP6364028B2 (ja) | 選択的エストロゲン受容体ディグレーダーとしてのベンゾチオフェン誘導体およびその組成物 | |
| CN107922431B (zh) | Hpk1抑制剂及其使用方法 | |
| KR102007056B1 (ko) | 과증식성 질환 치료시 Bub1 키나제 저해제로 사용하기 위한 치환된 벤질인다졸 | |
| JP6203439B2 (ja) | テトラヒドロピラニルメチル基を有するピリドン誘導体 | |
| JP2009534386A5 (OSRAM) | ||
| JP2016525078A5 (OSRAM) | ||
| JP2016522246A5 (OSRAM) | ||
| HRP20221090T1 (hr) | Određeni triazolopirazini, njihovi pripravci i postupci njihove upotrebe | |
| JP2013533879A5 (OSRAM) | ||
| CA2907592A1 (en) | 3-heteroaryl substituted indazoles | |
| HRP20210447T1 (hr) | Piridinski spoj | |
| JP2014506599A5 (OSRAM) | ||
| JP2013525476A (ja) | Ａｌｋ阻害剤としての複素環式誘導体 | |
| JP2017532360A5 (OSRAM) | ||
| JP2008156336A5 (OSRAM) | ||
| JP2017508782A5 (OSRAM) | ||
| RU2014101071A (ru) | КОМПЛЕКСНЫЕ ТЕРАПИИ ДЛЯ ЛЕЧЕНИЯ ГЕМАТОЛОГИЧЕСКИХ ЗЛОКАЧЕСТВЕННЫХ ЗАБОЛЕВАНИЙ С ИСПОЛЬЗОВАНИЕМ ПИРИДОПИРИМИДИНОНОВЫХ ИНГИБИТОРОВ РI3К/mTOR С БЕНДАМУСТИНОМ И/ИЛИ РИТУКСИМАБОМ | |
| JP2010523681A5 (OSRAM) | ||
| RU2012130929A (ru) | Гетероциклические соединения в качестве ингибиторов янус-киназы | |
| JP2010519174A5 (OSRAM) | ||
| JP2014506582A5 (OSRAM) | ||
| JP2019504826A (ja) | ヘテロ−１，５，６，７−テトラヒドロ−４ｈ−インドール−４−オン類 |