BRPI0514327A - compostos triazolopiridina - Google Patents

compostos triazolopiridina

Info

Publication number
BRPI0514327A
BRPI0514327A BRPI0514327-6A BRPI0514327A BRPI0514327A BR PI0514327 A BRPI0514327 A BR PI0514327A BR PI0514327 A BRPI0514327 A BR PI0514327A BR PI0514327 A BRPI0514327 A BR PI0514327A
Authority
BR
Brazil
Prior art keywords
activity
triazolopyridine
triazolopyridines
compounds
cyclooxygenase
Prior art date
Application number
BRPI0514327-6A
Other languages
English (en)
Inventor
Paul V Rucker
Shaun Raj Selness
Li Xing
Kevin De Wayne Jerome
John Edward Baldus
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0514327A publication Critical patent/BRPI0514327A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

COMPOSTOS TRIAZOLOPIRIDINA Essa invenção está direcionada de modo geral a compostos triazolopiridina que geralmente inibem a atividade da quinase p38, TNF, e/ou ciclooxigenase. Tal triazolopiridina inclui compostos que são geralmente correspondentes em estrutura à fórmula seguinte (I): onde R¬ ¹¬, R¬ ²¬, e R¬ ³¬, são como definidos nessa especificação. Essa invenção também está relacionada a composições de tais triazolopiridinas (particularmente composições farmacêuticas), intermediários para as sínteses de tais triazolopiridinas, métodos para produzir tais triazolopiridinas, e métodos para tratar (incluindo prevenir) as condições (tipicamente condições patológicas) associadas com a atividade da quinase p38, atividade do TNF, e/ou atividade da ciclooxigenase-2.
BRPI0514327-6A 2004-08-18 2005-08-08 compostos triazolopiridina BRPI0514327A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60234404P 2004-08-18 2004-08-18
PCT/IB2005/002868 WO2006018735A2 (en) 2004-08-18 2005-08-08 Triazolopyridine compounds

Publications (1)

Publication Number Publication Date
BRPI0514327A true BRPI0514327A (pt) 2008-06-10

Family

ID=35735197

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514327-6A BRPI0514327A (pt) 2004-08-18 2005-08-08 compostos triazolopiridina

Country Status (7)

Country Link
US (1) US20090209577A1 (pt)
EP (1) EP1786811A2 (pt)
JP (1) JP2008509987A (pt)
BR (1) BRPI0514327A (pt)
CA (1) CA2577478A1 (pt)
MX (1) MX2007002050A (pt)
WO (1) WO2006018735A2 (pt)

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MX2007001612A (es) * 2004-08-18 2007-04-10 Upjohn Co Compuestos novedosos de triazolopiridina para el tratamiento de la inflamacion.
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
US7579360B2 (en) 2005-06-09 2009-08-25 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
CN103641829A (zh) * 2006-08-30 2014-03-19 塞尔佐姆有限公司 作为激酶抑制剂的三唑衍生物
EP1894931A1 (en) * 2006-08-30 2008-03-05 Cellzome Ag Triazole derivatives as kinase inhibitors
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
KR20100086492A (ko) 2007-11-27 2010-07-30 셀좀 리미티드 Ｐｉ3ｋ 억제제로서의 아미노 트리아졸
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
WO2010010184A1 (en) * 2008-07-25 2010-01-28 Galapagos Nv [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
EP2519521B1 (en) 2009-12-29 2013-11-20 Eli Lilly and Company Tetrahydrotriazolopyridine compounds as selective mglu5 receptor potentiators useful for the treatment of schizophrenia
EA025466B1 (ru) 2009-12-31 2016-12-30 Хатчисон Медифарма Лимитед Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения
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