JP2008156336A5 - - Google Patents
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- Publication number
- JP2008156336A5 JP2008156336A5 JP2007267377A JP2007267377A JP2008156336A5 JP 2008156336 A5 JP2008156336 A5 JP 2008156336A5 JP 2007267377 A JP2007267377 A JP 2007267377A JP 2007267377 A JP2007267377 A JP 2007267377A JP 2008156336 A5 JP2008156336 A5 JP 2008156336A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclohepta
- benzo
- pyridin
- oxo
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69322905P | 2005-06-23 | 2005-06-23 | |
| US60/693,229 | 2005-06-23 | ||
| US72906105P | 2005-10-21 | 2005-10-21 | |
| US60/729,061 | 2005-10-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506834A Division JP4119478B1 (ja) | 2005-06-23 | 2006-06-22 | チロシンキナーゼインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008156336A JP2008156336A (ja) | 2008-07-10 |
| JP2008156336A5 true JP2008156336A5 (OSRAM) | 2009-07-09 |
| JP5086762B2 JP5086762B2 (ja) | 2012-11-28 |
Family
ID=37478833
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506834A Expired - Fee Related JP4119478B1 (ja) | 2005-06-23 | 2006-06-22 | チロシンキナーゼインヒビター |
| JP2007267377A Expired - Fee Related JP5086762B2 (ja) | 2005-06-23 | 2007-10-15 | チロシンキナーゼインヒビター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506834A Expired - Fee Related JP4119478B1 (ja) | 2005-06-23 | 2006-06-22 | チロシンキナーゼインヒビター |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7550478B2 (OSRAM) |
| EP (1) | EP1896421B1 (OSRAM) |
| JP (2) | JP4119478B1 (OSRAM) |
| AT (1) | ATE524445T1 (OSRAM) |
| AU (1) | AU2006262172B2 (OSRAM) |
| CA (1) | CA2611530C (OSRAM) |
| DK (1) | DK1896421T3 (OSRAM) |
| HR (1) | HRP20110804T1 (OSRAM) |
| RU (1) | RU2408584C2 (OSRAM) |
| SI (1) | SI1896421T1 (OSRAM) |
| WO (1) | WO2007002254A2 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20110804T1 (hr) | 2005-06-23 | 2011-11-30 | Merck Sharp & Dohme Corp. | Benzocikloheptapiridini kao inhibitori receptora tirozin kinaze met |
| JP2009512706A (ja) | 2005-10-21 | 2009-03-26 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼインヒビター |
| TW200813021A (en) * | 2006-07-10 | 2008-03-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| WO2009023846A2 (en) * | 2007-08-15 | 2009-02-19 | The Research Foundation Of State University Of New York | Methods for heat shock protein dependent cancer treatment |
| US7893081B2 (en) | 2007-12-20 | 2011-02-22 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| EP2482803B1 (en) | 2009-09-30 | 2021-12-22 | Merck Sharp & Dohme (UK) Limited | Formulations for c-met kinase inhibitors |
| US8674105B2 (en) | 2009-09-30 | 2014-03-18 | Merck Sharp & Dohme Limited | Crystalline hydrochloride salts of c-Met kinase inhibitors |
| EA201290400A1 (ru) * | 2009-11-30 | 2013-01-30 | Протеолоджикс, Лтд. | Малые производные пиримидина и способы их использования |
| CN101857594B (zh) * | 2010-06-18 | 2013-04-03 | 南方医科大学 | 一种四氢吡啶并吲哚类化合物及其制备方法和应用 |
| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| EP2727920B1 (en) | 2011-07-29 | 2016-11-02 | FUJIFILM Corporation | 1,5-naphthyridine derivative or salt thereof |
| CN104487059B (zh) | 2012-03-02 | 2017-06-23 | 伊利诺伊大学评议会 | 由双重化合物激活的强有效的抗癌活性 |
| KR102074530B1 (ko) | 2012-03-06 | 2020-02-06 | 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 | 조합 요법에 의한 프로카스파제 ３ 활성화 |
| US9421202B2 (en) | 2012-03-06 | 2016-08-23 | The Board Of Trustees Of The University Of Illinois | Procaspase combination therapy for glioblastoma |
| AU2013280644B2 (en) | 2012-06-26 | 2018-08-02 | Jeffrey A. BACHA | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| WO2014150996A1 (en) * | 2013-03-15 | 2014-09-25 | Cba Pharma, Inc. | Cancer treatment |
| JP2016519684A (ja) | 2013-04-08 | 2016-07-07 | デニス エム ブラウン | 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物 |
| ES2764299T3 (es) | 2014-12-09 | 2020-06-02 | Inst Nat Sante Rech Med | Anticuerpos monoclonales humanos contra AXL |
| WO2016094361A1 (en) * | 2014-12-10 | 2016-06-16 | Southern Research Institute | Antiviral agents |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| WO2017161004A1 (en) | 2016-03-15 | 2017-09-21 | University Of South Florida | PKCδ INHIBITOR FORMULATIONS AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS |
| CA3082575A1 (en) | 2017-11-17 | 2019-05-23 | The Board Of Trustees Of The University Of Illinois | Cancer therapy by degrading dual mek signaling |
| US12090153B2 (en) | 2018-10-05 | 2024-09-17 | The Board Of Trustees Of The University Of Illinois | Combination therapy for the treatment of uveal melanoma |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| WO2021063967A1 (en) * | 2019-10-01 | 2021-04-08 | Sanofi | Novel substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| KR20240115979A (ko) | 2021-11-08 | 2024-07-26 | 프로젠토스 테라퓨틱스, 인크. | 혈소판-유래 성장 인자 수용체(pdgfr) 알파 억제제 및 이의 용도 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL132137C (OSRAM) | 1963-04-24 | |||
| US4826853A (en) | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| JP2852659B2 (ja) | 1988-03-03 | 1999-02-03 | 富山化学工業株式会社 | ピペラジン誘導体およびその塩 |
| IE68935B1 (en) | 1990-06-22 | 1996-07-24 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use |
| US6365588B1 (en) | 1993-10-15 | 2002-04-02 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| ES2159047T3 (es) | 1995-10-16 | 2001-09-16 | Kyowa Hakko Kogyo Kk | Compuestos triciclicos. |
| CA2264569C (en) | 1996-09-13 | 2003-11-11 | Schering Corporation | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| KR20000036102A (ko) | 1996-09-13 | 2000-06-26 | 둘락 노먼 씨. | 파르네실-단백질 트랜스퍼라제 억제제로서 유용한 치환된 벤조사이클로헵타피리딘 |
| ID30349A (id) * | 1997-06-17 | 2001-11-22 | Schering Corp | Turunan benzo (5,6) siklohepta (1,2-b) piridin untuk menghambat transferase protein farnesil |
| WO2001054680A2 (en) * | 2000-01-26 | 2001-08-02 | Cedars-Sinai Medical Center | Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor |
| US7018979B1 (en) * | 2000-01-26 | 2006-03-28 | Cedars-Sinai Medical Center | Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor |
| EP1427706B1 (en) | 2001-09-19 | 2007-05-30 | Pharmacia Corporation | Substituted pyrazolo compounds for the treatment of inflammation |
| AU2003230758A1 (en) | 2002-04-02 | 2003-10-20 | Merck And Co., Inc. | 5h-benzo(4,5)cyclohepta(1,2-b)pyridine nmda/nr2b antagonists |
| ES2211315B1 (es) | 2002-11-12 | 2005-10-16 | Almirall Prodesfarma, S.A. | Nuevos compuestos triciclicos. |
| JP2006151809A (ja) | 2002-12-26 | 2006-06-15 | Ube Ind Ltd | ベンゾシクロヘプタピリジン化合物 |
| HRP20110804T1 (hr) | 2005-06-23 | 2011-11-30 | Merck Sharp & Dohme Corp. | Benzocikloheptapiridini kao inhibitori receptora tirozin kinaze met |
| US20090131423A1 (en) | 2005-10-21 | 2009-05-21 | Merck & Co., Inc. | Tyrosine Kinase Inhibitors |
| JP2009512706A (ja) | 2005-10-21 | 2009-03-26 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼインヒビター |
| JP2009512707A (ja) | 2005-10-21 | 2009-03-26 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼインヒビター |
| TW200813021A (en) | 2006-07-10 | 2008-03-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
-
2006
- 2006-06-22 HR HR20110804T patent/HRP20110804T1/hr unknown
- 2006-06-22 AU AU2006262172A patent/AU2006262172B2/en not_active Ceased
- 2006-06-22 DK DK06785313.5T patent/DK1896421T3/da active
- 2006-06-22 RU RU2008102381/04A patent/RU2408584C2/ru not_active IP Right Cessation
- 2006-06-22 JP JP2008506834A patent/JP4119478B1/ja not_active Expired - Fee Related
- 2006-06-22 AT AT06785313T patent/ATE524445T1/de not_active IP Right Cessation
- 2006-06-22 EP EP06785313A patent/EP1896421B1/en active Active
- 2006-06-22 CA CA2611530A patent/CA2611530C/en active Active
- 2006-06-22 US US11/473,273 patent/US7550478B2/en active Active
- 2006-06-22 WO PCT/US2006/024247 patent/WO2007002254A2/en not_active Ceased
- 2006-06-22 SI SI200631207T patent/SI1896421T1/sl unknown
- 2006-06-22 US US11/921,350 patent/US8207186B2/en active Active
-
2007
- 2007-10-15 JP JP2007267377A patent/JP5086762B2/ja not_active Expired - Fee Related
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