JP2007505922A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007505922A5 JP2007505922A5 JP2006527059A JP2006527059A JP2007505922A5 JP 2007505922 A5 JP2007505922 A5 JP 2007505922A5 JP 2006527059 A JP2006527059 A JP 2006527059A JP 2006527059 A JP2006527059 A JP 2006527059A JP 2007505922 A5 JP2007505922 A5 JP 2007505922A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- amino
- acyloxy
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004423 acyloxy group Chemical group 0.000 claims 51
- 125000002252 acyl group Chemical group 0.000 claims 46
- 125000000217 alkyl group Chemical group 0.000 claims 44
- 150000002431 hydrogen Chemical class 0.000 claims 44
- 229910052739 hydrogen Inorganic materials 0.000 claims 44
- 239000001257 hydrogen Substances 0.000 claims 44
- 150000001875 compounds Chemical class 0.000 claims 41
- 125000000547 substituted alkyl group Chemical group 0.000 claims 41
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 40
- 229910052717 sulfur Inorganic materials 0.000 claims 31
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 30
- 239000011593 sulfur Substances 0.000 claims 30
- -1 Amino, substituted amino Chemical group 0.000 claims 29
- 229910052736 halogen Inorganic materials 0.000 claims 26
- 150000002367 halogens Chemical class 0.000 claims 26
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 26
- 125000003545 alkoxy group Chemical group 0.000 claims 25
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 25
- 125000003118 aryl group Chemical group 0.000 claims 24
- 125000003342 alkenyl group Chemical group 0.000 claims 23
- 125000000304 alkynyl group Chemical group 0.000 claims 23
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 23
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 23
- 125000003107 substituted aryl group Chemical group 0.000 claims 23
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 17
- 229910052760 oxygen Inorganic materials 0.000 claims 17
- 239000001301 oxygen Substances 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 12
- ZNXFEZJRALUZGZ-UHFFFAOYSA-N 2-(2-oxo-6-sulfanylidenepiperidin-3-yl)-3-sulfanylideneisoindol-1-one Chemical compound S=C1C2=CC=CC=C2C(=O)N1C1CCC(=S)NC1=O ZNXFEZJRALUZGZ-UHFFFAOYSA-N 0.000 claims 8
- HPZIYTPFXVRSEL-UHFFFAOYSA-N 2-[2,6-bis(sulfanylidene)piperidin-3-yl]-3-sulfanylideneisoindol-1-one Chemical compound S=C1C2=CC=CC=C2C(=O)N1C1CCC(=S)NC1=S HPZIYTPFXVRSEL-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- YIVPAGQZXIJWBX-UHFFFAOYSA-N 2-[2,6-bis(sulfanylidene)piperidin-3-yl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=S)NC1=S YIVPAGQZXIJWBX-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- GXIXKSMAOXPPGZ-UHFFFAOYSA-N 2-cyclohex-3-en-1-ylisoindole-1,3-dithione Chemical compound S=C1C2=CC=CC=C2C(=S)N1C1CCC=CC1 GXIXKSMAOXPPGZ-UHFFFAOYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 3
- QFSZJXRBCXUCMD-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)pyrrolo[3,4-c]pyridine-1,3-dione Chemical compound O=C1C2=CN=CC=C2C(=O)N1C1CCC(=O)NC1=O QFSZJXRBCXUCMD-UHFFFAOYSA-N 0.000 claims 3
- FNFLWRDNFCUNQT-UHFFFAOYSA-N 2-(2-oxo-6-sulfanylidenepiperidin-3-yl)isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=S)NC1=O FNFLWRDNFCUNQT-UHFFFAOYSA-N 0.000 claims 3
- OTDLWDKISPNCQW-UHFFFAOYSA-N 2-[2,6-dioxo-1-(2-phenylethyl)piperidin-3-yl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C(C1=O)CCC(=O)N1CCC1=CC=CC=C1 OTDLWDKISPNCQW-UHFFFAOYSA-N 0.000 claims 3
- VDXNOKQEYGTPGZ-UHFFFAOYSA-N 2-cyclohex-3-en-1-yl-3-sulfanylideneisoindol-1-one Chemical compound S=C1C2=CC=CC=C2C(=O)N1C1CCC=CC1 VDXNOKQEYGTPGZ-UHFFFAOYSA-N 0.000 claims 3
- FVOWJCUUOBMLPE-UHFFFAOYSA-N 3-(1-oxo-3-sulfanylideneisoindol-2-yl)piperidine-2,6-dione Chemical compound S=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O FVOWJCUUOBMLPE-UHFFFAOYSA-N 0.000 claims 3
- QOVMQFRFRYWHFV-UHFFFAOYSA-N 3-n-(2,6-dioxopiperidin-3-yl)naphthalene-2,3-dicarboxamide Chemical compound NC(=O)C1=CC2=CC=CC=C2C=C1C(=O)NC1CCC(=O)NC1=O QOVMQFRFRYWHFV-UHFFFAOYSA-N 0.000 claims 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- KZVNYZQKCAGNHL-UHFFFAOYSA-N [2-[(2,6-dioxopiperidin-3-yl)carbamoyl]phenyl] acetate Chemical compound CC(=O)OC1=CC=CC=C1C(=O)NC1C(=O)NC(=O)CC1 KZVNYZQKCAGNHL-UHFFFAOYSA-N 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 3
- DZVUHHROHSPUED-UHFFFAOYSA-N dimethyl 2-(1-oxo-3-sulfanylideneisoindol-2-yl)pentanedioate Chemical compound C1=CC=C2C(=S)N(C(CCC(=O)OC)C(=O)OC)C(=O)C2=C1 DZVUHHROHSPUED-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- DNYJMSSHPMBPGB-UHFFFAOYSA-N 2-(1-oxo-3-sulfanylideneisoindol-2-yl)pentanedioic acid Chemical compound C1=CC=C2C(=S)N(C(CCC(=O)O)C(O)=O)C(=O)C2=C1 DNYJMSSHPMBPGB-UHFFFAOYSA-N 0.000 claims 2
- IOLMYDDAHXTLLS-UHFFFAOYSA-N 3-aminopiperidine-2,6-dione;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.NC1CCC(=O)NC1=O IOLMYDDAHXTLLS-UHFFFAOYSA-N 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000034038 Pathologic Neovascularization Diseases 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- NPWMTBZSRRLQNJ-UHFFFAOYSA-N pyroglutamine Chemical compound NC1CCC(=O)NC1=O NPWMTBZSRRLQNJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229960003433 thalidomide Drugs 0.000 claims 2
- VVNYDCGZZSTUBC-LURJTMIESA-N (2s)-5-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CCC(N)=O VVNYDCGZZSTUBC-LURJTMIESA-N 0.000 claims 1
- PAMWIQZMLLUFBP-UHFFFAOYSA-N 1-aminopiperidine-2,6-dione Chemical compound NN1C(=O)CCCC1=O PAMWIQZMLLUFBP-UHFFFAOYSA-N 0.000 claims 1
- MBYLNRRTUYQZAW-UHFFFAOYSA-N 2-(2-phenylethyl)isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1CCC1=CC=CC=C1 MBYLNRRTUYQZAW-UHFFFAOYSA-N 0.000 claims 1
- GWSCZWXCPVOCOC-UHFFFAOYSA-N 2-benzyl-3-benzyliminoisoindol-1-one Chemical compound C=1C=CC=CC=1CN=C1C2=CC=CC=C2C(=O)N1CC1=CC=CC=C1 GWSCZWXCPVOCOC-UHFFFAOYSA-N 0.000 claims 1
- ZIKDETHPMRZUKO-UHFFFAOYSA-N 2-cyclohex-3-en-1-ylisoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC=CC1 ZIKDETHPMRZUKO-UHFFFAOYSA-N 0.000 claims 1
- QFODIVSHCUILDZ-UHFFFAOYSA-N 3-(3-oxoisoindol-1-ylidene)piperidine-2,6-dione Chemical compound C12=CC=CC=C2C(=O)NC1=C1CCC(=O)NC1=O QFODIVSHCUILDZ-UHFFFAOYSA-N 0.000 claims 1
- JTZRBPSHQZOCBU-UHFFFAOYSA-N 6-sulfanylidenepiperidin-2-one Chemical compound O=C1CCCC(=S)N1 JTZRBPSHQZOCBU-UHFFFAOYSA-N 0.000 claims 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 claims 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 claims 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-L glutarate(2-) Chemical compound [O-]C(=O)CCCC([O-])=O JFCQEDHGNNZCLN-UHFFFAOYSA-L 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- CMTSCLKCQBPLSH-UHFFFAOYSA-N isoindole-1,3-dithione Chemical compound C1=CC=C2C(=S)NC(=S)C2=C1 CMTSCLKCQBPLSH-UHFFFAOYSA-N 0.000 claims 1
- ABLCLJKCIOWZAQ-UHFFFAOYSA-N piperidine-2,3,6-trione Chemical compound O=C1CCC(=O)NC1=O ABLCLJKCIOWZAQ-UHFFFAOYSA-N 0.000 claims 1
- ICJTYWLQSDUPRA-UHFFFAOYSA-N piperidine-2,6-dithione Chemical compound S=C1CCCC(=S)N1 ICJTYWLQSDUPRA-UHFFFAOYSA-N 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 0 CC(C)C(CC(*)C(*)C1=C(C*=C2*)[N+]([O-])=O)C1=C2O Chemical compound CC(C)C(CC(*)C(*)C1=C(C*=C2*)[N+]([O-])=O)C1=C2O 0.000 description 6
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50472403P | 2003-09-17 | 2003-09-17 | |
| US60/504,724 | 2003-09-17 | ||
| PCT/US2004/030506 WO2005028436A2 (en) | 2003-09-17 | 2004-09-17 | Thalidomide analogs as tnf-alpha modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007505922A JP2007505922A (ja) | 2007-03-15 |
| JP2007505922A5 true JP2007505922A5 (cg-RX-API-DMAC7.html) | 2007-10-11 |
| JP4943845B2 JP4943845B2 (ja) | 2012-05-30 |
Family
ID=34375538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006527059A Expired - Fee Related JP4943845B2 (ja) | 2003-09-17 | 2004-09-17 | サリドマイド類似体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7973057B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1663223B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4943845B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1867331B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004274474B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0414497A (cg-RX-API-DMAC7.html) |
| CA (2) | CA2538864C (cg-RX-API-DMAC7.html) |
| SG (1) | SG133603A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005028436A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2929331B2 (ja) * | 1990-07-18 | 1999-08-03 | 丸善石油化学株式会社 | トラクションドライブ用流体 |
| CN101119969B (zh) | 2004-07-15 | 2014-04-09 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用 |
| CN100383139C (zh) * | 2005-04-07 | 2008-04-23 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的哌啶-2，6-二酮衍生物 |
| CN1939922B (zh) * | 2005-09-27 | 2010-10-13 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物 |
| US20080064876A1 (en) * | 2006-05-16 | 2008-03-13 | Muller George W | Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| JP5523831B2 (ja) * | 2006-08-30 | 2014-06-18 | セルジーン コーポレイション | ５−置換イソインドリン化合物 |
| US8877780B2 (en) | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
| AU2013260742B2 (en) * | 2007-03-20 | 2016-06-16 | Celgene Corporation | 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same |
| AU2008229383B2 (en) | 2007-03-20 | 2013-09-05 | Celgene Corporation | 4'-O-substituted isoindoline derivatives and compositions comprising and methods of using the same |
| US7723301B2 (en) * | 2007-08-29 | 2010-05-25 | The Board Of Trustees Of The University Of Arkansas | Pharmaceutical compositions comprising an anti-teratogenic compound and applications of the same |
| US20090298882A1 (en) * | 2008-05-13 | 2009-12-03 | Muller George W | Thioxoisoindoline compounds and compositions comprising and methods of using the same |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| JP2012526823A (ja) | 2009-05-12 | 2012-11-01 | アルバニー モレキュラー リサーチ， インコーポレイテッド | アリール、ヘテロアリール、および複素環置換テトラヒドロイソキノリンならびにそれらの使用 |
| JP5764553B2 (ja) * | 2009-05-12 | 2015-08-19 | アルバニー モレキュラー リサーチ， インコーポレイテッド | ７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンおよびその使用 |
| JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| LT3202461T (lt) * | 2010-02-11 | 2019-04-25 | Celgene Corporation | Arilmetoksiizoindolino dariniai ir juos apimančios kompozicijos bei jų panaudojimo būdai |
| JP5857043B2 (ja) * | 2010-06-18 | 2016-02-10 | 大鵬薬品工業株式会社 | Ｐｒｐｋ−ｔｐｒｋｂモジュレーター及びその使用 |
| US8927725B2 (en) | 2011-12-02 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
| JP2015500001A (ja) | 2011-12-14 | 2015-01-05 | 大鵬薬品工業株式会社 | 組換えｐｒｐｋ−ｔｐｒｋｂ及びその使用 |
| US9383644B2 (en) | 2014-09-18 | 2016-07-05 | Heraeus Precious Metals North America Daychem LLC | Sulfonic acid derivative compounds as photoacid generators in resist applications |
| PT3214081T (pt) | 2014-10-30 | 2020-08-31 | Kangpu Biopharmaceuticals Ltd | Derivado de isoindolina, seu intermediário, seu método de preparação, sua composição farmacêutica e sua utilização |
| US9477150B2 (en) | 2015-03-13 | 2016-10-25 | Heraeus Precious Metals North America Daychem LLC | Sulfonic acid derivative compounds as photoacid generators in resist applications |
| WO2017007577A1 (en) * | 2015-07-08 | 2017-01-12 | Gilrose Pharmaceuticals, Llc | Pre-frontal cortex processing disorder, gait and limb impairment treatment |
| KR102838444B1 (ko) | 2015-09-30 | 2025-07-24 | 더 유니버시티 코트 오브 더 유니버시티 오브 애버딘 | 탈리도마이드 유사체 및 사용 방법 |
| MX2022008085A (es) * | 2016-03-16 | 2022-07-11 | H Lee Moffitt Cancer Ct & Res | Moleculas peque?as contra cereblon para mejorar la funcion efectora de los linfocitos t. |
| JP7143295B2 (ja) * | 2016-11-24 | 2022-09-28 | ティアンジン ヘメイ ファーマスーティカル サイ－テック カンパニー リミテッド | ピペリジン－２，６－ジオン誘導体及びクローン病の治療 |
| CA3079407A1 (en) | 2017-10-18 | 2019-04-25 | Novartis Ag | Compositions and methods for selective protein degradation |
| PE20210184A1 (es) | 2018-07-11 | 2021-02-02 | H Lee Moffitt Cancer Ct & Res | Compuestos inmunomoduladores dimericos contra mecanismos basados en cereblon |
| US11324731B2 (en) | 2018-09-13 | 2022-05-10 | City Of Hope | TXNIP-TRX complex inhibitors and methods of using the same |
| CA3119343C (en) | 2018-11-13 | 2024-01-16 | Biotheryx, Inc. | Substituted isoindolinones |
| CN111601789A (zh) * | 2018-12-20 | 2020-08-28 | 江苏凯迪恩医药科技有限公司 | 一种含氮杂环化合物、其制备方法及应用 |
| WO2020219742A1 (en) | 2019-04-24 | 2020-10-29 | Novartis Ag | Compositions and methods for selective protein degradation |
| CN114641337A (zh) * | 2019-08-27 | 2022-06-17 | 密歇根大学董事会 | Cereblon e3连接酶抑制剂 |
| KR102783667B1 (ko) | 2019-10-24 | 2025-03-21 | 삼성전자 주식회사 | 전자 장치 및 그의 디스플레이 동작 제어 방법 |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| TW202140448A (zh) * | 2020-01-16 | 2021-11-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 並環醯亞胺類衍生物、其製備方法及其在醫藥上的應用 |
| AU2021226514B2 (en) * | 2020-02-25 | 2023-10-19 | Shanghaitech University | Glutarimide skeleton-based compounds and application thereof |
| KR20220055171A (ko) * | 2020-10-26 | 2022-05-03 | 주식회사 아이비스바이오 | 포말리도마이드로부터 3,6'-디티오포말리도마이드를 선택적으로 합성하는 방법 |
| US20240166647A1 (en) * | 2021-03-03 | 2024-05-23 | The Regents Of The University Of Michigan | Cereblon Ligands |
| EP4484418A1 (en) | 2022-02-25 | 2025-01-01 | Aevis Bio, Inc. | Use of novel pomalidomide derivative for treating brain disease |
| TW202434562A (zh) | 2022-11-04 | 2024-09-01 | 美商必治妥美雅史谷比公司 | 化合物及其用於治療血紅素病變之用途 |
| CN119654316A (zh) * | 2023-07-14 | 2025-03-18 | 标新生物医药科技(上海)有限公司 | 基于硫代的戊二酰亚胺基异吲哚啉酮骨架的化合物及其应用 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2830991A (en) | 1954-05-17 | 1958-04-15 | Gruenenthal Chemie | Products of the amino-piperidine-2-6-dione series |
| GB962857A (en) | 1961-12-04 | 1964-07-08 | Distillers Co Yeast Ltd | Process for the production of imides |
| GB1049283A (en) * | 1962-04-14 | 1966-11-23 | Distillers Co Yeast Ltd | Substituted butyro-lactones and -thiolactones |
| US3320270A (en) * | 1963-10-08 | 1967-05-16 | Tri Kem Corp | Certain 2-acylimidothiazole compounds |
| US3314953A (en) | 1964-03-16 | 1967-04-18 | Richardson Merrell Inc | 1-substituted-3-phthalimido-2, 5-dioxopyrrolidines |
| US3560495A (en) | 1965-05-08 | 1971-02-02 | Ernst Frankus | 1-heterocyclic amino methyl or 1-heterocyclic hydrazino methyl-3-phthalimido or (3',6'-dithia-3',4',5',6'-tetrahydrophthalimido)-pyrrolidinediones-2,5 or piperidinediones-2,6 |
| IL25595A (en) | 1965-05-08 | 1971-01-28 | Gruenenthal Chemie | New history of cyclic amide compounds and process for the production of these compounds |
| GB1324718A (en) * | 1970-11-10 | 1973-07-25 | Nehezvegyipari Kutato Intezet | Phthalimido triazines |
| US4067718A (en) | 1975-11-12 | 1978-01-10 | American Cyanamid Company | Method for controlling the relative stem growth of plants |
| US4291048A (en) | 1978-07-06 | 1981-09-22 | Joseph Gold | Method of treating tumors and cancerous cachexia with L-tryptophan |
| US5354690A (en) | 1989-07-07 | 1994-10-11 | Karl Tryggvason | Immunological methods for the detection of the human type IV collagen α5 chain |
| US5902790A (en) | 1995-10-03 | 1999-05-11 | Cytran, Inc. | Pharmaceutical angiostatic dipeptide compositions and method of use thereof |
| GB9311281D0 (en) | 1993-06-01 | 1993-07-21 | Rhone Poulenc Rorer Ltd | Novel composition of matter |
| ES2098505T3 (es) | 1991-04-17 | 1997-05-01 | Gruenenthal Chemie | Nuevos derivados de la talidomida, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. |
| US6096768A (en) | 1992-01-28 | 2000-08-01 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
| US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| US6228879B1 (en) | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
| US20010056114A1 (en) | 2000-11-01 | 2001-12-27 | D'amato Robert | Methods for the inhibition of angiogenesis with 3-amino thalidomide |
| US5434170A (en) | 1993-12-23 | 1995-07-18 | Andrulis Pharmaceuticals Corp. | Method for treating neurocognitive disorders |
| US5443824A (en) | 1994-03-14 | 1995-08-22 | Piacquadio; Daniel J. | Topical thalidomide compositions for surface or mucosal wounds, ulcerations, and lesions |
| DE4422237A1 (de) | 1994-06-24 | 1996-01-04 | Gruenenthal Gmbh | Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe |
| US5789434A (en) | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| AU696817B2 (en) | 1994-12-30 | 1998-09-17 | Celgene Corporation | Immunotherapeutic imides/amides and their use for reducing levels of TNF alpha |
| US6429221B1 (en) | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
| US5783605A (en) | 1995-02-27 | 1998-07-21 | Kuo; Sheng-Chu | Helper inducers for differentiation therapy and chemoprevention of cancer |
| US5728844A (en) | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic agents |
| CA2251060C (en) | 1996-04-09 | 2006-09-12 | Grunenthal Gmbh | Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action |
| DE19613976C1 (de) | 1996-04-09 | 1997-11-20 | Gruenenthal Gmbh | Thalidomid-Prodrugs mit immunmodulatorischer Wirkung |
| AU3224997A (en) | 1996-05-29 | 1998-01-05 | Prototek, Inc | Prodrugs of thalidomide and methods for using same as modulators of t-cell function |
| CA2624949C (en) | 1996-07-24 | 2011-02-15 | Celgene Corporation | Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and method of reducing tnf.alpha. levels |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| AU746713B2 (en) | 1996-11-05 | 2002-05-02 | Children's Medical Center Corporation | Methods and compositions for inhibition of angiogenesis |
| AU5597098A (en) | 1996-12-13 | 1998-07-03 | Eli Lilly And Company | Inhibitors of the enzymatic activity of psa |
| DE19703763C1 (de) | 1997-02-01 | 1998-10-01 | Gruenenthal Gmbh | Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione |
| RU2108786C1 (ru) | 1997-09-15 | 1998-04-20 | Клавдия Степановна Евланенкова | Средство для лечения онкологических больных |
| DE19743968C2 (de) | 1997-10-06 | 2002-07-11 | Gruenenthal Gmbh | Intravenöse Applikationsform von Thalidomid zur Therapie immunologischer Erkrankungen |
| EP1091726A2 (en) | 1998-05-11 | 2001-04-18 | EntreMed, Inc. | Analogs of 2-phthalimidinoglutaric acid and their use as inhibitors of angiogenesis |
| TR200003355T2 (tr) | 1998-05-15 | 2001-03-21 | Astrazeneca Ab | Sitokinin sebep olduğu hastalıkların tedavisinde benzamid türevlerinin kullanılması |
| DE19843793C2 (de) | 1998-09-24 | 2000-08-03 | Gruenenthal Gmbh | Substituierte Benzamide |
| US20030013739A1 (en) | 1998-12-23 | 2003-01-16 | Pharmacia Corporation | Methods of using a combination of cyclooxygenase-2 selective inhibitors and thalidomide for the treatment of neoplasia |
| ATE235256T1 (de) | 1999-03-31 | 2003-04-15 | Gruenenthal Gmbh | Stabile wässrige lösung von 3-(1-oxo-1,3-dihydro- isoindol-2-yl)-piperidin-2,6-dion |
| AU4515001A (en) | 1999-12-02 | 2001-06-18 | Regents Of The University Of Michigan, The | Compositions and methods for locally treating inflammatory diseases |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| PT1353672E (pt) | 2000-11-30 | 2008-01-11 | Childrens Medical Center | Síntese da 4-amino talidomida enantiómeros |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| EP1389203B8 (en) * | 2001-02-27 | 2010-03-10 | The Governement of the United States of America, represented by The Secretary Department of Health and Human services | Analogs of thalidomide as angiogenesis inhibitors |
| AU2002323063B2 (en) | 2001-08-06 | 2007-11-08 | Entremed, Inc. | Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs |
| EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| CA2752140A1 (en) | 2002-05-17 | 2003-11-27 | Celgene Corporation | Methods and compositions using 3-(4-amino-1-oxo-1,3-dihydroisoindol-1-yl)-piperidine-2,6-dione for treatment and management of renal cancer |
| CN100488959C (zh) | 2003-03-27 | 2009-05-20 | 天津和美生物技术有限公司 | 水溶性的酞胺哌啶酮衍生物 |
| WO2005016326A2 (en) | 2003-07-11 | 2005-02-24 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
-
2004
- 2004-09-17 US US10/572,485 patent/US7973057B2/en not_active Expired - Fee Related
- 2004-09-17 EP EP04784385.9A patent/EP1663223B1/en not_active Expired - Lifetime
- 2004-09-17 CA CA2538864A patent/CA2538864C/en not_active Expired - Fee Related
- 2004-09-17 WO PCT/US2004/030506 patent/WO2005028436A2/en not_active Ceased
- 2004-09-17 AU AU2004274474A patent/AU2004274474B2/en not_active Ceased
- 2004-09-17 BR BRPI0414497-0A patent/BRPI0414497A/pt not_active IP Right Cessation
- 2004-09-17 SG SG200704530-5A patent/SG133603A1/en unknown
- 2004-09-17 CN CN2004800268113A patent/CN1867331B/zh not_active Expired - Fee Related
- 2004-09-17 JP JP2006527059A patent/JP4943845B2/ja not_active Expired - Fee Related
- 2004-09-17 CA CA2808646A patent/CA2808646C/en not_active Expired - Fee Related
-
2011
- 2011-06-03 US US13/153,355 patent/US8546430B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007505922A5 (cg-RX-API-DMAC7.html) | ||
| TWI354666B (en) | Heterocyclic aspartyl protease inhibitors | |
| RU2005137403A (ru) | Новые замещенные 3-сера-индолы | |
| JP2005535586A5 (cg-RX-API-DMAC7.html) | ||
| JP2007519695A5 (cg-RX-API-DMAC7.html) | ||
| JP2018511587A5 (cg-RX-API-DMAC7.html) | ||
| RU2007118632A (ru) | Ингибиторы митотического кинезина и способы их использования | |
| RU2005136368A (ru) | Производные пиперазина и их применение для лечения неврологических и психиатрических заболеваний | |
| JP2005504039A5 (cg-RX-API-DMAC7.html) | ||
| RU2012134306A (ru) | Азотосодержащие производные гетероарилов | |
| RU2008126391A (ru) | Производные 1,5-замещенного индол-2-иламида | |
| JP2005526076A5 (cg-RX-API-DMAC7.html) | ||
| JP2006524222A5 (cg-RX-API-DMAC7.html) | ||
| JP2005538955A5 (cg-RX-API-DMAC7.html) | ||
| RU2005104434A (ru) | Производные 1-гетероциклилалкил-3-сульфонилиндола или - индазола как лиганды 5-гидрокситриптамина-6 | |
| JP2002534519A5 (cg-RX-API-DMAC7.html) | ||
| JP2005518414A5 (cg-RX-API-DMAC7.html) | ||
| JP2011527686A5 (cg-RX-API-DMAC7.html) | ||
| RU2219179C2 (ru) | Азациклические соединения, фармацевтические композиции | |
| RU2007124545A (ru) | Производные [4-(гетероарил)пиперазин-1-ил]-(2,5-замещенный фенил)метанона в качестве ингибиторов переносчика глицина-1 (glyt-1) для лечения неврологических и психоневрологических заболеваний | |
| RU2000105266A (ru) | Производные 1-(n-фениламиноалкил)-пиперазина, замещенные в положении 2 фенильного кольца | |
| JP2002030084A5 (cg-RX-API-DMAC7.html) | ||
| JP2002505286A5 (cg-RX-API-DMAC7.html) | ||
| RU2005117374A (ru) | Индолы, полезные для лечения заболеваний, связанных с андрогеновыми рецепторами | |
| RU2006125748A (ru) | Ингибиторы сомт |