JP2007145875A5 - - Google Patents

Download PDF

Info

Publication number
JP2007145875A5
JP2007145875A5 JP2007069618A JP2007069618A JP2007145875A5 JP 2007145875 A5 JP2007145875 A5 JP 2007145875A5 JP 2007069618 A JP2007069618 A JP 2007069618A JP 2007069618 A JP2007069618 A JP 2007069618A JP 2007145875 A5 JP2007145875 A5 JP 2007145875A5
Authority
JP
Japan
Prior art keywords
compound
disease
group
pharmaceutical composition
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007069618A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007145875A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2007145875A publication Critical patent/JP2007145875A/ja
Publication of JP2007145875A5 publication Critical patent/JP2007145875A5/ja
Withdrawn legal-status Critical Current

Links

JP2007069618A 2000-05-26 2007-03-16 アデノシンa2aレセプターアンタゴニスト Withdrawn JP2007145875A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20714300P 2000-05-26 2000-05-26

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2002500877A Division JP4574112B2 (ja) 2000-05-26 2001-05-24 アデノシンa2aレセプターアンタゴニスト

Publications (2)

Publication Number Publication Date
JP2007145875A JP2007145875A (ja) 2007-06-14
JP2007145875A5 true JP2007145875A5 (US07794700-20100914-C00152.png) 2009-12-24

Family

ID=22769372

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002500877A Expired - Lifetime JP4574112B2 (ja) 2000-05-26 2001-05-24 アデノシンa2aレセプターアンタゴニスト
JP2006128415A Expired - Lifetime JP4938348B2 (ja) 2000-05-26 2006-05-02 アデノシンa2aレセプターアンタゴニスト
JP2007069618A Withdrawn JP2007145875A (ja) 2000-05-26 2007-03-16 アデノシンa2aレセプターアンタゴニスト

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2002500877A Expired - Lifetime JP4574112B2 (ja) 2000-05-26 2001-05-24 アデノシンa2aレセプターアンタゴニスト
JP2006128415A Expired - Lifetime JP4938348B2 (ja) 2000-05-26 2006-05-02 アデノシンa2aレセプターアンタゴニスト

Country Status (31)

Country Link
US (4) US6630475B2 (US07794700-20100914-C00152.png)
EP (1) EP1283839B1 (US07794700-20100914-C00152.png)
JP (3) JP4574112B2 (US07794700-20100914-C00152.png)
KR (1) KR100520907B1 (US07794700-20100914-C00152.png)
CN (2) CN100384847C (US07794700-20100914-C00152.png)
AR (1) AR028621A1 (US07794700-20100914-C00152.png)
AT (1) ATE293627T1 (US07794700-20100914-C00152.png)
AU (2) AU6808901A (US07794700-20100914-C00152.png)
BR (1) BRPI0111015B8 (US07794700-20100914-C00152.png)
CA (1) CA2410237C (US07794700-20100914-C00152.png)
CZ (1) CZ303790B6 (US07794700-20100914-C00152.png)
DE (1) DE60110219T2 (US07794700-20100914-C00152.png)
DK (1) DK1283839T3 (US07794700-20100914-C00152.png)
EC (1) ECSP024364A (US07794700-20100914-C00152.png)
ES (1) ES2237576T3 (US07794700-20100914-C00152.png)
HK (1) HK1049007B (US07794700-20100914-C00152.png)
HU (1) HU230420B1 (US07794700-20100914-C00152.png)
IL (3) IL152726A0 (US07794700-20100914-C00152.png)
MX (1) MXPA02011625A (US07794700-20100914-C00152.png)
MY (1) MY132006A (US07794700-20100914-C00152.png)
NO (1) NO325008B1 (US07794700-20100914-C00152.png)
NZ (1) NZ522326A (US07794700-20100914-C00152.png)
PE (1) PE20020062A1 (US07794700-20100914-C00152.png)
PL (1) PL218764B1 (US07794700-20100914-C00152.png)
PT (1) PT1283839E (US07794700-20100914-C00152.png)
RU (1) RU2315053C2 (US07794700-20100914-C00152.png)
SI (1) SI1283839T1 (US07794700-20100914-C00152.png)
SK (1) SK287748B6 (US07794700-20100914-C00152.png)
TW (1) TWI288137B (US07794700-20100914-C00152.png)
WO (1) WO2001092264A1 (US07794700-20100914-C00152.png)
ZA (1) ZA200208898B (US07794700-20100914-C00152.png)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2237576T3 (es) * 2000-05-26 2005-08-01 Schering Corporation Antagonistas del receptor a2a de adenosina.
JP2005516891A (ja) * 2001-09-13 2005-06-09 シェーリング コーポレイション アデノシンA2aレセプタアンタゴニストと抗鬱薬または抗不安薬との組合せ
PE20030477A1 (es) 2001-10-15 2003-06-06 Schering Corp ANTAGONISTAS DEL RECEPTOR DE ADENOSINA A2a
FR2832405B1 (fr) * 2001-11-19 2004-12-10 Sanofi Synthelabo Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant
PE20030739A1 (es) 2001-11-30 2003-08-28 Schering Corp Antagonistas del receptor de adenosina a2a
ATE358130T1 (de) 2001-11-30 2007-04-15 Schering Corp Bicyclische (1,2,4ö-triazol adenosin a2a rezeptor antagonisten
JP4284182B2 (ja) * 2001-11-30 2009-06-24 シェーリング コーポレイション アデノシンA2aレセプターアンタゴニスト
PT2942082T (pt) 2002-01-28 2019-06-06 Kyowa Hakko Kogyo Kk Antagonistas do recetor de a2a para utilização no tratamento de distúrbios de movimento
AU2003245380A1 (en) * 2002-05-30 2003-12-19 King Pharmaceuticals Research & Development, Inc. Pharmaceutically active compounds having a tricyclic pyrazolotriazolopyrimidine ring structure and methods of use
US20060106040A1 (en) * 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
ES2354875T3 (es) * 2002-12-19 2011-03-18 Schering Corporation Uso de antagonistas del receptor a2a de la adenosina para el tratamiento o prevención del síndrome extrapiramidal.
EP1618109A2 (en) 2003-04-09 2006-01-25 Biogen Idec MA Inc. Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists
TWI375677B (en) * 2003-04-23 2012-11-01 Schering Corp 2-alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine a2a receptor antagonists
MXPA05013148A (es) * 2003-06-10 2006-03-17 Kyowa Hakko Kogyo Kk Un metodo de tratamiento de un trastorno de la ansiedad.
JP2006527212A (ja) * 2003-06-12 2006-11-30 ノボ ノルディスク アクティーゼルスカブ ホルモン感受性リパーゼの阻害剤として使用するための、置換ピペラジンカルバメート
US7816353B2 (en) * 2003-10-24 2010-10-19 Exelixis, Inc. P70S6 kinase modulators and method of use
PL1678182T3 (pl) 2003-10-28 2007-05-31 Schering Corp Sposób wytwarzania podstawionych 5-aminopirazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pirymidyn
DE602004009962T2 (de) 2003-12-01 2008-08-28 Schering Corp. Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen
CN100528162C (zh) * 2003-12-19 2009-08-19 先灵公司 药物组合物
US7709492B2 (en) * 2004-04-21 2010-05-04 Schering Corporation Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
US7851478B2 (en) 2005-06-07 2010-12-14 Kyowa Hakko Kirin Co., Ltd. Agent for preventing and/or treating movement disorder
CN101312978A (zh) * 2005-09-19 2008-11-26 先灵公司 作为腺苷A2a受体拮抗剂的2-杂芳基-吡唑并-[4,3-e]-1,2,4-三唑并-[1,5-c]-嘧啶
AR056080A1 (es) * 2005-09-23 2007-09-19 Schering Corp 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
JP5539717B2 (ja) * 2006-07-14 2014-07-02 塩野義製薬株式会社 オキシム化合物およびその使用
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
US7691869B2 (en) 2007-03-30 2010-04-06 King Pharmaceuticals Research And Development, Inc. Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity
US8669260B2 (en) * 2008-02-29 2014-03-11 Albert Einstein College Of Medicine Of Yeshiva University Ketoconazole-derivative antagonist of human pregnane X receptor and uses thereof
EP2262811B1 (en) 2008-03-04 2016-04-27 Merck Sharp & Dohme Corp. 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e]-1,2,4-triazolo [4,3-c]pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists
US20110064671A1 (en) 2008-03-10 2011-03-17 Cornell University Modulation of blood brain barrier permeability
TWI473614B (zh) * 2008-05-29 2015-02-21 Kyowa Hakko Kirin Co Ltd Anti-analgesic inhibitors
NZ590793A (en) * 2008-07-23 2012-07-27 Kyowa Hakko Kirin Co Ltd Therapeutic agent for migraine
US20100093702A1 (en) * 2008-10-13 2010-04-15 Barbay J Kent METHYLENE AMINES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
US8273754B2 (en) 2008-12-30 2012-09-25 Arqule, Inc. Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds
MX2011007678A (es) 2009-01-20 2011-08-08 Schering Corp Metodos para aliviar o tratar señales y/o sintomas asociados con enfermedad de parkinson de moderada a severa.
EP2389362B1 (en) 2009-01-21 2019-12-11 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
BRPI1009398A2 (pt) 2009-03-13 2016-03-08 Advinus Therapeutics Private Ltd compostos de pirimidina fundida substituída
CA2756871A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted heterocyclic compounds
US8537177B2 (en) * 2009-06-15 2013-09-17 Marvell World Trade Ltd. System and methods for gamut bounded saturation adaptive color enhancement
WO2011017299A2 (en) 2009-08-07 2011-02-10 Schering Corporation PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE
KR101736218B1 (ko) 2009-09-25 2017-05-16 오리존 지노믹스 에스.에이. 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
WO2011106105A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
ES2607081T3 (es) 2010-04-19 2017-03-29 Oryzon Genomics, S.A. Inhibidores de desmetilasa específica de lisina-1 y su uso
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
HUE037937T2 (hu) 2010-07-29 2021-11-29 Oryzon Genomics Sa Arilciklopropilamin-alapú LSD1-demetiláz inhibitorok és gyógyászati alkalmazásuk
CA2812378C (en) * 2010-09-24 2016-11-29 Advinus Therapeutics Limited Fused tricyclic compounds as adenosine receptor antagonist
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
WO2012107498A1 (en) 2011-02-08 2012-08-16 Oryzon Genomics S.A. Lysine demethylase inhibitors for myeloproliferative disorders
WO2012127472A1 (en) * 2011-03-22 2012-09-27 Mapi Pharma Ltd. Process and intermediates for the preparation of preladenant and related compounds
WO2012129381A1 (en) * 2011-03-22 2012-09-27 Concert Pharmaceuticals Inc. Deuterated preladenant
WO2013024474A1 (en) * 2011-08-18 2013-02-21 Mapi Phrarma Ltd. Polymorphs of preladenant
EP2768805B1 (en) 2011-10-20 2020-03-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
PE20141692A1 (es) 2011-10-20 2014-11-08 Oryzon Genomics Sa Compuestos de (hetero) aril ciclopropilamina como inhibidores de lsd1
WO2014071512A1 (en) * 2012-11-06 2014-05-15 Universite Laval Combination therapy and methods for the treatment of respiratory diseases
WO2014101120A1 (en) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
US10472347B2 (en) 2014-11-18 2019-11-12 Merck Sharp & Dohme Corp. Aminopyrazine compounds with A2A antagonist properties
US10138212B2 (en) 2015-02-06 2018-11-27 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as A2A antagonist
EP3307067B1 (en) 2015-06-11 2022-11-02 Merck Sharp & Dohme LLC Aminopyrazine compounds with a2a antagonist properties
WO2017008205A1 (en) 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
US9687475B1 (en) 2016-03-24 2017-06-27 Ezra Pharma Llc Extended release pharmaceutical formulations with controlled impurity levels
US9675585B1 (en) 2016-03-24 2017-06-13 Ezra Pharma Extended release pharmaceutical formulations
CN115991679A (zh) * 2017-03-30 2023-04-21 伊忒欧斯比利时股份公司 作为a2a抑制剂的2-氧代噻唑衍生物和用于治疗癌症的化合物
WO2018178338A1 (en) * 2017-03-30 2018-10-04 Iteos Therapeutics 2-oxo-thiazole derivatives as a2a inhibitors and compounds for use in the treatment of cancers
WO2019118313A1 (en) 2017-12-13 2019-06-20 Merck Sharp & Dohme Corp. Imidazo [1,2-c] quinazolin-5-amine compounds with a2a antagonist properties
CA3087655A1 (en) * 2018-01-04 2019-07-11 Impetis Biosciences Ltd. Tricyclic compounds, compositions and medicinal applications thereof
CN112384515A (zh) 2018-02-27 2021-02-19 因赛特公司 作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶
CN108276345A (zh) * 2018-03-22 2018-07-13 重庆奥舍生物化工有限公司 一种药物中间体嘧啶-5-甲醛的制备方法
EA202092036A1 (ru) * 2018-04-08 2021-01-28 Бейджин, Лтд. Производные пиразолотриазолопиримидина в качестве антагониста рецептора a2a
JP7391046B2 (ja) 2018-05-18 2023-12-04 インサイト・コーポレイション A2a/a2b阻害剤としての縮合ピリミジン誘導体
CN108864114B (zh) * 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 选择性a2a受体拮抗剂
EP3818063A1 (en) 2018-07-05 2021-05-12 Incyte Corporation Fused pyrazine derivatives as a2a / a2b inhibitors
CN110742893B (zh) * 2018-07-23 2024-04-05 百济神州(北京)生物科技有限公司 A2a受体拮抗剂治疗癌症的方法
EA202191498A1 (ru) 2018-11-30 2021-08-20 Мерк Шарп энд Доум Корп. 9-замещенные производные аминотриазолохиназолина в качестве антагонистов аденозиновых рецепторов, фармацевтические композиции и их применение
MX2021007426A (es) 2018-12-20 2021-09-08 Incyte Corp Compuestos de imidazopiridazina e imidazopiridina como inhibidores de cinasa-2 de tipo receptor de activina.
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
WO2020227156A1 (en) * 2019-05-03 2020-11-12 Nektar Therapeutics Adenosine 2 receptor antagonists
DE102019116986A1 (de) 2019-06-24 2020-12-24 Helmholtz-Zentrum Dresden-Rossendorf E. V. Deuterierte 7-(3-(4-(2-([18F]Fluor)ethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amin-Derivate
CN114667287A (zh) * 2019-07-17 2022-06-24 泰昂治疗公司 腺苷a2a受体拮抗剂及其用途
CN112592354B (zh) 2019-07-30 2022-05-27 厦门宝太生物科技股份有限公司 一种异噁唑并嘧啶类杂环化合物的制备方法
CN112479956A (zh) 2019-07-30 2021-03-12 杭州阿诺生物医药科技有限公司 一种用于制备腺苷受体抑制剂中间体的方法
CN111072675A (zh) * 2019-12-12 2020-04-28 广东东阳光药业有限公司 含氮稠合三环衍生物及其用途
JP7431665B2 (ja) 2020-05-20 2024-02-15 Ykk Ap株式会社 接合構造および建具
CN113773327B (zh) * 2021-09-13 2022-07-15 八叶草健康产业研究院(厦门)有限公司 一种吡唑并嘧啶并三唑环类化合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU466232A1 (ru) * 1973-05-23 1975-04-05 Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко Споссоб получени конденсированных пиримидо- -триазиниевых соединений с мостиковыми атомами азота
EP0217748B1 (en) 1985-09-30 1991-02-06 Ciba-Geigy Ag 2-Substituted-e-fused-[1,2,4,]triazolo-[1,5-c]pyrimidines pharmaceutical compositions and uses thereof
SU1739850A3 (ru) * 1987-08-31 1992-06-07 Такеда Кемикал Индастриз, Лтд (Фирма) Способ получени конденсированных производных пиразоло[3,4- @ ]пиримидина
IT1264901B1 (it) * 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
CA2144330A1 (en) 1993-07-27 1995-02-09 Fumio Suzuki A therapeutic agent for parkinson's disease
IT1277392B1 (it) 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
IT1291372B1 (it) * 1997-05-21 1999-01-07 Schering Plough S P A Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
ES2237576T3 (es) * 2000-05-26 2005-08-01 Schering Corporation Antagonistas del receptor a2a de adenosina.
JP4284182B2 (ja) * 2001-11-30 2009-06-24 シェーリング コーポレイション アデノシンA2aレセプターアンタゴニスト
ES2354875T3 (es) * 2002-12-19 2011-03-18 Schering Corporation Uso de antagonistas del receptor a2a de la adenosina para el tratamiento o prevención del síndrome extrapiramidal.
PL1678182T3 (pl) * 2003-10-28 2007-05-31 Schering Corp Sposób wytwarzania podstawionych 5-aminopirazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pirymidyn
DE602004009962T2 (de) * 2003-12-01 2008-08-28 Schering Corp. Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen
US7709492B2 (en) * 2004-04-21 2010-05-04 Schering Corporation Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
CN101312978A (zh) * 2005-09-19 2008-11-26 先灵公司 作为腺苷A2a受体拮抗剂的2-杂芳基-吡唑并-[4,3-e]-1,2,4-三唑并-[1,5-c]-嘧啶

Similar Documents

Publication Publication Date Title
JP2007145875A5 (US07794700-20100914-C00152.png)
JP2013542247A5 (US07794700-20100914-C00152.png)
JP2008513510A5 (US07794700-20100914-C00152.png)
JP2009502743A5 (US07794700-20100914-C00152.png)
LU92602I2 (fr) Trametinib, optionnellement sous la forme d'un sel, hydrate ou solvate pharmaceutiquement acceptablede celui-ci
JP2009545527A5 (US07794700-20100914-C00152.png)
JP2013507439A5 (US07794700-20100914-C00152.png)
JP2004534850A5 (US07794700-20100914-C00152.png)
JP2013518107A5 (US07794700-20100914-C00152.png)
JP2010504343A5 (US07794700-20100914-C00152.png)
JP2009523760A5 (US07794700-20100914-C00152.png)
JP2009541443A5 (US07794700-20100914-C00152.png)
JP2013509429A5 (US07794700-20100914-C00152.png)
JP2010077141A5 (US07794700-20100914-C00152.png)
HRP20220902T3 (hr) Pripravci i njihova upotreba u liječenju multiple skleroze
JP2015501783A5 (US07794700-20100914-C00152.png)
EP2397476A3 (en) Indole derivative having PGD2 receptor antagonist activity
PL1735278T3 (pl) Związki receptora histaminowego H3, wytwarzanie i zastosowania terapeutyczne
JP2007537301A5 (US07794700-20100914-C00152.png)
EP2202222A3 (en) Indene derivatives, their preparation and use as medicaments
ATE457988T1 (de) A2a-adenosin-rezeptor-antagonisten
JP2006524660A5 (US07794700-20100914-C00152.png)
IL179599A0 (en) Glucagon receptor antagonists, preparation and therapeutic uses
JP2007302689A5 (US07794700-20100914-C00152.png)
JP2011527299A5 (US07794700-20100914-C00152.png)