MX2021007426A - Compuestos de imidazopiridazina e imidazopiridina como inhibidores de cinasa-2 de tipo receptor de activina. - Google Patents
Compuestos de imidazopiridazina e imidazopiridina como inhibidores de cinasa-2 de tipo receptor de activina.Info
- Publication number
- MX2021007426A MX2021007426A MX2021007426A MX2021007426A MX2021007426A MX 2021007426 A MX2021007426 A MX 2021007426A MX 2021007426 A MX2021007426 A MX 2021007426A MX 2021007426 A MX2021007426 A MX 2021007426A MX 2021007426 A MX2021007426 A MX 2021007426A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- imidazopyridazine
- kinase
- inhibitors
- activin receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Se describen compuestos de Fórmula (I), métodos para usarse los compuestos para inhibir la actividad de ALK2 y composiciones farmacéuticas que comprenden tales compuestos. Los compuestos son útiles para tratar, prevenir o mejorar enfermedades o trastornos asociados con la actividad de ALK2, como el cáncer (ver fórmula I).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862782994P | 2018-12-20 | 2018-12-20 | |
US201962935891P | 2019-11-15 | 2019-11-15 | |
PCT/US2019/067403 WO2020132197A1 (en) | 2018-12-20 | 2019-12-19 | Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021007426A true MX2021007426A (es) | 2021-09-08 |
Family
ID=69467674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007426A MX2021007426A (es) | 2018-12-20 | 2019-12-19 | Compuestos de imidazopiridazina e imidazopiridina como inhibidores de cinasa-2 de tipo receptor de activina. |
Country Status (20)
Country | Link |
---|---|
US (2) | US11459329B2 (es) |
EP (1) | EP3898627A1 (es) |
JP (2) | JP7414827B2 (es) |
KR (1) | KR20210116488A (es) |
CN (1) | CN114787160A (es) |
AU (1) | AU2019401649A1 (es) |
BR (1) | BR112021011948A2 (es) |
CA (1) | CA3124088A1 (es) |
CL (1) | CL2021001656A1 (es) |
CO (1) | CO2021008117A2 (es) |
CR (1) | CR20210336A (es) |
EC (1) | ECSP21044843A (es) |
IL (1) | IL284139A (es) |
MA (1) | MA54551A (es) |
MX (1) | MX2021007426A (es) |
PE (1) | PE20220277A1 (es) |
PH (1) | PH12021551446A1 (es) |
SG (1) | SG11202106582YA (es) |
TW (1) | TW202039502A (es) |
WO (1) | WO2020132197A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2019401649A1 (en) * | 2018-12-20 | 2021-07-08 | Incyte Corporation | Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2 |
AU2021288107A1 (en) | 2020-06-12 | 2022-12-15 | Incyte Corporation | Imidazopyridazine compounds with activity as ALK2 inhibitors |
WO2023066204A1 (zh) * | 2021-10-18 | 2023-04-27 | 上海美悦生物科技发展有限公司 | Sik抑制剂及其组合物、制备方法和用途 |
Family Cites Families (32)
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CN1321628C (zh) | 2000-06-28 | 2007-06-20 | 史密斯克莱·比奇曼公司 | 湿磨方法 |
JP2005343889A (ja) | 2004-05-06 | 2005-12-15 | Taisho Pharmaceut Co Ltd | イミダゾピリジン誘導体 |
US7528138B2 (en) | 2004-11-04 | 2009-05-05 | Vertex Pharmaceuticals Incorporated | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases |
JP5572388B2 (ja) * | 2006-11-22 | 2014-08-13 | インサイト・コーポレイション | キナーゼ阻害剤としてのイミダゾトリアジンおよびイミダゾピリミジン |
AU2008280135B2 (en) | 2007-07-26 | 2012-02-23 | Novartis Ag | Organic compounds |
CA2703037A1 (en) | 2007-10-17 | 2009-04-23 | Novartis Ag | Organic compounds |
WO2011008640A1 (en) | 2009-07-14 | 2011-01-20 | Beth Israel Deaconess Medical Center, Inc. | Methods of increasing liver proliferation |
CA2806655A1 (en) * | 2010-07-28 | 2012-02-02 | Bayer Intellectual Property Gmbh | Substituted imidazo[1,2-b]pyridazines |
US9738636B2 (en) | 2012-09-28 | 2017-08-22 | Vanderbilt University | Fused heterocyclic compounds as selective BMP inhibitors |
KR20150081354A (ko) | 2012-11-07 | 2015-07-13 | 에프. 호프만-라 로슈 아게 | 트라이아졸로 화합물 |
JP6542192B2 (ja) | 2013-03-14 | 2019-07-10 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | Bmp阻害剤およびその使用方法 |
WO2017070089A1 (en) | 2015-10-19 | 2017-04-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
EP4141002A1 (en) | 2015-11-19 | 2023-03-01 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
MA44075A (fr) | 2015-12-17 | 2021-05-19 | Incyte Corp | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1 |
PL3394033T3 (pl) | 2015-12-22 | 2021-05-31 | Incyte Corporation | Związki heterocykliczne jako immunomodulatory |
TW201808950A (zh) | 2016-05-06 | 2018-03-16 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
MA45116A (fr) | 2016-05-26 | 2021-06-02 | Incyte Corp | Composés hétérocycliques comme immunomodulateurs |
MX2018016273A (es) | 2016-06-20 | 2019-07-04 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores. |
EP3484866B1 (en) | 2016-07-14 | 2022-09-07 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
LT3500571T (lt) | 2016-08-17 | 2021-04-12 | Children`S Hospital Medical Center | Imidazo[1,2-a]piridino junginiai, juos apimančios kompozicijos, ligų gydymo būdai juos panaudojant, ir jų paruošimo būdai |
MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
EP3512834A4 (en) | 2016-09-14 | 2020-05-06 | Vanderbilt University | INHIBIT OF BMP SIGNALING, CONNECTIONS, COMPOSITIONS AND USES THEREOF |
WO2018119286A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
WO2018119263A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds derivatives as pd-l1 internalization inducers |
ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
MD3558990T2 (ro) | 2016-12-22 | 2023-02-28 | Incyte Corp | Derivați tetrahidro imidazo[4,5-c]piridină ca inductori de internalizare a PD-L1 |
CN110582493B (zh) | 2016-12-22 | 2024-03-08 | 因赛特公司 | 作为免疫调节剂的苯并噁唑衍生物 |
EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
JP2020511424A (ja) | 2017-01-18 | 2020-04-16 | ヴァンダービルト ユニバーシティーVanderbilt University | 選択的bmp阻害としての縮合複素環式化合物 |
WO2018165569A1 (en) | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Therapeutic compounds and methods |
MX2019010302A (es) | 2017-03-30 | 2019-11-21 | Hoffmann La Roche | Isoquinolinas como inhibidores de hpk1. |
AU2019401649A1 (en) | 2018-12-20 | 2021-07-08 | Incyte Corporation | Imidazopyridazine and imidazopyridine compounds as inhibitors of activin receptor-like kinase-2 |
-
2019
- 2019-12-19 AU AU2019401649A patent/AU2019401649A1/en active Pending
- 2019-12-19 PE PE2021001046A patent/PE20220277A1/es unknown
- 2019-12-19 TW TW108146732A patent/TW202039502A/zh unknown
- 2019-12-19 JP JP2021535854A patent/JP7414827B2/ja active Active
- 2019-12-19 KR KR1020217022783A patent/KR20210116488A/ko unknown
- 2019-12-19 MX MX2021007426A patent/MX2021007426A/es unknown
- 2019-12-19 SG SG11202106582YA patent/SG11202106582YA/en unknown
- 2019-12-19 CN CN201980092367.1A patent/CN114787160A/zh active Pending
- 2019-12-19 BR BR112021011948-5A patent/BR112021011948A2/pt unknown
- 2019-12-19 MA MA054551A patent/MA54551A/fr unknown
- 2019-12-19 US US16/720,935 patent/US11459329B2/en active Active
- 2019-12-19 EP EP19848840.5A patent/EP3898627A1/en active Pending
- 2019-12-19 CA CA3124088A patent/CA3124088A1/en active Pending
- 2019-12-19 CR CR20210336A patent/CR20210336A/es unknown
- 2019-12-19 WO PCT/US2019/067403 patent/WO2020132197A1/en unknown
-
2021
- 2021-06-17 IL IL284139A patent/IL284139A/en unknown
- 2021-06-18 CL CL2021001656A patent/CL2021001656A1/es unknown
- 2021-06-18 PH PH12021551446A patent/PH12021551446A1/en unknown
- 2021-06-21 EC ECSENADI202144843A patent/ECSP21044843A/es unknown
- 2021-06-21 CO CONC2021/0008117A patent/CO2021008117A2/es unknown
-
2022
- 2022-06-09 US US17/836,602 patent/US20220315595A1/en active Pending
-
2023
- 2023-12-28 JP JP2023222944A patent/JP2024045155A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022514650A (ja) | 2022-02-14 |
BR112021011948A2 (pt) | 2021-09-08 |
WO2020132197A1 (en) | 2020-06-25 |
SG11202106582YA (en) | 2021-07-29 |
JP2024045155A (ja) | 2024-04-02 |
CR20210336A (es) | 2021-12-06 |
AU2019401649A1 (en) | 2021-07-08 |
JP7414827B2 (ja) | 2024-01-16 |
CO2021008117A2 (es) | 2021-09-20 |
US11459329B2 (en) | 2022-10-04 |
CN114787160A (zh) | 2022-07-22 |
MA54551A (fr) | 2021-10-27 |
US20220315595A1 (en) | 2022-10-06 |
US20200199131A1 (en) | 2020-06-25 |
PE20220277A1 (es) | 2022-02-25 |
CA3124088A1 (en) | 2020-06-25 |
EP3898627A1 (en) | 2021-10-27 |
IL284139A (en) | 2021-08-31 |
TW202039502A (zh) | 2020-11-01 |
KR20210116488A (ko) | 2021-09-27 |
ECSP21044843A (es) | 2021-09-30 |
CL2021001656A1 (es) | 2021-12-17 |
PH12021551446A1 (en) | 2021-12-06 |
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