|
HU228769B1
(en)
*
|
1996-07-24 |
2013-05-28 |
Celgene Corp |
Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
|
|
US7629360B2
(en)
*
|
1999-05-07 |
2009-12-08 |
Celgene Corporation |
Methods for the treatment of cachexia and graft v. host disease
|
|
US6458810B1
(en)
|
2000-11-14 |
2002-10-01 |
George Muller |
Pharmaceutically active isoindoline derivatives
|
|
ATE374609T1
(de)
|
2000-11-30 |
2007-10-15 |
Childrens Medical Center |
Synthese von 4-aminothalidomid enantiomeren
|
|
US7091353B2
(en)
*
|
2000-12-27 |
2006-08-15 |
Celgene Corporation |
Isoindole-imide compounds, compositions, and uses thereof
|
|
US7498171B2
(en)
|
2002-04-12 |
2009-03-03 |
Anthrogenesis Corporation |
Modulation of stem and progenitor cell differentiation, assays, and uses thereof
|
|
US7393862B2
(en)
|
2002-05-17 |
2008-07-01 |
Celgene Corporation |
Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
|
|
US7968569B2
(en)
*
|
2002-05-17 |
2011-06-28 |
Celgene Corporation |
Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
|
US7323479B2
(en)
*
|
2002-05-17 |
2008-01-29 |
Celgene Corporation |
Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
|
|
USRE48890E1
(en)
|
2002-05-17 |
2022-01-11 |
Celgene Corporation |
Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
|
|
DE60332358D1
(de)
*
|
2002-09-09 |
2010-06-10 |
Hanall Pharmaceutical Co Ltd |
Protease-resistente modifizierte interferon alpha polypeptide
|
|
US8404716B2
(en)
*
|
2002-10-15 |
2013-03-26 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
|
US7189740B2
(en)
|
2002-10-15 |
2007-03-13 |
Celgene Corporation |
Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
|
|
US11116782B2
(en)
|
2002-10-15 |
2021-09-14 |
Celgene Corporation |
Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
|
|
US7563810B2
(en)
|
2002-11-06 |
2009-07-21 |
Celgene Corporation |
Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
|
|
US6943249B2
(en)
|
2003-03-17 |
2005-09-13 |
Ash Stevens, Inc. |
Methods for isolating crystalline Form I of 5-azacytidine
|
|
US6887855B2
(en)
|
2003-03-17 |
2005-05-03 |
Pharmion Corporation |
Forms of 5-azacytidine
|
|
US7825136B2
(en)
*
|
2003-07-10 |
2010-11-02 |
Vertex Pharmaceuticals Incorporated |
Potentiators of antibacterial activity
|
|
UA83504C2
(en)
|
2003-09-04 |
2008-07-25 |
Селджин Корпорейшн |
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
|
US20050100529A1
(en)
*
|
2003-11-06 |
2005-05-12 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
|
|
KR20060109979A
(ko)
*
|
2003-12-02 |
2006-10-23 |
셀진 코포레이션 |
혈색소병증 및 빈혈의 치료 및 관리를 위한 방법및 조성물
|
|
US20050143344A1
(en)
*
|
2003-12-30 |
2005-06-30 |
Zeldis Jerome B. |
Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
|
|
CA2560221C
(en)
*
|
2004-03-22 |
2010-12-07 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of skin diseases or disorders
|
|
US20050222209A1
(en)
*
|
2004-04-01 |
2005-10-06 |
Zeldis Jerome B |
Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
|
|
AU2004319758A1
(en)
*
|
2004-04-14 |
2005-11-24 |
Celgene Corporation |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes
|
|
US20050239842A1
(en)
*
|
2004-04-23 |
2005-10-27 |
Zeldis Jerome B |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of pulmonary hypertension
|
|
JP2007536223A
(ja)
*
|
2004-05-05 |
2007-12-13 |
セルジーン・コーポレーション |
骨髄増殖性疾患の治療及び管理のための免疫調節化合物を含む組成物、及びその使用方法
|
|
EP1797068B1
(en)
*
|
2004-09-03 |
2013-10-09 |
Celgene Corporation |
Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines
|
|
ZA200704890B
(en)
*
|
2004-11-23 |
2008-09-25 |
Celgene Corp |
Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
|
|
MX2007016290A
(es)
|
2005-06-30 |
2008-03-10 |
Celgene Corp |
Procesos para la preparacion de compuestos de 4-amino-2(2,6-dioxopiperidin-3-il)isoindolin-1,3-diona.
|
|
US20070066512A1
(en)
*
|
2005-09-12 |
2007-03-22 |
Dominique Verhelle |
Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
|
|
MY171061A
(en)
*
|
2005-11-09 |
2019-09-24 |
Onyx Therapeutics Inc |
Compounds for enzyme inhibition
|
|
CA2633980A1
(en)
*
|
2005-12-29 |
2007-07-12 |
Anthrogenesis Corporation |
Improved composition for collecting and preserving placental stem cells and methods of using the composition
|
|
US20080064876A1
(en)
*
|
2006-05-16 |
2008-03-13 |
Muller George W |
Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
|
|
CA2657213C
(en)
|
2006-06-19 |
2017-01-03 |
Proteolix, Inc. |
Peptide epoxyketones for proteasome inhibition
|
|
US8877780B2
(en)
|
2006-08-30 |
2014-11-04 |
Celgene Corporation |
5-substituted isoindoline compounds
|
|
ME02420B
(me)
|
2006-09-26 |
2016-09-20 |
Celgene Corp |
5-supstituirani derivati kinazolinona kao sredstva protiv raka
|
|
AP2009004834A0
(en)
*
|
2006-10-19 |
2009-04-30 |
Celgene Corp |
Methods and compositions using immunomodulatory c ompounds for the treatment and management of spirochete and other obligate intracellular bacterial diseases
|
|
CA2704710C
(en)
|
2007-09-26 |
2016-02-02 |
Celgene Corporation |
6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising the same
|
|
KR20170125413A
(ko)
|
2007-10-04 |
2017-11-14 |
오닉스 세라퓨틱스, 인크. |
결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성
|
|
EP2211870A1
(en)
*
|
2007-11-01 |
2010-08-04 |
Celgene Corporation |
Cytidine analogs for treatment of myelodysplastic syndromes
|
|
JP2011510983A
(ja)
*
|
2008-01-29 |
2011-04-07 |
セルジーン コーポレイション |
Cd59のレベルを調節するための、免疫調節化合物を使用する方法
|
|
US20090298882A1
(en)
*
|
2008-05-13 |
2009-12-03 |
Muller George W |
Thioxoisoindoline compounds and compositions comprising and methods of using the same
|
|
PL3692983T3
(pl)
|
2008-05-15 |
2021-12-27 |
Celgene Corporation |
Doustne formulacje analogów cytydyny i sposoby ich zastosowania
|
|
EP3090737A1
(en)
|
2008-10-21 |
2016-11-09 |
Onyx Therapeutics, Inc. |
Combination therapy with peptide epoxyketones
|
|
US8110578B2
(en)
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
|
PT2358697E
(pt)
|
2008-10-29 |
2016-02-03 |
Celgene Corp |
Compostos de isoindolina para utilização no tratamento do cancro
|
|
US20120046315A1
(en)
*
|
2008-11-14 |
2012-02-23 |
Katrin Rimkus |
Intermediate and oral administrative formats containing lenalidomide
|
|
EP2367553B1
(en)
|
2008-12-05 |
2017-05-03 |
Novo Nordisk A/S |
Combination therapy to enhance nk cell mediated cytotoxicity
|
|
US20120053159A1
(en)
|
2009-02-11 |
2012-03-01 |
Muller George W |
Isotopologues of lenalidomide
|
|
TWI504598B
(zh)
|
2009-03-20 |
2015-10-21 |
Onyx Therapeutics Inc |
結晶性三肽環氧酮蛋白酶抑制劑
|
|
BRPI1007855B1
(pt)
|
2009-05-19 |
2020-03-10 |
Celgene Corporation |
Formas de dosagem oral compreendendo 4-amino-2-(2,6-dioxopiperidina-3-il)isoindolina-1,3-diona
|
|
EP2436387B1
(en)
|
2009-05-25 |
2018-07-25 |
Celgene Corporation |
Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex
|
|
CN101696205B
(zh)
|
2009-11-02 |
2011-10-19 |
南京卡文迪许生物工程技术有限公司 |
3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
|
|
US8853147B2
(en)
|
2009-11-13 |
2014-10-07 |
Onyx Therapeutics, Inc. |
Use of peptide epoxyketones for metastasis suppression
|
|
BR112012015129A2
(pt)
|
2009-12-22 |
2019-09-24 |
Celgene Corp |
"composto, composição farmacêutica e método para tratar, controlar ou prevenir uma doença ou distúrbio"
|
|
PL3202460T3
(pl)
|
2010-02-11 |
2019-12-31 |
Celgene Corporation |
Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania
|
|
EP2542238B1
(en)
|
2010-03-01 |
2015-08-12 |
Onyx Therapeutics, Inc. |
Compounds for immunoproteasome inhibition
|
|
NZ602872A
(en)
|
2010-04-07 |
2014-05-30 |
Onyx Therapeutics Inc |
Crystalline peptide epoxyketone immunoproteasome inhibitor
|
|
LT2556145T
(lt)
|
2010-04-07 |
2016-11-10 |
Anthrogenesis Corporation |
Angiogenezė naudojant placentos kamienines ląsteles
|
|
US20110301199A1
(en)
*
|
2010-06-07 |
2011-12-08 |
Telik, Inc. |
Compositions and methods for treating myelodysplastic syndrome
|
|
US8759303B2
(en)
|
2010-06-07 |
2014-06-24 |
Telik, Inc. |
Compositions and methods for treating myelodysplastic syndrome
|
|
WO2011160042A2
(en)
|
2010-06-18 |
2011-12-22 |
Makoto Life Sciences, Inc. |
Prpk-tprkb modulators and uses thereof
|
|
US8969315B2
(en)
|
2010-12-31 |
2015-03-03 |
Anthrogenesis Corporation |
Enhancement of placental stem cell potency using modulatory RNA molecules
|
|
EP2663549B1
(en)
|
2011-01-10 |
2018-03-14 |
Celgene Corporation |
Phenethylsulfone isoindoline derivatives as inhibitors of pde 4 and/or cytokines
|
|
JP2014503597A
(ja)
|
2011-01-31 |
2014-02-13 |
セルジーン コーポレイション |
シチジンアナログの医薬組成物及びその使用方法
|
|
DK2683708T3
(da)
|
2011-03-11 |
2018-01-29 |
Celgene Corp |
Faste former af 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidin-2,6-dion og farmaceutiske sammensætninger og anvendelser deraf
|
|
EP2699091B1
(en)
|
2011-03-28 |
2017-06-21 |
DeuteRx, LLC |
2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
|
|
CN103619864A
(zh)
|
2011-03-31 |
2014-03-05 |
细胞基因国际有限公司 |
5-氮杂胞苷的合成
|
|
AU2012249491B2
(en)
|
2011-04-29 |
2016-12-15 |
Celgene Corporation |
Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
|
|
JP6104896B2
(ja)
|
2011-06-01 |
2017-03-29 |
アントフロゲネシス コーポレーション |
胎盤幹細胞を使用する疼痛の治療
|
|
US20140221427A1
(en)
|
2011-06-22 |
2014-08-07 |
Celgene Corporation |
Isotopologues of pomalidomide
|
|
WO2013022872A1
(en)
|
2011-08-10 |
2013-02-14 |
Celgene Corporation |
Gene methylation biomarkers and methods of use thereof
|
|
RU2627471C2
(ru)
|
2011-09-14 |
2017-08-08 |
Селджин Корпорейшн |
Препараты { 2-[(1s)-1-(3-этокси-4-метоксифенил)-2-метансульфонилэтил]-3-оксо-2,3-дигидро-1h-изоиндол-4-ил} амида циклопропанкарбоновой кислоты
|
|
RS60415B1
(sr)
|
2011-12-27 |
2020-07-31 |
Amgen (Europe) GmbH |
Formulacije (+)-2-[1-(3-etoksi-4-metoksi-fenil)-2-metansulfonil-etil]-4-acetil aminoizoindolin-1,3-diona
|
|
WO2013126394A1
(en)
|
2012-02-21 |
2013-08-29 |
Celgene Corporation |
Solid forms of 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
|
|
ES2872967T3
(es)
|
2012-06-29 |
2021-11-03 |
Celgene Corp |
Métodos para determinar la eficacia de fármacos usando IKZF3 (AIOLOS)
|
|
US20140105921A1
(en)
|
2012-07-09 |
2014-04-17 |
Onyx Therapeutics, Inc. |
Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
|
|
ES2885769T3
(es)
|
2012-08-09 |
2021-12-15 |
Celgene Corp |
Una forma sólida de clorhidrato de (s)-3-(4-((4-morpholinometil)bencil)oxi)-1-oxoisoindolin-2-il)piperidina-2,6-diona
|
|
US9587281B2
(en)
|
2012-08-14 |
2017-03-07 |
Celgene Corporation |
Cereblon isoforms and their use as biomarkers for therapeutic treatment
|
|
AU2013353573B2
(en)
*
|
2012-12-06 |
2019-01-17 |
Enlivex Therapeutics R&D Ltd |
Therapeutic apoptotic cell preparations, method for producing same and uses thereof
|
|
JP6359563B2
(ja)
|
2013-01-14 |
2018-07-18 |
デュートルクス・リミテッド・ライアビリティ・カンパニーDeuteRx, LLC |
3−(5置換−4−オキソキナゾリン−3(4h)−イル)−3−ジュウテロピペリジン−2,6−ジオン誘導体
|
|
WO2014116573A1
(en)
|
2013-01-22 |
2014-07-31 |
Celgene Corporation |
Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
|
|
EP2764866A1
(en)
|
2013-02-07 |
2014-08-13 |
IP Gesellschaft für Management mbH |
Inhibitors of nedd8-activating enzyme
|
|
CA2941560A1
(en)
|
2013-03-14 |
2014-09-25 |
Deuterx, Llc |
3-(substituted-4-oxo-quinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
|
|
BR112015025252A2
(pt)
|
2013-04-02 |
2017-07-18 |
Celgene Corp |
métodos e composições usando 4-amino-2-(2,6-dioxo-piperidina-3-il)-isoindolina-1,3-diona para tratamento e gestão de cânceres de sistema nervoso central
|
|
EP2983661B1
(en)
|
2013-04-09 |
2024-05-29 |
Lixte Biotechnology, Inc. |
Formulations of oxabicycloheptanes and oxabicycloheptenes
|
|
EP2815749A1
(en)
|
2013-06-20 |
2014-12-24 |
IP Gesellschaft für Management mbH |
Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
|
|
UA117141C2
(uk)
|
2013-10-08 |
2018-06-25 |
Селджин Корпорейшн |
Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону
|
|
TW201540323A
(zh)
|
2014-01-15 |
2015-11-01 |
Celgene Corp |
3-(5-胺基-2-甲基-4-側氧基-4h-喹唑啉-3-基)-哌啶-2,6-二酮之調配物
|
|
AU2015210999A1
(en)
|
2014-01-29 |
2016-07-21 |
Otsuka Pharmaceutical Co., Ltd. |
Device-based risk management of a therapeutic
|
|
EP3827836A1
(en)
|
2014-06-27 |
2021-06-02 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
|
|
US10071094B2
(en)
|
2014-07-24 |
2018-09-11 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Protein phosphatase 2A inhibitors for treating myelodysplastic syndromes
|
|
AU2015305449B2
(en)
|
2014-08-22 |
2021-05-06 |
Celgene Corporation |
Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
|
|
WO2016105518A1
(en)
|
2014-12-23 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
US10488411B2
(en)
*
|
2015-05-01 |
2019-11-26 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Inflammasome activation in myelodysplastic syndromes
|
|
WO2017007612A1
(en)
|
2015-07-07 |
2017-01-12 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
SMT202100712T1
(it)
|
2015-08-17 |
2022-01-10 |
Kura Oncology Inc |
Metodi di trattamento di pazienti di cancro con inibitori di farnesil trasferasi
|
|
US9809603B1
(en)
|
2015-08-18 |
2017-11-07 |
Deuterx, Llc |
Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
|
|
WO2017117118A1
(en)
|
2015-12-28 |
2017-07-06 |
Celgene Corporation |
Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
|
|
US10245258B2
(en)
|
2016-06-06 |
2019-04-02 |
Celgene Corporation |
Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
|
|
WO2018013689A1
(en)
|
2016-07-13 |
2018-01-18 |
Celgene Corporation |
Solid dispersions and solid forms comprising 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, method of preparation and use thereof
|
|
EP3493809B1
(en)
*
|
2016-08-03 |
2023-08-23 |
Celgene Corporation |
Enasidenib for treatment of myelodysplastic syndrome
|
|
MX2019006694A
(es)
|
2016-12-08 |
2019-08-21 |
Lixte Biotechnology Inc |
Oxabicicloheptanos para la modulacion de la respuesta inmunitaria.
|
|
ES2914123T3
(es)
|
2017-01-09 |
2022-06-07 |
Shuttle Pharmaceuticals Inc |
Inhibidores selectivos de la histona desacetilasa para el tratamiento de una enfermedad humana
|
|
US11584733B2
(en)
|
2017-01-09 |
2023-02-21 |
Shuttle Pharmaceuticals, Inc. |
Selective histone deacetylase inhibitors for the treatment of human disease
|
|
US10093647B1
(en)
|
2017-05-26 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate, compositions and methods of use thereof
|
|
US10093648B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof
|
|
US10093649B1
(en)
|
2017-09-22 |
2018-10-09 |
Celgene Corporation |
Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione monohydrate, compositions and methods of use thereof
|
|
WO2019113269A1
(en)
|
2017-12-08 |
2019-06-13 |
Kura Oncology, Inc. |
Methods of treating cancer patients with farnesyltransferase inhibitors
|
|
US10537585B2
(en)
|
2017-12-18 |
2020-01-21 |
Dexcel Pharma Technologies Ltd. |
Compositions comprising dexamethasone
|
|
CN112004537A
(zh)
|
2018-01-09 |
2020-11-27 |
穿梭药业公司 |
用于治疗人疾病的选择性组蛋白去乙酰化酶抑制剂
|
|
EP3773576A4
(en)
|
2018-03-26 |
2021-12-29 |
C4 Therapeutics, Inc. |
Cereblon binders for the degradation of ikaros
|
|
US20220143006A1
(en)
|
2019-03-15 |
2022-05-12 |
Kura Oncology, Inc. |
Methods of treating cancer with farnesyltransferase inhibitors
|
|
CN116887844A
(zh)
*
|
2021-01-18 |
2023-10-13 |
活跃生物技术有限公司 |
用于治疗骨髓增生异常综合征的他喹莫德或其药学上可接受的盐
|
|
ES3057099T3
(en)
*
|
2021-01-18 |
2026-02-26 |
Active Biotech Ab |
Tasquinimod or a pharmaceutically acceptable salt thereof for use in the treatment of myelodysplastic syndrome
|