JP2013526525A5 - - Google Patents
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- JP2013526525A5 JP2013526525A5 JP2013510219A JP2013510219A JP2013526525A5 JP 2013526525 A5 JP2013526525 A5 JP 2013526525A5 JP 2013510219 A JP2013510219 A JP 2013510219A JP 2013510219 A JP2013510219 A JP 2013510219A JP 2013526525 A5 JP2013526525 A5 JP 2013526525A5
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- Prior art keywords
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- pharmaceutical composition
- composition according
- isoindol
- dione
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 45
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 15
- NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 claims 12
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 12
- 229960002756 azacitidine Drugs 0.000 claims 12
- 239000013543 active substance Substances 0.000 claims 10
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 6
- 208000009527 Refractory anemia Diseases 0.000 claims 6
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims 4
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 4
- 229960005280 isotretinoin Drugs 0.000 claims 4
- 108010008165 Etanercept Proteins 0.000 claims 3
- 229960000403 etanercept Drugs 0.000 claims 3
- 229960003297 gemtuzumab ozogamicin Drugs 0.000 claims 3
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108010092408 Eosinophil Peroxidase Proteins 0.000 claims 2
- 102100028471 Eosinophil peroxidase Human genes 0.000 claims 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 102000003810 Interleukin-18 Human genes 0.000 claims 2
- 108090000171 Interleukin-18 Proteins 0.000 claims 2
- 108010002386 Interleukin-3 Proteins 0.000 claims 2
- 102100039064 Interleukin-3 Human genes 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 2
- 208000033833 Myelomonocytic Chronic Leukemia Diseases 0.000 claims 2
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims 2
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 201000010902 chronic myelomonocytic leukemia Diseases 0.000 claims 2
- 229960003405 ciprofloxacin Drugs 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000011132 hemopoiesis Effects 0.000 claims 2
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 2
- 229960002411 imatinib Drugs 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 229960000598 infliximab Drugs 0.000 claims 2
- 229960004768 irinotecan Drugs 0.000 claims 2
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 2
- 229960001476 pentoxifylline Drugs 0.000 claims 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
- 239000003207 proteasome inhibitor Substances 0.000 claims 2
- 229960000303 topotecan Drugs 0.000 claims 2
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 2
- 229960003048 vinblastine Drugs 0.000 claims 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 2
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 2
- 229960002066 vinorelbine Drugs 0.000 claims 2
- -1 4-amino-1-oxo-1,3-dihydro-isoindol-2-yl Chemical group 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 210000001167 myeloblast Anatomy 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/777,765 US8404716B2 (en) | 2002-10-15 | 2010-05-11 | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US12/777,765 | 2010-05-11 | ||
| PCT/US2011/035822 WO2011143147A1 (en) | 2010-05-11 | 2011-05-10 | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013526525A JP2013526525A (ja) | 2013-06-24 |
| JP2013526525A5 true JP2013526525A5 (https=) | 2014-04-17 |
Family
ID=44314968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510219A Pending JP2013526525A (ja) | 2010-05-11 | 2011-05-10 | レナリドミド及びアザシチジン併用療法による骨髄異形成症候群の治療方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US8404716B2 (https=) |
| EP (2) | EP3219317A1 (https=) |
| JP (1) | JP2013526525A (https=) |
| CN (1) | CN103025330A (https=) |
| AU (1) | AU2011253161B2 (https=) |
| WO (1) | WO2011143147A1 (https=) |
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| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
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-
2010
- 2010-05-11 US US12/777,765 patent/US8404716B2/en not_active Expired - Fee Related
-
2011
- 2011-05-10 EP EP17154180.8A patent/EP3219317A1/en not_active Withdrawn
- 2011-05-10 AU AU2011253161A patent/AU2011253161B2/en active Active
- 2011-05-10 CN CN2011800341566A patent/CN103025330A/zh active Pending
- 2011-05-10 WO PCT/US2011/035822 patent/WO2011143147A1/en not_active Ceased
- 2011-05-10 EP EP11731546A patent/EP2568983A1/en not_active Withdrawn
- 2011-05-10 JP JP2013510219A patent/JP2013526525A/ja active Pending
-
2013
- 2013-03-13 US US13/801,262 patent/US9056120B2/en not_active Expired - Lifetime
-
2014
- 2014-10-17 US US14/517,280 patent/US9925207B2/en not_active Expired - Lifetime
-
2018
- 2018-03-20 US US15/926,740 patent/US20180207185A1/en not_active Abandoned
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