JP2006528621A5 - - Google Patents
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- Publication number
- JP2006528621A5 JP2006528621A5 JP2006520928A JP2006520928A JP2006528621A5 JP 2006528621 A5 JP2006528621 A5 JP 2006528621A5 JP 2006520928 A JP2006520928 A JP 2006520928A JP 2006520928 A JP2006520928 A JP 2006520928A JP 2006528621 A5 JP2006528621 A5 JP 2006528621A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- nhch
- cycloalkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49001203P | 2003-07-24 | 2003-07-24 | |
| US60/490,012 | 2003-07-24 | ||
| PCT/IB2004/002355 WO2005009975A2 (en) | 2003-07-24 | 2004-07-12 | Benzimidazole derivatives as mek inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006528621A JP2006528621A (ja) | 2006-12-21 |
| JP2006528621A5 true JP2006528621A5 (enExample) | 2007-08-30 |
| JP4896717B2 JP4896717B2 (ja) | 2012-03-14 |
Family
ID=34102957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520928A Expired - Fee Related JP4896717B2 (ja) | 2003-07-24 | 2004-07-12 | Ｎ−メチル−置換ベンゾアミダゾール |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7160915B2 (enExample) |
| EP (1) | EP1651214B1 (enExample) |
| JP (1) | JP4896717B2 (enExample) |
| AT (1) | ATE442847T1 (enExample) |
| BR (1) | BRPI0412851A (enExample) |
| CA (1) | CA2532067C (enExample) |
| DE (1) | DE602004023207D1 (enExample) |
| ES (1) | ES2331246T3 (enExample) |
| MX (1) | MXPA06000921A (enExample) |
| WO (1) | WO2005009975A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| DE60330227D1 (de) | 2002-03-13 | 2010-01-07 | Array Biopharma Inc | N3-alkylierte benzimidazol-derivate als mek-hemmer |
| US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| CN101247806B (zh) | 2005-06-23 | 2012-05-16 | 阵列生物制药公司 | 用于制备苯并咪唑化合物的SNAr方法 |
| ES2567133T3 (es) * | 2005-06-23 | 2016-04-20 | Array Biopharma, Inc. | Proceso para preparar compuestos de benzoimidazol |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| WO2007025090A2 (en) * | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase |
| DE602006021205D1 (de) | 2005-10-07 | 2011-05-19 | Exelixis Inc | Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen |
| GB0601962D0 (en) | 2006-01-31 | 2006-03-15 | Ucb Sa | Therapeutic agents |
| JP5311673B2 (ja) | 2006-12-14 | 2013-10-09 | エグゼリクシス， インコーポレイテッド | Ｍｅｋ阻害剤の使用方法 |
| JO2985B1 (ar) | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
| GB0714384D0 (en) | 2007-07-23 | 2007-09-05 | Ucb Pharma Sa | theraputic agents |
| US7557221B2 (en) | 2007-08-16 | 2009-07-07 | Hoffman-La Roche Inc. | Substituted hydantoins |
| WO2009037705A2 (en) * | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation |
| US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
| CA2705452C (en) | 2007-11-12 | 2016-05-31 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors |
| MX2010006331A (es) | 2007-12-20 | 2010-07-05 | Hoffmann La Roche | Hidantoinas sustituidas como inhibidores de cinasa mek. |
| EP2240494B1 (en) | 2008-01-21 | 2016-03-30 | UCB Biopharma SPRL | Thieno-pyridine derivatives as mek inhibitors |
| GB0811304D0 (en) | 2008-06-19 | 2008-07-30 | Ucb Pharma Sa | Therapeutic agents |
| EP2307364B1 (en) * | 2008-07-01 | 2013-06-19 | Genentech, Inc. | Isoindolone derivatives as mek kinase inhibitors and methods of use |
| WO2010051933A2 (en) | 2008-11-10 | 2010-05-14 | Bayer Schering Pharma Aktiengesellschaft | Substituted sulphonamido phenoxybenzamides |
| US9084781B2 (en) | 2008-12-10 | 2015-07-21 | Novartis Ag | MEK mutations conferring resistance to MEK inhibitors |
| US20120172351A1 (en) | 2009-06-09 | 2012-07-05 | Nobuyuki Negoro | Novel fused cyclic compound and use thereof |
| CA2777430A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Pharma Aktiengesellschaft | Substituted benzosulphonamides |
| JP2013508318A (ja) | 2009-10-21 | 2013-03-07 | バイエル・ファルマ・アクチェンゲゼルシャフト | 置換されたベンゾスルホンアミド誘導体 |
| US20120263714A1 (en) | 2009-10-21 | 2012-10-18 | Bayer Intellectual Property Gmbh | Substituted halophenoxybenzamide derivatives |
| MX340392B (es) | 2010-02-25 | 2016-07-06 | Dana Farber Cancer Inst Inc | Mutaciones del protooncogen de serina/treonina-proteina cinasa b-raf (braf) que confieren resistencia a los inhibidores del protooncogen de serina/treonina-proteina cinasa b-raf. |
| CN103038364A (zh) | 2010-03-09 | 2013-04-10 | 达纳－法伯癌症研究所公司 | 诊断和治疗具有或发展对于第一种癌症治疗的抗性的患者中的癌症的方法 |
| WO2012055953A1 (en) | 2010-10-29 | 2012-05-03 | Bayer Pharma Aktiengesellschaft | Substituted phenoxypyridines |
| CN103204827B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途 |
| US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| CN104394855A (zh) | 2012-05-31 | 2015-03-04 | 拜耳医药股份有限公司 | 用于测定肝细胞癌(hcc)患者的治疗的有效响应的生物标记 |
| JP6300042B2 (ja) | 2012-10-12 | 2018-03-28 | エグゼリクシス， インコーポレイテッド | 癌の処置に使用するための化合物の製造方法 |
| HRP20240033T1 (hr) * | 2012-10-19 | 2024-03-29 | Array Biopharma, Inc. | Formulacija koja sadrži inhibitor mek |
| CN111518031B (zh) * | 2020-05-29 | 2023-01-17 | 中国药科大学 | 一种含有异羟肟酸的化合物及其制备方法、应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155110A (en) | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
| US5525625A (en) | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
| WO1998037881A1 (en) | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
| IL132840A (en) | 1997-07-01 | 2004-12-15 | Warner Lambert Co | Derivatives 4 - bromo or 4 - benzohydroxamic acid iodine amino iodine and pharmaceutical preparations containing them for use as MEK inhibitors |
| US6310060B1 (en) | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
| IL125425A (en) | 1998-07-20 | 2008-12-29 | Israel State | ADPGPPase CONTROL OF STARCH SYNTHESIS IN TOMATOES |
| EP1143957A3 (en) | 1998-12-16 | 2002-02-27 | Warner-Lambert Company | Treatment of arthritis with mek inhibitors |
| HRP20010524A2 (en) * | 1999-01-13 | 2002-08-31 | Warner Lambert Co | Benzoheterocycles and their use as mek inhibitors |
| JP2000204079A (ja) * | 1999-01-13 | 2000-07-25 | Warner Lambert Co | ジアリ―ルアミン |
| CN1373660A (zh) * | 1999-07-16 | 2002-10-09 | 沃尼尔·朗伯公司 | 使用mek抑制剂治疗慢性疼痛的方法 |
| CA2377092A1 (en) * | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
| CA2439263C (en) * | 2001-03-02 | 2012-10-23 | Frank Becker | Three hybrid assay system |
| DE60330227D1 (de) | 2002-03-13 | 2010-01-07 | Array Biopharma Inc | N3-alkylierte benzimidazol-derivate als mek-hemmer |
| RU2300528C2 (ru) | 2002-03-13 | 2007-06-10 | Эррэй Биофарма, Инк. | N3-алкилированные бензимидазольные производные в качестве ингибиторов мек |
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
-
2004
- 2004-07-12 EP EP04744015A patent/EP1651214B1/en not_active Expired - Lifetime
- 2004-07-12 DE DE602004023207T patent/DE602004023207D1/de not_active Expired - Lifetime
- 2004-07-12 BR BRPI0412851-6A patent/BRPI0412851A/pt not_active IP Right Cessation
- 2004-07-12 MX MXPA06000921A patent/MXPA06000921A/es unknown
- 2004-07-12 CA CA2532067A patent/CA2532067C/en not_active Expired - Fee Related
- 2004-07-12 JP JP2006520928A patent/JP4896717B2/ja not_active Expired - Fee Related
- 2004-07-12 ES ES04744015T patent/ES2331246T3/es not_active Expired - Lifetime
- 2004-07-12 AT AT04744015T patent/ATE442847T1/de not_active IP Right Cessation
- 2004-07-12 WO PCT/IB2004/002355 patent/WO2005009975A2/en not_active Ceased
- 2004-07-22 US US10/897,464 patent/US7160915B2/en not_active Expired - Fee Related
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