ES2567133T3 - Proceso para preparar compuestos de benzoimidazol - Google Patents
Proceso para preparar compuestos de benzoimidazol Download PDFInfo
- Publication number
- ES2567133T3 ES2567133T3 ES06785244T ES06785244T ES2567133T3 ES 2567133 T3 ES2567133 T3 ES 2567133T3 ES 06785244 T ES06785244 T ES 06785244T ES 06785244 T ES06785244 T ES 06785244T ES 2567133 T3 ES2567133 T3 ES 2567133T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- hydrogen
- preparing
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *c1cc(N)c(*)c(*)c1*=* Chemical compound *c1cc(N)c(*)c(*)c1*=* 0.000 description 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un proceso para preparar un compuesto de fórmula Ia-1**Fórmula** y sales y solvatos del mismo, en donde Z es -C(>=O)OR1; R1 es hidrógeno o alquilo C1-C10; R2 es hidrógeno; X1 y X2 son independientemente seleccionados de entre hidrógeno, F, Cl, Br e I; X5 es F, Cl, Br o I; y R10 es alquilo C1-C10; método que comprende: nitrar un compuesto que tiene la fórmula**Fórmula** en donde X3 y X4 son independientemente F, Cl, Br, I o un éster de sulfonato, para obtener un compuesto de fórmula II II**Fórmula** tratar dicho compuesto de fórmula II, opcionalmente a temperaturas y/o presión elevadas, con dos o más equivalentes de (i) un reactivo que contiene o genera amoníaco, o (ii) una amina primaria que no es una amina aromática, o (iii) un reactivo seleccionado de entre amoníaco protegido o equivalentes amídicos, agentes nucleófilos nitrogenados que tienen la fórmula MNR2R2a en donde M es un metal, y silil-amiduros metálicos, para obtener un compuesto de fórmula VI-11 en donde A es -NR2R2a,
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69327005P | 2005-06-23 | 2005-06-23 | |
US693270P | 2005-06-23 | ||
PCT/US2006/024084 WO2007002157A2 (en) | 2005-06-23 | 2006-06-21 | Process for preparing benzimidazole compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2567133T3 true ES2567133T3 (es) | 2016-04-20 |
Family
ID=37595779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES06785244T Active ES2567133T3 (es) | 2005-06-23 | 2006-06-21 | Proceso para preparar compuestos de benzoimidazol |
Country Status (17)
Country | Link |
---|---|
US (4) | US8039637B2 (es) |
EP (1) | EP1904481B1 (es) |
JP (1) | JP5237798B2 (es) |
KR (2) | KR101351190B1 (es) |
CN (1) | CN101248060B (es) |
AR (1) | AR054623A1 (es) |
AU (1) | AU2006262259B2 (es) |
BR (1) | BRPI0611993B1 (es) |
CA (1) | CA2612419C (es) |
ES (1) | ES2567133T3 (es) |
HK (1) | HK1118809A1 (es) |
IL (2) | IL188273A (es) |
MX (1) | MX351820B (es) |
MY (1) | MY177122A (es) |
SG (1) | SG162815A1 (es) |
TW (1) | TWI391380B (es) |
WO (1) | WO2007002157A2 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI3702351T3 (fi) | 2012-10-19 | 2024-01-24 | Array Biopharma Inc | MEK-inhibiittorin käsittävä koostumus |
US11242341B2 (en) * | 2016-10-06 | 2022-02-08 | Assia Chemical Industries Ltd. | Solid state forms of valbenazine |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2334973A1 (de) * | 1973-07-10 | 1975-01-23 | Boehringer Mannheim Gmbh | Neue biphenyl-derivate |
US4870074A (en) * | 1986-04-30 | 1989-09-26 | Dainippon Pharmaceutical Co., Ltd. | Substituted benzamide derivatives, for enhancing gastrointestinal motility |
JP2550456B2 (ja) * | 1990-11-06 | 1996-11-06 | 山之内製薬株式会社 | 縮合ピラジン誘導体 |
DE4115983A1 (de) | 1991-05-16 | 1992-11-19 | Henkel Kgaa | Haarfaerbemittel |
JPH06332129A (ja) | 1993-03-25 | 1994-12-02 | Konica Corp | カラー画像の形成方法 |
AU688459B2 (en) * | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
WO1995029891A1 (fr) * | 1994-04-28 | 1995-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de n-(3-pyrrolidinyl)benzamide |
US5597823A (en) | 1995-01-27 | 1997-01-28 | Abbott Laboratories | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
JP2001513084A (ja) * | 1997-02-25 | 2001-08-28 | ザ ガバメント オブ ザ ユナイテッド ステーツ オブ アメリカ,レプリゼンテッド バイ ザ セクレタリー,デパートメント オブ ヘルス アンド ヒューマン サービシズ | 逆転写酵素の非ヌクレオシド阻害剤としての置換ベンズイミダゾール |
US5817823A (en) * | 1997-04-17 | 1998-10-06 | Sepracor Inc. | Method for synthesizing 2-substituted imidazoles |
US6087368A (en) | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
HUP0105113A3 (en) | 1999-01-13 | 2004-11-29 | Warner Lambert Co | Benzoheterocycles and their use as mek inhibitors and pharmaceutical compositions containing the compounds |
PL352835A1 (en) | 1999-07-16 | 2003-09-08 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
DK1202724T3 (da) | 1999-07-16 | 2004-01-26 | Warner Lambert Co | Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer |
WO2002083622A2 (en) | 2001-04-10 | 2002-10-24 | Leo Pharma A/S | Novel aminophenyl ketone derivatives |
DK1379511T3 (da) * | 2001-04-12 | 2005-11-07 | Hoffmann La Roche | Dihydro-benzo[b][1,4]diazepin-2-on-derivater som mGLuR2-antagonister II |
US7271261B2 (en) * | 2001-10-19 | 2007-09-18 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted benzimidazoles and imidazo-[4,5]-pyridines |
UA76837C2 (uk) | 2002-03-13 | 2006-09-15 | Еррей Байофарма Інк. | N3 алкіловані похідні бензімідазолу як інгібітори мек |
ES2549159T3 (es) * | 2002-03-13 | 2015-10-23 | Array Biopharma, Inc. | Derivados de bencimidazol N3-alquilados como inhibidores de MEK |
JPWO2004106348A1 (ja) | 2003-05-28 | 2006-07-20 | アステラス製薬株式会社 | アミノメチル置換フルオロチアゾロベンゾイミダゾール誘導体 |
WO2005009975A2 (en) * | 2003-07-24 | 2005-02-03 | Warner-Lambert Company Llc | Benzimidazole derivatives as mek inhibitors |
JP2005263787A (ja) | 2004-02-17 | 2005-09-29 | Ishihara Sangyo Kaisha Ltd | アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤 |
EP1720841B1 (en) * | 2004-02-19 | 2015-11-04 | Rexahn Pharmaceuticals, Inc. | Quinazoline derivatives and therapeutic use thereof |
-
2006
- 2006-06-21 EP EP06785244.2A patent/EP1904481B1/en active Active
- 2006-06-21 JP JP2008518344A patent/JP5237798B2/ja active Active
- 2006-06-21 CA CA2612419A patent/CA2612419C/en active Active
- 2006-06-21 WO PCT/US2006/024084 patent/WO2007002157A2/en active Application Filing
- 2006-06-21 ES ES06785244T patent/ES2567133T3/es active Active
- 2006-06-21 US US11/993,745 patent/US8039637B2/en active Active
- 2006-06-21 KR KR1020087001710A patent/KR101351190B1/ko active IP Right Grant
- 2006-06-21 MY MYPI20062949A patent/MY177122A/en unknown
- 2006-06-21 BR BRPI0611993-0A patent/BRPI0611993B1/pt active IP Right Grant
- 2006-06-21 AU AU2006262259A patent/AU2006262259B2/en active Active
- 2006-06-21 AR ARP060102652A patent/AR054623A1/es active IP Right Grant
- 2006-06-21 TW TW095122196A patent/TWI391380B/zh active
- 2006-06-21 CN CN200680031060.3A patent/CN101248060B/zh active Active
- 2006-06-21 MX MX2014000386A patent/MX351820B/es unknown
- 2006-06-21 SG SG201004400-6A patent/SG162815A1/en unknown
- 2006-06-21 KR KR1020137031714A patent/KR20140000721A/ko not_active Application Discontinuation
-
2007
- 2007-12-19 IL IL188273A patent/IL188273A/en active IP Right Grant
-
2008
- 2008-09-12 HK HK08110177.6A patent/HK1118809A1/zh unknown
-
2011
- 2011-09-09 US US13/229,491 patent/US8501956B2/en active Active
- 2011-09-09 US US13/229,459 patent/US8383832B2/en active Active
-
2012
- 2012-09-13 US US13/614,941 patent/US9024040B2/en active Active
- 2012-11-28 IL IL223313A patent/IL223313A/en active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DOP2015000014A (es) | Derivados de azaadamantano y metodos de uso de los mismos | |
ECSP066463A (es) | Nuevas sulfonamidas como agentes fitosanitarios | |
AR081385A1 (es) | Composiciones metodo y uso | |
CA2495967A1 (fr) | Nouveau procede de synthese et nouvelle forme cristalline de l'agomelatine ainsi que les compositions pharmaceutiques qui la contiennent | |
RS51044B (sr) | 2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-oni | |
TW200738683A (en) | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation | |
HUP0402454A2 (hu) | Szubsztituált kinazolinszármazékok mint az aurora kinázok inhibitorai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
CR9331A (es) | Inhibidores de vegf-r2 y metodos | |
CO4900036A1 (es) | Compuestos inhibidores de metaloproteasas de amina ciclica substituida composiciones farmaceuticas que los contienen y metodos para su utilizacion | |
AR026173A1 (es) | Inhibidores de neuraminidasas. | |
CO5210949A1 (es) | Trifluorometilalquilaminotriazolopirimidinas fungicidas | |
AR068479A1 (es) | (carboxilalquilenfenil) feniloxamidas, procedimiento para su preparacion y una coomposicion farmaceutica | |
PE20070829A1 (es) | Inhibidores cetp heterociclicos | |
CY1107468T1 (el) | Καρβαμιδικες ενωσεις για χρηση στην προληψη ή την αγωγη διαταραχων του αγχους | |
RU2009134516A (ru) | Фармацевтическая композиция, содержащая производное пиразина, и способ применения производного пиразина в комбинации | |
ATE481387T1 (de) | Pyridin-n-oxidverbindungen alsphosphodiesterase-4-inhibitoren | |
EA200500268A1 (ru) | Производные диоксан-2-алкилкарбаматов, способ их получения и применение в терапии | |
CY1105330T1 (el) | Καρβαμιδικα παραγωγα για χρηση στην προληψη ή την αγωγη της διπολικης διαταραχης | |
TW200616954A (en) | N-(1h-indolyl)-1h-indole-2-carboxamide derivatives, their preparation and their application in therapeutics | |
CR10206A (es) | Acidos4-fenil-tiazol-5-carboxilicos amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1 | |
DE602006008962D1 (de) | Verfahren zur herstellung von valsartan | |
CU20210023A7 (es) | Inhibidores fenil sustituidos de la piridinil 1,2-oxaborolan-2-ol fosfodiesterasa 4 | |
CO5580821A2 (es) | 4-cetolactamas y -lactonas 3-fenil-3-substituidas, espirociclicas | |
BR112015011974A2 (pt) | derivados de azaquinazolina carboxamida | |
ES2524972T3 (es) | Método y sustancias para la preparación de compuestos de piridinio N-sustituidos |