MX351820B - Proceso para preparar compuestos de bencimidazol. - Google Patents
Proceso para preparar compuestos de bencimidazol.Info
- Publication number
- MX351820B MX351820B MX2014000386A MX2014000386A MX351820B MX 351820 B MX351820 B MX 351820B MX 2014000386 A MX2014000386 A MX 2014000386A MX 2014000386 A MX2014000386 A MX 2014000386A MX 351820 B MX351820 B MX 351820B
- Authority
- MX
- Mexico
- Prior art keywords
- benzimidazole compounds
- compounds
- preparing benzimidazole
- formula
- synthetic intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Se proporcionan métodos para la síntesis de compuestos heterocíclicos tales como estructuras de núcleo de ácido carboxílico de bencimidazol que tiene la Fórmula Ia-1 y sus intermediarios sintéticos: en donde Z, X1, X2, X5, R2 y R10 son como se definen en la presente. Los compuestos de la Fórmula Ia-1 y sus intermediarios sintéticos se pueden utilizar para preparar derivados heterocíclicos tales como derivados de bencimidazol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69327005P | 2005-06-23 | 2005-06-23 | |
PCT/US2006/024084 WO2007002157A2 (en) | 2005-06-23 | 2006-06-21 | Process for preparing benzimidazole compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX351820B true MX351820B (es) | 2017-10-30 |
Family
ID=37595779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014000386A MX351820B (es) | 2005-06-23 | 2006-06-21 | Proceso para preparar compuestos de bencimidazol. |
Country Status (17)
Country | Link |
---|---|
US (4) | US8039637B2 (es) |
EP (1) | EP1904481B1 (es) |
JP (1) | JP5237798B2 (es) |
KR (2) | KR20140000721A (es) |
CN (1) | CN101248060B (es) |
AR (1) | AR054623A1 (es) |
AU (1) | AU2006262259B2 (es) |
BR (1) | BRPI0611993B1 (es) |
CA (1) | CA2612419C (es) |
ES (1) | ES2567133T3 (es) |
HK (1) | HK1118809A1 (es) |
IL (2) | IL188273A (es) |
MX (1) | MX351820B (es) |
MY (1) | MY177122A (es) |
SG (1) | SG162815A1 (es) |
TW (1) | TWI391380B (es) |
WO (1) | WO2007002157A2 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112015008623B1 (pt) | 2012-10-19 | 2022-10-25 | Novartis Ag | Processos de preparação de (2-hidroxietióxi)-amida do ácido 6-(4-bromo-2-fluorfenilamino) -7-flúor-3-metil-3h-benzoimidazol-5-carboxílico cristalizado e seus intermediários |
KR20190062460A (ko) * | 2016-10-06 | 2019-06-05 | 아시아 케미컬 인더스트리스 리미티드 | 발베나진의 고체상 형태 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2334973A1 (de) | 1973-07-10 | 1975-01-23 | Boehringer Mannheim Gmbh | Neue biphenyl-derivate |
SK289787A3 (en) | 1986-04-30 | 1998-06-03 | Dainippon Pharmaceutical Co | Substituted n-£(2-morpholinyl)alkyl|benzamide derivative, method of producing the same and a pharmaceutical composition on its base |
RU2095352C1 (ru) | 1990-11-06 | 1997-11-10 | Яманоути Фармасьютикал Ко., Лтд. | Производное сконденсированного пиразина |
DE4115983A1 (de) * | 1991-05-16 | 1992-11-19 | Henkel Kgaa | Haarfaerbemittel |
JPH06332129A (ja) * | 1993-03-25 | 1994-12-02 | Konica Corp | カラー画像の形成方法 |
AU688459B2 (en) * | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
CN1147248A (zh) * | 1994-04-28 | 1997-04-09 | 山之内制药株式会社 | N-(3-吡咯烷基)苯甲酰胺衍生物 |
US5597823A (en) | 1995-01-27 | 1997-01-28 | Abbott Laboratories | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
JP2001513084A (ja) * | 1997-02-25 | 2001-08-28 | ザ ガバメント オブ ザ ユナイテッド ステーツ オブ アメリカ,レプリゼンテッド バイ ザ セクレタリー,デパートメント オブ ヘルス アンド ヒューマン サービシズ | 逆転写酵素の非ヌクレオシド阻害剤としての置換ベンズイミダゾール |
US5817823A (en) | 1997-04-17 | 1998-10-06 | Sepracor Inc. | Method for synthesizing 2-substituted imidazoles |
US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
WO2000042022A1 (en) | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Benzoheterocycles and their use as mek inhibitors |
WO2001005390A2 (en) | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
PL352712A1 (en) | 1999-07-16 | 2003-09-08 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
WO2002083622A2 (en) | 2001-04-10 | 2002-10-24 | Leo Pharma A/S | Novel aminophenyl ketone derivatives |
WO2002083652A1 (en) * | 2001-04-12 | 2002-10-24 | F. Hoffmann-La Roche Ag | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II |
RS50939B (sr) * | 2001-10-19 | 2010-08-31 | Ortho-Mcneil Pharmaceutical Inc. | 2-fenil benzimidazoli i imidazo-/4,5/-piridini kao cdsi/chk2 -inhibitori i pomoćna sredstva u hemoterapiji ili terapiji zračenja pri lečenju kancera |
US20030216460A1 (en) | 2002-03-13 | 2003-11-20 | Wallace Eli M. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
KR100984613B1 (ko) * | 2002-03-13 | 2010-09-30 | 어레이 바이오파마 인크. | Mek 억제제로서의 n3 알킬화 벤즈이미다졸 유도체 |
JPWO2004106348A1 (ja) * | 2003-05-28 | 2006-07-20 | アステラス製薬株式会社 | アミノメチル置換フルオロチアゾロベンゾイミダゾール誘導体 |
WO2005009975A2 (en) | 2003-07-24 | 2005-02-03 | Warner-Lambert Company Llc | Benzimidazole derivatives as mek inhibitors |
JP2005263787A (ja) | 2004-02-17 | 2005-09-29 | Ishihara Sangyo Kaisha Ltd | アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤 |
CA2557433C (en) * | 2004-02-19 | 2013-05-14 | Rexahn Corporation | Quinazoline derivatives and therapeutic use thereof |
-
2006
- 2006-06-21 KR KR1020137031714A patent/KR20140000721A/ko not_active Application Discontinuation
- 2006-06-21 SG SG201004400-6A patent/SG162815A1/en unknown
- 2006-06-21 JP JP2008518344A patent/JP5237798B2/ja active Active
- 2006-06-21 AR ARP060102652A patent/AR054623A1/es active IP Right Grant
- 2006-06-21 AU AU2006262259A patent/AU2006262259B2/en active Active
- 2006-06-21 CA CA2612419A patent/CA2612419C/en active Active
- 2006-06-21 US US11/993,745 patent/US8039637B2/en active Active
- 2006-06-21 BR BRPI0611993-0A patent/BRPI0611993B1/pt active IP Right Grant
- 2006-06-21 MY MYPI20062949A patent/MY177122A/en unknown
- 2006-06-21 KR KR1020087001710A patent/KR101351190B1/ko active IP Right Grant
- 2006-06-21 TW TW095122196A patent/TWI391380B/zh active
- 2006-06-21 ES ES06785244T patent/ES2567133T3/es active Active
- 2006-06-21 CN CN200680031060.3A patent/CN101248060B/zh active Active
- 2006-06-21 MX MX2014000386A patent/MX351820B/es unknown
- 2006-06-21 EP EP06785244.2A patent/EP1904481B1/en active Active
- 2006-06-21 WO PCT/US2006/024084 patent/WO2007002157A2/en active Application Filing
-
2007
- 2007-12-19 IL IL188273A patent/IL188273A/en active IP Right Grant
-
2008
- 2008-09-12 HK HK08110177.6A patent/HK1118809A1/zh unknown
-
2011
- 2011-09-09 US US13/229,491 patent/US8501956B2/en active Active
- 2011-09-09 US US13/229,459 patent/US8383832B2/en active Active
-
2012
- 2012-09-13 US US13/614,941 patent/US9024040B2/en active Active
- 2012-11-28 IL IL223313A patent/IL223313A/en active IP Right Grant
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