MX351820B - Proceso para preparar compuestos de bencimidazol. - Google Patents

Proceso para preparar compuestos de bencimidazol.

Info

Publication number
MX351820B
MX351820B MX2014000386A MX2014000386A MX351820B MX 351820 B MX351820 B MX 351820B MX 2014000386 A MX2014000386 A MX 2014000386A MX 2014000386 A MX2014000386 A MX 2014000386A MX 351820 B MX351820 B MX 351820B
Authority
MX
Mexico
Prior art keywords
benzimidazole compounds
compounds
preparing benzimidazole
formula
synthetic intermediates
Prior art date
Application number
MX2014000386A
Other languages
English (en)
Inventor
Gair Ford James
Demattei John
Shakya Sagar
D Piscopio Anthony
P Hache Bruno
Charles Evans Matthew
Mark Pointon Simon
Peeters Koen
John Lilley Timothy
Leonard John
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX351820B publication Critical patent/MX351820B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Se proporcionan métodos para la síntesis de compuestos heterocíclicos tales como estructuras de núcleo de ácido carboxílico de bencimidazol que tiene la Fórmula Ia-1 y sus intermediarios sintéticos: en donde Z, X1, X2, X5, R2 y R10 son como se definen en la presente. Los compuestos de la Fórmula Ia-1 y sus intermediarios sintéticos se pueden utilizar para preparar derivados heterocíclicos tales como derivados de bencimidazol.
MX2014000386A 2005-06-23 2006-06-21 Proceso para preparar compuestos de bencimidazol. MX351820B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69327005P 2005-06-23 2005-06-23
PCT/US2006/024084 WO2007002157A2 (en) 2005-06-23 2006-06-21 Process for preparing benzimidazole compounds

Publications (1)

Publication Number Publication Date
MX351820B true MX351820B (es) 2017-10-30

Family

ID=37595779

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000386A MX351820B (es) 2005-06-23 2006-06-21 Proceso para preparar compuestos de bencimidazol.

Country Status (17)

Country Link
US (4) US8039637B2 (es)
EP (1) EP1904481B1 (es)
JP (1) JP5237798B2 (es)
KR (2) KR20140000721A (es)
CN (1) CN101248060B (es)
AR (1) AR054623A1 (es)
AU (1) AU2006262259B2 (es)
BR (1) BRPI0611993B1 (es)
CA (1) CA2612419C (es)
ES (1) ES2567133T3 (es)
HK (1) HK1118809A1 (es)
IL (2) IL188273A (es)
MX (1) MX351820B (es)
MY (1) MY177122A (es)
SG (1) SG162815A1 (es)
TW (1) TWI391380B (es)
WO (1) WO2007002157A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015008623B1 (pt) 2012-10-19 2022-10-25 Novartis Ag Processos de preparação de (2-hidroxietióxi)-amida do ácido 6-(4-bromo-2-fluorfenilamino) -7-flúor-3-metil-3h-benzoimidazol-5-carboxílico cristalizado e seus intermediários
KR20190062460A (ko) * 2016-10-06 2019-06-05 아시아 케미컬 인더스트리스 리미티드 발베나진의 고체상 형태

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2334973A1 (de) 1973-07-10 1975-01-23 Boehringer Mannheim Gmbh Neue biphenyl-derivate
SK289787A3 (en) 1986-04-30 1998-06-03 Dainippon Pharmaceutical Co Substituted n-£(2-morpholinyl)alkyl|benzamide derivative, method of producing the same and a pharmaceutical composition on its base
RU2095352C1 (ru) 1990-11-06 1997-11-10 Яманоути Фармасьютикал Ко., Лтд. Производное сконденсированного пиразина
DE4115983A1 (de) * 1991-05-16 1992-11-19 Henkel Kgaa Haarfaerbemittel
JPH06332129A (ja) * 1993-03-25 1994-12-02 Konica Corp カラー画像の形成方法
AU688459B2 (en) * 1994-04-08 1998-03-12 Shionogi & Co., Ltd. Oxopyridinylquinoxaline derivative
CN1147248A (zh) * 1994-04-28 1997-04-09 山之内制药株式会社 N-(3-吡咯烷基)苯甲酰胺衍生物
US5597823A (en) 1995-01-27 1997-01-28 Abbott Laboratories Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists
JP2001513084A (ja) * 1997-02-25 2001-08-28 ザ ガバメント オブ ザ ユナイテッド ステーツ オブ アメリカ，レプリゼンテッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシズ 逆転写酵素の非ヌクレオシド阻害剤としての置換ベンズイミダゾール
US5817823A (en) 1997-04-17 1998-10-06 Sepracor Inc. Method for synthesizing 2-substituted imidazoles
US6087368A (en) * 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
WO2000042022A1 (en) 1999-01-13 2000-07-20 Warner-Lambert Company Benzoheterocycles and their use as mek inhibitors
WO2001005390A2 (en) 1999-07-16 2001-01-25 Warner-Lambert Company Method for treating chronic pain using mek inhibitors
PL352712A1 (en) 1999-07-16 2003-09-08 Warner-Lambert Company Method for treating chronic pain using mek inhibitors
WO2002083622A2 (en) 2001-04-10 2002-10-24 Leo Pharma A/S Novel aminophenyl ketone derivatives
WO2002083652A1 (en) * 2001-04-12 2002-10-24 F. Hoffmann-La Roche Ag DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II
RS50939B (sr) * 2001-10-19 2010-08-31 Ortho-Mcneil Pharmaceutical Inc. 2-fenil benzimidazoli i imidazo-/4,5/-piridini kao cdsi/chk2 -inhibitori i pomoćna sredstva u hemoterapiji ili terapiji zračenja pri lečenju kancera
US20030216460A1 (en) 2002-03-13 2003-11-20 Wallace Eli M. N3 alkylated benzimidazole derivatives as MEK inhibitors
KR100984613B1 (ko) * 2002-03-13 2010-09-30 어레이 바이오파마 인크. Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
JPWO2004106348A1 (ja) * 2003-05-28 2006-07-20 アステラス製薬株式会社 アミノメチル置換フルオロチアゾロベンゾイミダゾール誘導体
WO2005009975A2 (en) 2003-07-24 2005-02-03 Warner-Lambert Company Llc Benzimidazole derivatives as mek inhibitors
JP2005263787A (ja) 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
CA2557433C (en) * 2004-02-19 2013-05-14 Rexahn Corporation Quinazoline derivatives and therapeutic use thereof

Also Published As

Publication number Publication date
IL223313A0 (en) 2013-02-03
KR101351190B1 (ko) 2014-01-14
WO2007002157A2 (en) 2007-01-04
US8039637B2 (en) 2011-10-18
US20110319631A1 (en) 2011-12-29
US20100145065A1 (en) 2010-06-10
CN101248060A (zh) 2008-08-20
BRPI0611993A2 (pt) 2010-10-13
AR054623A1 (es) 2007-07-04
TW200738647A (en) 2007-10-16
CA2612419C (en) 2017-06-13
BRPI0611993B1 (pt) 2023-11-28
KR20080028443A (ko) 2008-03-31
SG162815A1 (en) 2010-07-29
MY177122A (en) 2020-09-07
ES2567133T3 (es) 2016-04-20
US8501956B2 (en) 2013-08-06
US9024040B2 (en) 2015-05-05
EP1904481A4 (en) 2010-11-10
US8383832B2 (en) 2013-02-26
IL188273A (en) 2015-03-31
IL188273A0 (en) 2008-04-13
US20110319632A1 (en) 2011-12-29
JP2009501146A (ja) 2009-01-15
EP1904481B1 (en) 2016-02-17
EP1904481A2 (en) 2008-04-02
AU2006262259B2 (en) 2013-03-14
KR20140000721A (ko) 2014-01-03
AU2006262259A1 (en) 2007-01-04
US20130245279A1 (en) 2013-09-19
IL223313A (en) 2015-07-30
CN101248060B (zh) 2014-09-10
JP5237798B2 (ja) 2013-07-17
CA2612419A1 (en) 2007-01-04
WO2007002157A3 (en) 2007-11-01
TWI391380B (zh) 2013-04-01
HK1118809A1 (zh) 2009-04-09

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