MX351820B - Proceso para preparar compuestos de bencimidazol. - Google Patents

Proceso para preparar compuestos de bencimidazol.

Info

Publication number
MX351820B
MX351820B MX2014000386A MX2014000386A MX351820B MX 351820 B MX351820 B MX 351820B MX 2014000386 A MX2014000386 A MX 2014000386A MX 2014000386 A MX2014000386 A MX 2014000386A MX 351820 B MX351820 B MX 351820B
Authority
MX
Mexico
Prior art keywords
benzimidazole compounds
compounds
preparing benzimidazole
formula
synthetic intermediates
Prior art date
Application number
MX2014000386A
Other languages
English (en)
Inventor
Gair Ford James
Demattei John
Shakya Sagar
D Piscopio Anthony
P Hache Bruno
Charles Evans Matthew
Mark Pointon Simon
Peeters Koen
John Lilley Timothy
Leonard John
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX351820B publication Critical patent/MX351820B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Se proporcionan métodos para la síntesis de compuestos heterocíclicos tales como estructuras de núcleo de ácido carboxílico de bencimidazol que tiene la Fórmula Ia-1 y sus intermediarios sintéticos: en donde Z, X1, X2, X5, R2 y R10 son como se definen en la presente. Los compuestos de la Fórmula Ia-1 y sus intermediarios sintéticos se pueden utilizar para preparar derivados heterocíclicos tales como derivados de bencimidazol.
MX2014000386A 2005-06-23 2006-06-21 Proceso para preparar compuestos de bencimidazol. MX351820B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69327005P 2005-06-23 2005-06-23
PCT/US2006/024084 WO2007002157A2 (en) 2005-06-23 2006-06-21 Process for preparing benzimidazole compounds

Publications (1)

Publication Number Publication Date
MX351820B true MX351820B (es) 2017-10-30

Family

ID=37595779

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000386A MX351820B (es) 2005-06-23 2006-06-21 Proceso para preparar compuestos de bencimidazol.

Country Status (17)

Country Link
US (4) US8039637B2 (es)
EP (1) EP1904481B1 (es)
JP (1) JP5237798B2 (es)
KR (2) KR101351190B1 (es)
CN (1) CN101248060B (es)
AR (1) AR054623A1 (es)
AU (1) AU2006262259B2 (es)
BR (1) BRPI0611993B1 (es)
CA (1) CA2612419C (es)
ES (1) ES2567133T3 (es)
HK (1) HK1118809A1 (es)
IL (2) IL188273A (es)
MX (1) MX351820B (es)
MY (1) MY177122A (es)
SG (1) SG162815A1 (es)
TW (1) TWI391380B (es)
WO (1) WO2007002157A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI3702351T3 (fi) 2012-10-19 2024-01-24 Array Biopharma Inc MEK-inhibiittorin käsittävä koostumus
US11242341B2 (en) * 2016-10-06 2022-02-08 Assia Chemical Industries Ltd. Solid state forms of valbenazine

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2334973A1 (de) * 1973-07-10 1975-01-23 Boehringer Mannheim Gmbh Neue biphenyl-derivate
US4870074A (en) * 1986-04-30 1989-09-26 Dainippon Pharmaceutical Co., Ltd. Substituted benzamide derivatives, for enhancing gastrointestinal motility
JP2550456B2 (ja) * 1990-11-06 1996-11-06 山之内製薬株式会社 縮合ピラジン誘導体
DE4115983A1 (de) 1991-05-16 1992-11-19 Henkel Kgaa Haarfaerbemittel
JPH06332129A (ja) 1993-03-25 1994-12-02 Konica Corp カラー画像の形成方法
AU688459B2 (en) * 1994-04-08 1998-03-12 Shionogi & Co., Ltd. Oxopyridinylquinoxaline derivative
WO1995029891A1 (fr) * 1994-04-28 1995-11-09 Yamanouchi Pharmaceutical Co., Ltd. Derive de n-(3-pyrrolidinyl)benzamide
US5597823A (en) 1995-01-27 1997-01-28 Abbott Laboratories Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists
JP2001513084A (ja) * 1997-02-25 2001-08-28 ザ ガバメント オブ ザ ユナイテッド ステーツ オブ アメリカ，レプリゼンテッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシズ 逆転写酵素の非ヌクレオシド阻害剤としての置換ベンズイミダゾール
US5817823A (en) * 1997-04-17 1998-10-06 Sepracor Inc. Method for synthesizing 2-substituted imidazoles
US6087368A (en) 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
HUP0105113A3 (en) 1999-01-13 2004-11-29 Warner Lambert Co Benzoheterocycles and their use as mek inhibitors and pharmaceutical compositions containing the compounds
PL352835A1 (en) 1999-07-16 2003-09-08 Warner-Lambert Company Method for treating chronic pain using mek inhibitors
DK1202724T3 (da) 1999-07-16 2004-01-26 Warner Lambert Co Fremgangsmåde til behandling af kronisk smerte under anvendelse af mek-inhibitorer
WO2002083622A2 (en) 2001-04-10 2002-10-24 Leo Pharma A/S Novel aminophenyl ketone derivatives
DK1379511T3 (da) * 2001-04-12 2005-11-07 Hoffmann La Roche Dihydro-benzo[b][1,4]diazepin-2-on-derivater som mGLuR2-antagonister II
US7271261B2 (en) * 2001-10-19 2007-09-18 Ortho-Mcneil Pharmaceutical, Inc. Substituted benzimidazoles and imidazo-[4,5]-pyridines
UA76837C2 (uk) 2002-03-13 2006-09-15 Еррей Байофарма Інк. N3 алкіловані похідні бензімідазолу як інгібітори мек
ES2549159T3 (es) * 2002-03-13 2015-10-23 Array Biopharma, Inc. Derivados de bencimidazol N3-alquilados como inhibidores de MEK
JPWO2004106348A1 (ja) 2003-05-28 2006-07-20 アステラス製薬株式会社 アミノメチル置換フルオロチアゾロベンゾイミダゾール誘導体
WO2005009975A2 (en) * 2003-07-24 2005-02-03 Warner-Lambert Company Llc Benzimidazole derivatives as mek inhibitors
JP2005263787A (ja) 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
EP1720841B1 (en) * 2004-02-19 2015-11-04 Rexahn Pharmaceuticals, Inc. Quinazoline derivatives and therapeutic use thereof

Also Published As

Publication number Publication date
JP5237798B2 (ja) 2013-07-17
WO2007002157A3 (en) 2007-11-01
AR054623A1 (es) 2007-07-04
TW200738647A (en) 2007-10-16
US9024040B2 (en) 2015-05-05
KR101351190B1 (ko) 2014-01-14
KR20080028443A (ko) 2008-03-31
IL188273A (en) 2015-03-31
IL223313A (en) 2015-07-30
SG162815A1 (en) 2010-07-29
MY177122A (en) 2020-09-07
WO2007002157A2 (en) 2007-01-04
AU2006262259A1 (en) 2007-01-04
HK1118809A1 (zh) 2009-04-09
US8501956B2 (en) 2013-08-06
BRPI0611993B1 (pt) 2023-11-28
CA2612419C (en) 2017-06-13
US20130245279A1 (en) 2013-09-19
BRPI0611993A2 (pt) 2010-10-13
IL223313A0 (en) 2013-02-03
JP2009501146A (ja) 2009-01-15
TWI391380B (zh) 2013-04-01
US8383832B2 (en) 2013-02-26
CN101248060B (zh) 2014-09-10
KR20140000721A (ko) 2014-01-03
CA2612419A1 (en) 2007-01-04
EP1904481A2 (en) 2008-04-02
AU2006262259B2 (en) 2013-03-14
ES2567133T3 (es) 2016-04-20
US20110319632A1 (en) 2011-12-29
US8039637B2 (en) 2011-10-18
EP1904481B1 (en) 2016-02-17
US20100145065A1 (en) 2010-06-10
IL188273A0 (en) 2008-04-13
CN101248060A (zh) 2008-08-20
US20110319631A1 (en) 2011-12-29
EP1904481A4 (en) 2010-11-10

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