ES2524972T3 - Método y sustancias para la preparación de compuestos de piridinio N-sustituidos - Google Patents

Método y sustancias para la preparación de compuestos de piridinio N-sustituidos Download PDF

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Publication number
ES2524972T3
ES2524972T3 ES10742424.4T ES10742424T ES2524972T3 ES 2524972 T3 ES2524972 T3 ES 2524972T3 ES 10742424 T ES10742424 T ES 10742424T ES 2524972 T3 ES2524972 T3 ES 2524972T3
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Spain
Prior art keywords
formula
substances
preparation
substituted
substituted pyridinium
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ES10742424.4T
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English (en)
Inventor
Dieter Heindl
Peter Gebauer
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Método para la síntesis de un compuesto de piridinio carboxilado N-sustituido, que comprende las etapas de: a) proporcionar una sal pentametinio según la fórmula I:**Fórmula** en la que X- es un contraión, R1 es alcoxi seleccionado de entre O-metilo, O-etilo, O-propilo y O-isobutilo, y R2 a R5 son, independientemente, metilo o etilo. b) Hacer reaccionar la sal pentametinio de la etapa (a) con una amina primaria de fórmula II:**Fórmula** en la que R6 es alquilo lineal, ramificado o cíclico, sustituido opcionalmente, c) obteniendo de esta manera un compuesto de piridinio N-sustituido de fórmula III:**Fórmula** en la que X, R1 y R6 son tal como se ha definido anteriormente.

Description

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Claims (1)

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    imagen2
ES10742424.4T 2009-07-27 2010-07-23 Método y sustancias para la preparación de compuestos de piridinio N-sustituidos Active ES2524972T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09166456 2009-07-27
EP09166456 2009-07-27
PCT/EP2010/004524 WO2011012271A2 (en) 2009-07-27 2010-07-23 Method and substances for preparation of n-substituted pyridinium compounds

Publications (1)

Publication Number Publication Date
ES2524972T3 true ES2524972T3 (es) 2014-12-16

Family

ID=41119996

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10742424.4T Active ES2524972T3 (es) 2009-07-27 2010-07-23 Método y sustancias para la preparación de compuestos de piridinio N-sustituidos

Country Status (7)

Country Link
US (1) US9085535B2 (es)
EP (1) EP2459536B1 (es)
JP (1) JP5544423B2 (es)
CN (1) CN102471272B (es)
CA (1) CA2769156C (es)
ES (1) ES2524972T3 (es)
WO (1) WO2011012271A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2819989C (en) * 2011-01-26 2019-03-12 Peter Gebauer Method and substances for preparation of n-substituted pyridinium compounds
CN104870982B (zh) 2012-12-20 2019-02-15 霍夫曼-拉罗奇有限公司 用于评估医学测量曲线的方法
JP6441812B2 (ja) 2012-12-20 2018-12-19 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 体液試料を分析する方法
EP2781919A1 (en) 2013-03-19 2014-09-24 Roche Diagniostics GmbH Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid
CA3035874A1 (en) 2016-10-05 2018-04-12 F. Hoffmann-La Roche Ag Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same
RU2754453C1 (ru) 2018-02-28 2021-09-02 Ф. Хоффманн-Ля Рош Аг Обеспечивающее биосовместимость покрытие для непрерывного измерения аналита
CN112851730B (zh) * 2021-01-08 2023-02-21 厦门瑞林药业有限公司 一种nmn中间体nr氯化物合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411995A (en) 1981-09-28 1983-10-25 Massachusetts Institute Of Technology Synthesis of nicotinamide cofactors
DE3328808A1 (de) * 1983-08-10 1985-02-21 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Verfahren zur herstellung von pyridinaldehyden
US4668354A (en) * 1986-08-29 1987-05-26 E. I. Du Pont De Nemours And Company Electrocatalytic deposition of metals in solid polymeric matrices
DE102005035461A1 (de) 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate

Also Published As

Publication number Publication date
EP2459536B1 (en) 2014-10-29
JP2013500289A (ja) 2013-01-07
CN102471272A (zh) 2012-05-23
CA2769156A1 (en) 2011-02-03
US9085535B2 (en) 2015-07-21
EP2459536A2 (en) 2012-06-06
JP5544423B2 (ja) 2014-07-09
CA2769156C (en) 2015-02-10
WO2011012271A2 (en) 2011-02-03
WO2011012271A3 (en) 2011-08-11
US20120190855A1 (en) 2012-07-26
CN102471272B (zh) 2014-09-10

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