EA201170277A1 - Синтез и составы на основе солей изофосфорамидного иприта и его аналогов - Google Patents

Синтез и составы на основе солей изофосфорамидного иприта и его аналогов

Info

Publication number
EA201170277A1
EA201170277A1 EA201170277A EA201170277A EA201170277A1 EA 201170277 A1 EA201170277 A1 EA 201170277A1 EA 201170277 A EA201170277 A EA 201170277A EA 201170277 A EA201170277 A EA 201170277A EA 201170277 A1 EA201170277 A1 EA 201170277A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ipritis
isophosphoramide
analogues
synthesis
salts
Prior art date
Application number
EA201170277A
Other languages
English (en)
Other versions
EA022655B1 (ru
Inventor
Фрэнк Уолтер Валигора
Джон С. мл. Амедио
Original Assignee
Зайофарм Онколоджи, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зайофарм Онколоджи, Инк. filed Critical Зайофарм Онколоджи, Инк.
Publication of EA201170277A1 publication Critical patent/EA201170277A1/ru
Publication of EA022655B1 publication Critical patent/EA022655B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
    • C07F9/1406—Esters of phosphoric acids containing P(=O)-halide groups containing the structure Hal-P(=O)-O-aryl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/20—Esters of thiophosphoric acids containing P-halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

В настоящем описании раскрыты составы и способы получения соединения формулы (Е)в котором Х и Y независимо представляют собой уходящие группы, а Апредставляет собой аммониевый катион.
EA201170277A 2008-07-31 2009-07-30 Синтез и составы на основе солей изофосфорамидного иприта и его аналогов EA022655B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13753808P 2008-07-31 2008-07-31
PCT/US2009/052295 WO2010014841A1 (en) 2008-07-31 2009-07-30 Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof

Publications (2)

Publication Number Publication Date
EA201170277A1 true EA201170277A1 (ru) 2011-08-30
EA022655B1 EA022655B1 (ru) 2016-02-29

Family

ID=41610732

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170277A EA022655B1 (ru) 2008-07-31 2009-07-30 Синтез и составы на основе солей изофосфорамидного иприта и его аналогов

Country Status (16)

Country Link
US (4) US8664201B2 (ru)
EP (1) EP2318013A4 (ru)
JP (2) JP5711660B2 (ru)
KR (1) KR20110038696A (ru)
CN (2) CN102137674A (ru)
AU (1) AU2009276512B2 (ru)
BR (1) BRPI0916739A2 (ru)
CA (1) CA2732290A1 (ru)
EA (1) EA022655B1 (ru)
IL (1) IL210921A (ru)
MX (1) MX2011001122A (ru)
NZ (3) NZ590995A (ru)
SG (2) SG10201600595PA (ru)
TW (1) TWI454266B (ru)
WO (1) WO2010014841A1 (ru)
ZA (1) ZA201100878B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336139A3 (en) * 2004-10-25 2012-01-04 Dekk-Tec, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
EP2134260B1 (en) 2007-03-07 2016-05-04 Becton Dickinson and Company Safety blood collection assembly with indicator
US8888713B2 (en) 2007-03-07 2014-11-18 Becton, Dickinson And Company Safety blood collection assembly with indicator
US8603009B2 (en) 2008-03-07 2013-12-10 Becton, Dickinson And Company Flashback blood collection needle
BRPI0916739A2 (pt) 2008-07-31 2015-11-03 Ziopharm Oncology Inc síntese e formulações de sais de mostarda de isofosforamida e análogos dos mesmos
CN102924507A (zh) * 2011-11-10 2013-02-13 安徽四维药业有限公司 一种抗肿瘤化合物及其制备方法与应用、药物组合物
US20130196000A1 (en) * 2012-01-31 2013-08-01 Ziopharm Oncology, Inc. Combination therapy including isophosphoramide mustard, analogs, or salts thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU427945A1 (ru) * 1972-07-24 1974-05-15 Институт элементоорганических соединений СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ
WO1993021173A1 (en) 1992-04-17 1993-10-28 Abbott Laboratories Taxol derivatives
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
CA2373634C (en) 1999-05-24 2010-04-13 Southern Research Institute Isophosphoramide mustard analogs and use thereof
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
KR101173510B1 (ko) 2002-08-23 2012-08-21 슬로안-케테링인스티튜트퍼캔서리서치 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도
EP2336139A3 (en) * 2004-10-25 2012-01-04 Dekk-Tec, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
KR101505415B1 (ko) * 2007-04-06 2015-03-25 지오팜 온콜로지 인코포레이티드 이소포스포르아미드 머스타드의 염 및 이의 동족체
BRPI0916739A2 (pt) 2008-07-31 2015-11-03 Ziopharm Oncology Inc síntese e formulações de sais de mostarda de isofosforamida e análogos dos mesmos

Also Published As

Publication number Publication date
TW201004631A (en) 2010-02-01
WO2010014841A1 (en) 2010-02-04
JP5711660B2 (ja) 2015-05-07
NZ601139A (en) 2014-02-28
JP2011529907A (ja) 2011-12-15
US20160215005A1 (en) 2016-07-28
EP2318013A1 (en) 2011-05-11
CA2732290A1 (en) 2010-02-04
WO2010014841A8 (en) 2011-02-17
KR20110038696A (ko) 2011-04-14
SG10201600595PA (en) 2016-02-26
ZA201100878B (en) 2011-10-26
IL210921A0 (en) 2011-04-28
US9145431B2 (en) 2015-09-29
NZ590995A (en) 2012-12-21
US20150328238A1 (en) 2015-11-19
JP5769831B2 (ja) 2015-08-26
US9254298B2 (en) 2016-02-09
IL210921A (en) 2016-04-21
US8664201B2 (en) 2014-03-04
CN104490900A (zh) 2015-04-08
AU2009276512A1 (en) 2010-02-04
EA022655B1 (ru) 2016-02-29
NZ603801A (en) 2014-01-31
AU2009276512B2 (en) 2014-12-18
EP2318013A4 (en) 2013-07-24
US20140378704A1 (en) 2014-12-25
BRPI0916739A2 (pt) 2015-11-03
CN102137674A (zh) 2011-07-27
JP2014114304A (ja) 2014-06-26
TWI454266B (zh) 2014-10-01
US20110212921A1 (en) 2011-09-01
MX2011001122A (es) 2011-03-29
SG183657A1 (en) 2012-09-27

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU