JP2006522126A - βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体 - Google Patents

βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体 Download PDF

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Publication number
JP2006522126A
JP2006522126A JP2006509331A JP2006509331A JP2006522126A JP 2006522126 A JP2006522126 A JP 2006522126A JP 2006509331 A JP2006509331 A JP 2006509331A JP 2006509331 A JP2006509331 A JP 2006509331A JP 2006522126 A JP2006522126 A JP 2006522126A
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JP
Japan
Prior art keywords
trifluoro
sulfonamide
thiophene
hydroxymethyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006509331A
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English (en)
Japanese (ja)
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JP2006522126A5 (US07547725-20090616-C00032.png
Inventor
アンソニー・フランク・クレフト
リン・レズニック
スコット・クリスティアン・メイヤー
ジョージ・ディアマンティディス
デレク・セシル・コール
ワン・ティンジョン
ロッコ・ジョン・ガラント
モリー・ホーク
ボイド・リン・ハリソン
ミンシェン・ジャン
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Wyeth LLC
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Wyeth LLC
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Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of JP2006522126A publication Critical patent/JP2006522126A/ja
Publication of JP2006522126A5 publication Critical patent/JP2006522126A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
JP2006509331A 2003-03-31 2004-03-26 βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体 Pending JP2006522126A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31
PCT/US2004/009268 WO2004092155A1 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Publications (2)

Publication Number Publication Date
JP2006522126A true JP2006522126A (ja) 2006-09-28
JP2006522126A5 JP2006522126A5 (US07547725-20090616-C00032.png) 2009-06-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006509331A Pending JP2006522126A (ja) 2003-03-31 2004-03-26 βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体

Country Status (22)

Country Link
US (3) US7300951B2 (US07547725-20090616-C00032.png)
EP (1) EP1608638A1 (US07547725-20090616-C00032.png)
JP (1) JP2006522126A (US07547725-20090616-C00032.png)
KR (1) KR20060002908A (US07547725-20090616-C00032.png)
CN (2) CN1780829B (US07547725-20090616-C00032.png)
AR (1) AR043940A1 (US07547725-20090616-C00032.png)
AU (1) AU2004230844B2 (US07547725-20090616-C00032.png)
BR (1) BRPI0408962A (US07547725-20090616-C00032.png)
CA (1) CA2517155A1 (US07547725-20090616-C00032.png)
CL (1) CL2004000647A1 (US07547725-20090616-C00032.png)
CO (1) CO5640049A2 (US07547725-20090616-C00032.png)
CR (1) CR7951A (US07547725-20090616-C00032.png)
EC (1) ECSP056128A (US07547725-20090616-C00032.png)
MX (1) MXPA05010368A (US07547725-20090616-C00032.png)
NO (1) NO20054263L (US07547725-20090616-C00032.png)
NZ (1) NZ542468A (US07547725-20090616-C00032.png)
RU (1) RU2342374C2 (US07547725-20090616-C00032.png)
SG (1) SG167669A1 (US07547725-20090616-C00032.png)
TW (1) TWI336698B (US07547725-20090616-C00032.png)
UA (1) UA82093C2 (US07547725-20090616-C00032.png)
WO (1) WO2004092155A1 (US07547725-20090616-C00032.png)
ZA (1) ZA200507896B (US07547725-20090616-C00032.png)

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NZ542468A (en) 2009-01-31
BRPI0408962A (pt) 2006-04-04
UA82093C2 (uk) 2008-03-11
CR7951A (es) 2008-10-29
CL2004000647A1 (es) 2005-02-04
ZA200507896B (en) 2007-03-28
RU2005133434A (ru) 2006-07-10
CN1780829B (zh) 2010-12-29
AU2004230844B2 (en) 2010-12-09
CN1780829A (zh) 2006-05-31
US7300951B2 (en) 2007-11-27
NO20054263L (no) 2005-12-14
US7858658B2 (en) 2010-12-28
US20090227667A1 (en) 2009-09-10
EP1608638A1 (en) 2005-12-28
MXPA05010368A (es) 2005-11-17
RU2342374C2 (ru) 2008-12-27
CO5640049A2 (es) 2006-05-31
US7547725B2 (en) 2009-06-16
TW200504047A (en) 2005-02-01
ECSP056128A (es) 2006-03-01
NO20054263D0 (no) 2005-09-15
CN101274926A (zh) 2008-10-01
SG167669A1 (en) 2011-01-28
US20070254929A1 (en) 2007-11-01
WO2004092155A1 (en) 2004-10-28
CA2517155A1 (en) 2004-10-28
TWI336698B (en) 2011-02-01
AR043940A1 (es) 2005-08-17
US20040198778A1 (en) 2004-10-07
AU2004230844A1 (en) 2004-10-28
KR20060002908A (ko) 2006-01-09

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