JP2006516949A5 - - Google Patents
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- JP2006516949A5 JP2006516949A5 JP2004536551A JP2004536551A JP2006516949A5 JP 2006516949 A5 JP2006516949 A5 JP 2006516949A5 JP 2004536551 A JP2004536551 A JP 2004536551A JP 2004536551 A JP2004536551 A JP 2004536551A JP 2006516949 A5 JP2006516949 A5 JP 2006516949A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- pharmaceutical composition
- methionine
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 66
- 108020004705 Codon Proteins 0.000 claims 60
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 60
- 229930182817 methionine Natural products 0.000 claims 60
- 230000035772 mutation Effects 0.000 claims 47
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 45
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 45
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 45
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 45
- 150000002148 esters Chemical class 0.000 claims 45
- 229940002612 prodrug Drugs 0.000 claims 45
- 239000000651 prodrug Substances 0.000 claims 45
- 150000003839 salts Chemical class 0.000 claims 45
- 239000004474 valine Substances 0.000 claims 45
- 125000002252 acyl group Chemical group 0.000 claims 39
- 125000000539 amino acid group Chemical group 0.000 claims 38
- 239000003937 drug carrier Substances 0.000 claims 37
- 239000000546 pharmaceutical excipient Substances 0.000 claims 36
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 33
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 33
- 229910052739 hydrogen Inorganic materials 0.000 claims 33
- 150000002431 hydrogen Chemical class 0.000 claims 30
- 239000001257 hydrogen Substances 0.000 claims 30
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 27
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 27
- 235000011178 triphosphate Nutrition 0.000 claims 27
- 239000001226 triphosphate Substances 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 26
- 239000003814 drug Substances 0.000 claims 26
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 24
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 claims 24
- 229940079593 drug Drugs 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 18
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 15
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 15
- 230000001747 exhibiting effect Effects 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- 108010050904 Interferons Proteins 0.000 claims 12
- 102000014150 Interferons Human genes 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 229940079322 interferon Drugs 0.000 claims 12
- -1 L-valinyl Chemical group 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 239000003085 diluting agent Substances 0.000 claims 5
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 4
- 108010047761 Interferon-alpha Proteins 0.000 claims 4
- 102000006992 Interferon-alpha Human genes 0.000 claims 4
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 3
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 3
- 229910005965 SO 2 Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 239000011574 phosphorus Substances 0.000 claims 3
- 150000003212 purines Chemical class 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 3
- ZLCOWUKVVFVVKA-WDSKDSINSA-N (2r)-3-[[(2r)-2-acetamido-2-carboxyethyl]disulfanyl]-2-aminopropanoic acid Chemical compound CC(=O)N[C@H](C(O)=O)CSSC[C@H](N)C(O)=O ZLCOWUKVVFVVKA-WDSKDSINSA-N 0.000 claims 2
- 108010005716 Interferon beta-1a Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 claims 2
- GWFOVSGRNGAGDL-FSDSQADBSA-N 2-amino-9-[(1r,2r,3s)-2,3-bis(hydroxymethyl)cyclobutyl]-3h-purin-6-one Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1C[C@H](CO)[C@H]1CO GWFOVSGRNGAGDL-FSDSQADBSA-N 0.000 claims 1
- YLDCUKJMEKGGFI-QCSRICIXSA-N 4-acetamidobenzoic acid;9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;1-(dimethylamino)propan-2-ol Chemical compound CC(O)CN(C)C.CC(O)CN(C)C.CC(O)CN(C)C.CC(=O)NC1=CC=C(C(O)=O)C=C1.CC(=O)NC1=CC=C(C(O)=O)C=C1.CC(=O)NC1=CC=C(C(O)=O)C=C1.O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(NC=NC2=O)=C2N=C1 YLDCUKJMEKGGFI-QCSRICIXSA-N 0.000 claims 1
- CKTSBUTUHBMZGZ-CHKWXVPMSA-N 4-amino-1-[(2s,4r,5s)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 CKTSBUTUHBMZGZ-CHKWXVPMSA-N 0.000 claims 1
- 101001054334 Homo sapiens Interferon beta Proteins 0.000 claims 1
- 102100026720 Interferon beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims 1
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- RLAHNGKRJJEIJL-RFZPGFLSSA-N [(2r,4r)-4-(2,6-diaminopurin-9-yl)-1,3-dioxolan-2-yl]methanol Chemical compound C12=NC(N)=NC(N)=C2N=CN1[C@H]1CO[C@@H](CO)O1 RLAHNGKRJJEIJL-RFZPGFLSSA-N 0.000 claims 1
- 229960001997 adefovir Drugs 0.000 claims 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims 1
- GBBJCSTXCAQSSJ-XQXXSGGOSA-N clevudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1[C@H](F)[C@@H](O)[C@H](CO)O1 GBBJCSTXCAQSSJ-XQXXSGGOSA-N 0.000 claims 1
- QDGZDCVAUDNJFG-FXQIFTODSA-N entecavir (anhydrous) Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)C1=C QDGZDCVAUDNJFG-FXQIFTODSA-N 0.000 claims 1
- LLYJISDUHFXOHK-GOCONZMPSA-N ferroptocide Chemical compound C[C@@H]1CC[C@@]23C[C@@H](C(=O)[C@]2([C@@]1([C@@H](C[C@H]([C@@H]3C)C4=CCN5C(=O)N(C(=O)N5C4)C6=CC=CC=C6)OC(=O)CCl)C)O)O LLYJISDUHFXOHK-GOCONZMPSA-N 0.000 claims 1
- 229960002963 ganciclovir Drugs 0.000 claims 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 1
- 229940090438 infergen Drugs 0.000 claims 1
- 108010010648 interferon alfacon-1 Proteins 0.000 claims 1
- 229960004461 interferon beta-1a Drugs 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 108010042414 interferon gamma-1b Proteins 0.000 claims 1
- 229940028862 interferon gamma-1b Drugs 0.000 claims 1
- 108010045648 interferon omega 1 Proteins 0.000 claims 1
- 108700027921 interferon tau Proteins 0.000 claims 1
- 229960001388 interferon-beta Drugs 0.000 claims 1
- 229960001614 levamisole Drugs 0.000 claims 1
- 229950005339 lobucavir Drugs 0.000 claims 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 1
- 229940002988 pegasys Drugs 0.000 claims 1
- 108010092853 peginterferon alfa-2a Proteins 0.000 claims 1
- 108010092851 peginterferon alfa-2b Proteins 0.000 claims 1
- 229940106366 pegintron Drugs 0.000 claims 1
- 229960001179 penciclovir Drugs 0.000 claims 1
- 229940038850 rebif Drugs 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 claims 1
- 229960004556 tenofovir Drugs 0.000 claims 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 1
- YFNGWGVTFYSJHE-UHFFFAOYSA-K trisodium;phosphonoformate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O YFNGWGVTFYSJHE-UHFFFAOYSA-K 0.000 claims 1
- 0 CC(C)[C@@](C(OC[C@](C(CO)C1)O[C@@]1N1C=CC(*)=NC1O)=O)N Chemical compound CC(C)[C@@](C(OC[C@](C(CO)C1)O[C@@]1N1C=CC(*)=NC1O)=O)N 0.000 description 5
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41067502P | 2002-09-13 | 2002-09-13 | |
| PCT/US2003/029017 WO2004024095A2 (en) | 2002-09-13 | 2003-09-15 | ß-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008099992A Division JP2008273960A (ja) | 2002-09-13 | 2008-04-08 | 耐性ＨＢＶ菌株の治療のためのβ−Ｌ−２’−デオキシヌクレオシド及び併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006516949A JP2006516949A (ja) | 2006-07-13 |
| JP2006516949A5 true JP2006516949A5 (https=) | 2006-11-02 |
| JP4173861B2 JP4173861B2 (ja) | 2008-10-29 |
Family
ID=31994179
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004536551A Expired - Fee Related JP4173861B2 (ja) | 2002-09-13 | 2003-09-15 | 耐性ＨＢＶ菌株の治療のためのβ−Ｌ−２’−デオキシヌクレオシド及び併用療法 |
| JP2008099992A Pending JP2008273960A (ja) | 2002-09-13 | 2008-04-08 | 耐性ＨＢＶ菌株の治療のためのβ−Ｌ−２’−デオキシヌクレオシド及び併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008099992A Pending JP2008273960A (ja) | 2002-09-13 | 2008-04-08 | 耐性ＨＢＶ菌株の治療のためのβ−Ｌ−２’−デオキシヌクレオシド及び併用療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7186700B2 (https=) |
| EP (1) | EP1572095B1 (https=) |
| JP (2) | JP4173861B2 (https=) |
| KR (2) | KR100855907B1 (https=) |
| CN (1) | CN100536853C (https=) |
| AU (1) | AU2003278816A1 (https=) |
| BR (1) | BR0314259A (https=) |
| CA (1) | CA2498731C (https=) |
| DK (1) | DK1572095T3 (https=) |
| ES (1) | ES2547002T3 (https=) |
| HU (1) | HUE027522T2 (https=) |
| PT (1) | PT1572095E (https=) |
| SI (1) | SI1572095T1 (https=) |
| WO (1) | WO2004024095A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| SK287400B6 (sk) * | 1999-09-25 | 2010-08-09 | University Of Iowa Research Foundation | Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie |
| US20030129251A1 (en) * | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| PT1572095E (pt) * | 2002-09-13 | 2015-10-13 | Novartis Ag | Β-l-2'-desoxinucleósidos para tratamento de estirpes resistentes de vhb |
| AU2004226605A1 (en) * | 2003-04-02 | 2004-10-14 | Coley Pharmaceutical Group, Ltd. | Immunostimulatory nucleic acid oil-in-water formulations for topical application |
| EP2345657A1 (en) * | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| US20070167353A1 (en) * | 2003-10-24 | 2007-07-19 | John Hilfinger | Prodrug composition |
| CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| AU2005285045B2 (en) * | 2004-09-14 | 2011-10-13 | Gilead Sciences, Inc. | Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
| AU2006220835B2 (en) | 2005-03-04 | 2012-01-19 | Dynavax Technologies Corporation | Vaccines comprising oligonucleotides having immunostimulatory sequences (ISS) wherein the ISS are conjugated to antigens and stabilized by buffer conditions and further excipients |
| MX2008002015A (es) * | 2005-08-15 | 2008-03-25 | Hoffmann La Roche | Polietilenglicol-interferon alfa y ribavirina para el tratamiento del virus de hepatitis b. |
| WO2008079206A1 (en) * | 2006-12-20 | 2008-07-03 | Merck & Co., Inc. | Nucleoside cyclic phosphoramidates for the treatment of rna-dependent rna viral infection |
| WO2008106167A1 (en) * | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases |
| PT2144604E (pt) * | 2007-02-28 | 2011-10-19 | Conatus Pharmaceuticals Inc | Métodos para o tratamento da hepatite c viral crónica utilizando ro-113-0830 |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| US20090082306A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched telbivudine |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| KR20110098849A (ko) | 2008-12-23 | 2011-09-01 | 파마셋 인코포레이티드 | 뉴클레오시드 유사체 |
| SG194404A1 (en) | 2008-12-23 | 2013-11-29 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| PT2376088T (pt) | 2008-12-23 | 2017-05-02 | Gilead Pharmasset Llc | Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| PT2609923T (pt) | 2010-03-31 | 2017-08-30 | Gilead Pharmasset Llc | Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo |
| AU2011336632B2 (en) | 2010-11-30 | 2015-09-03 | Gilead Pharmasset Llc | Compounds |
| CN102140534A (zh) * | 2010-12-15 | 2011-08-03 | 深圳华大基因科技有限公司 | 一种hbv基因的核苷酸突变位点的检测方法 |
| PH12019502377A1 (en) | 2011-04-21 | 2022-11-14 | Isis Pharmaceuticals Inc | Modulation of hepatitis b virus (hbv) expression |
| PL2709613T5 (pl) | 2011-09-16 | 2020-12-14 | Gilead Pharmasset Llc | Metody leczenia hcv |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| EP2841055A4 (en) * | 2012-04-04 | 2015-09-16 | Univ Duke | METHOD OF USE OF CERIUM OXIDE NANOPARTICLES TO REDUCE OR PROTECT FROM RADIATION DAMAGE |
| PT2950786T (pt) | 2013-01-31 | 2020-03-03 | Gilead Pharmasset Llc | Formulação de combinação de dois compostos antivirais |
| EP2953945A2 (en) * | 2013-02-07 | 2015-12-16 | Tobira Therapeutics, Inc. | Lamivudine salts |
| EA201690473A1 (ru) | 2013-08-27 | 2017-03-31 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | Комбинированный состав двух противовирусных соединений |
| US10933067B2 (en) | 2016-11-16 | 2021-03-02 | National Center For Global Health And Medicine | Nucleoside derivative having physiological activity such as antiviral activity |
| US11944679B2 (en) | 2017-03-14 | 2024-04-02 | The Regents Of The University Of California | Genome-wide identification of immune evasion functions in a virus |
| US11446303B2 (en) * | 2019-06-21 | 2022-09-20 | Tosk, Inc. | Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions |
| WO2022010778A1 (en) | 2020-07-07 | 2022-01-13 | Tosk, Inc. | Uridine phosphorylase inhibitors to treat or prevent pulmonary disease |
| CN115607532A (zh) * | 2021-07-15 | 2023-01-17 | 上海市公共卫生临床中心 | 大黄酸在制备改善老年机体免疫功能药物中的应用 |
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-
2003
- 2003-09-15 PT PT37703345T patent/PT1572095E/pt unknown
- 2003-09-15 BR BR0314259-0A patent/BR0314259A/pt not_active Application Discontinuation
- 2003-09-15 CA CA2498731A patent/CA2498731C/en not_active Expired - Lifetime
- 2003-09-15 CN CNB038251159A patent/CN100536853C/zh not_active Expired - Lifetime
- 2003-09-15 WO PCT/US2003/029017 patent/WO2004024095A2/en not_active Ceased
- 2003-09-15 ES ES03770334.5T patent/ES2547002T3/es not_active Expired - Lifetime
- 2003-09-15 AU AU2003278816A patent/AU2003278816A1/en not_active Abandoned
- 2003-09-15 KR KR1020057004375A patent/KR100855907B1/ko not_active Expired - Lifetime
- 2003-09-15 DK DK03770334.5T patent/DK1572095T3/en active
- 2003-09-15 HU HUE03770334A patent/HUE027522T2/en unknown
- 2003-09-15 EP EP03770334.5A patent/EP1572095B1/en not_active Expired - Lifetime
- 2003-09-15 JP JP2004536551A patent/JP4173861B2/ja not_active Expired - Fee Related
- 2003-09-15 US US10/662,641 patent/US7186700B2/en not_active Expired - Lifetime
- 2003-09-15 KR KR1020087012404A patent/KR20080053419A/ko not_active Withdrawn
- 2003-09-15 SI SI200332444T patent/SI1572095T1/sl unknown
-
2007
- 2007-01-09 US US11/651,353 patent/US7928086B2/en not_active Expired - Fee Related
-
2008
- 2008-04-08 JP JP2008099992A patent/JP2008273960A/ja active Pending
-
2011
- 2011-03-21 US US13/052,750 patent/US8158606B2/en not_active Expired - Fee Related
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