JP2005503358A5 - - Google Patents
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- JP2005503358A5 JP2005503358A5 JP2003506646A JP2003506646A JP2005503358A5 JP 2005503358 A5 JP2005503358 A5 JP 2005503358A5 JP 2003506646 A JP2003506646 A JP 2003506646A JP 2003506646 A JP2003506646 A JP 2003506646A JP 2005503358 A5 JP2005503358 A5 JP 2005503358A5
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- JP
- Japan
- Prior art keywords
- nucleoside
- hiv
- triphosphate
- chem
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 2-Fluoroadenosine-5′-phosphate ester Chemical class 0.000 description 37
- 239000001226 triphosphate Substances 0.000 description 16
- 235000011178 triphosphate Nutrition 0.000 description 15
- 229910052717 sulfur Inorganic materials 0.000 description 14
- 238000003786 synthesis reaction Methods 0.000 description 14
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- 239000002773 nucleotide Substances 0.000 description 10
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- 239000000651 prodrug Substances 0.000 description 10
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- 125000003835 nucleoside group Chemical group 0.000 description 9
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- 229910019142 PO4 Inorganic materials 0.000 description 8
- 125000003118 aryl group Chemical group 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
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| NZ575481A (en) * | 2000-10-18 | 2010-10-29 | Pharmasset Inc | Simultaneous quantification of nucleic acids in diseased cells |
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| US7105499B2 (en) | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| US8481712B2 (en) | 2001-01-22 | 2013-07-09 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| US7241890B2 (en) | 2001-10-30 | 2007-07-10 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
| US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| NZ537662A (en) | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| PL374781A1 (en) | 2002-06-28 | 2005-10-31 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| EP1610797A1 (en) * | 2003-03-27 | 2006-01-04 | Boehringer Ingelheim International GmbH | Antiviral combination of nevirapine and a further antiretroviral compound |
| EP2345657A1 (en) | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
| KR20060070572A (ko) | 2003-09-18 | 2006-06-23 | 콘포마 세러퓨틱스 코포레이션 | Ｈｓｐ90-저해제로서의 신규 헤테로시클릭 화합물 |
| JP2005289964A (ja) * | 2004-03-12 | 2005-10-20 | Ajinomoto Co Inc | ２−デオキシ−ｌ−リボース化合物の製造方法 |
| GB0505781D0 (en) * | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
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| NZ567272A (en) * | 2005-09-26 | 2012-02-24 | Pharmasset Inc | Modified 4'-nucleosides as antiviral agents |
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| WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| BR112013026345A2 (pt) | 2011-04-13 | 2019-04-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv |
| WO2012142093A2 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| US9416154B2 (en) | 2011-07-13 | 2016-08-16 | Merck Sharp & Dohme Corp. | 5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| WO2013009737A1 (en) | 2011-07-13 | 2013-01-17 | Merck Sharp & Dohme Corp. | 5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases |
| SG11201404706XA (en) | 2012-02-14 | 2014-09-26 | Univ Georgia | Spiro [2.4]heptanes for treatment of flaviviridae infections |
| AU2013241341B2 (en) | 2012-03-28 | 2016-09-08 | Fujifilm Corporation | Salt of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine |
| DK2883866T3 (da) | 2012-08-13 | 2019-05-13 | Fujifilm Corp | MELLEMPRODUKT TIL SYNTESE AF 1-(2-DEOXY-2-FLUOR-4-THIO-beta-D- ARABINOFURANOSYL)CYTOSIN, MELLEMPRODUKT TIL SYNTESE AF THIONUKLEOSID OG FREMGANGSMÅDER TIL FREMSTILLING AF DISSE MELLEMPRODUKTER |
| WO2015125781A1 (ja) * | 2014-02-18 | 2015-08-27 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
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| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| CA3182565A1 (en) | 2015-03-06 | 2016-09-15 | Atea Pharmaceuticals, Inc. | .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
| US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| EP3508205B1 (en) | 2016-08-31 | 2022-05-18 | FUJIFILM Corporation | Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit |
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| EP3773753A4 (en) | 2018-04-10 | 2021-12-22 | ATEA Pharmaceuticals, Inc. | TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS |
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| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
-
2002
- 2002-06-24 CN CNB028164555A patent/CN100343268C/zh not_active Expired - Fee Related
- 2002-06-24 JP JP2003506646A patent/JP2005503358A/ja active Pending
- 2002-06-24 BR BR0210594-2A patent/BR0210594A/pt not_active IP Right Cessation
- 2002-06-24 KR KR1020037016775A patent/KR20050059975A/ko not_active Ceased
- 2002-06-24 CA CA002451745A patent/CA2451745A1/en not_active Abandoned
- 2002-06-24 WO PCT/US2002/020245 patent/WO2003000200A2/en not_active Ceased
- 2002-06-24 US US10/179,612 patent/US6949522B2/en not_active Expired - Fee Related
- 2002-06-24 EP EP02756310A patent/EP1478322A4/en not_active Withdrawn
- 2002-06-24 AU AU2002322325A patent/AU2002322325A1/en not_active Abandoned
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