JP2006516652A5 - - Google Patents
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- JP2006516652A5 JP2006516652A5 JP2006503317A JP2006503317A JP2006516652A5 JP 2006516652 A5 JP2006516652 A5 JP 2006516652A5 JP 2006503317 A JP2006503317 A JP 2006503317A JP 2006503317 A JP2006503317 A JP 2006503317A JP 2006516652 A5 JP2006516652 A5 JP 2006516652A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- peptide
- amino acids
- minimum
- net positive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44477703P | 2003-02-04 | 2003-02-04 | |
| US60/444,777 | 2003-02-04 | ||
| US53569004P | 2004-01-08 | 2004-01-08 | |
| US60/535,690 | 2004-01-08 | ||
| PCT/US2004/003193 WO2004070054A2 (en) | 2003-02-04 | 2004-02-03 | Methods for preventing mitochondrial permeability transition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010241738A Division JP5775285B2 (ja) | 2003-02-04 | 2010-10-28 | ミトコンドリア透過性転移の阻止方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006516652A JP2006516652A (ja) | 2006-07-06 |
| JP2006516652A5 true JP2006516652A5 (enExample) | 2007-10-18 |
| JP4838114B2 JP4838114B2 (ja) | 2011-12-14 |
Family
ID=32853391
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503317A Expired - Lifetime JP4838114B2 (ja) | 2003-02-04 | 2004-02-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2010241738A Expired - Lifetime JP5775285B2 (ja) | 2003-02-04 | 2010-10-28 | ミトコンドリア透過性転移の阻止方法 |
| JP2013182343A Expired - Lifetime JP5837542B2 (ja) | 2003-02-04 | 2013-09-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2014202889A Expired - Lifetime JP6126059B2 (ja) | 2003-02-04 | 2014-10-01 | ミトコンドリア透過性転移の阻止方法 |
| JP2015135207A Expired - Lifetime JP6166312B2 (ja) | 2003-02-04 | 2015-07-06 | ミトコンドリア透過性転移の阻止方法 |
| JP2017025764A Pending JP2017095519A (ja) | 2003-02-04 | 2017-02-15 | ミトコンドリア透過性転移の阻止方法 |
| JP2019001256A Pending JP2019089773A (ja) | 2003-02-04 | 2019-01-08 | ミトコンドリア透過性転移の阻止方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010241738A Expired - Lifetime JP5775285B2 (ja) | 2003-02-04 | 2010-10-28 | ミトコンドリア透過性転移の阻止方法 |
| JP2013182343A Expired - Lifetime JP5837542B2 (ja) | 2003-02-04 | 2013-09-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2014202889A Expired - Lifetime JP6126059B2 (ja) | 2003-02-04 | 2014-10-01 | ミトコンドリア透過性転移の阻止方法 |
| JP2015135207A Expired - Lifetime JP6166312B2 (ja) | 2003-02-04 | 2015-07-06 | ミトコンドリア透過性転移の阻止方法 |
| JP2017025764A Pending JP2017095519A (ja) | 2003-02-04 | 2017-02-15 | ミトコンドリア透過性転移の阻止方法 |
| JP2019001256A Pending JP2019089773A (ja) | 2003-02-04 | 2019-01-08 | ミトコンドリア透過性転移の阻止方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US7576061B2 (enExample) |
| EP (9) | EP3659618A1 (enExample) |
| JP (7) | JP4838114B2 (enExample) |
| CN (3) | CN102784383B (enExample) |
| AU (1) | AU2004209663B2 (enExample) |
| CA (1) | CA2515080C (enExample) |
| CY (2) | CY1114959T1 (enExample) |
| DK (3) | DK1599216T3 (enExample) |
| ES (3) | ES2436011T3 (enExample) |
| HU (1) | HUE027110T2 (enExample) |
| PT (2) | PT1599216E (enExample) |
| SI (1) | SI2656854T1 (enExample) |
| WO (1) | WO2004070054A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2436011T3 (es) | 2003-02-04 | 2013-12-26 | Cornell Research Foundation, Inc. | Métodos para prevenir la transición de la permeabilidad mitocondrial |
| CN100506841C (zh) | 2003-05-01 | 2009-07-01 | 科内尔研究基金会 | 将分子递送到细胞的方法和载体复合物 |
| RU2376028C2 (ru) * | 2004-01-23 | 2009-12-20 | Корнелл Рисеч Фаундейшн, Инк. | Способ уменьшения окислительного повреждения (варианты) |
| CA2947330C (en) * | 2005-09-16 | 2018-06-05 | Cornell Research Foundation, Inc. | Methods for reducing cd36 expression |
| AU2014203126B2 (en) * | 2005-09-16 | 2016-03-10 | Cornell Research Foundation, Inc. | Methods for reducing cd36 expression |
| CA2713150C (en) | 2008-02-07 | 2016-01-05 | Cornell University | Methods for preventing or treating insulin resistance |
| DK2262520T3 (en) | 2008-02-26 | 2017-08-07 | Univ Cornell | COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury |
| DE102008061044A1 (de) * | 2008-12-11 | 2010-06-17 | Henkel Ag & Co. Kgaa | Zusammensetzung mit antioxidativ wirksamen Peptiden |
| CN102573881A (zh) * | 2009-03-20 | 2012-07-11 | 通用医疗公司以马萨诸塞州通用医疗公司名义经营 | 预防和治疗烧伤损伤和继发性并发症的方法 |
| DK2464371T3 (en) * | 2009-08-12 | 2016-06-27 | Univ Cornell | Methods for preventing or treating metabolic syndrome |
| WO2011025734A1 (en) * | 2009-08-24 | 2011-03-03 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating ophthalmic conditions |
| EP2764871A1 (en) * | 2009-10-05 | 2014-08-13 | Cornell University | Methods for the prevention or treatment of heart failure |
| US20130190244A1 (en) * | 2009-12-31 | 2013-07-25 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| WO2011082324A1 (en) * | 2009-12-31 | 2011-07-07 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of vessel occlusion injury |
| WO2011091357A1 (en) * | 2010-01-25 | 2011-07-28 | Cornell University | Aromatic-cationic peptides and uses of same |
| EP3511012A1 (en) * | 2010-02-26 | 2019-07-17 | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP2547352A4 (en) * | 2010-03-15 | 2013-10-09 | Stealth Peptides Int Inc | COMBINATION THERAPIES USING CYCLOSPORINE AND AROMATIC CATIONIC PEPTIDES |
| US20110245183A1 (en) | 2010-04-06 | 2011-10-06 | Perricone Nicholas V | Topical Uses of Szeto-Schiller Peptides |
| US20110245182A1 (en) | 2010-04-06 | 2011-10-06 | Perricone Nicholas V | Topical Uses of Szeto-Schiller Peptides |
| EP3290433A1 (en) * | 2010-05-03 | 2018-03-07 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| WO2014137496A1 (en) * | 2013-03-08 | 2014-09-12 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
| JP6319738B2 (ja) * | 2010-07-09 | 2018-05-09 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 虚血/再灌流障害に続くノーリフローの予防又は処置方法 |
| US20160176930A1 (en) | 2010-07-09 | 2016-06-23 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
| US20120083452A1 (en) * | 2010-09-30 | 2012-04-05 | Perricone Nicholas V | Topical Anesthetic Uses of Szeto-Schiller Peptides |
| EP2688579A4 (en) * | 2011-03-24 | 2015-10-21 | Univ Cornell | CATIONIC AROMATIC PEPTIDES AND USES THEREOF |
| HK1200459A1 (en) * | 2011-09-19 | 2015-08-07 | Gencia Corporation | Modified creatine compounds |
| WO2013049697A1 (en) | 2011-09-29 | 2013-04-04 | Mayo Foundation For Medical Education And Research | Aromatic-cationic peptides and methods for using same |
| CA2852454A1 (en) * | 2011-10-17 | 2013-04-25 | Cornell University | Aromatic-cationic peptides and uses of same |
| EP3466439A1 (en) | 2011-12-09 | 2019-04-10 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| JP6317324B2 (ja) | 2012-03-30 | 2018-04-25 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 神経障害を予防および処置するための方法および組成物 |
| JP2015524439A (ja) * | 2012-08-02 | 2015-08-24 | ステルス ペプチドズ インターナショナル インコーポレイテッド | アテローム性硬化症の処置方法 |
| ES3058737T3 (en) * | 2012-10-22 | 2026-03-12 | Stealth Biotherapeutics Inc | Treatment of left ventricular remodeling |
| ES2750258T3 (es) * | 2013-03-01 | 2020-03-25 | Stealth Biotherapeutics Corp | Métodos y composiciones para la prevención o tratamiento del síndrome de Barth |
| CN117752766A (zh) * | 2013-03-01 | 2024-03-26 | 康德生物医疗有限公司 | 治疗线粒体疾病的方法 |
| US9850278B2 (en) | 2013-04-25 | 2017-12-26 | Carmel-Haifa University Economic Corp. | Synthetic anti-inflammatory peptides and use thereof |
| WO2014209905A2 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods and compositions for detecting and diagnosing diseases and conditions |
| CA2919992C (en) * | 2013-08-01 | 2022-08-09 | Stealth Biotherapeutics Corp | Methods and compositions for preventing or treating leber's hereditary optic neuropathy |
| US20160166633A1 (en) | 2013-08-02 | 2016-06-16 | Stealth Bio Therapeutics Corp | Methods and compositions for the prevention and treatment of friedreich's ataxia |
| WO2015048647A1 (en) * | 2013-09-30 | 2015-04-02 | Cornell University | Cardiolipin-targeted peptides inhibit beta-amyloid oligomer toxicity |
| EP3154694B1 (en) | 2014-06-13 | 2025-01-29 | Children's Medical Center Corporation | Products and methods to isolate mitochondria |
| EP3160984B1 (en) | 2014-06-25 | 2021-04-14 | Flamma S.P.A. | Process for preparing d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide |
| PL3160985T3 (pl) | 2014-06-30 | 2021-12-27 | Flamma S.P.A. | Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylo-l-fenyloalaninoamidu |
| WO2016004093A2 (en) * | 2014-07-01 | 2016-01-07 | Stealth Biotherapeutics Corp | Therapeutic compositions including galectin-3 inhibitors and uses thereof |
| CN104306954B (zh) * | 2014-09-25 | 2016-08-24 | 中山大学 | Wry三肽在制备治疗阿尔茨海默症药物中的用途 |
| WO2016069556A2 (en) | 2014-10-29 | 2016-05-06 | University Of Maryland | Methods of treating age-related symptoms in mammals and compositions therefor |
| WO2017015660A1 (en) * | 2015-07-23 | 2017-01-26 | Salk Institute For Biological Studies | Prevention and treatment of aging and neurodegenerative diseases |
| WO2017093897A1 (en) * | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| ES3057779T3 (en) | 2016-01-15 | 2026-03-04 | Childrens Medical Ct Corp | Therapeutic use of mitochondria and combined mitochondrial agents |
| JP7038675B2 (ja) * | 2016-03-11 | 2022-03-18 | ステルス バイオセラピューティクス インコーポレイテッド | 結晶塩形態 |
| WO2017180535A1 (en) | 2016-04-11 | 2017-10-19 | Carnot, Llc | Chiral peptides |
| WO2018100893A1 (ja) | 2016-11-30 | 2018-06-07 | 株式会社ダイセル | 撮像装置用レンズモジュール及びその製造方法 |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| EP3668837B1 (en) | 2017-08-17 | 2022-07-06 | XWPharma Ltd. | Preparation and uses of reactive oxygen species scavenger derivatives |
| EP3988561B1 (en) | 2017-09-04 | 2023-06-07 | XWPharma Ltd. | Preparation and use of reactive oxygen species scavenger |
| JP6958860B2 (ja) * | 2017-11-07 | 2021-11-02 | 学校法人自治医科大学 | ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| IL284006B2 (en) * | 2018-12-18 | 2024-12-01 | Stealth Biotherapeutics Corp | Mitochondria-targeting peptides |
| WO2020222866A1 (en) * | 2019-05-02 | 2020-11-05 | Children's Medical Center Corporation | Prophylactic and therapeutic use of mitochondria and combined mitochondrial agents |
| EP3771467A1 (en) | 2019-07-30 | 2021-02-03 | Fundacio Institut de Recerca de l'Hospital de la Santa Creu i sant Pau | Ss-31 for the prevention and/or treatment of aneurysm |
| KR20240073137A (ko) * | 2020-09-09 | 2024-05-24 | 소셜 프로핏 네트워크 | 미토콘드리아에 비오틴의 전달을 위한 방법 및 조성물 |
| CN117881411A (zh) | 2021-06-01 | 2024-04-12 | 艾迪雅生物有限责任公司 | 用于眼部药物的延长释放药物递送系统和使用方法 |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| EP0350221B1 (en) | 1988-06-30 | 1996-04-17 | Astra Aktiebolag | Dermorphin analogs, their methods of preparation, pharmaceutical compositions, and methods of therapeutic treatment using the same |
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| WO1991010361A1 (en) * | 1990-01-17 | 1991-07-25 | The Regents Of The University Of California | Composition to improve survival of biological materials |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
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| CA2947330C (en) | 2005-09-16 | 2018-06-05 | Cornell Research Foundation, Inc. | Methods for reducing cd36 expression |
-
2004
- 2004-02-03 ES ES04707809T patent/ES2436011T3/es not_active Expired - Lifetime
- 2004-02-03 WO PCT/US2004/003193 patent/WO2004070054A2/en not_active Ceased
- 2004-02-03 EP EP19207802.0A patent/EP3659618A1/en not_active Withdrawn
- 2004-02-03 JP JP2006503317A patent/JP4838114B2/ja not_active Expired - Lifetime
- 2004-02-03 ES ES13178043.9T patent/ES2540897T3/es not_active Expired - Lifetime
- 2004-02-03 EP EP18199147.2A patent/EP3479838A1/en not_active Withdrawn
- 2004-02-03 SI SI200432258T patent/SI2656854T1/sl unknown
- 2004-02-03 EP EP11009660.9A patent/EP2491943B1/en not_active Expired - Lifetime
- 2004-02-03 DK DK04707809.2T patent/DK1599216T3/da active
- 2004-02-03 EP EP17192437.6A patent/EP3305313A1/en not_active Withdrawn
- 2004-02-03 CN CN201210177633.0A patent/CN102784383B/zh not_active Expired - Lifetime
- 2004-02-03 HU HUE13178043A patent/HUE027110T2/en unknown
- 2004-02-03 DK DK13178043.9T patent/DK2656854T3/en active
- 2004-02-03 PT PT47078092T patent/PT1599216E/pt unknown
- 2004-02-03 ES ES14186875.2T patent/ES2605504T3/es not_active Expired - Lifetime
- 2004-02-03 CA CA2515080A patent/CA2515080C/en not_active Expired - Lifetime
- 2004-02-03 CN CN201410412683.1A patent/CN104225574B/zh not_active Expired - Lifetime
- 2004-02-03 EP EP14186875.2A patent/EP2865385B1/en not_active Expired - Lifetime
- 2004-02-03 AU AU2004209663A patent/AU2004209663B2/en not_active Expired
- 2004-02-03 EP EP16192437.8A patent/EP3144009A1/en not_active Withdrawn
- 2004-02-03 EP EP04707809.2A patent/EP1599216B9/en not_active Expired - Lifetime
- 2004-02-03 CN CN2012100218642A patent/CN102617706A/zh active Pending
- 2004-02-03 EP EP20210900.5A patent/EP3842055A1/en active Pending
- 2004-02-03 US US10/771,232 patent/US7576061B2/en not_active Expired - Lifetime
- 2004-02-03 PT PT131780439T patent/PT2656854E/pt unknown
- 2004-02-03 DK DK14186875.2T patent/DK2865385T3/en active
- 2004-02-03 EP EP20130178043 patent/EP2656854B1/en not_active Expired - Lifetime
-
2006
- 2006-06-30 US US11/427,804 patent/US7718620B2/en active Active
-
2010
- 2010-04-02 US US12/753,403 patent/US20100190718A1/en not_active Abandoned
- 2010-10-28 JP JP2010241738A patent/JP5775285B2/ja not_active Expired - Lifetime
-
2011
- 2011-09-28 US US13/247,648 patent/US8404646B2/en not_active Expired - Fee Related
-
2013
- 2013-02-27 US US13/778,994 patent/US8957030B2/en not_active Expired - Lifetime
- 2013-09-03 JP JP2013182343A patent/JP5837542B2/ja not_active Expired - Lifetime
-
2014
- 2014-01-24 CY CY20141100064T patent/CY1114959T1/el unknown
- 2014-10-01 JP JP2014202889A patent/JP6126059B2/ja not_active Expired - Lifetime
-
2015
- 2015-01-13 US US14/595,946 patent/US20150359838A1/en not_active Abandoned
- 2015-07-06 JP JP2015135207A patent/JP6166312B2/ja not_active Expired - Lifetime
- 2015-08-03 CY CY20151100675T patent/CY1116575T1/el unknown
-
2017
- 2017-02-15 JP JP2017025764A patent/JP2017095519A/ja active Pending
-
2019
- 2019-01-08 JP JP2019001256A patent/JP2019089773A/ja active Pending
- 2019-09-12 US US16/569,573 patent/US20200038472A1/en not_active Abandoned
-
2022
- 2022-02-10 US US17/668,744 patent/US20230293624A1/en not_active Abandoned
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