JP2006508036A5 - - Google Patents

Download PDF

Info

Publication number
JP2006508036A5
JP2006508036A5 JP2004512756A JP2004512756A JP2006508036A5 JP 2006508036 A5 JP2006508036 A5 JP 2006508036A5 JP 2004512756 A JP2004512756 A JP 2004512756A JP 2004512756 A JP2004512756 A JP 2004512756A JP 2006508036 A5 JP2006508036 A5 JP 2006508036A5
Authority
JP
Japan
Prior art keywords
group
independently selected
haloalkyl
alkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004512756A
Other languages
English (en)
Japanese (ja)
Other versions
JP4723242B2 (ja
JP2006508036A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2003/018660 external-priority patent/WO2003105853A1/en
Publication of JP2006508036A publication Critical patent/JP2006508036A/ja
Publication of JP2006508036A5 publication Critical patent/JP2006508036A5/ja
Application granted granted Critical
Publication of JP4723242B2 publication Critical patent/JP4723242B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2004512756A 2002-06-12 2003-06-11 炎症および免疫障害治療用ｃｃｒ１アンタゴニストとして使用するための１−アリール−４−置換ピペラジン誘導体 Expired - Lifetime JP4723242B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45371102P 2002-06-12 2002-06-12
US60/453,711 2002-06-12
PCT/US2003/018660 WO2003105853A1 (en) 2002-06-12 2003-06-11 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders

Publications (3)

Publication Number Publication Date
JP2006508036A JP2006508036A (ja) 2006-03-09
JP2006508036A5 true JP2006508036A5 (enExample) 2006-08-03
JP4723242B2 JP4723242B2 (ja) 2011-07-13

Family

ID=29736828

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004512756A Expired - Lifetime JP4723242B2 (ja) 2002-06-12 2003-06-11 炎症および免疫障害治療用ｃｃｒ１アンタゴニストとして使用するための１−アリール−４−置換ピペラジン誘導体

Country Status (13)

Country Link
US (2) US7157464B2 (enExample)
EP (1) EP1531822B1 (enExample)
JP (1) JP4723242B2 (enExample)
KR (1) KR101255356B1 (enExample)
CN (1) CN1867336B (enExample)
AT (1) ATE438401T1 (enExample)
AU (1) AU2003236500B9 (enExample)
CA (1) CA2488202C (enExample)
DE (1) DE60328690D1 (enExample)
DK (1) DK1531822T3 (enExample)
ES (1) ES2329356T3 (enExample)
MX (1) MXPA04012393A (enExample)
WO (1) WO2003105853A1 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
AU2003236500B9 (en) 2002-06-12 2009-07-02 Chemocentryx, Inc. 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
AU2004221812B2 (en) * 2003-03-19 2010-02-18 Exelixis Inc. Tie-2 modulators and methods of use
US7754711B2 (en) * 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
AU2004293026B2 (en) 2003-11-21 2012-01-19 Array Biopharma Inc. AKT protein kinase inhibitors
AU2011265309B2 (en) * 2003-11-21 2014-06-05 Array Biopharma, Inc. AKT protein kinase inhibitors
CN100542534C (zh) * 2003-12-09 2009-09-23 凯莫森特里克斯股份有限公司 取代的哌嗪
GB0401269D0 (en) * 2004-01-21 2004-02-25 Astrazeneca Ab Compounds
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
AU2005219438B2 (en) * 2004-03-03 2011-02-17 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
JP2008502652A (ja) * 2004-06-18 2008-01-31 ノイロサーチ アクティーゼルスカブ モノアミン神経伝達物質再取込み阻害剤としての、新規アルキル置換ピペラジン誘導体及びその使用
PE20060484A1 (es) * 2004-07-14 2006-07-06 Ucb Farchim Sa Preparaciones farmaceuticas liquidas que comprenden un compuesto de benzhidril piperizina
KR101220615B1 (ko) 2004-07-26 2013-01-11 메르크 세로노 에스.에이. N-히드록시아미드 유도체 및 그의 용도
BRPI0515499A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de piridina para a inibição de estearoil-coa-desaturase humana
US7482353B2 (en) 2005-06-15 2009-01-27 Applied Biosystems Inc. Compositions and methods pertaining to PNA synthons and oligomers comprising a universal base
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
HRP20150832T1 (hr) * 2005-06-22 2015-09-25 Chemocentryx, Inc. Spojevi azaindazola i postupci njihove upotrebe
US7790726B2 (en) * 2005-08-16 2010-09-07 Chemocentryx, Inc. Monocyclic and bicyclic compounds and methods of use
US7576218B2 (en) * 2005-10-11 2009-08-18 Chemocentryx, Inc. 4-phenylpiperdine-pyrazole CCR1 antagonists
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
WO2007146230A2 (en) * 2006-06-14 2007-12-21 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
BR122020011920A2 (pt) 2006-06-16 2020-08-25 Lundbeck & Co As H composto, composição farmacêutica, método para tratar uma doença, uso de um composto, e processos para a preparação de um composto, e para a fabricação de um composto
US20090252779A1 (en) * 2006-06-22 2009-10-08 Chemocentryx, Inc. Azaindazole compounds and methods of use
WO2008147815A1 (en) 2007-05-22 2008-12-04 Chemocentryx, Inc. 3-(imidazolyl)-pyrazolo[3,4-b]pyridines
JP5292400B2 (ja) * 2007-07-24 2013-09-18 ブリストル−マイヤーズ スクイブ カンパニー ケモカイン受容体活性のモジュレーターとしてのピペリジン誘導体
US8008327B2 (en) 2008-04-29 2011-08-30 Boehringer Ingelheim International Gmbh Indazole compounds as CCR1 receptor antagonists
WO2009132785A1 (de) * 2008-04-30 2009-11-05 Bayer Cropscience Aktiengesellschaft Thiazol-4-carbonsäureester und thioester als pflanzenschutzmittel
CA2722811C (en) 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
TWI433838B (zh) 2008-06-25 2014-04-11 必治妥美雅史谷比公司 作為趨化因子受體活性調節劑之六氫吡啶衍生物
DK2323663T3 (en) * 2008-09-11 2015-06-01 Chemocentryx Inc 4-amino-3- (imidazolyl) pyrazolo [3,4-d] pyrimidines
CA2737472A1 (en) * 2008-09-26 2010-04-01 Boehringer Ingelheim International Gmbh Azaindazole compounds as ccr1 receptor antagonists
AU2009308687A1 (en) * 2008-11-03 2010-05-06 Chemocentryx, Inc. Compounds for the treatment of osteoporosis and cancers
US8362249B2 (en) * 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
WO2010126811A1 (en) * 2009-04-27 2010-11-04 Boehringer Ingelheim International Gmbh Cxcr3 receptor antagonists
WO2011049917A1 (en) 2009-10-21 2011-04-28 Boehringer Ingelheim International Gmbh Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
JP2013517281A (ja) * 2010-01-13 2013-05-16 テンペロ、ファーマシューティカルズ、インコーポレイテッド 化合物及び方法
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
WO2012087782A1 (en) 2010-12-23 2012-06-28 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as ccr1 receptor antagonists
US20140329809A1 (en) 2011-10-28 2014-11-06 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
US8822464B2 (en) 2011-11-28 2014-09-02 Boehringer Ingelheim International Gmbh N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8741892B2 (en) 2011-12-05 2014-06-03 Boehringer Ingelheim International Gmbh Compounds
US8642774B2 (en) 2011-12-08 2014-02-04 Boehringer Ingelheim International Gmbh Compounds
US8796467B2 (en) 2011-12-13 2014-08-05 Boehringer Ingelheim International Gmbh Compounds
US8846948B2 (en) 2011-12-13 2014-09-30 Boehringer Ingelheim International Gmbh Compounds
US8883789B2 (en) 2011-12-14 2014-11-11 Boehringer Ingelheim International Gmbh Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8716277B2 (en) 2011-12-14 2014-05-06 Boehringer Ingelheim International Gmbh Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity
US8937176B2 (en) 2011-12-14 2015-01-20 Boehringer Ingelheim International Gmbh Compounds
US8889677B2 (en) 2012-01-17 2014-11-18 Boehringer Ingellheim International GmbH Substituted triazoles useful as mGlu5 receptor modulators
PL3024832T3 (pl) 2013-07-22 2018-10-31 Idorsia Pharmaceuticals Ltd Pochodne 1-(piperazyn-1-ylo)-2-([1,2,4]triazol-1-ilo)-etanonu
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
PL3245203T3 (pl) 2015-01-15 2019-05-31 Idorsia Pharmaceuticals Ltd Pochodne hydroksyalkilopiperazyny jako modulatory receptora cxcr3
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
MX383697B (es) * 2016-06-23 2025-03-14 St Jude Childrens Res Hospital Inc Moduladores de moleculas peque?as de pantotenato cinasas
CA3086711A1 (en) 2017-12-27 2019-07-04 St. Jude Children's Research Hospital, Inc. Use of arylpiperazine-1-carboxamide derivatives in the treatment of coenzyme a-mediated disorders
KR102728619B1 (ko) 2017-12-27 2024-11-08 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 판토테네이트 키나제의 소분자 조절제
EP3996711A4 (en) 2019-07-10 2023-08-16 ChemoCentryx, Inc. Indanes as pd-l1 inhibitors
WO2021039961A1 (ja) * 2019-08-30 2021-03-04 大日本住友製薬株式会社 縮環ピラゾール誘導体
US11866429B2 (en) 2019-10-16 2024-01-09 Chemocentryx, Inc. Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases
KR20220084119A (ko) 2019-10-16 2022-06-21 케모센트릭스, 인크. Pd-l1 질환의 치료를 위한 헤테로아릴-바이페닐 아미드

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE663344A (enExample) 1964-05-04
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3491098A (en) * 1967-05-29 1970-01-20 Sterling Drug Inc 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines
US3778433A (en) 1969-04-18 1973-12-11 Sumitomo Chemical Co Process for producing benzodiazepine derivatives
DE2247187A1 (de) * 1972-09-26 1974-03-28 Bayer Ag Imidazolylessigsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3994890A (en) * 1974-01-31 1976-11-30 Chugai Seiyaku Kabushiki Kaisha 1-Aminoalkyl, 3-phenyl indazoles
JPS5944313B2 (ja) * 1974-11-26 1984-10-29 中外製薬株式会社 インダゾ−ル誘導体の製法
US4174393A (en) 1975-07-09 1979-11-13 Duphar International Research B.V. 1,3,4-Substituted pyrazoline derivatives
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4243619A (en) * 1978-03-31 1981-01-06 Union Carbide Corporation Process for making film from low density ethylene hydrocarbon copolymer
US4310429A (en) 1978-06-19 1982-01-12 The B. F. Goodrich Company Stabilized polymers, novel stabilizers, and synthesis thereof
DE2842539A1 (de) * 1978-09-29 1980-04-10 Bayer Ag 1-isocyanato-anthrachinone
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
DE3132915A1 (de) 1981-08-20 1983-03-03 Kali-Chemie Pharma Gmbh, 3000 Hannover 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS5852256A (ja) 1981-09-24 1983-03-28 Nippon Nohyaku Co Ltd 置換又は非置換脂肪酸アミド誘導体及びその塩類
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4547505A (en) 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4562189A (en) 1984-10-09 1985-12-31 American Cyanamid Company Pyrazolylpiperazines
DE3442860A1 (de) 1984-11-24 1986-05-28 Kali-Chemie Pharma Gmbh, 3000 Hannover 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES2052545T3 (es) 1986-02-27 1994-07-16 Duphar Int Res (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas.
IL85700A0 (en) 1987-03-24 1988-08-31 Takeda Chemical Industries Ltd 1,4-disubstituted piperazine compounds,their production and use
US4997836A (en) 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use
EP0385043A1 (en) 1989-02-28 1990-09-05 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) New derivatives of 4-substituted piperazines
US5215989A (en) 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
FR2672052B1 (fr) 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
GB9021453D0 (en) 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
FR2673628B1 (fr) 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
GB9305623D0 (en) 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
US5681954A (en) 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
US5464788A (en) 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5486534A (en) 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
US5607936A (en) 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
US5719156A (en) 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
AU6517196A (en) 1995-07-13 1997-02-10 Knoll Aktiengesellschaft Piperazine derivatives as therapeutic agents
GB9518552D0 (en) * 1995-09-11 1995-11-08 Fujisawa Pharmaceutical Co New heterocyclic compounds
US5760028A (en) 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
CA2256492C (en) 1996-05-20 2006-04-04 Teijin Limited Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
US5760225A (en) 1996-11-15 1998-06-02 Neurogen Corporation Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands
CA2273102A1 (en) * 1996-12-03 1998-06-11 Banyu Pharmaceutical Co., Ltd. Urea derivatives
WO1998025617A1 (en) 1996-12-13 1998-06-18 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
AU743609B2 (en) 1997-03-03 2002-01-31 Eisai Co. Ltd. Use of cholinesterase inhibitors to treat disorders of attention
US6979686B1 (en) * 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
US6207665B1 (en) 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
US5968938A (en) 1997-06-18 1999-10-19 Merck & Co., Inc. Piperazine oxytocin receptor antagonists
ES2125206B1 (es) * 1997-07-21 1999-11-16 Esteve Labor Dr Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
JP2001526178A (ja) 1997-08-28 2001-12-18 メルク エンド カムパニー インコーポレーテッド ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤
DK1273572T3 (da) 1997-10-09 2005-03-29 Ortho Mcneil Pharm Inc Thiophensubstituerede piperaziner anvendelige til behandling af binign prostatisk hyperplasi
AU744685B2 (en) 1997-11-18 2002-02-28 Teijin Pharma Limited Cyclic amine derivatives and their use as drugs
ZA9811576B (en) 1997-12-19 2000-06-19 Takeda Chemical Industries Ltd Anilide derivative, production and use thereof.
EP1047675A1 (en) 1998-01-21 2000-11-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
AU2331999A (en) 1998-01-21 1999-08-09 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
DE69920888T2 (de) 1998-03-27 2006-02-02 Bristol-Myers Squibb Pharma Co. Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
EP1131288A1 (en) 1998-11-20 2001-09-12 F. Hoffmann-La Roche Ag Pyrrolidine derivatives-ccr-3 receptor antagonists
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902459D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
JP3533134B2 (ja) 1999-02-15 2004-05-31 三井化学株式会社 フッ素化剤及びその製法と使用
GB9905010D0 (en) 1999-03-04 1999-04-28 Merck Sharp & Dohme Therapeutic agents
AU2942000A (en) 1999-03-11 2000-09-28 Banyu Pharmaceutical Co., Ltd. Novel piperidine derivatives
AU4796700A (en) 1999-05-13 2000-12-05 Dupont Pharmaceuticals Research Laboratories, Inc. Ureido-substituted cyclic amine derivatives and their use as drug
US6492516B1 (en) 1999-05-14 2002-12-10 Merck & Co., Inc. Compounds having cytokine inhibitory activity
US7125895B1 (en) 1999-05-14 2006-10-24 Bristol-Myers Squibb Pharma Research Labs, Inc. Cyclic amine derivatives and their uses
ATE376996T1 (de) 2000-01-13 2007-11-15 Amgen Inc Antibakterielle mittel
US20030087917A1 (en) 2000-03-27 2003-05-08 Dorothea Strack Use of dopamine-d3 receptor ligands for the treatment of diseases of the central nervous system
CZ20023154A3 (cs) 2000-03-31 2003-11-12 Pfizer Products Inc. Nové deriváty piperazinu
US20020045613A1 (en) 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
WO2001082930A1 (en) 2000-05-03 2001-11-08 Tularik Inc. Pyrazole antimicrobial agents
EP1289960A2 (en) 2000-06-15 2003-03-12 Pharmacia Corporation Cycloalkyl alkanoic acids as integrin receptor antagonists
GB0017256D0 (en) * 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
KR20030024799A (ko) 2000-07-20 2003-03-26 뉴로젠 코포레이션 캡사이신 수용체 리간드
EP1309591B1 (en) * 2000-08-14 2007-01-24 Ortho-McNeil Pharmaceutical, Inc. Substituted pyrazoles
IL154912A0 (en) 2000-10-19 2003-10-31 Pfizer Prod Inc Bridged piperazine derivatives
US6451399B1 (en) * 2001-02-05 2002-09-17 Daniel G. Boyce Display mat
MXPA03008109A (es) 2001-03-07 2003-12-12 Pfizer Prod Inc Moduladores de la actividad de receptores de quimiocinas.
CN1157388C (zh) 2001-05-29 2004-07-14 北京大学 哌嗪基二硫代甲酸酯类化合物,它们的制备方法和在抗肿瘤药物中的应用
ES2180456B1 (es) * 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. Isoxazoles sustituidos y su utilizacion como antibioticos.
WO2003024450A1 (en) 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating prion diseases
PL373156A1 (en) * 2001-12-14 2005-08-22 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
NO315724B1 (no) * 2001-12-20 2003-10-13 Sten Hellvik Datainnsamlingssystem for et fartöy
AU2003236500B9 (en) 2002-06-12 2009-07-02 Chemocentryx, Inc. 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders
US20050256130A1 (en) 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
PA8575901A1 (es) 2002-07-18 2004-07-20 Pfizer Prod Inc Derivados de piperidina novedosos
RU2005105696A (ru) * 2002-08-02 2005-11-10 Арджента Дискавери Лимитед (Gb) Замещенные тиенилгидроксамовые кислоты в качестве ингибиторов гистондеацетилазы

Similar Documents

Publication Publication Date Title
JP2006508036A5 (enExample)
JP2009539912A5 (enExample)
JP2007246474A5 (enExample)
JP2010280669A5 (enExample)
MX2007012090A (es) Derivados sustituidos de pirazoliloxifenilo como herbicidas.
ATE282592T1 (de) 2-oxo-1-pyrrolidinderivate, verfahren zu ihrer herstellung und ihre verwendung
JP2011121940A5 (ja) 発光素子
JPWO2020189540A5 (enExample)
PL1838674T3 (pl) Heteroarylosulfonamidy i CCR2
JP2011528706A5 (enExample)
JP2006096962A5 (enExample)
EA200800784A1 (ru) Пиридиновые производные и их применение для лечения психотических расстройств
JP2006511484A5 (enExample)
JP2004083852A5 (enExample)
JP2006527170A5 (enExample)
JP2010500432A5 (enExample)
JP2003530366A5 (enExample)
JP2004269496A5 (enExample)
DE50106790D1 (de) Fungizide wirkstoffkombinationen
JP2004162044A5 (enExample)
JP2005532487A5 (enExample)
JP2006525972A5 (enExample)
JP2010195907A5 (enExample)
JP2004517961A5 (enExample)
JP2009055850A5 (enExample)