BR9915520A - Antagonistas receptores ccr-3 derivados de pirrolidina - Google Patents

Antagonistas receptores ccr-3 derivados de pirrolidina

Info

Publication number
BR9915520A
BR9915520A BR9915520-6A BR9915520A BR9915520A BR 9915520 A BR9915520 A BR 9915520A BR 9915520 A BR9915520 A BR 9915520A BR 9915520 A BR9915520 A BR 9915520A
Authority
BR
Brazil
Prior art keywords
carbon atoms
ccr
receptor antagonists
alkylene
group selected
Prior art date
Application number
BR9915520-6A
Other languages
English (en)
Inventor
Daniel Harry Rogers
John Saunders Corbin Jr
John Patrick Williams
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9915520A publication Critical patent/BR9915520A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Patente de Invenção: <B>"ANTAGONISTAS RECEPTORES CCR-3 DERIVADOS DE PIRROLIDINA"<D>. Esta invenção refere-se a certos derivados de 3-aminometil-pirrolidina da fórmula (I) onde: Z é -N- ou -(N^ +^r)- X^ -^ onde R é alquila, haloalquila, aralquila, hidroxialquila, carboxialquila, alcoxicarbonilalquila ou cianoalquila, e X^ -^ é um contra-íon farmaceuticamente aceitável; Ar^ 1^ e Ar^ 2^ são, independentemente um do outro, arila ou heteroarila; Q é um alquileno reto ou ramificado com 1-3 átomos de carbono; R^ 1^ é hidrogênio ou alquila; A é ou: (I) -N(R^ 2^)C(O)- quando: B é: (i) um alquileno com 1-4 átomos de carbono inclusive onde um dos átomos de carbono pode ser opcionalmente substituído por um grupo selecionado de -C(O)-, -N(R^ 4^)-, -O-, -S(O)~ n~- (onde n é 0, 1 ou 2), NR^ 5^C(O)- e N(R^ 6^)SO~ 2~-; ou (ii) uma cadeia alquinileno; ou (II) um grupo selecionado de -N(R^ 2^)C(S)-, -N(R^ 2^)C(O)N(R^ 3^)-, -N(R^ 2^)C(S)N(R^ 3^)-, -N(R^ 2^)SO~ 2~-, -N(R^ 2^)SO~ 2~N(R^ 3^)-, -N(R2)C(O)O- e OC(O)N(R~ 3~)- quando: B é: (i) uma ligação; (ii) uma cadeia alquileno de 1-4 átomos de carbono inclusive onde um dos átomos de carbono pode opcionalmente ser substituídos por um grupo selecionado de -C(O)-, N(R^ 4^)-, -O-, -S(O)n- onde n é 0, 1 ou 2), - NR^ 5^C(O)- 2 e N(R^ 6^)SO~ 2~-; (iii) uma cadeia alquenileno; ou (iv) uma cadeia alquinileno; que são antagonistas receptores de CCR-3, composições farmacêuticas contendo-os, métodos para o seu uso e métodos para a preparação desses composto.
BR9915520-6A 1998-11-20 1999-11-11 Antagonistas receptores ccr-3 derivados de pirrolidina BR9915520A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10929798P 1998-11-20 1998-11-20
PCT/EP1999/008665 WO2000031032A1 (en) 1998-11-20 1999-11-11 Pyrrolidine derivatives-ccr-3 receptor antagonists

Publications (1)

Publication Number Publication Date
BR9915520A true BR9915520A (pt) 2001-07-17

Family

ID=22326918

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915520-6A BR9915520A (pt) 1998-11-20 1999-11-11 Antagonistas receptores ccr-3 derivados de pirrolidina

Country Status (27)

Country Link
US (1) US6166015A (pt)
EP (1) EP1131288A1 (pt)
JP (1) JP3593037B2 (pt)
KR (1) KR20010086045A (pt)
CN (1) CN1158256C (pt)
AR (1) AR023707A1 (pt)
AU (1) AU763960B2 (pt)
BR (1) BR9915520A (pt)
CA (1) CA2350903A1 (pt)
CO (1) CO5140119A1 (pt)
CZ (1) CZ20011760A3 (pt)
DE (1) DE19955794A1 (pt)
ES (1) ES2158814B1 (pt)
FR (1) FR2786185A1 (pt)
GB (1) GB2343893B (pt)
HU (1) HUP0104364A2 (pt)
ID (1) ID29067A (pt)
IL (1) IL143226A0 (pt)
IT (1) IT1307900B1 (pt)
MA (1) MA26762A1 (pt)
NO (1) NO20012411L (pt)
PE (1) PE20001403A1 (pt)
PL (1) PL348375A1 (pt)
TR (1) TR200101398T2 (pt)
UY (1) UY25811A1 (pt)
WO (1) WO2000031032A1 (pt)
ZA (1) ZA200103942B (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6316623B1 (en) * 1998-08-21 2001-11-13 Isis Pharmaceuticals, Inc. Ethylenediamine compound libraries
DE69938193D1 (de) 1998-11-20 2008-04-03 Hoffmann La Roche Piperidin ccr-3 rezeptor-hemmer
CA2373942A1 (en) * 1999-05-18 2000-11-23 Teijin Limited Remedies or prophylactis for diseases in association with chemokines
KR100667645B1 (ko) * 1999-08-04 2007-02-28 데이진 가부시키가이샤 환상 아민 ｃｃｒ3 길항제
CN1208318C (zh) * 1999-12-08 2005-06-29 帝人株式会社 环胺ccr5受体拮抗剂
AU2001290146A1 (en) * 2000-09-29 2002-04-08 Glaxo Group Limited Compounds useful in the treatment of inflammatory diseases
AR035205A1 (es) 2000-09-29 2004-05-05 Glaxo Group Ltd Compuestos utiles en el tratamiento de enfermedades inflamatorias, proceso para su preparacion, intermediarios y composiciones farmaceuticas
BR0116352A (pt) * 2000-12-19 2003-12-02 Hoffmann La Roche Pirrolidinas substituìdas como antagonistas de receptor ccr-3
FR2821356A1 (fr) 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
CN1267412C (zh) * 2001-09-13 2006-08-02 霍夫曼-拉罗奇有限公司 Ccr－3受体拮抗剂v
US7067549B2 (en) * 2001-12-31 2006-06-27 Actelion Pharmaceuticals Ag Pyrrolidone carboxamides
GB0207439D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207436D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207432D0 (en) 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207443D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0212355D0 (en) * 2002-05-29 2002-07-10 Glaxo Group Ltd Novel compounds
CN1867336B (zh) 2002-06-12 2010-05-12 凯莫森特里克斯股份有限公司 1-芳基-4-取代的哌嗪衍生物及其制药用途
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
JP2006502107A (ja) 2002-07-02 2006-01-19 エフ．ホフマン−ラ　ロシュ　アーゲー Ｃｃｒ−３レセプターアンタゴニストｉｘとしての２，５−置換ピリミジン誘導体
US6919356B2 (en) * 2002-09-26 2005-07-19 Bristol Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
EP1603899B1 (en) 2003-03-06 2009-08-26 Glaxo Group Limited Heterocyclic urea derivatives for the treatment of pain
US7514562B2 (en) 2003-03-07 2009-04-07 Glaxo Group Limited Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain
GB0305426D0 (en) * 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
CA2517888C (en) 2003-03-14 2012-05-01 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
JP4710606B2 (ja) 2003-04-18 2011-06-29 小野薬品工業株式会社 スピロピペリジン化合物およびその医薬用途
RU2006117631A (ru) * 2003-10-24 2007-12-10 Ф.Хоффманн-Ля Рош Аг (Ch) Антагонисты рецептора ссr3
AU2005219438B2 (en) 2004-03-03 2011-02-17 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
NZ551196A (en) * 2004-05-14 2010-08-27 Emisphere Tech Inc Compounds and compositions for delivering active agents
TWI400232B (zh) 2004-09-13 2013-07-01 Ono Pharmaceutical Co 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑
WO2006088541A2 (en) 2005-02-17 2006-08-24 State Of Oregon Acting By & Through The State Board Of Higher Edu. On Behalf Of Portland State Unv. Quinoline derivatives and uses thereof
US20110052612A1 (en) 2005-05-31 2011-03-03 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
WO2007011292A1 (en) * 2005-07-21 2007-01-25 Astrazeneca Ab N-benzyl-morpholine derivatives as modulators of the chemokine receptor
KR100743617B1 (ko) * 2005-08-25 2007-07-27 주식회사 알에스텍 고광학순도를 갖는 키랄 3-히드록시 피롤리딘 및 그유도체를 제조하는 방법
HUP0500879A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
RU2008115499A (ru) * 2005-09-22 2009-10-27 Санофи-Авентис (Fr) Новые производные аминокиламидов в качестве антагонистов лигандов рецепторов ccr3
ES2427989T3 (es) 2005-10-28 2013-11-05 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
PL1961744T3 (pl) 2005-11-18 2013-09-30 Ono Pharmaceutical Co Związek zawierający grupę zasadową oraz jego zastosowanie
CA2644368A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
JP5257068B2 (ja) 2006-05-16 2013-08-07 小野薬品工業株式会社 保護されていてもよい酸性基を含有する化合物およびその用途
WO2008016006A1 (en) 2006-07-31 2008-02-07 Ono Pharmaceutical Co., Ltd. Compound having cyclic group bound thereto through spiro binding and use thereof
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
CN101906060B (zh) * 2010-05-06 2012-07-04 爱斯医药科技(南京)有限公司 N-取代的3-氨甲基吡咯烷的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459757A (en) * 1965-10-22 1969-08-05 American Cyanamid Co Imidazolidines
NZ186175A (en) * 1977-01-27 1980-03-05 Shionogi & Co Meta-sulphonamidobenzamide derivatives
JPS59186969A (ja) * 1983-04-08 1984-10-23 Yoshitomi Pharmaceut Ind Ltd ベンゾフラン−およびベンゾピランカルボキサミド誘導体
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JPH01117860A (ja) * 1987-10-30 1989-05-10 Dainippon Pharmaceut Co Ltd 安息香酸アミド誘導体
JPH02104572A (ja) * 1988-10-13 1990-04-17 Dainippon Pharmaceut Co Ltd 安息香酸アミド誘導体
US5214055A (en) * 1990-05-18 1993-05-25 Adir Et Compagnie Aminopiperidine 4-oxo-4H-chromen-2-yl compounds
FR2662162B1 (fr) * 1990-05-18 1995-01-20 Adir Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5254569A (en) * 1991-01-14 1993-10-19 The Du Pont Merck Pharmaceutical Company (Amidomethyl)nitrogen heterocyclic analgesics
GB9113031D0 (en) * 1991-06-17 1991-08-07 Smithkline Beecham Plc Compounds
FR2679906B1 (fr) * 1991-07-31 1995-01-20 Adir Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
AU2435092A (en) * 1991-08-20 1993-03-16 Smithkline Beecham Plc 5-ht4 receptor antagonists
JPH06212757A (ja) * 1993-01-19 1994-08-02 Ribaa Kentetsu Kk ソリ型運搬治具による折板屋根葺き工法
EP0742208A1 (en) * 1995-05-05 1996-11-13 Grelan Pharmaceutical Co., Ltd. 2-Ureido-benzamide derivatives
US5827875A (en) * 1996-05-10 1998-10-27 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
EP0916668A4 (en) * 1996-07-29 2000-08-16 Banyu Pharma Co Ltd CHEMOKINE RECEPTOR ANTAGONISTS
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
JPH11140276A (ja) * 1997-11-11 1999-05-25 Sumitomo Chem Co Ltd 多官能シアン酸エステル樹脂組成物および樹脂封止型半導体装置
WO1999025686A1 (en) * 1997-11-18 1999-05-27 Teijin Limited Cyclic amine derivatives and their use as drugs

Also Published As

Publication number Publication date
ES2158814A1 (es) 2001-09-01
CN1158256C (zh) 2004-07-21
AU1382500A (en) 2000-06-13
JP3593037B2 (ja) 2004-11-24
CO5140119A1 (es) 2002-03-22
NO20012411D0 (no) 2001-05-16
NO20012411L (no) 2001-05-16
IT1307900B1 (it) 2001-11-19
AR023707A1 (es) 2002-09-04
DE19955794A1 (de) 2000-05-31
EP1131288A1 (en) 2001-09-12
TR200101398T2 (tr) 2001-09-21
US6166015A (en) 2000-12-26
IL143226A0 (en) 2002-04-21
ID29067A (id) 2001-07-26
GB2343893B (en) 2002-01-09
FR2786185A1 (fr) 2000-05-26
CZ20011760A3 (cs) 2001-12-12
KR20010086045A (ko) 2001-09-07
MA26762A1 (fr) 2004-12-20
ES2158814B1 (es) 2002-03-16
UY25811A1 (es) 2001-07-31
ITTO991009A0 (it) 1999-11-19
AU763960B2 (en) 2003-08-07
ZA200103942B (en) 2002-08-15
CA2350903A1 (en) 2000-06-02
HUP0104364A2 (hu) 2002-04-29
PL348375A1 (en) 2002-05-20
GB9927227D0 (en) 2000-01-12
ITTO991009A1 (it) 2001-05-19
PE20001403A1 (es) 2000-12-15
JP2002530374A (ja) 2002-09-17
WO2000031032A1 (en) 2000-06-02
CN1331677A (zh) 2002-01-16
GB2343893A (en) 2000-05-24

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