ITTO991009A0 - Antagonisti iii del recettore ccr-3. - Google Patents

Antagonisti iii del recettore ccr-3.

Info

Publication number
ITTO991009A0
ITTO991009A0 IT99TO001009A ITTO991009A ITTO991009A0 IT TO991009 A0 ITTO991009 A0 IT TO991009A0 IT 99TO001009 A IT99TO001009 A IT 99TO001009A IT TO991009 A ITTO991009 A IT TO991009A IT TO991009 A0 ITTO991009 A0 IT TO991009A0
Authority
IT
Italy
Prior art keywords
ccr
receptor antagonists
iii
antagonists iii
receptor
Prior art date
Application number
IT99TO001009A
Other languages
English (en)
Inventor
Daniel Harry Rogers
John Saunders
John Patrick Williams
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ITTO991009A0 publication Critical patent/ITTO991009A0/it
Publication of ITTO991009A1 publication Critical patent/ITTO991009A1/it
Application granted granted Critical
Publication of IT1307900B1 publication Critical patent/IT1307900B1/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT1999TO001009A 1998-11-20 1999-11-19 Antagonisti iii del recettore ccr-3. IT1307900B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10929798P 1998-11-20 1998-11-20

Publications (3)

Publication Number Publication Date
ITTO991009A0 true ITTO991009A0 (it) 1999-11-19
ITTO991009A1 ITTO991009A1 (it) 2001-05-19
IT1307900B1 IT1307900B1 (it) 2001-11-19

Family

ID=22326918

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999TO001009A IT1307900B1 (it) 1998-11-20 1999-11-19 Antagonisti iii del recettore ccr-3.

Country Status (27)

Country Link
US (1) US6166015A (it)
EP (1) EP1131288A1 (it)
JP (1) JP3593037B2 (it)
KR (1) KR20010086045A (it)
CN (1) CN1158256C (it)
AR (1) AR023707A1 (it)
AU (1) AU763960B2 (it)
BR (1) BR9915520A (it)
CA (1) CA2350903A1 (it)
CO (1) CO5140119A1 (it)
CZ (1) CZ20011760A3 (it)
DE (1) DE19955794A1 (it)
ES (1) ES2158814B1 (it)
FR (1) FR2786185A1 (it)
GB (1) GB2343893B (it)
HU (1) HUP0104364A2 (it)
ID (1) ID29067A (it)
IL (1) IL143226A0 (it)
IT (1) IT1307900B1 (it)
MA (1) MA26762A1 (it)
NO (1) NO20012411L (it)
PE (1) PE20001403A1 (it)
PL (1) PL348375A1 (it)
TR (1) TR200101398T2 (it)
UY (1) UY25811A1 (it)
WO (1) WO2000031032A1 (it)
ZA (1) ZA200103942B (it)

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EP1131290B1 (en) 1998-11-20 2008-02-20 F. Hoffmann-La Roche Ag Piperidine ccr-3 receptor antagonists
EP1179341B1 (en) * 1999-05-18 2005-11-09 Teijin Limited Remedies or preventives for diseases in association with chemokines
AU779610B2 (en) * 1999-08-04 2005-02-03 Teijin Limited Cyclic amine CCR3 antagonists
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ES2275729T3 (es) * 2000-09-29 2007-06-16 Glaxo Group Limited Compuestos utiles en el tratamiento de enfermedades inflamatorias.
ES2527688T3 (es) 2000-09-29 2015-01-28 Glaxo Group Limited Derivados de morfolin-acetamida para el tratamiento de enfermedades inflamatorias
BR0116352A (pt) * 2000-12-19 2003-12-02 Hoffmann La Roche Pirrolidinas substituìdas como antagonistas de receptor ccr-3
FR2821356A1 (fr) * 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
JP2005502700A (ja) * 2001-09-13 2005-01-27 エフ.ホフマン−ラ ロシュ アーゲー Ccr−3受容体アンタゴニストv
US7067549B2 (en) * 2001-12-31 2006-06-27 Actelion Pharmaceuticals Ag Pyrrolidone carboxamides
GB0207432D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207443D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207439D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207436D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0212355D0 (en) * 2002-05-29 2002-07-10 Glaxo Group Ltd Novel compounds
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
JP4723242B2 (ja) 2002-06-12 2011-07-13 ケモセントリックス インコーポレーティッド 炎症および免疫障害治療用ccr1アンタゴニストとして使用するための1−アリール−4−置換ピペラジン誘導体
BR0312358A (pt) * 2002-07-02 2005-04-05 Hoffmann La Roche Derivados de pirimidina 2,5-substituìda como antagonistas ix de receptor de ccr-3
AU2003275257A1 (en) * 2002-09-26 2004-04-19 Bristol-Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
ES2330107T3 (es) 2003-03-06 2009-12-04 Glaxo Group Limited Derivados de urea heterociclicos para el tratamiento del dolor.
JP2006519806A (ja) 2003-03-07 2006-08-31 グラクソ グループ リミテッド 尿素誘導体および疼痛治療におけるバニロイド受容体拮抗剤としてのそれらの使用。
GB0305426D0 (en) * 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
BRPI0408332A (pt) 2003-03-14 2006-03-21 Ono Pharmaceutical Co derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo
WO2004092169A1 (ja) 2003-04-18 2004-10-28 Ono Pharmaceutical Co., Ltd. スピロピペリジン化合物およびその医薬用途
BRPI0415767A (pt) * 2003-10-24 2006-12-26 Hoffmann La Roche antagonistas de receptor de ccr-3
CA2558211C (en) 2004-03-03 2013-09-03 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8273794B2 (en) * 2004-05-14 2012-09-25 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
RU2530889C2 (ru) * 2004-05-14 2014-10-20 Эмисфире Текнолоджис, Инк. Соединения и составы для доставки активных веществ
AR050643A1 (es) 2004-09-13 2006-11-08 Ono Pharmaceutical Co Un derivado heterociclico que contiene nitrogeno y un farmaco que contiene el mismo como el ingrediente activo
WO2006088541A2 (en) * 2005-02-17 2006-08-24 State Of Oregon Acting By & Through The State Board Of Higher Edu. On Behalf Of Portland State Unv. Quinoline derivatives and uses thereof
JPWO2006129679A1 (ja) 2005-05-31 2009-01-08 小野薬品工業株式会社 スピロピペリジン化合物およびその医薬用途
JP2009501792A (ja) * 2005-07-21 2009-01-22 アストラゼネカ・アクチエボラーグ ケモカイン受容体のモジュレーターとしてのn−ベンジル−モルホリン誘導体
KR100743617B1 (ko) * 2005-08-25 2007-07-27 주식회사 알에스텍 고광학순도를 갖는 키랄 3-히드록시 피롤리딘 및 그유도체를 제조하는 방법
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
AU2006293635A1 (en) * 2005-09-22 2007-03-29 Sanofi-Aventis Amino-alkyl-amide derivatives as CCR3 receptor liquids
HUP0500879A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
WO2007049771A1 (ja) 2005-10-28 2007-05-03 Ono Pharmaceutical Co., Ltd. 塩基性基を含有する化合物およびその用途
US8168783B2 (en) 2005-11-18 2012-05-01 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonists and use thereof
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Also Published As

Publication number Publication date
AR023707A1 (es) 2002-09-04
CA2350903A1 (en) 2000-06-02
FR2786185A1 (fr) 2000-05-26
JP3593037B2 (ja) 2004-11-24
NO20012411D0 (no) 2001-05-16
EP1131288A1 (en) 2001-09-12
CN1158256C (zh) 2004-07-21
ID29067A (id) 2001-07-26
PL348375A1 (en) 2002-05-20
CN1331677A (zh) 2002-01-16
PE20001403A1 (es) 2000-12-15
DE19955794A1 (de) 2000-05-31
GB2343893B (en) 2002-01-09
GB2343893A (en) 2000-05-24
ZA200103942B (en) 2002-08-15
BR9915520A (pt) 2001-07-17
UY25811A1 (es) 2001-07-31
WO2000031032A1 (en) 2000-06-02
NO20012411L (no) 2001-05-16
KR20010086045A (ko) 2001-09-07
AU763960B2 (en) 2003-08-07
ITTO991009A1 (it) 2001-05-19
TR200101398T2 (tr) 2001-09-21
IT1307900B1 (it) 2001-11-19
US6166015A (en) 2000-12-26
ES2158814B1 (es) 2002-03-16
CZ20011760A3 (cs) 2001-12-12
MA26762A1 (fr) 2004-12-20
JP2002530374A (ja) 2002-09-17
GB9927227D0 (en) 2000-01-12
AU1382500A (en) 2000-06-13
IL143226A0 (en) 2002-04-21
HUP0104364A2 (hu) 2002-04-29
ES2158814A1 (es) 2001-09-01
CO5140119A1 (es) 2002-03-22

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