ES2158814A1 - Antagonistas iii del receptor ccr-3. - Google Patents

Antagonistas iii del receptor ccr-3.

Info

Publication number
ES2158814A1
ES2158814A1 ES009902547A ES9902547A ES2158814A1 ES 2158814 A1 ES2158814 A1 ES 2158814A1 ES 009902547 A ES009902547 A ES 009902547A ES 9902547 A ES9902547 A ES 9902547A ES 2158814 A1 ES2158814 A1 ES 2158814A1
Authority
ES
Spain
Prior art keywords
carbon atoms
ccr
group selected
receptor antagonists
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009902547A
Other languages
English (en)
Other versions
ES2158814B1 (es
Inventor
Daniel Harry Rogers
John Saunders
John Patrick Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES2158814A1 publication Critical patent/ES2158814A1/es
Application granted granted Critical
Publication of ES2158814B1 publication Critical patent/ES2158814B1/es
Anticipated expiration legal-status Critical
Withdrawn - After Issue legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Derivados de pirrolidina antagonistas del receptor CCR-3. Estos antagonistas están formados por derivados de pirrolidina, de fórmula (I), en donde los radicales R{sub,1} , Ar{sup,1} , Ar{sup,2}, A, B, Z y Q tienen el significado expresado en las reivindicaciones. La invención se refiere también a composiciones farmacéuticas que contienen a estos antagonistas del receptor CCR-3, a métodos para su uso y a métodos para preparar dichos compuestos. Estos productos se usan para el tratamiento de enfermedades respiratorias, tales como el asma.
ES009902547A 1998-11-20 1999-11-19 Derivados de pirrolidina antagonistas del receptor ccr-3 Withdrawn - After Issue ES2158814B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10929798P 1998-11-20 1998-11-20

Publications (2)

Publication Number Publication Date
ES2158814A1 true ES2158814A1 (es) 2001-09-01
ES2158814B1 ES2158814B1 (es) 2002-03-16

Family

ID=22326918

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009902547A Withdrawn - After Issue ES2158814B1 (es) 1998-11-20 1999-11-19 Derivados de pirrolidina antagonistas del receptor ccr-3

Country Status (27)

Country Link
US (1) US6166015A (es)
EP (1) EP1131288A1 (es)
JP (1) JP3593037B2 (es)
KR (1) KR20010086045A (es)
CN (1) CN1158256C (es)
AR (1) AR023707A1 (es)
AU (1) AU763960B2 (es)
BR (1) BR9915520A (es)
CA (1) CA2350903A1 (es)
CO (1) CO5140119A1 (es)
CZ (1) CZ20011760A3 (es)
DE (1) DE19955794A1 (es)
ES (1) ES2158814B1 (es)
FR (1) FR2786185A1 (es)
GB (1) GB2343893B (es)
HU (1) HUP0104364A2 (es)
ID (1) ID29067A (es)
IL (1) IL143226A0 (es)
IT (1) IT1307900B1 (es)
MA (1) MA26762A1 (es)
NO (1) NO20012411D0 (es)
PE (1) PE20001403A1 (es)
PL (1) PL348375A1 (es)
TR (1) TR200101398T2 (es)
UY (1) UY25811A1 (es)
WO (1) WO2000031032A1 (es)
ZA (1) ZA200103942B (es)

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EP1201239A4 (en) 1999-08-04 2004-12-08 Teijin Ltd CYCLIC AMINES AS CCR3 ANTAGONISTS
CN1208318C (zh) * 1999-12-08 2005-06-29 帝人株式会社 环胺ccr5受体拮抗剂
MXPA03002814A (es) 2000-09-29 2003-10-14 Glaxo Group Ltd Derivados de morfolin-acetamida para el tratamiento de enfermedades inflamatorias.
US7157457B2 (en) 2000-09-29 2007-01-02 Glaxo Group Limited Compounds useful in the treatment of inflammatory diseases
CA2431767A1 (en) 2000-12-19 2002-06-27 F. Hoffmann-La Roche Ag Substituted pyrrolidines as ccr-3 receptor antagonists
FR2821356A1 (fr) 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
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GB0207439D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
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GB0207436D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
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GB0212355D0 (en) * 2002-05-29 2002-07-10 Glaxo Group Ltd Novel compounds
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US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
EP1521582A1 (en) * 2002-07-02 2005-04-13 F. Hoffmann-La Roche Ag 2,5-substituted pyrimidine derivatives as ccr-3 receptor antagonists
US6919356B2 (en) * 2002-09-26 2005-07-19 Bristol Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
EP1603899B1 (en) 2003-03-06 2009-08-26 Glaxo Group Limited Heterocyclic urea derivatives for the treatment of pain
EP1601665A2 (en) 2003-03-07 2005-12-07 Glaxo Group Limited Urea derivatives
GB0305426D0 (en) * 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
TW201018661A (en) 2003-03-14 2010-05-16 Ono Pharmaceutical Co Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
WO2004092169A1 (ja) 2003-04-18 2004-10-28 Ono Pharmaceutical Co., Ltd. スピロピペリジン化合物およびその医薬用途
CN1871222A (zh) * 2003-10-24 2006-11-29 霍夫曼-拉罗奇有限公司 Ccr3受体拮抗剂
CA2558211C (en) 2004-03-03 2013-09-03 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
JP5254610B2 (ja) * 2004-05-14 2013-08-07 エミスフェアー・テクノロジーズ・インク 活性薬剤を送達するための化合物および組成物
MX2007002886A (es) 2004-09-13 2007-05-16 Ono Pharmaceutical Co Derivado heterociclico que contiene nitrogeno y un farmaco que contiene el mismo como el ingrediente activo.
WO2006088541A2 (en) 2005-02-17 2006-08-24 State Of Oregon Acting By & Through The State Board Of Higher Edu. On Behalf Of Portland State Unv. Quinoline derivatives and uses thereof
EP1889622A4 (en) 2005-05-31 2009-12-23 Ono Pharmaceutical Co SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
US20090118288A1 (en) * 2005-07-21 2009-05-07 Astrazeneca Ab N-Benzyl-Morpholine Derivatives as Modulators of the Chemokine Receptor
JP2009507783A (ja) * 2005-08-25 2009-02-26 アールエステック コーポレイション 高光学純度を有するキラル３−ヒドロキシピロリジン化合物及びその誘導体の製造方法
KR20080046209A (ko) * 2005-09-22 2008-05-26 사노피-아벤티스 Ｃｃｒ3 수용체 리간드로서의 신규한 아미노-알킬-아미드 유도체
HUP0500879A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
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PT1961744E (pt) 2005-11-18 2013-05-15 Ono Pharmaceutical Co Composto que contém um grupo básico e sua utilização
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Citations (4)

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EP0903349A2 (en) * 1997-08-18 1999-03-24 F. Hoffmann-La Roche Ag CCR-3 receptor antagonists
EP0916668A1 (en) * 1996-07-29 1999-05-19 Banyu Pharmaceutical Co., Ltd. Chemokine receptor antagonists
WO1999025686A1 (en) * 1997-11-18 1999-05-27 Teijin Limited Cyclic amine derivatives and their use as drugs

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EP0916668A1 (en) * 1996-07-29 1999-05-19 Banyu Pharmaceutical Co., Ltd. Chemokine receptor antagonists
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WO1999025686A1 (en) * 1997-11-18 1999-05-27 Teijin Limited Cyclic amine derivatives and their use as drugs

Also Published As

Publication number Publication date
ZA200103942B (en) 2002-08-15
GB2343893A (en) 2000-05-24
EP1131288A1 (en) 2001-09-12
AR023707A1 (es) 2002-09-04
PL348375A1 (en) 2002-05-20
FR2786185A1 (fr) 2000-05-26
BR9915520A (pt) 2001-07-17
IT1307900B1 (it) 2001-11-19
CN1158256C (zh) 2004-07-21
AU763960B2 (en) 2003-08-07
ID29067A (id) 2001-07-26
UY25811A1 (es) 2001-07-31
WO2000031032A1 (en) 2000-06-02
HUP0104364A2 (hu) 2002-04-29
NO20012411L (no) 2001-05-16
GB9927227D0 (en) 2000-01-12
US6166015A (en) 2000-12-26
PE20001403A1 (es) 2000-12-15
IL143226A0 (en) 2002-04-21
CA2350903A1 (en) 2000-06-02
TR200101398T2 (tr) 2001-09-21
KR20010086045A (ko) 2001-09-07
JP3593037B2 (ja) 2004-11-24
ITTO991009A1 (it) 2001-05-19
ITTO991009A0 (it) 1999-11-19
AU1382500A (en) 2000-06-13
NO20012411D0 (no) 2001-05-16
CZ20011760A3 (cs) 2001-12-12
ES2158814B1 (es) 2002-03-16
MA26762A1 (fr) 2004-12-20
CO5140119A1 (es) 2002-03-22
JP2002530374A (ja) 2002-09-17
DE19955794A1 (de) 2000-05-31
GB2343893B (en) 2002-01-09
CN1331677A (zh) 2002-01-16

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