IL143226A0 - Pyrrolidine derivatives-ccr-3 receptor antagonists - Google Patents
Pyrrolidine derivatives-ccr-3 receptor antagonistsInfo
- Publication number
- IL143226A0 IL143226A0 IL14322699A IL14322699A IL143226A0 IL 143226 A0 IL143226 A0 IL 143226A0 IL 14322699 A IL14322699 A IL 14322699A IL 14322699 A IL14322699 A IL 14322699A IL 143226 A0 IL143226 A0 IL 143226A0
- Authority
- IL
- Israel
- Prior art keywords
- ccr
- receptor antagonists
- pyrrolidine derivatives
- pyrrolidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10929798P | 1998-11-20 | 1998-11-20 | |
| PCT/EP1999/008665 WO2000031032A1 (en) | 1998-11-20 | 1999-11-11 | Pyrrolidine derivatives-ccr-3 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL143226A0 true IL143226A0 (en) | 2002-04-21 |
Family
ID=22326918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14322699A IL143226A0 (en) | 1998-11-20 | 1999-11-11 | Pyrrolidine derivatives-ccr-3 receptor antagonists |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6166015A (pt) |
| EP (1) | EP1131288A1 (pt) |
| JP (1) | JP3593037B2 (pt) |
| KR (1) | KR20010086045A (pt) |
| CN (1) | CN1158256C (pt) |
| AR (1) | AR023707A1 (pt) |
| AU (1) | AU763960B2 (pt) |
| BR (1) | BR9915520A (pt) |
| CA (1) | CA2350903A1 (pt) |
| CO (1) | CO5140119A1 (pt) |
| CZ (1) | CZ20011760A3 (pt) |
| DE (1) | DE19955794A1 (pt) |
| ES (1) | ES2158814B1 (pt) |
| FR (1) | FR2786185A1 (pt) |
| GB (1) | GB2343893B (pt) |
| HU (1) | HUP0104364A2 (pt) |
| ID (1) | ID29067A (pt) |
| IL (1) | IL143226A0 (pt) |
| IT (1) | IT1307900B1 (pt) |
| MA (1) | MA26762A1 (pt) |
| NO (1) | NO20012411D0 (pt) |
| PE (1) | PE20001403A1 (pt) |
| PL (1) | PL348375A1 (pt) |
| TR (1) | TR200101398T2 (pt) |
| UY (1) | UY25811A1 (pt) |
| WO (1) | WO2000031032A1 (pt) |
| ZA (1) | ZA200103942B (pt) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| US6316623B1 (en) * | 1998-08-21 | 2001-11-13 | Isis Pharmaceuticals, Inc. | Ethylenediamine compound libraries |
| TR200101397T2 (tr) | 1998-11-20 | 2001-11-21 | F.Hoffmann-La Roche Ag | Piperidin CCR-3 reseptörü antagonistleri |
| ES2250132T3 (es) * | 1999-05-18 | 2006-04-16 | Teijin Limited | Remedios preventivos para enfermedades asociadas a quimioquinas. |
| CA2378499A1 (en) * | 1999-08-04 | 2001-02-15 | Teijin Limited | Cyclic amine ccr3 antagonists |
| ES2276706T3 (es) * | 1999-12-08 | 2007-07-01 | Teijin Limited | Antagonistas del receptor ccr5 de aminas ciclicas. |
| IL155092A0 (en) * | 2000-09-29 | 2003-10-31 | Glaxo Group Ltd | Compounds useful in the treatment of inflammatory diseases |
| CA2423251A1 (en) | 2000-09-29 | 2002-04-04 | Glaxo Group Limited | Morpholin-acetamide derivatives for the treatment of inflammatory diseases |
| DE60130684T2 (de) | 2000-12-19 | 2008-08-14 | F. Hoffmann-La Roche Ag | Substituierte pyrrolidine als ccr-3-rezeptorantagonisten |
| FR2821356A1 (fr) | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
| GB0117387D0 (en) * | 2001-07-17 | 2001-09-05 | Novartis Ag | Organic compounds |
| MXPA04001977A (es) * | 2001-09-13 | 2004-06-07 | Hoffmann La Roche | Antagonistas v de receptor ccr-3. |
| US7067549B2 (en) * | 2001-12-31 | 2006-06-27 | Actelion Pharmaceuticals Ag | Pyrrolidone carboxamides |
| GB0207432D0 (en) | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0207436D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0207443D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0207439D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0212355D0 (en) * | 2002-05-29 | 2002-07-10 | Glaxo Group Ltd | Novel compounds |
| US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| KR101255356B1 (ko) | 2002-06-12 | 2013-04-17 | 케모센트릭스, 인크. | 염증 및 면역 질병의 치료를 위한 ｃｃｒ１ 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체 |
| PL375263A1 (en) * | 2002-07-02 | 2005-11-28 | F.Hoffmann-La Roche Ag | 2,5-substituted pyrimidine derivatives as ccr-3 receptor antagonists |
| AU2003275257A1 (en) * | 2002-09-26 | 2004-04-19 | Bristol-Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| EP1603899B1 (en) | 2003-03-06 | 2009-08-26 | Glaxo Group Limited | Heterocyclic urea derivatives for the treatment of pain |
| JP2006519806A (ja) | 2003-03-07 | 2006-08-31 | グラクソ グループ リミテッド | 尿素誘導体および疼痛治療におけるバニロイド受容体拮抗剤としてのそれらの使用。 |
| GB0305426D0 (en) | 2003-03-08 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| JP4736043B2 (ja) | 2003-03-14 | 2011-07-27 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| WO2004092169A1 (ja) | 2003-04-18 | 2004-10-28 | Ono Pharmaceutical Co., Ltd. | スピロピペリジン化合物およびその医薬用途 |
| SG131946A1 (en) * | 2003-10-24 | 2007-05-28 | Hoffmann La Roche | Ccr3 receptor antagonists |
| JP4845873B2 (ja) | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
| US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| NZ551196A (en) * | 2004-05-14 | 2010-08-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| TWI400232B (zh) | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
| US7968539B2 (en) | 2005-02-17 | 2011-06-28 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University | Quinoline derivatives and uses thereof |
| JPWO2006129679A1 (ja) | 2005-05-31 | 2009-01-08 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
| EP1919884A1 (en) * | 2005-07-21 | 2008-05-14 | AstraZeneca AB | N-benzyl-morpholine derivatives as modulators of the chemokine receptor |
| KR100743617B1 (ko) * | 2005-08-25 | 2007-07-27 | 주식회사 알에스텍 | 고광학순도를 갖는 키랄 3-히드록시 피롤리딘 및 그유도체를 제조하는 방법 |
| HUP0500879A2 (en) * | 2005-09-22 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates |
| HUP0500886A2 (en) * | 2005-09-23 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use |
| JP2009508929A (ja) * | 2005-09-22 | 2009-03-05 | サノフイ−アベンテイス | Ｃｃｒ３受容体リガンドとしてのアミノ−アルキル−アミド誘導体 |
| HUP0500877A2 (en) * | 2005-09-22 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates |
| EP2657235A1 (en) | 2005-10-28 | 2013-10-30 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
| ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
| AU2007225836A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
| US8618122B2 (en) | 2006-05-16 | 2013-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
| JP5245827B2 (ja) | 2006-07-31 | 2013-07-24 | 小野薬品工業株式会社 | スピロ結合した環状基を含有する化合物およびその用途 |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| CN101906060B (zh) * | 2010-05-06 | 2012-07-04 | 爱斯医药科技(南京)有限公司 | N-取代的3-氨甲基吡咯烷的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459757A (en) * | 1965-10-22 | 1969-08-05 | American Cyanamid Co | Imidazolidines |
| NZ186175A (en) * | 1977-01-27 | 1980-03-05 | Shionogi & Co | Meta-sulphonamidobenzamide derivatives |
| JPS59186969A (ja) * | 1983-04-08 | 1984-10-23 | Yoshitomi Pharmaceut Ind Ltd | ベンゾフラン−およびベンゾピランカルボキサミド誘導体 |
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| JPH01117860A (ja) * | 1987-10-30 | 1989-05-10 | Dainippon Pharmaceut Co Ltd | 安息香酸アミド誘導体 |
| JPH02104572A (ja) * | 1988-10-13 | 1990-04-17 | Dainippon Pharmaceut Co Ltd | 安息香酸アミド誘導体 |
| US5214055A (en) * | 1990-05-18 | 1993-05-25 | Adir Et Compagnie | Aminopiperidine 4-oxo-4H-chromen-2-yl compounds |
| FR2662162B1 (fr) * | 1990-05-18 | 1995-01-20 | Adir | Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5254569A (en) * | 1991-01-14 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | (Amidomethyl)nitrogen heterocyclic analgesics |
| GB9113031D0 (en) * | 1991-06-17 | 1991-08-07 | Smithkline Beecham Plc | Compounds |
| FR2679906B1 (fr) * | 1991-07-31 | 1995-01-20 | Adir | Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| CA2116024A1 (en) * | 1991-08-20 | 1993-03-04 | Francis David King | 5-ht4 receptor antagonists |
| JPH06212757A (ja) * | 1993-01-19 | 1994-08-02 | Ribaa Kentetsu Kk | ソリ型運搬治具による折板屋根葺き工法 |
| EP0742208A1 (en) * | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamide derivatives |
| US5827875A (en) * | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| CA2261633A1 (en) * | 1996-07-29 | 1998-02-05 | Banyu Pharmaceutical Co., Ltd. | Chemokine receptor antagonists |
| IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| JPH11140276A (ja) * | 1997-11-11 | 1999-05-25 | Sumitomo Chem Co Ltd | 多官能シアン酸エステル樹脂組成物および樹脂封止型半導体装置 |
| BR9814645A (pt) * | 1997-11-18 | 2001-07-31 | Teijin Ltd | Derivados de amina cìclica e seu uso como medicamentos |
-
1999
- 1999-11-11 CA CA002350903A patent/CA2350903A1/en not_active Abandoned
- 1999-11-11 AU AU13825/00A patent/AU763960B2/en not_active Ceased
- 1999-11-11 KR KR1020017006362A patent/KR20010086045A/ko not_active Application Discontinuation
- 1999-11-11 TR TR2001/01398T patent/TR200101398T2/xx unknown
- 1999-11-11 JP JP2000583860A patent/JP3593037B2/ja not_active Expired - Fee Related
- 1999-11-11 CZ CZ20011760A patent/CZ20011760A3/cs unknown
- 1999-11-11 CN CNB99813287XA patent/CN1158256C/zh not_active Expired - Fee Related
- 1999-11-11 HU HU0104364A patent/HUP0104364A2/hu unknown
- 1999-11-11 BR BR9915520-6A patent/BR9915520A/pt not_active IP Right Cessation
- 1999-11-11 ID IDW00200101080A patent/ID29067A/id unknown
- 1999-11-11 IL IL14322699A patent/IL143226A0/xx unknown
- 1999-11-11 PL PL99348375A patent/PL348375A1/xx not_active Application Discontinuation
- 1999-11-11 EP EP99972623A patent/EP1131288A1/en not_active Withdrawn
- 1999-11-11 WO PCT/EP1999/008665 patent/WO2000031032A1/en not_active Application Discontinuation
- 1999-11-16 PE PE1999001161A patent/PE20001403A1/es not_active Application Discontinuation
- 1999-11-17 GB GB9927227A patent/GB2343893B/en not_active Expired - Fee Related
- 1999-11-18 FR FR9914495A patent/FR2786185A1/fr not_active Withdrawn
- 1999-11-18 CO CO99072639A patent/CO5140119A1/es unknown
- 1999-11-18 US US09/442,656 patent/US6166015A/en not_active Expired - Fee Related
- 1999-11-18 AR ARP990105860A patent/AR023707A1/es unknown
- 1999-11-19 ES ES009902547A patent/ES2158814B1/es not_active Withdrawn - After Issue
- 1999-11-19 IT IT1999TO001009A patent/IT1307900B1/it active
- 1999-11-19 UY UY25811A patent/UY25811A1/es unknown
- 1999-11-19 DE DE19955794A patent/DE19955794A1/de not_active Withdrawn
-
2001
- 2001-05-15 ZA ZA200103942A patent/ZA200103942B/en unknown
- 2001-05-16 NO NO20012411A patent/NO20012411D0/no not_active Application Discontinuation
- 2001-05-17 MA MA26199A patent/MA26762A1/fr unknown
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