AU2003236500B9 - 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders - Google Patents

1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders Download PDF

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Publication number
AU2003236500B9
AU2003236500B9 AU2003236500A AU2003236500A AU2003236500B9 AU 2003236500 B9 AU2003236500 B9 AU 2003236500B9 AU 2003236500 A AU2003236500 A AU 2003236500A AU 2003236500 A AU2003236500 A AU 2003236500A AU 2003236500 B9 AU2003236500 B9 AU 2003236500B9
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group
chloro
alkyl
phenyl
haloalkyl
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AU2003236500B2 (en
AU2003236500A1 (en
Inventor
James B. Aggen
Daniel Joseph Dairaghi
Valeri V. Martichonok
Brian E. Mcmaster
Andrew M. K. Pennell
Subhabrata Sen
J. J. Kim Wright
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Chemocentryx Inc
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Chemocentryx Inc
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
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    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003236500A 2002-06-12 2003-06-11 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders Ceased AU2003236500B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45371102P 2002-06-12 2002-06-12
US60/453,711 2002-06-12
PCT/US2003/018660 WO2003105853A1 (en) 2002-06-12 2003-06-11 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders

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AU2003236500A1 AU2003236500A1 (en) 2003-12-31
AU2003236500B2 AU2003236500B2 (en) 2009-01-08
AU2003236500B9 true AU2003236500B9 (en) 2009-07-02

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AU2003236500A Ceased AU2003236500B9 (en) 2002-06-12 2003-06-11 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders

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US (2) US7157464B2 (enExample)
EP (1) EP1531822B1 (enExample)
JP (1) JP4723242B2 (enExample)
KR (1) KR101255356B1 (enExample)
CN (1) CN1867336B (enExample)
AT (1) ATE438401T1 (enExample)
AU (1) AU2003236500B9 (enExample)
CA (1) CA2488202C (enExample)
DE (1) DE60328690D1 (enExample)
DK (1) DK1531822T3 (enExample)
ES (1) ES2329356T3 (enExample)
MX (1) MXPA04012393A (enExample)
WO (1) WO2003105853A1 (enExample)

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