JP2006507231A5 - - Google Patents
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- Publication number
- JP2006507231A5 JP2006507231A5 JP2004521793A JP2004521793A JP2006507231A5 JP 2006507231 A5 JP2006507231 A5 JP 2006507231A5 JP 2004521793 A JP2004521793 A JP 2004521793A JP 2004521793 A JP2004521793 A JP 2004521793A JP 2006507231 A5 JP2006507231 A5 JP 2006507231A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- cell
- composition according
- agonist
- cell population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 36
- 210000004027 cell Anatomy 0.000 claims 20
- 102000004527 Interleukin-21 Receptors Human genes 0.000 claims 10
- 108010017411 Interleukin-21 Receptors Proteins 0.000 claims 10
- 108010074108 interleukin-21 Proteins 0.000 claims 10
- 239000000556 agonist Substances 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 102100030704 Interleukin-21 Human genes 0.000 claims 7
- 230000004069 differentiation Effects 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 5
- 210000004241 Th2 cell Anatomy 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- -1 SEQ ID NO: 2 amino acid Chemical class 0.000 claims 2
- 210000000447 Th1 cell Anatomy 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39616002P | 2002-07-15 | 2002-07-15 | |
| US60/396,160 | 2002-07-15 | ||
| US40300102P | 2002-08-12 | 2002-08-12 | |
| US60/403,001 | 2002-08-12 | ||
| PCT/US2003/021975 WO2004007682A2 (en) | 2002-07-15 | 2003-07-15 | Methods and compositions for modulating t helper (th) cell development and function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009270851A Division JP2010090133A (ja) | 2002-07-15 | 2009-11-27 | Ｔヘルパー（ｔｈ）細胞の発生および機能を調節するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006507231A JP2006507231A (ja) | 2006-03-02 |
| JP2006507231A5 true JP2006507231A5 (cg-RX-API-DMAC7.html) | 2006-09-21 |
| JP4776228B2 JP4776228B2 (ja) | 2011-09-21 |
Family
ID=30118569
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521793A Expired - Fee Related JP4776228B2 (ja) | 2002-07-15 | 2003-07-15 | Ｔヘルパー（ｔｈ）細胞の発生および機能を調節するための方法および組成物 |
| JP2009270851A Pending JP2010090133A (ja) | 2002-07-15 | 2009-11-27 | Ｔヘルパー（ｔｈ）細胞の発生および機能を調節するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009270851A Pending JP2010090133A (ja) | 2002-07-15 | 2009-11-27 | Ｔヘルパー（ｔｈ）細胞の発生および機能を調節するための方法および組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7314623B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1553982A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4776228B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20050037552A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1688340A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003251900B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0312738A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2491320A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA011686B1 (cg-RX-API-DMAC7.html) |
| IL (2) | IL165990A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA05000655A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20050717L (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004007682A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200500480B (cg-RX-API-DMAC7.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
| PT1531850E (pt) | 2002-06-07 | 2012-05-07 | Zymogenetics Inc | Utilização de il-21 e anticorpo monoclonal para tratar cancros sólidos |
| ZA200500480B (en) | 2002-07-15 | 2006-10-25 | Wyeth Corp | Methods and compositions for modulating T helper (TH) cell development and function |
| WO2004083249A2 (en) | 2003-03-14 | 2004-09-30 | Wyeth | Antibodies against human il-21 receptor and uses therefor |
| ZA200507235B (en) * | 2003-03-21 | 2007-03-28 | Wyeth Corp | Treating immunological disorders using agonists of interleukin-21/interleukin-21 receptor |
| WO2005030196A2 (en) * | 2003-09-25 | 2005-04-07 | Zymogenetics, Inc. | Methods of treating autoimmune diseases using il-21 |
| DE602004029173D1 (de) | 2003-10-10 | 2010-10-28 | Novo Nordisk As | Il-21-derivate |
| RU2007102287A (ru) * | 2004-08-05 | 2008-09-10 | Вайет (Us) | Антагонисты активности рецептора интерлейкина-21 |
| GT200600148A (es) | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
| PL1963369T3 (pl) | 2005-11-28 | 2013-10-31 | Zymogenetics Inc | Antagoniści IL-21 |
| US7592427B2 (en) * | 2005-11-28 | 2009-09-22 | Zymogenetics, Inc. | Antibodies to IL-21 receptor |
| WO2007126439A2 (en) * | 2005-12-02 | 2007-11-08 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r |
| EP2426146B1 (en) | 2007-12-07 | 2016-02-17 | ZymoGenetics, Inc. | Anti-human IL-21 monoclonal antibodies |
| WO2009092087A2 (en) | 2008-01-18 | 2009-07-23 | The Brigham And Women's Hospital, Inc. | Selective differentiation, identification, and modulation of human th17 cells |
| MX2010012812A (es) * | 2008-05-23 | 2011-01-21 | Wyeth Llc | Metodos de tratamiento que utilizan proteinas de union del receptor de la interleucina-21. |
| PE20100141A1 (es) * | 2008-05-23 | 2010-02-22 | Wyeth Corp | Proteina de union al receptor de interleuquina 21 |
| MX342405B (es) | 2010-06-03 | 2016-09-28 | Pharmacyclics Inc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| RS60050B1 (sr) | 2011-01-18 | 2020-04-30 | Bioniz Llc | Kompozicije za modulaciju aktivnosti gama-c-citokina |
| US9920932B2 (en) | 2011-01-26 | 2018-03-20 | United Technologies Corporation | Mixer assembly for a gas turbine engine |
| KR20130011056A (ko) * | 2011-07-20 | 2013-01-30 | 주식회사에이앤알쎄라퓨틱스 | 염증표적 수용체 및 염증 질환 치료용 약물 운반체 |
| BR112015001690A2 (pt) | 2012-07-24 | 2017-11-07 | Pharmacyclics Inc | mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk) |
| CA2890111A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
| PE20150944A1 (es) | 2012-11-08 | 2015-06-20 | Bristol Myers Squibb Co | COMPUESTOS HETEROCICLICOS SUSTITUIDOS CON AMIDA UTILES COMO MODULADORES DE LAS RESPUESTAS DE INTERLEUCINA 12(IL-12), INTERLEUCINA 23 (IL-23) Y/O INTERFERON ALFA (IFN(alfa)) |
| US20140170727A1 (en) * | 2012-12-19 | 2014-06-19 | Nanomr, Inc. | Affinity medium using fixed whole cells |
| JP2017509336A (ja) | 2014-03-20 | 2017-04-06 | ファーマサイクリックス エルエルシー | ホスホリパーゼｃガンマ２及び耐性に関連した変異 |
| KR102654684B1 (ko) | 2015-10-09 | 2024-04-04 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-ｃ-사이토카인 활성의 조정 |
| WO2020227019A1 (en) | 2019-05-03 | 2020-11-12 | Bioniz, Llc | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| GB201910605D0 (en) * | 2019-07-24 | 2019-09-04 | Immetacyte Ltd | Tumour infltracting lymphocyte therapy amd uses thereo |
| JP7217071B2 (ja) | 2019-09-30 | 2023-02-02 | エルジー・ケム・リミテッド | 高吸水性樹脂およびその製造方法 |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
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| US20040016010A1 (en) * | 2002-04-17 | 2004-01-22 | Marion Kasaian | IL-21 receptor knockout animal and methods of use thereof |
| ZA200500480B (en) | 2002-07-15 | 2006-10-25 | Wyeth Corp | Methods and compositions for modulating T helper (TH) cell development and function |
| WO2004083249A2 (en) * | 2003-03-14 | 2004-09-30 | Wyeth | Antibodies against human il-21 receptor and uses therefor |
| ZA200507235B (en) | 2003-03-21 | 2007-03-28 | Wyeth Corp | Treating immunological disorders using agonists of interleukin-21/interleukin-21 receptor |
| AU2005244942A1 (en) | 2004-05-19 | 2005-12-01 | Wyeth | Modulation of immunoglobulin production and atopic disorders |
| RU2007102287A (ru) * | 2004-08-05 | 2008-09-10 | Вайет (Us) | Антагонисты активности рецептора интерлейкина-21 |
| GT200600148A (es) * | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
| WO2009100035A2 (en) | 2008-02-01 | 2009-08-13 | Wyeth | Interleukin-21 (il-21) and il-21 receptor (il-21r) modulation of regulatory t cells and forkhead box p3 (foxp3) |
-
2003
- 2003-07-15 ZA ZA200500480A patent/ZA200500480B/en unknown
- 2003-07-15 WO PCT/US2003/021975 patent/WO2004007682A2/en not_active Ceased
- 2003-07-15 US US10/620,169 patent/US7314623B2/en not_active Expired - Fee Related
- 2003-07-15 BR BRPI0312738-9A patent/BR0312738A/pt not_active IP Right Cessation
- 2003-07-15 JP JP2004521793A patent/JP4776228B2/ja not_active Expired - Fee Related
- 2003-07-15 KR KR1020057000735A patent/KR20050037552A/ko not_active Ceased
- 2003-07-15 CN CNA038169150A patent/CN1688340A/zh active Pending
- 2003-07-15 CA CA002491320A patent/CA2491320A1/en not_active Abandoned
- 2003-07-15 AU AU2003251900A patent/AU2003251900B2/en not_active Ceased
- 2003-07-15 MX MXPA05000655A patent/MXPA05000655A/es active IP Right Grant
- 2003-07-15 EP EP03764624A patent/EP1553982A4/en not_active Withdrawn
- 2003-07-15 EA EA200500206A patent/EA011686B1/ru not_active IP Right Cessation
-
2004
- 2004-12-26 IL IL16599004A patent/IL165990A0/xx unknown
-
2005
- 2005-02-10 NO NO20050717A patent/NO20050717L/no not_active Application Discontinuation
-
2007
- 2007-11-12 US US11/938,618 patent/US7731946B2/en not_active Expired - Fee Related
-
2008
- 2008-12-07 IL IL195769A patent/IL195769A0/en unknown
-
2009
- 2009-11-27 JP JP2009270851A patent/JP2010090133A/ja active Pending
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