BR0312738A - processos e composições para a modulação do desenvolvimento e da função de células t auxiliares (th) - Google Patents
processos e composições para a modulação do desenvolvimento e da função de células t auxiliares (th)Info
- Publication number
- BR0312738A BR0312738A BRPI0312738-9A BR0312738A BR0312738A BR 0312738 A BR0312738 A BR 0312738A BR 0312738 A BR0312738 A BR 0312738A BR 0312738 A BR0312738 A BR 0312738A
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- function
- modulating
- helper
- processes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000011712 cell development Effects 0.000 title 1
- 230000003915 cell function Effects 0.000 title 1
- 210000002443 helper t lymphocyte Anatomy 0.000 title 1
- 101001010621 Homo sapiens Interleukin-21 Proteins 0.000 abstract 1
- 108010074108 interleukin-21 Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PORCESSOS E COMPOSIçõES PARA A MODULAçãO DO DESENVOLVIMENTO E DA FUNçãO DE CéLULAS T AUXILIARES (T<sym>) processo e composições para a modulação do desenvolvimento e da função de células T auxiliares (T<sym>) empregando-se moduladores de atividade ou de níveis de IL-21,de IL-21 humana, por exemplo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39616002P | 2002-07-15 | 2002-07-15 | |
US40300102P | 2002-08-12 | 2002-08-12 | |
PCT/US2003/021975 WO2004007682A2 (en) | 2002-07-15 | 2003-07-15 | Methods and compositions for modulating t helper (th) cell development and function |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0312738A true BR0312738A (pt) | 2007-06-26 |
Family
ID=30118569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0312738-9A BR0312738A (pt) | 2002-07-15 | 2003-07-15 | processos e composições para a modulação do desenvolvimento e da função de células t auxiliares (th) |
Country Status (14)
Country | Link |
---|---|
US (2) | US7314623B2 (pt) |
EP (1) | EP1553982A4 (pt) |
JP (2) | JP4776228B2 (pt) |
KR (1) | KR20050037552A (pt) |
CN (1) | CN1688340A (pt) |
AU (1) | AU2003251900B2 (pt) |
BR (1) | BR0312738A (pt) |
CA (1) | CA2491320A1 (pt) |
EA (1) | EA011686B1 (pt) |
IL (2) | IL165990A0 (pt) |
MX (1) | MXPA05000655A (pt) |
NO (1) | NO20050717L (pt) |
WO (1) | WO2004007682A2 (pt) |
ZA (1) | ZA200500480B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
EP1531850B1 (en) | 2002-06-07 | 2012-02-22 | ZymoGenetics, Inc. | Use of IL-21 and monoclonal antibody for treating solid cancers |
ZA200500480B (en) | 2002-07-15 | 2006-10-25 | Wyeth Corp | Methods and compositions for modulating T helper (TH) cell development and function |
RU2005131852A (ru) | 2003-03-14 | 2006-04-20 | Уайт (Us) | Антитела против человеческого рецептора il-21 и их применение |
BRPI0408523A (pt) * | 2003-03-21 | 2006-03-21 | Wyeth Corp | métodos para melhorar um sintoma de esclerose múltipla em um indivìduo, para melhorar esclerose múltipla em um indivìduo mamìfero, para modular uma deficiência de il-10, ou um distúrbio associado com uma deficiência de il-10 em um indivìduo mamìfero, para tratar ou prevenir um distúrbio imunológico em um indivìduo mamìfero e para avaliar o tratamento de esclerose múltipla em um indivìduo mamìfero, composição farmacêutica, e, artigo de manufatura |
JP2007506789A (ja) * | 2003-09-25 | 2007-03-22 | ザイモジェネティクス, インコーポレイテッド | Il−21を用いた自己免疫疾患の治療方法 |
EP1673387B1 (en) | 2003-10-10 | 2010-09-15 | Novo Nordisk A/S | Il-21 derivatives |
KR20070057789A (ko) * | 2004-08-05 | 2007-06-07 | 와이어쓰 | 인터루킨-21 수용체 활성의 상쇄 |
GT200600148A (es) | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
AU2006341398B9 (en) * | 2005-11-28 | 2012-02-02 | Zymogenetics, Inc. | IL-21 receptor antagonists |
US20070122413A1 (en) * | 2005-11-28 | 2007-05-31 | Sivakumar Pallavur V | Il-21 antagonists |
CA2631961A1 (en) * | 2005-12-02 | 2007-11-08 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling relating to antibodies that bind to il-22 |
DK2217268T3 (en) | 2007-12-07 | 2016-08-15 | Zymogenetics Inc | MONOCLONAL ANTI-HUMAN IL-21 ANTIBODIES |
JP2011509676A (ja) | 2008-01-18 | 2011-03-31 | ザ ブライハム アンド ウイメンズ ホスピタル, インコーポレイテッド | ヒトTh17細胞の選択的分化、同定および調節 |
WO2009143526A1 (en) * | 2008-05-23 | 2009-11-26 | Wyeth | Methods of treatment utilizing binding proteins of the interleukin-21 receptor |
PE20100141A1 (es) * | 2008-05-23 | 2010-02-22 | Wyeth Corp | Proteina de union al receptor de interleuquina 21 |
MX2020004501A (es) | 2010-06-03 | 2021-11-09 | Pharmacyclics Llc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
CN103501805B (zh) | 2011-01-18 | 2018-09-14 | 比奥尼斯有限责任公司 | 调节γ-C-细胞因子活性的组合物及方法 |
US9920932B2 (en) | 2011-01-26 | 2018-03-20 | United Technologies Corporation | Mixer assembly for a gas turbine engine |
KR20130011056A (ko) * | 2011-07-20 | 2013-01-30 | 주식회사에이앤알쎄라퓨틱스 | 염증표적 수용체 및 염증 질환 치료용 약물 운반체 |
KR20180088926A (ko) | 2012-07-24 | 2018-08-07 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이 |
MX2015005633A (es) | 2012-11-02 | 2016-02-03 | Pharmacyclics Inc | Terapia adyuvante con inhibidores de quinasa de la familia tec. |
MX2015005731A (es) | 2012-11-08 | 2015-09-16 | Bristol Myers Squibb Co | Compuestos heterciclicos sustituidos con amida utiles como moduladores de las respuestas de interleucina 12(il-12), interleucina 23 (il-23) y/o interferon alfa (ifnalfa). |
US20140170727A1 (en) * | 2012-12-19 | 2014-06-19 | Nanomr, Inc. | Affinity medium using fixed whole cells |
US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
US9885086B2 (en) | 2014-03-20 | 2018-02-06 | Pharmacyclics Llc | Phospholipase C gamma 2 and resistance associated mutations |
ES2884357T3 (es) | 2015-10-09 | 2021-12-10 | Bioniz Llc | Modulación de la actividad de las citocinas gamma-c |
CA3137971A1 (en) | 2019-05-03 | 2020-11-12 | Bioniz, Llc | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
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ZA200500480B (en) | 2002-07-15 | 2006-10-25 | Wyeth Corp | Methods and compositions for modulating T helper (TH) cell development and function |
RU2005131852A (ru) * | 2003-03-14 | 2006-04-20 | Уайт (Us) | Антитела против человеческого рецептора il-21 и их применение |
BRPI0408523A (pt) * | 2003-03-21 | 2006-03-21 | Wyeth Corp | métodos para melhorar um sintoma de esclerose múltipla em um indivìduo, para melhorar esclerose múltipla em um indivìduo mamìfero, para modular uma deficiência de il-10, ou um distúrbio associado com uma deficiência de il-10 em um indivìduo mamìfero, para tratar ou prevenir um distúrbio imunológico em um indivìduo mamìfero e para avaliar o tratamento de esclerose múltipla em um indivìduo mamìfero, composição farmacêutica, e, artigo de manufatura |
CN1980698A (zh) | 2004-05-19 | 2007-06-13 | 惠氏公司 | 免疫球蛋白产生和特应性疾病的调节 |
KR20070057789A (ko) * | 2004-08-05 | 2007-06-07 | 와이어쓰 | 인터루킨-21 수용체 활성의 상쇄 |
GT200600148A (es) * | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
WO2009100035A2 (en) | 2008-02-01 | 2009-08-13 | Wyeth | Interleukin-21 (il-21) and il-21 receptor (il-21r) modulation of regulatory t cells and forkhead box p3 (foxp3) |
-
2003
- 2003-07-15 ZA ZA200500480A patent/ZA200500480B/en unknown
- 2003-07-15 US US10/620,169 patent/US7314623B2/en not_active Expired - Fee Related
- 2003-07-15 JP JP2004521793A patent/JP4776228B2/ja not_active Expired - Fee Related
- 2003-07-15 CA CA002491320A patent/CA2491320A1/en not_active Abandoned
- 2003-07-15 KR KR1020057000735A patent/KR20050037552A/ko not_active Application Discontinuation
- 2003-07-15 EP EP03764624A patent/EP1553982A4/en not_active Withdrawn
- 2003-07-15 EA EA200500206A patent/EA011686B1/ru not_active IP Right Cessation
- 2003-07-15 BR BRPI0312738-9A patent/BR0312738A/pt not_active IP Right Cessation
- 2003-07-15 AU AU2003251900A patent/AU2003251900B2/en not_active Ceased
- 2003-07-15 CN CNA038169150A patent/CN1688340A/zh active Pending
- 2003-07-15 WO PCT/US2003/021975 patent/WO2004007682A2/en active Application Filing
- 2003-07-15 MX MXPA05000655A patent/MXPA05000655A/es active IP Right Grant
-
2004
- 2004-12-26 IL IL16599004A patent/IL165990A0/xx unknown
-
2005
- 2005-02-10 NO NO20050717A patent/NO20050717L/no not_active Application Discontinuation
-
2007
- 2007-11-12 US US11/938,618 patent/US7731946B2/en not_active Expired - Fee Related
-
2008
- 2008-12-07 IL IL195769A patent/IL195769A0/en unknown
-
2009
- 2009-11-27 JP JP2009270851A patent/JP2010090133A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1688340A (zh) | 2005-10-26 |
AU2003251900A1 (en) | 2004-02-02 |
US7731946B2 (en) | 2010-06-08 |
CA2491320A1 (en) | 2004-01-22 |
US20040136954A1 (en) | 2004-07-15 |
US20090197803A1 (en) | 2009-08-06 |
EA200500206A1 (ru) | 2006-06-30 |
EP1553982A4 (en) | 2008-03-26 |
MXPA05000655A (es) | 2006-02-22 |
EP1553982A2 (en) | 2005-07-20 |
ZA200500480B (en) | 2006-10-25 |
JP2006507231A (ja) | 2006-03-02 |
EA011686B1 (ru) | 2009-04-28 |
AU2003251900B2 (en) | 2008-12-18 |
WO2004007682A3 (en) | 2004-12-29 |
JP2010090133A (ja) | 2010-04-22 |
IL165990A0 (en) | 2006-01-15 |
JP4776228B2 (ja) | 2011-09-21 |
KR20050037552A (ko) | 2005-04-22 |
US7314623B2 (en) | 2008-01-01 |
NO20050717L (no) | 2005-04-11 |
IL195769A0 (en) | 2009-09-01 |
WO2004007682A2 (en) | 2004-01-22 |
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