JP2006502112A5 - - Google Patents
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- JP2006502112A5 JP2006502112A5 JP2004520114A JP2004520114A JP2006502112A5 JP 2006502112 A5 JP2006502112 A5 JP 2006502112A5 JP 2004520114 A JP2004520114 A JP 2004520114A JP 2004520114 A JP2004520114 A JP 2004520114A JP 2006502112 A5 JP2006502112 A5 JP 2006502112A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- substituted
- membered
- alkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 amino, hydroxy Chemical group 0.000 claims 113
- 125000000623 heterocyclic group Chemical group 0.000 claims 47
- 150000001875 compounds Chemical class 0.000 claims 41
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 26
- 125000001424 substituent group Chemical group 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 7
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 7
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 6
- 101150065749 Churc1 gene Proteins 0.000 claims 6
- 102100038239 Protein Churchill Human genes 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims 5
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 4
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 claims 2
- SZPWXAOBLNYOHY-UHFFFAOYSA-N [C]1=CC=NC2=CC=CC=C12 Chemical group [C]1=CC=NC2=CC=CC=C12 SZPWXAOBLNYOHY-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- ZXOFVTMVRJWTAG-UHFFFAOYSA-N n-(1-acetyl-3,3-dimethyl-2h-indol-6-yl)-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1=C2N(C(=O)C)CC(C)(C)C2=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 ZXOFVTMVRJWTAG-UHFFFAOYSA-N 0.000 claims 2
- BPPJLUFEJJNKCY-UHFFFAOYSA-N n-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 BPPJLUFEJJNKCY-UHFFFAOYSA-N 0.000 claims 2
- FNFSNNWULZMNNC-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-2-[[2-(methylamino)pyrimidin-4-yl]methylamino]benzamide Chemical compound CNC1=NC=CC(CNC=2C(=CC=CC=2)C(=O)NC=2C=C3C(C(CNC3)(C)C)=CC=2)=N1 FNFSNNWULZMNNC-UHFFFAOYSA-N 0.000 claims 2
- HBLHQDSWCAZXOG-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-quinolin-7-yl)-2-(quinazolin-6-ylamino)benzamide Chemical compound N1=CN=CC2=CC(NC3=CC=CC=C3C(=O)NC=3C=C4NCCC(C4=CC=3)(C)C)=CC=C21 HBLHQDSWCAZXOG-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000004942 pyridazin-6-yl group Chemical group N1=NC=CC=C1* 0.000 claims 2
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 2
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 2
- 125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims 2
- 125000004547 quinazolin-6-yl group Chemical group N1=CN=CC2=CC(=CC=C12)* 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- 125000005877 1,4-benzodioxanyl group Chemical group 0.000 claims 1
- PYWPWPPRAYOLIB-UHFFFAOYSA-N 1-(3,3-dimethyl-2h-indol-1-yl)ethanone Chemical compound C1=CC=C2N(C(=O)C)CC(C)(C)C2=C1 PYWPWPPRAYOLIB-UHFFFAOYSA-N 0.000 claims 1
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims 1
- 125000004484 1-methylpiperidin-4-yl group Chemical group CN1CCC(CC1)* 0.000 claims 1
- OIPPARMLEWQGSK-UHFFFAOYSA-N 2-[(4-fluorophenyl)methylamino]-n-[4-[2-(1-methylpiperidin-4-yl)propan-2-yl]phenyl]benzamide Chemical compound C1CN(C)CCC1C(C)(C)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=C(F)C=C1 OIPPARMLEWQGSK-UHFFFAOYSA-N 0.000 claims 1
- IKDAWKWPRPYNJA-UHFFFAOYSA-N 2-[1-(2-aminopyrimidin-4-yl)ethylamino]-n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)benzamide Chemical compound C=1C=CC=C(C(=O)NC=2C=C3C(C(CNC3)(C)C)=CC=2)C=1NC(C)C1=CC=NC(N)=N1 IKDAWKWPRPYNJA-UHFFFAOYSA-N 0.000 claims 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- COZSLNKBURQTJX-UHFFFAOYSA-N n-(1-acetyl-3,3-dimethyl-2h-indol-6-yl)-2-(quinolin-4-ylmethylamino)benzamide Chemical compound C1=CC=C2C(CNC3=CC=CC=C3C(=O)NC3=CC=C4C(C)(C)CN(C4=C3)C(=O)C)=CC=NC2=C1 COZSLNKBURQTJX-UHFFFAOYSA-N 0.000 claims 1
- IKTFEBNTUYTPCK-UHFFFAOYSA-N n-(1-ethyl-3,3-dimethyl-2h-indol-6-yl)-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1=C2N(CC)CC(C)(C)C2=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 IKTFEBNTUYTPCK-UHFFFAOYSA-N 0.000 claims 1
- YYVHACOWHFZZJT-UHFFFAOYSA-N n-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(quinolin-4-ylmethylamino)benzamide Chemical compound C1=CC=C2C(CNC3=CC=CC=C3C(=O)NC=3C=C4NCC(C4=CC=3)(C)C)=CC=NC2=C1 YYVHACOWHFZZJT-UHFFFAOYSA-N 0.000 claims 1
- QLFQMDKFOJZHBK-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-2-(pyridazin-4-ylmethylamino)benzamide Chemical compound C=1C=C2C(C)(C)CNCC2=CC=1NC(=O)C1=CC=CC=C1NCC1=CC=NN=C1 QLFQMDKFOJZHBK-UHFFFAOYSA-N 0.000 claims 1
- JQVREGRYMBTPRO-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-2-[(2-methoxypyridin-4-yl)methylamino]benzamide Chemical compound C1=NC(OC)=CC(CNC=2C(=CC=CC=2)C(=O)NC=2C=C3C(C(CNC3)(C)C)=CC=2)=C1 JQVREGRYMBTPRO-UHFFFAOYSA-N 0.000 claims 1
- FTNKCGULGWHQPV-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-2-[(4-fluorophenyl)methylamino]benzamide Chemical compound C=1C=C2C(C)(C)CNCC2=CC=1NC(=O)C1=CC=CC=C1NCC1=CC=C(F)C=C1 FTNKCGULGWHQPV-UHFFFAOYSA-N 0.000 claims 1
- GUIOOGNPPDHMRU-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-2-[1-[2-(methylamino)pyrimidin-4-yl]ethylamino]benzamide Chemical compound CNC1=NC=CC(C(C)NC=2C(=CC=CC=2)C(=O)NC=2C=C3C(C(CNC3)(C)C)=CC=2)=N1 GUIOOGNPPDHMRU-UHFFFAOYSA-N 0.000 claims 1
- GUIOOGNPPDHMRU-MRXNPFEDSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-2-[[(1r)-1-[2-(methylamino)pyrimidin-4-yl]ethyl]amino]benzamide Chemical compound CNC1=NC=CC([C@@H](C)NC=2C(=CC=CC=2)C(=O)NC=2C=C3C(C(CNC3)(C)C)=CC=2)=N1 GUIOOGNPPDHMRU-MRXNPFEDSA-N 0.000 claims 1
- SKHDQKQGFCSJDS-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-2-fluoro-6-[(2-methoxypyridin-4-yl)methylamino]benzamide Chemical compound C1=NC(OC)=CC(CNC=2C(=C(F)C=CC=2)C(=O)NC=2C=C3C(C(CNC3)(C)C)=CC=2)=C1 SKHDQKQGFCSJDS-UHFFFAOYSA-N 0.000 claims 1
- YAWXEPJVBFFVAI-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-3-fluoro-2-[(4-fluorophenyl)methylamino]benzamide Chemical compound C=1C=C2C(C)(C)CNCC2=CC=1NC(=O)C1=CC=CC(F)=C1NCC1=CC=C(F)C=C1 YAWXEPJVBFFVAI-UHFFFAOYSA-N 0.000 claims 1
- SHNBMTHPUCMPQC-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-4-fluoro-2-[(2-methoxypyridin-4-yl)methylamino]benzamide Chemical compound C1=NC(OC)=CC(CNC=2C(=CC=C(F)C=2)C(=O)NC=2C=C3C(C(CNC3)(C)C)=CC=2)=C1 SHNBMTHPUCMPQC-UHFFFAOYSA-N 0.000 claims 1
- FBSYURCCDOMSHX-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-5-fluoro-2-[(2-methoxypyridin-4-yl)methylamino]benzamide Chemical compound C1=NC(OC)=CC(CNC=2C(=CC(F)=CC=2)C(=O)NC=2C=C3C(C(CNC3)(C)C)=CC=2)=C1 FBSYURCCDOMSHX-UHFFFAOYSA-N 0.000 claims 1
- JQUISUUSKKADNO-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-isoquinolin-7-yl)-6-fluoro-6-[(4-fluorophenyl)methylamino]cyclohexa-2,4-diene-1-carboxamide Chemical compound C=1C=C2C(C)(C)CNCC2=CC=1NC(=O)C1C=CC=CC1(F)NCC1=CC=C(F)C=C1 JQUISUUSKKADNO-UHFFFAOYSA-N 0.000 claims 1
- YHNUIHYDPTVZRY-UHFFFAOYSA-N n-(4,4-dimethyl-2,3-dihydro-1h-quinolin-7-yl)-2-(1h-pyrrolo[2,3-b]pyridin-3-ylmethylamino)benzamide Chemical compound C1=CC=C2C(CNC3=CC=CC=C3C(=O)NC=3C=C4NCCC(C4=CC=3)(C)C)=CNC2=N1 YHNUIHYDPTVZRY-UHFFFAOYSA-N 0.000 claims 1
- YTITUUIWIKQKDQ-UHFFFAOYSA-N n-(4-tert-butylphenyl)-2-(isoquinolin-7-ylamino)benzamide Chemical compound C1=CC(C(C)(C)C)=CC=C1NC(=O)C1=CC=CC=C1NC1=CC=C(C=CN=C2)C2=C1 YTITUUIWIKQKDQ-UHFFFAOYSA-N 0.000 claims 1
- MXMQURVEDWCCER-UHFFFAOYSA-N n-[4-[2-(1-methylpiperidin-4-yl)propan-2-yl]phenyl]-2-(pyridin-4-ylmethylamino)benzamide Chemical compound C1CN(C)CCC1C(C)(C)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC=C1 MXMQURVEDWCCER-UHFFFAOYSA-N 0.000 claims 1
- HAZZWCMIYVZRGW-UHFFFAOYSA-N n-[4-[2-(1-methylpiperidin-4-yl)propan-2-yl]phenyl]-2-(quinolin-4-ylmethylamino)benzamide Chemical compound C1CN(C)CCC1C(C)(C)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1NCC1=CC=NC2=CC=CC=C12 HAZZWCMIYVZRGW-UHFFFAOYSA-N 0.000 claims 1
- 125000005246 nonafluorobutyl group Chemical group FC(F)(F)C(F)(F)C(F)(F)C(F)(F)* 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39514402P | 2002-07-09 | 2002-07-09 | |
| US10/615,809 US7307088B2 (en) | 2002-07-09 | 2003-07-08 | Substituted anthranilic amide derivatives and methods of use |
| PCT/US2003/021601 WO2004005279A2 (en) | 2002-07-09 | 2003-07-09 | Substituted anthranilic amide derivatives and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006502112A JP2006502112A (ja) | 2006-01-19 |
| JP2006502112A5 true JP2006502112A5 (https=) | 2006-08-24 |
Family
ID=30118477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520114A Pending JP2006502112A (ja) | 2002-07-09 | 2003-07-09 | 置換アントラニルアミド誘導体および使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7307088B2 (https=) |
| EP (1) | EP1519921A2 (https=) |
| JP (1) | JP2006502112A (https=) |
| AU (1) | AU2003256481B2 (https=) |
| CA (1) | CA2489166A1 (https=) |
| MX (1) | MXPA05000120A (https=) |
| PL (1) | PL375586A1 (https=) |
| WO (1) | WO2004005279A2 (https=) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10023484A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Anthranylamide und deren Verwendung als Arzneimittel |
| US7615565B2 (en) * | 2002-07-31 | 2009-11-10 | Bayer Schering Pharma Aktiengesellschaft | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
| US7202260B2 (en) * | 2003-06-13 | 2007-04-10 | Schering Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones |
| TWI476206B (zh) | 2003-07-18 | 2015-03-11 | Amgen Inc | 對肝細胞生長因子具專一性之結合劑 |
| US20050130986A1 (en) * | 2003-11-21 | 2005-06-16 | Eklund Kari K. | Treatment of spondylarthropathies |
| US7507748B2 (en) * | 2004-07-22 | 2009-03-24 | Amgen Inc. | Substituted aryl-amine derivatives and methods of use |
| EP1657241A1 (en) * | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
| US7906533B2 (en) * | 2004-11-03 | 2011-03-15 | Bayer Schering Pharma Ag | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors |
| EP1655295A1 (en) * | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
| JP2008521900A (ja) | 2004-11-30 | 2008-06-26 | アムジエン・インコーポレーテツド | キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用 |
| EP1864977B1 (en) | 2005-03-31 | 2015-07-29 | Santen Pharmaceutical Co., Ltd. | Novel cyclic compound having pyrimidinylalkylthio group |
| JP4834441B2 (ja) * | 2005-03-31 | 2011-12-14 | 参天製薬株式会社 | ピリミジニルアルキルチオ基を有する新規環式化合物 |
| US8247556B2 (en) * | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| CA2629964A1 (en) | 2005-11-30 | 2007-06-07 | Astellas Pharma Inc. | 2-aminobenzamide derivative |
| US20080108664A1 (en) | 2005-12-23 | 2008-05-08 | Liu Belle B | Solid-state form of AMG 706 and pharmaceutical compositions thereof |
| AR059066A1 (es) * | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| JP2009526050A (ja) | 2006-02-10 | 2009-07-16 | アムジエン・インコーポレーテツド | Ａｍｇ７０６の水和物形態 |
| PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
| US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
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| WO2002076959A1 (en) * | 2001-03-23 | 2002-10-03 | Takeda Chemical Industries, Ltd. | Five-membered heterocyclic alkanoic acid derivative |
| US7312235B2 (en) * | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
| WO2002090352A2 (de) * | 2001-05-08 | 2002-11-14 | Schering Aktiengesellschaft | Selektive anthranylamidpyridinamide als vegfr-2 und vegfr-3 inhibitoren |
| JP4343681B2 (ja) * | 2001-05-08 | 2009-10-14 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | シアノアントラニルアミド誘導体およびそれらの薬剤としての使用 |
| WO2002090349A1 (de) * | 2001-05-08 | 2002-11-14 | Schering Aktiengesellschaft | N-oxidanthranylamid-derivate und deren verwendung als arzneimittel |
| DE10125295A1 (de) | 2001-05-15 | 2002-11-21 | Schering Ag | Cyanoanthranylamid-Derivate und deren Verwendung als Arzneimittel (II) |
| GB0126902D0 (en) | 2001-11-08 | 2002-01-02 | Novartis Ag | Organic compounds |
| GB0126901D0 (en) * | 2001-11-08 | 2002-01-02 | Novartis Ag | Organic compounds |
| GB0203193D0 (en) | 2002-02-11 | 2002-03-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
| MXPA04007737A (es) | 2002-02-11 | 2004-10-15 | Pfizer | Derivados de nicotinamida utiles como inhibidores de fosfodesterasas 4. |
| US20030195192A1 (en) | 2002-04-05 | 2003-10-16 | Fortuna Haviv | Nicotinamides having antiangiogenic activity |
| US7517894B2 (en) * | 2002-07-31 | 2009-04-14 | Bayer Schering Pharma Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
-
2003
- 2003-07-08 US US10/615,809 patent/US7307088B2/en not_active Expired - Lifetime
- 2003-07-09 PL PL03375586A patent/PL375586A1/xx unknown
- 2003-07-09 WO PCT/US2003/021601 patent/WO2004005279A2/en not_active Ceased
- 2003-07-09 JP JP2004520114A patent/JP2006502112A/ja active Pending
- 2003-07-09 CA CA002489166A patent/CA2489166A1/en not_active Abandoned
- 2003-07-09 AU AU2003256481A patent/AU2003256481B2/en not_active Ceased
- 2003-07-09 MX MXPA05000120A patent/MXPA05000120A/es not_active Application Discontinuation
- 2003-07-09 EP EP03763451A patent/EP1519921A2/en not_active Withdrawn
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