JP2006501260A - サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン - Google Patents

サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン Download PDF

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Publication number
JP2006501260A
JP2006501260A JP2004534424A JP2004534424A JP2006501260A JP 2006501260 A JP2006501260 A JP 2006501260A JP 2004534424 A JP2004534424 A JP 2004534424A JP 2004534424 A JP2004534424 A JP 2004534424A JP 2006501260 A JP2006501260 A JP 2006501260A
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JP
Japan
Prior art keywords
compound
group
alkyl
aryl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2004534424A
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Japanese (ja)
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JP2006501260A5 (enExample
Inventor
ティモシー ジェイ． グジ，
カミル パルク，
マイケル ピー． ドゥイヤー，
ドール，　ロナルド　ジェイ．
ビッヨール ムーピル ギリジャヴァラバン，
ローレンス ダブリュー． ディラード，
ヴィン ディー． トラン，
ゼン ミン ヘー，
レイ アンソニー ジェームス，
ヘンスーン パーク，
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Merck Sharp and Dohme LLC
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Schering Corp
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Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2006501260A publication Critical patent/JP2006501260A/ja
Publication of JP2006501260A5 publication Critical patent/JP2006501260A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004534424A 2002-09-04 2003-09-03 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン Withdrawn JP2006501260A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40803002P 2002-09-04 2002-09-04
PCT/US2003/027405 WO2004022559A1 (en) 2002-09-04 2003-09-03 Pyrazolopyrimidines as cyclin dependent kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010045900A Division JP2010132704A (ja) 2002-09-04 2010-03-02 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン

Publications (2)

Publication Number Publication Date
JP2006501260A true JP2006501260A (ja) 2006-01-12
JP2006501260A5 JP2006501260A5 (enExample) 2006-09-21

Family

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JP2004534424A Withdrawn JP2006501260A (ja) 2002-09-04 2003-09-03 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
JP2010045900A Pending JP2010132704A (ja) 2002-09-04 2010-03-02 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン

Family Applications After (1)

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JP2010045900A Pending JP2010132704A (ja) 2002-09-04 2010-03-02 サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン

Country Status (17)

Country Link
US (2) US7078525B2 (enExample)
EP (1) EP1534709B1 (enExample)
JP (2) JP2006501260A (enExample)
KR (1) KR20050058507A (enExample)
CN (1) CN1310918C (enExample)
AR (1) AR041134A1 (enExample)
AT (1) ATE364608T1 (enExample)
CA (1) CA2497444C (enExample)
DE (1) DE60314427T2 (enExample)
ES (1) ES2285164T3 (enExample)
MX (1) MXPA05002573A (enExample)
MY (1) MY139336A (enExample)
NZ (1) NZ539162A (enExample)
PE (1) PE20041076A1 (enExample)
TW (1) TW200413377A (enExample)
WO (1) WO2004022559A1 (enExample)
ZA (1) ZA200501851B (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006502163A (ja) * 2002-09-04 2006-01-19 シェーリング　コーポレイション サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
JP2006519226A (ja) * 2003-02-28 2006-08-24 帝人ファーマ株式会社 ピラゾロ［１，５−ａ］ピリミジン誘導体
JP2010505839A (ja) * 2006-10-04 2010-02-25 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターのピラゾロピリミジン
JP2010505838A (ja) * 2006-10-04 2010-02-25 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
JP2010132704A (ja) * 2002-09-04 2010-06-17 Schering Corp サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
JP2010520867A (ja) * 2007-03-09 2010-06-17 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 新規除草剤
JP2018520201A (ja) * 2015-07-23 2018-07-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｔｇｆベーター受容体アンタゴニスト
JP2019533729A (ja) * 2016-11-02 2019-11-21 深▲せん▼▲ブォ▼立健医薬有限公司Ｓｈｅｎｚｈｅｎ Ｂｏ Ｌｉ Ｊｉａｎ Ｍｅｄｉｃｉｎｅ Ｃｏ．， Ｌｔｄ． Ｐｉ３ｋ阻害剤とするピラゾロピリミジン化合物とその使用

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JP4579351B2 (ja) * 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
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US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7067661B2 (en) * 2002-09-04 2006-06-27 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196092B2 (en) * 2002-09-04 2007-03-27 Schering Corporation N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
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WO2004087707A1 (en) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
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JP2014517079A (ja) 2011-06-22 2014-07-17 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
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SMT202000713T1 (it) 2012-12-07 2021-03-15 Vertex Pharma Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro
EP2970307B1 (en) * 2013-03-13 2020-03-11 Genentech, Inc. Pyrazolo compounds and uses thereof
EP2970289A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
US9663519B2 (en) 2013-03-15 2017-05-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
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ES2768678T3 (es) 2013-12-06 2020-06-23 Vertex Pharma Compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inhibidor de la ATR quinasa, su preparación, diferentes formas sólidas y derivados radiomarcados de las mismas
SG10201902206QA (en) 2014-06-05 2019-04-29 Vertex Pharma Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
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JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2006502163A (ja) * 2002-09-04 2006-01-19 シェーリング　コーポレイション サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン

Cited By (8)

* Cited by examiner, † Cited by third party
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JP2006502163A (ja) * 2002-09-04 2006-01-19 シェーリング　コーポレイション サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
JP2010132704A (ja) * 2002-09-04 2010-06-17 Schering Corp サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
JP2006519226A (ja) * 2003-02-28 2006-08-24 帝人ファーマ株式会社 ピラゾロ［１，５−ａ］ピリミジン誘導体
JP2010505839A (ja) * 2006-10-04 2010-02-25 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターのピラゾロピリミジン
JP2010505838A (ja) * 2006-10-04 2010-02-25 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
JP2010520867A (ja) * 2007-03-09 2010-06-17 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 新規除草剤
JP2018520201A (ja) * 2015-07-23 2018-07-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｔｇｆベーター受容体アンタゴニスト
JP2019533729A (ja) * 2016-11-02 2019-11-21 深▲せん▼▲ブォ▼立健医薬有限公司Ｓｈｅｎｚｈｅｎ Ｂｏ Ｌｉ Ｊｉａｎ Ｍｅｄｉｃｉｎｅ Ｃｏ．， Ｌｔｄ． Ｐｉ３ｋ阻害剤とするピラゾロピリミジン化合物とその使用

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AR041134A1 (es) 2005-05-04
US20040102451A1 (en) 2004-05-27
US20060235025A1 (en) 2006-10-19
CN1738821A (zh) 2006-02-22
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US7470695B2 (en) 2008-12-30
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CA2497444A1 (en) 2004-03-18
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ATE364608T1 (de) 2007-07-15
AU2003268357A1 (en) 2004-03-29
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MY139336A (en) 2009-09-30
MXPA05002573A (es) 2005-09-08
EP1534709B1 (en) 2007-06-13
JP2010132704A (ja) 2010-06-17
HK1071570A1 (en) 2005-07-22
DE60314427T2 (de) 2008-06-12
TW200413377A (en) 2004-08-01
ES2285164T3 (es) 2007-11-16
WO2004022559A1 (en) 2004-03-18

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