CN1310918C - 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶 - Google Patents

作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶 Download PDF

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Publication number
CN1310918C
CN1310918C CNB038244489A CN03824448A CN1310918C CN 1310918 C CN1310918 C CN 1310918C CN B038244489 A CNB038244489 A CN B038244489A CN 03824448 A CN03824448 A CN 03824448A CN 1310918 C CN1310918 C CN 1310918C
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CN
China
Prior art keywords
compound
alkyl
aryl
cycloalkyl
heteroaryl
Prior art date
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Expired - Fee Related
Application number
CNB038244489A
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English (en)
Chinese (zh)
Other versions
CN1738821A (zh
Inventor
T·J·古兹
K·帕鲁奇
M·P·德怀尔
R·J·多尔
V·M·吉里亚瓦拉布汉
L·W·迪拉德
V·D·特兰
Z·M·何
R·A·詹姆斯
朴涵宋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Pharmacopeia LLC
Original Assignee
Pharmacopeia Drug Discovery Inc
Schering Corp
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Publication of CN1738821A publication Critical patent/CN1738821A/zh
Application granted granted Critical
Publication of CN1310918C publication Critical patent/CN1310918C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB038244489A 2002-09-04 2003-09-03 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶 Expired - Fee Related CN1310918C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40803002P 2002-09-04 2002-09-04
US60/408,030 2002-09-04

Publications (2)

Publication Number Publication Date
CN1738821A CN1738821A (zh) 2006-02-22
CN1310918C true CN1310918C (zh) 2007-04-18

Family

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Family Applications (1)

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CNB038244489A Expired - Fee Related CN1310918C (zh) 2002-09-04 2003-09-03 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶

Country Status (17)

Country Link
US (2) US7078525B2 (enExample)
EP (1) EP1534709B1 (enExample)
JP (2) JP2006501260A (enExample)
KR (1) KR20050058507A (enExample)
CN (1) CN1310918C (enExample)
AR (1) AR041134A1 (enExample)
AT (1) ATE364608T1 (enExample)
CA (1) CA2497444C (enExample)
DE (1) DE60314427T2 (enExample)
ES (1) ES2285164T3 (enExample)
MX (1) MXPA05002573A (enExample)
MY (1) MY139336A (enExample)
NZ (1) NZ539162A (enExample)
PE (1) PE20041076A1 (enExample)
TW (1) TW200413377A (enExample)
WO (1) WO2004022559A1 (enExample)
ZA (1) ZA200501851B (enExample)

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CA2497444C (en) 2010-11-30
ZA200501851B (en) 2005-09-08
US7078525B2 (en) 2006-07-18
KR20050058507A (ko) 2005-06-16
EP1534709A1 (en) 2005-06-01
AR041134A1 (es) 2005-05-04
US20040102451A1 (en) 2004-05-27
US20060235025A1 (en) 2006-10-19
CN1738821A (zh) 2006-02-22
NZ539162A (en) 2006-07-28
US7470695B2 (en) 2008-12-30
CA2497444A1 (en) 2004-03-18
DE60314427D1 (de) 2007-07-26
JP2006501260A (ja) 2006-01-12
ATE364608T1 (de) 2007-07-15
AU2003268357A1 (en) 2004-03-29
PE20041076A1 (es) 2005-01-22
MY139336A (en) 2009-09-30
MXPA05002573A (es) 2005-09-08
EP1534709B1 (en) 2007-06-13
JP2010132704A (ja) 2010-06-17
HK1071570A1 (en) 2005-07-22
DE60314427T2 (de) 2008-06-12
TW200413377A (en) 2004-08-01
ES2285164T3 (es) 2007-11-16
WO2004022559A1 (en) 2004-03-18

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