JP2006501181A5 - - Google Patents

Info

Publication number

JP2006501181A5

JP2006501181A5 JP2004518651A JP2004518651A JP2006501181A5 JP 2006501181 A5 JP2006501181 A5 JP 2006501181A5 JP 2004518651 A JP2004518651 A JP 2004518651A JP 2004518651 A JP2004518651 A JP 2004518651A JP 2006501181 A5 JP2006501181 A5 JP 2006501181A5

Authority

JP

Japan

Prior art keywords

alkyl

cycloalkyl

substituted

phenyl

het

Prior art date

2003-07-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims description 9
• 125000000217 alkyl group Chemical group 0.000 claims 15
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
• 125000003118 aryl group Chemical group 0.000 claims 6
• 125000000753 cycloalkyl group Chemical group 0.000 claims 6
• 230000002062 proliferating effect Effects 0.000 claims 6
• 229910052799 carbon Inorganic materials 0.000 claims 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 229910052736 halogen Inorganic materials 0.000 claims 4
• 150000002367 halogens Chemical class 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 125000001424 substituent group Chemical group 0.000 claims 4
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
• 206010036790 Productive cough Diseases 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 125000004122 cyclic group Chemical group 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 210000003802 sputum Anatomy 0.000 claims 2
• 208000024794 sputum Diseases 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 210000000170 cell membrane Anatomy 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000007858 starting material Substances 0.000 description 1