JP2005536577A5 - - Google Patents
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- Publication number
- JP2005536577A5 JP2005536577A5 JP2004513335A JP2004513335A JP2005536577A5 JP 2005536577 A5 JP2005536577 A5 JP 2005536577A5 JP 2004513335 A JP2004513335 A JP 2004513335A JP 2004513335 A JP2004513335 A JP 2004513335A JP 2005536577 A5 JP2005536577 A5 JP 2005536577A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- pharmaceutically acceptable
- acyl
- formula
- here
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 11
- IAJILQKETJEXLJ-LECHCGJUSA-N iduronic acid Chemical group O=C[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-LECHCGJUSA-N 0.000 claims description 11
- 150000001768 cations Chemical class 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical group O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
- 229940097043 glucuronic acid Drugs 0.000 claims description 6
- 230000019635 sulfation Effects 0.000 claims description 6
- 238000005670 sulfation reaction Methods 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
- MCHWWJLLPNDHGL-KVTDHHQDSA-N (2r,3s,4s,5r)-2,5-bis(hydroxymethyl)oxolane-3,4-diol Chemical group OC[C@H]1O[C@H](CO)[C@@H](O)[C@@H]1O MCHWWJLLPNDHGL-KVTDHHQDSA-N 0.000 description 4
- 229910000033 sodium borohydride Inorganic materials 0.000 description 4
- 239000012279 sodium borohydride Substances 0.000 description 4
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 0 CCC(CC)(CC1C=*C(*)C1*)OCCC(C1O*)OCC(COC=C([C@@](C(C)O*)N*)O**CCCC(C2O*)OCC(*)C2O*)C1O* Chemical compound CCC(CC)(CC1C=*C(*)C1*)OCCC(C1O*)OCC(COC=C([C@@](C(C)O*)N*)O**CCCC(C2O*)OCC(*)C2O*)C1O* 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI001346A ITMI20021346A1 (it) | 2002-06-18 | 2002-06-18 | Polisaccaridi a basso peso molecolare e procedimento per la loro preparazione |
| IT2002MI001345A ITMI20021345A1 (it) | 2002-06-18 | 2002-06-18 | Derivati epimerizzati del polissacaride k5 a elevatissimo grado di solfatazione |
| ITMI20021854 ITMI20021854A1 (it) | 2002-08-27 | 2002-08-27 | Polisaccaride supersolfatato a basso peso molecolare. |
| PCT/IB2003/002339 WO2003106505A1 (en) | 2002-06-18 | 2003-06-17 | Process for the manufacture of n-acyl-(epi)k5-amine-o-sulfate-derivatives and products thus obtained |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536577A JP2005536577A (ja) | 2005-12-02 |
| JP2005536577A5 true JP2005536577A5 (enExample) | 2006-01-19 |
Family
ID=29740492
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513335A Pending JP2005536577A (ja) | 2002-06-18 | 2003-06-17 | Ｎ−アシル−（エピ）ｋ５−アミン−ｏ−硫酸塩誘導体の製造方法およびｎ−アシル−（エピ）ｋ５−アミン−ｏ−硫酸塩誘導体 |
| JP2004513336A Pending JP2005530877A (ja) | 2002-06-18 | 2003-06-17 | 低分子量過硫酸化多糖類 |
| JP2004513334A Expired - Fee Related JP5053512B2 (ja) | 2002-06-18 | 2003-06-17 | 非常に大きい硫酸化度を持つｋ５多糖体のエピマー化誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513336A Pending JP2005530877A (ja) | 2002-06-18 | 2003-06-17 | 低分子量過硫酸化多糖類 |
| JP2004513334A Expired - Fee Related JP5053512B2 (ja) | 2002-06-18 | 2003-06-17 | 非常に大きい硫酸化度を持つｋ５多糖体のエピマー化誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20050256079A1 (enExample) |
| EP (3) | EP1513880B1 (enExample) |
| JP (3) | JP2005536577A (enExample) |
| CN (3) | CN1675250B (enExample) |
| AT (1) | ATE485308T1 (enExample) |
| AU (3) | AU2003242881A1 (enExample) |
| BR (3) | BR0312179A (enExample) |
| CA (3) | CA2489862C (enExample) |
| DE (1) | DE60334617D1 (enExample) |
| IL (2) | IL165807A (enExample) |
| MX (3) | MXPA04012805A (enExample) |
| NO (3) | NO20050247L (enExample) |
| NZ (3) | NZ537215A (enExample) |
| PL (3) | PL375087A1 (enExample) |
| WO (3) | WO2003106506A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20032498A1 (it) | 2003-12-17 | 2005-06-18 | Pasqua Anna Oreste | Polisaccaridi antitrombotici a basso peso molecolare e |
| ITMI20010397A1 (it) * | 2001-02-27 | 2002-08-27 | Giorgio Zoppetti | Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione |
| US8513407B2 (en) * | 2002-06-18 | 2013-08-20 | Glycores 2000 S.R.L. | Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained |
| DE60334617D1 (de) * | 2002-06-18 | 2010-12-02 | Glycores 2000 Srl | Epimerderivate von k5-polysaccharid mit hohem sulfatierungsgrad |
| US20120253029A1 (en) | 2002-06-18 | 2012-10-04 | Pasqua Anna Oreste | Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein |
| ITMI20031618A1 (it) * | 2003-08-06 | 2005-02-07 | Inalco Spa | Derivati polisaccaridici dotati di alta attivita' |
| FR2871379B1 (fr) * | 2004-06-14 | 2006-09-29 | Ifremer | Utilisation de derives polysaccharidiques hautement sulfates et de faible masse molaire pour moduler l'angiogenese |
| FR2871476B1 (fr) * | 2004-06-14 | 2011-04-01 | Ifremer | Derives depolymerises sulfates d'exopolysaccharides (eps) provenant de bacteries marines mesophiles, leur procede de preparation et leurs utilisations en regeneration tissulaire |
| US8318973B2 (en) | 2005-10-21 | 2012-11-27 | Bezwada Biomedical, Llc | Functionalized sinapic acid and methyl sinapate |
| CA3187652A1 (en) * | 2020-07-02 | 2022-01-06 | Institut Francais De Recherche Pour L'exploitation De La Mer (Ifremer) | Marine bacterial exopolysaccharide derivatives and uses thereof in the treatment of mucopolysaccharidoses |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1141483B (it) * | 1980-04-18 | 1986-10-01 | Crinos Industria Farmaco | Resina poliamminica per la separazione selettiva di eparina da altri glucosamminoglicani e procedimento per la sua preparazione |
| FR2503714B1 (fr) * | 1981-04-10 | 1986-11-21 | Choay Sa | Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine |
| DE3787996T2 (de) * | 1986-05-16 | 1994-03-03 | Italfarmaco Spa | Heparine, frei von E.D.T.A., Fraktionen und Fragmente von Heparin, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, welche diese enthalten. |
| EP0333243A3 (en) * | 1988-03-10 | 1989-09-27 | Akzo N.V. | Sulphated k5 antigen and sulphated k5 antigen fragments |
| FR2669932B1 (fr) * | 1990-12-03 | 1994-07-01 | Sanofi Sa | Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent. |
| GB2254083A (en) | 1991-03-28 | 1992-09-30 | Italfarmaco Spa | Anticoagulants from e.coli saccharide |
| FR2684385B1 (fr) * | 1991-11-28 | 1997-08-01 | Sanofi Elf | Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| IT1271057B (it) * | 1994-11-04 | 1997-05-26 | Inalco Spa | Polisaccaridi aventi un elevato contenuto di acido iduronico |
| US5798356A (en) * | 1995-08-07 | 1998-08-25 | Alcon Laboratories, Inc. | Angiostatic compounds |
| IT1282994B1 (it) * | 1996-05-10 | 1998-04-03 | Inalco Spa | Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante |
| IT1284143B1 (it) * | 1996-09-06 | 1998-05-08 | Istituto Scient Di Chimica E B | Eparansolfati semi-sintetici ad elevata attivita' antimetastica e ridotto rischio emorragico |
| GB9620459D0 (en) | 1996-10-01 | 1996-11-20 | Mclaughlin Andrew | Improvements in or relating to blocked isocyanates and their production |
| IT1289613B1 (it) * | 1997-02-07 | 1998-10-15 | Inalco Spa | Polisaccaridi batterici o-solfatati |
| IT1290814B1 (it) * | 1997-03-24 | 1998-12-11 | Istituto Scient Di Chimica E B | Glicosaminoglicani aventi elevata attivita' antitrombotica |
| US6329351B1 (en) * | 1997-08-28 | 2001-12-11 | Istituto Scientifico Di Chimica E Biochimica “G. Ronzoni” | Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk |
| US6388060B1 (en) * | 1998-11-06 | 2002-05-14 | Vascular Therapeutics Inc. | Process for the sulfation of uronic acid-containing polysaccharides |
| US20020062019A1 (en) * | 2000-03-30 | 2002-05-23 | Pasqua Oreste | Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation |
| IT1318432B1 (it) | 2000-03-30 | 2003-08-25 | Inalco Spa | Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro |
| ITMI20032498A1 (it) * | 2003-12-17 | 2005-06-18 | Pasqua Anna Oreste | Polisaccaridi antitrombotici a basso peso molecolare e |
| US20050027117A1 (en) * | 2000-12-18 | 2005-02-03 | Pasqua Oreste | Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation |
| ITMI20010397A1 (it) * | 2001-02-27 | 2002-08-27 | Giorgio Zoppetti | Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione |
| ITMI20010779A1 (it) * | 2001-04-12 | 2002-10-12 | Giorgio Zoppetti | Uso di polisaccaridi batterici solfati atti all'inibizione dell'angiogenesi |
| ITMI20011633A1 (it) * | 2001-07-27 | 2003-01-27 | San Raffaele Centro Fond | Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv |
| ITMI20012200A1 (it) * | 2001-10-22 | 2003-04-22 | Ibsa Inst Biochimique Sa | Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti |
| ITMI20021294A1 (it) * | 2002-06-12 | 2003-12-12 | Inalco Spa | Polisaccaridi batterici o-solfatati e loro uso |
| DE60334617D1 (de) * | 2002-06-18 | 2010-12-02 | Glycores 2000 Srl | Epimerderivate von k5-polysaccharid mit hohem sulfatierungsgrad |
| ITMI20032614A1 (it) * | 2003-12-30 | 2005-06-30 | Altergon Sa | Nuova composizione comprendente cs |
-
2003
- 2003-06-17 DE DE60334617T patent/DE60334617D1/de not_active Expired - Lifetime
- 2003-06-17 CN CN038195607A patent/CN1675250B/zh not_active Expired - Fee Related
- 2003-06-17 NZ NZ537215A patent/NZ537215A/en not_active IP Right Cessation
- 2003-06-17 JP JP2004513335A patent/JP2005536577A/ja active Pending
- 2003-06-17 BR BR0312179-8A patent/BR0312179A/pt not_active IP Right Cessation
- 2003-06-17 JP JP2004513336A patent/JP2005530877A/ja active Pending
- 2003-06-17 US US10/518,303 patent/US20050256079A1/en not_active Abandoned
- 2003-06-17 JP JP2004513334A patent/JP5053512B2/ja not_active Expired - Fee Related
- 2003-06-17 WO PCT/IB2003/002347 patent/WO2003106506A1/en not_active Ceased
- 2003-06-17 MX MXPA04012805A patent/MXPA04012805A/es not_active Application Discontinuation
- 2003-06-17 US US10/518,229 patent/US20050245736A1/en not_active Abandoned
- 2003-06-17 CN CNA03818933XA patent/CN1675249A/zh active Pending
- 2003-06-17 PL PL03375087A patent/PL375087A1/xx unknown
- 2003-06-17 BR BR0312197-6A patent/BR0312197A/pt not_active Application Discontinuation
- 2003-06-17 CA CA2489862A patent/CA2489862C/en not_active Expired - Fee Related
- 2003-06-17 PL PL03373004A patent/PL373004A1/xx unknown
- 2003-06-17 MX MXPA04012721A patent/MXPA04012721A/es not_active Application Discontinuation
- 2003-06-17 NZ NZ537216A patent/NZ537216A/en unknown
- 2003-06-17 US US10/518,302 patent/US7838644B2/en not_active Expired - Fee Related
- 2003-06-17 CN CNA038175711A patent/CN1671744A/zh active Pending
- 2003-06-17 AU AU2003242881A patent/AU2003242881A1/en not_active Abandoned
- 2003-06-17 BR BR0312182-8A patent/BR0312182A/pt not_active Application Discontinuation
- 2003-06-17 AU AU2003240190A patent/AU2003240190B2/en not_active Ceased
- 2003-06-17 CA CA002489870A patent/CA2489870A1/en not_active Abandoned
- 2003-06-17 EP EP03732805A patent/EP1513880B1/en not_active Expired - Lifetime
- 2003-06-17 AT AT03732805T patent/ATE485308T1/de not_active IP Right Cessation
- 2003-06-17 MX MXPA04012714A patent/MXPA04012714A/es not_active Application Discontinuation
- 2003-06-17 WO PCT/IB2003/002338 patent/WO2003106504A1/en not_active Ceased
- 2003-06-17 WO PCT/IB2003/002339 patent/WO2003106505A1/en not_active Ceased
- 2003-06-17 PL PL03375088A patent/PL375088A1/xx unknown
- 2003-06-17 AU AU2003240191A patent/AU2003240191A1/en not_active Abandoned
- 2003-06-17 EP EP03760100A patent/EP1519961A1/en not_active Withdrawn
- 2003-06-17 NZ NZ537217A patent/NZ537217A/en unknown
- 2003-06-17 EP EP03732806A patent/EP1517924A1/en not_active Withdrawn
- 2003-06-17 CA CA002489866A patent/CA2489866A1/en not_active Abandoned
-
2004
- 2004-12-16 IL IL165807A patent/IL165807A/en not_active IP Right Cessation
- 2004-12-16 IL IL16580804A patent/IL165808A0/xx unknown
-
2005
- 2005-01-17 NO NO20050247A patent/NO20050247L/no not_active Application Discontinuation
- 2005-01-17 NO NO20050245A patent/NO20050245L/no not_active Application Discontinuation
- 2005-01-17 NO NO20050244A patent/NO20050244L/no not_active Application Discontinuation
-
2010
- 2010-10-01 US US12/895,894 patent/US8193166B2/en not_active Expired - Fee Related
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