JP2005535644A5 - - Google Patents
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- Publication number
- JP2005535644A5 JP2005535644A5 JP2004518239A JP2004518239A JP2005535644A5 JP 2005535644 A5 JP2005535644 A5 JP 2005535644A5 JP 2004518239 A JP2004518239 A JP 2004518239A JP 2004518239 A JP2004518239 A JP 2004518239A JP 2005535644 A5 JP2005535644 A5 JP 2005535644A5
- Authority
- JP
- Japan
- Prior art keywords
- parecoxib
- composition
- liquid solvent
- component
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 20
- 239000002904 solvent Substances 0.000 claims 16
- 229960004662 parecoxib Drugs 0.000 claims 13
- 239000007788 liquid Substances 0.000 claims 11
- 239000002202 Polyethylene glycol Substances 0.000 claims 8
- 229920001223 polyethylene glycol Polymers 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000003381 stabilizer Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 229940072107 ascorbate Drugs 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 239000006174 pH buffer Substances 0.000 claims 2
- 229960003925 parecoxib sodium Drugs 0.000 claims 2
- ICJGKYTXBRDUMV-UHFFFAOYSA-N trichloro(6-trichlorosilylhexyl)silane Chemical group Cl[Si](Cl)(Cl)CCCCCC[Si](Cl)(Cl)Cl ICJGKYTXBRDUMV-UHFFFAOYSA-N 0.000 claims 2
- 229960002004 valdecoxib Drugs 0.000 claims 2
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims 2
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 235000006109 methionine Nutrition 0.000 claims 1
- 229960004452 methionine Drugs 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39171402P | 2002-06-26 | 2002-06-26 | |
| PCT/US2003/021028 WO2004002533A1 (en) | 2002-06-26 | 2003-06-18 | Stable liquid parenteral parecoxib formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005535644A JP2005535644A (ja) | 2005-11-24 |
| JP2005535644A5 true JP2005535644A5 (enExample) | 2006-08-03 |
Family
ID=30000741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004518239A Withdrawn JP2005535644A (ja) | 2002-06-26 | 2003-06-18 | 安定な非経口パレコキシブ液体製剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040127537A1 (enExample) |
| EP (1) | EP1524997A1 (enExample) |
| JP (1) | JP2005535644A (enExample) |
| AR (1) | AR039747A1 (enExample) |
| AU (1) | AU2003247793A1 (enExample) |
| BR (1) | BR0312111A (enExample) |
| CA (1) | CA2488526A1 (enExample) |
| MX (1) | MXPA05000011A (enExample) |
| PA (1) | PA8576601A1 (enExample) |
| PE (1) | PE20040303A1 (enExample) |
| TW (1) | TW200409645A (enExample) |
| WO (1) | WO2004002533A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003303591A1 (en) * | 2002-12-30 | 2004-07-29 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| EP1708700A1 (en) * | 2003-12-24 | 2006-10-11 | Pharmacia Corporation | Metal salts of parecoxib as prodrugs of the cox-2 inhibitor valdecoxib for the treatment of inflammation, pain and/or fever |
| EA201101084A1 (ru) | 2005-12-22 | 2012-04-30 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Феноксиуксусные кислоты в качестве активаторов ppar дельта |
| GB0612749D0 (en) * | 2006-06-27 | 2006-08-09 | Univ College London Hospitals | Treatment and/or prevention of pain |
| DE102014115951A1 (de) * | 2014-11-03 | 2016-05-04 | Merlion Pharmaceuticals Pte Ltd. | Zusammensetzungen, die Finafloxacin und Tris enthalten |
| CN104965041B (zh) * | 2015-06-11 | 2016-06-29 | 成都克莱蒙医药科技有限公司 | 一种帕瑞昔布钠异构体的高效液相色谱检测方法 |
| CN109568277B (zh) * | 2019-01-30 | 2022-06-21 | 成都欣捷高新技术开发股份有限公司 | 枸橼酸在制备帕瑞昔布钠冻干制剂组合物中的应用及其组合物和制备方法 |
| CN112409283A (zh) * | 2020-11-24 | 2021-02-26 | 苏州璞正医药有限公司 | 一种帕瑞昔布衍生物及其制备方法和应用 |
| WO2023214433A1 (en) * | 2022-05-05 | 2023-11-09 | Inventia Healthcare Limited | Stable parenteral compositions of parecoxib |
| CN117003769B (zh) * | 2023-07-11 | 2024-11-22 | 中国科学院宁波材料技术与工程研究所 | 氯诺昔康复合物、氯诺昔康-小檗碱共晶及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430057A (en) * | 1993-09-30 | 1995-07-04 | Board Of Regents, The University Of Texas System | Parenteral busulfan for treatment of malignant disease |
| SE9501189D0 (sv) * | 1995-03-31 | 1995-03-31 | Pharmacia Ab | Protein formulation |
| ATE212551T1 (de) * | 1995-12-21 | 2002-02-15 | Pfizer | Injizierbare quinolonformulierungen |
| WO1997038986A1 (en) * | 1996-04-12 | 1997-10-23 | G.D. Searle & Co. | Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors |
| US6413965B1 (en) * | 1999-06-30 | 2002-07-02 | Pfizer Inc. | Compositions and treatment for diabetic complications |
| CA2362816C (en) * | 1999-12-08 | 2007-02-06 | Pharmacia Corporation | Valdecoxib compositions |
| US6649629B2 (en) * | 1999-12-23 | 2003-11-18 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| GB0002336D0 (en) * | 2000-02-01 | 2000-03-22 | Glaxo Group Ltd | Medicaments |
| AU2001282886A1 (en) * | 2000-07-13 | 2002-01-30 | Pharmacia Corporation | Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain |
| US20030105144A1 (en) * | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
-
2003
- 2003-06-18 JP JP2004518239A patent/JP2005535644A/ja not_active Withdrawn
- 2003-06-18 BR BR0312111-9A patent/BR0312111A/pt not_active IP Right Cessation
- 2003-06-18 CA CA002488526A patent/CA2488526A1/en not_active Abandoned
- 2003-06-18 EP EP03762337A patent/EP1524997A1/en not_active Withdrawn
- 2003-06-18 WO PCT/US2003/021028 patent/WO2004002533A1/en not_active Ceased
- 2003-06-18 MX MXPA05000011A patent/MXPA05000011A/es not_active Application Discontinuation
- 2003-06-18 US US10/464,015 patent/US20040127537A1/en not_active Abandoned
- 2003-06-18 AU AU2003247793A patent/AU2003247793A1/en not_active Abandoned
- 2003-06-25 PE PE2003000637A patent/PE20040303A1/es not_active Application Discontinuation
- 2003-06-25 AR ARP030102282A patent/AR039747A1/es unknown
- 2003-06-26 TW TW092117433A patent/TW200409645A/zh unknown
- 2003-06-26 PA PA20038576601A patent/PA8576601A1/es unknown
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