JP2013513586A5 - - Google Patents
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- Publication number
- JP2013513586A5 JP2013513586A5 JP2012542577A JP2012542577A JP2013513586A5 JP 2013513586 A5 JP2013513586 A5 JP 2013513586A5 JP 2012542577 A JP2012542577 A JP 2012542577A JP 2012542577 A JP2012542577 A JP 2012542577A JP 2013513586 A5 JP2013513586 A5 JP 2013513586A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- carbon atoms
- active ingredient
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 150000002430 hydrocarbons Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229930105110 Cyclosporin A Natural products 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000006184 cosolvent Substances 0.000 claims 2
- 206010023332 keratitis Diseases 0.000 claims 2
- 201000010666 keratoconjunctivitis Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09015423.8 | 2009-12-14 | ||
| EP09015423A EP2335735A1 (en) | 2009-12-14 | 2009-12-14 | Pharmaceutical composition for treatment of dry eye syndrome |
| PCT/EP2010/069495 WO2011073134A1 (en) | 2009-12-14 | 2010-12-13 | Pharmaceutical composition for treatment of dry eye syndrome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014203406A Division JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513586A JP2013513586A (ja) | 2013-04-22 |
| JP2013513586A5 true JP2013513586A5 (enExample) | 2014-01-09 |
| JP5663595B2 JP5663595B2 (ja) | 2015-02-04 |
Family
ID=41731659
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542577A Active JP5663595B2 (ja) | 2009-12-14 | 2010-12-13 | ドライアイ症候群の治療のための医薬組成物 |
| JP2014203406A Active JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
| JP2016248533A Active JP6397472B2 (ja) | 2009-12-14 | 2016-12-22 | ドライアイ症候群の治療のための医薬組成物 |
| JP2018163569A Pending JP2019006803A (ja) | 2009-12-14 | 2018-08-31 | ドライアイ症候群の治療のための医薬組成物 |
| JP2018248700A Active JP6731039B2 (ja) | 2009-12-14 | 2018-12-28 | ドライアイ症候群の治療のための医薬組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014203406A Active JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
| JP2016248533A Active JP6397472B2 (ja) | 2009-12-14 | 2016-12-22 | ドライアイ症候群の治療のための医薬組成物 |
| JP2018163569A Pending JP2019006803A (ja) | 2009-12-14 | 2018-08-31 | ドライアイ症候群の治療のための医薬組成物 |
| JP2018248700A Active JP6731039B2 (ja) | 2009-12-14 | 2018-12-28 | ドライアイ症候群の治療のための医薬組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8614178B2 (enExample) |
| EP (2) | EP2335735A1 (enExample) |
| JP (5) | JP5663595B2 (enExample) |
| KR (2) | KR101722039B1 (enExample) |
| CN (1) | CN102652022B (enExample) |
| AU (1) | AU2010333039B2 (enExample) |
| BR (3) | BR112012014190B8 (enExample) |
| CA (2) | CA2776860C (enExample) |
| DK (1) | DK2512515T3 (enExample) |
| ES (1) | ES2449308T3 (enExample) |
| IN (1) | IN2012DN03128A (enExample) |
| MX (1) | MX2012006720A (enExample) |
| PL (1) | PL2512515T3 (enExample) |
| PT (1) | PT2512515E (enExample) |
| WO (1) | WO2011073134A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010256558B2 (en) | 2009-06-03 | 2013-10-03 | Forsight Labs, Llc | Anterior segment drug delivery |
| ES2564502T3 (es) | 2010-03-17 | 2016-03-23 | Novaliq Gmbh | Composición farmacéutica para el tratamiento de la presión intraocular aumentada |
| EP2444063A1 (en) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
| EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
| JP6039145B2 (ja) | 2011-05-25 | 2016-12-07 | ノバリック ゲーエムベーハー | 半フッ化アルカンを基礎にした局所薬学的組成物 |
| JP6023181B2 (ja) | 2011-05-25 | 2016-11-09 | ノバリック ゲーエムベーハー | 爪に投与するための医薬組成物 |
| CN104066442B (zh) | 2012-01-23 | 2018-05-18 | 诺瓦利克有限责任公司 | 基于半氟化烷烃的稳定蛋白质组合物 |
| EP2708228B1 (en) | 2012-09-12 | 2018-05-16 | Novaliq GmbH | Eye wash compositions |
| MX360469B (es) * | 2012-09-12 | 2018-11-05 | Novaliq Gmbh | Composiciones que comprenden mezclas de alcanos semifluorados. |
| DE202013012753U1 (de) * | 2012-09-12 | 2019-03-04 | Novaliq Gmbh | Zusammensetzungen semifluorierter Alkane zur Verwendung in der Behandlung von Keratoconjunctivitis Sicca |
| EP2730291A1 (en) * | 2012-11-09 | 2014-05-14 | Fluoron Gmbh | Internal Tamponade Composition |
| DK2948134T3 (da) | 2013-01-24 | 2020-06-02 | Palvella Therapeutics Inc | Sammensætninger til transdermal indgivelse af mtor-inhibitorer |
| JP6304475B2 (ja) * | 2013-01-31 | 2018-04-04 | ロート製薬株式会社 | 点眼剤 |
| US20160022648A1 (en) * | 2013-03-13 | 2016-01-28 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for meibomian gland dysfunction |
| WO2015011199A1 (en) | 2013-07-23 | 2015-01-29 | Novaliq Gmbh | Stabilized antibody compositions |
| EP3057514A4 (en) * | 2013-10-15 | 2017-08-02 | Forsight Vision5, Inc. | Formulations and methods for increasing or reducing mucus |
| US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
| US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| US11013403B2 (en) * | 2015-09-29 | 2021-05-25 | The Regents Of The University Of California | Methods of diagnosing diseases of mucosal surfaces |
| CN120884568A (zh) | 2015-09-30 | 2025-11-04 | 诺瓦利克有限责任公司 | 半氟化化合物和其组合物 |
| ES2953837T3 (es) * | 2015-09-30 | 2023-11-16 | Novaliq Gmbh | 2-perfluorobutil pentano para administración oftálmica |
| EP3442480B1 (en) | 2016-06-23 | 2019-10-02 | Novaliq GmbH | Topical administration method |
| US11684589B2 (en) | 2016-09-22 | 2023-06-27 | Novaliq Gmbh | Pharmaceutical compositions for use in the therapy of blepharitis |
| JP6869336B2 (ja) * | 2016-09-23 | 2021-05-12 | ノバリック ゲーエムベーハー | シクロスポリンを含む眼科用組成物 |
| EP3698785A1 (en) * | 2016-09-28 | 2020-08-26 | Novaliq GmbH | Compositions comprising a cannabinoid receptor binding ligand |
| CA3045733C (en) * | 2016-12-22 | 2024-01-16 | Novaliq Gmbh | Compositions comprising tacrolimus for the treatment of intraocular inflammatory eye diseases |
| DK3399962T3 (da) * | 2016-12-23 | 2020-09-07 | Novaliq Gmbh | Oftalmisk sammensætning til behandling af tør øjensygdom |
| CN110520097B (zh) | 2017-01-06 | 2023-10-27 | 帕尔维拉治疗股份有限公司 | Mtor抑制剂的无水组合物及其使用方法 |
| MX388460B (es) * | 2017-04-21 | 2025-03-20 | Dermaliq Therapeutics Inc | Composiciones de yodo. |
| US10717691B2 (en) | 2017-05-05 | 2020-07-21 | Novaliq Gmbh | Process for the production of semifluorinated alkanes |
| CN110650734B (zh) * | 2017-05-12 | 2024-11-15 | 诺瓦利克有限责任公司 | 治疗与隐形眼镜有关病症的包含半氟化烷烃的药物组合物 |
| IL273531B2 (en) | 2017-09-27 | 2024-05-01 | Novaliq Gmbh | Ophthalmic compositions comprising latanoprost for use in the treatment of ocular diseases |
| US11896559B2 (en) | 2017-10-04 | 2024-02-13 | Novaliq Gmbh | Opthalmic compositions comprising F6H8 |
| EP3758676A1 (en) | 2018-03-02 | 2021-01-06 | Novaliq GmbH | Pharmaceutical compositions comprising nebivolol |
| JP2021522219A (ja) | 2018-04-27 | 2021-08-30 | ノバリック ゲーエムベーハー | 緑内障の治療のためのタフルプロストを含む眼科用組成物 |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物および使用方法 |
| KR20210080388A (ko) * | 2018-09-22 | 2021-06-30 | 노바리크 게엠베하 | 안구 표면 손상 및 건조 증상 치료를 위한 안약 조성물 |
| US12029757B2 (en) | 2018-09-27 | 2024-07-09 | Dermaliq Therapeutics, Inc. | Lipid barrier repair |
| WO2020074697A1 (en) | 2018-10-12 | 2020-04-16 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
| US20220008397A1 (en) * | 2019-01-21 | 2022-01-13 | Novaliq Gmbh | Pharmaceutical composition for the treatment of ocular neovascularisation |
| WO2020165132A1 (en) | 2019-02-13 | 2020-08-20 | Novaliq Gmbh | Compositions and methods for the treatment of ocular neovascularization |
| EP3975989A1 (en) | 2019-05-24 | 2022-04-06 | Novaliq GmbH | Ophthalmic composition for the treatment of ocular allergy |
| WO2021044045A1 (en) | 2019-09-06 | 2021-03-11 | Novaliq Gmbh | Ophthalmic composition for the treatment of uveitis |
| WO2021048803A1 (en) | 2019-09-13 | 2021-03-18 | Minas Coroneo | Eye drop dispenser |
| US20210308154A1 (en) | 2020-03-24 | 2021-10-07 | Hovione Scientia Limited | Methods and Compositions for Treating Meibomian Gland Dysfunction |
| US11191751B1 (en) * | 2020-10-08 | 2021-12-07 | Ads Therapeutics Llc | Topical ophthalmological atropine free base compositions |
| IL322635A (en) * | 2023-02-13 | 2025-10-01 | Novaliq Gmbh | Ophthalmic preparation for eye surgery in patients with ocular surface disease |
| AU2023270196B2 (en) * | 2023-11-20 | 2025-06-26 | Dyer, Gordon Wayne DR | Method of Arthropod Egress |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839342A (en) | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| WO1989001772A1 (en) | 1987-09-03 | 1989-03-09 | University Of Georgia Research Foundation, Inc. | Ocular cyclosporin composition |
| US5874481A (en) * | 1995-06-07 | 1999-02-23 | Alliance Pharmaceutical Corp. | Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents |
| DE19536504C2 (de) * | 1995-09-29 | 1999-09-23 | H Meinert | Verwendung fluorierter Alkane |
| DE19861012A1 (de) * | 1998-03-18 | 1999-09-30 | Pharm Pur Gmbh | Behandlungsmittel für die Ophthalmologie |
| AU777915B2 (en) * | 1999-04-30 | 2004-11-04 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
| DE19938668B4 (de) * | 1999-08-14 | 2006-01-26 | Bausch & Lomb Inc. | Tränenersatzmittel |
| US20030018044A1 (en) * | 2000-02-18 | 2003-01-23 | Peyman Gholam A. | Treatment of ocular disease |
| CA2563544A1 (en) * | 2004-04-19 | 2005-10-27 | Centre National De La Recherche Scientifique (C.N.R.S.) | Lung surfactant supplements |
| MXPA06014425A (es) * | 2004-06-08 | 2007-05-23 | Ocularis Pharma Inc | Composiciones oftalmicas hidrofobas y metodo de uso. |
| DE102007055046A1 (de) * | 2007-11-19 | 2009-05-28 | Fluoron Gmbh | Infusionslösung |
| DK2110126T3 (da) | 2008-04-18 | 2012-02-27 | Novaliq Gmbh | Inhalations- og instillationsanvendelse af semifluorerede alkaner som aktiv bestanddel-bærere inden for det intrapulmonale område |
-
2009
- 2009-12-14 EP EP09015423A patent/EP2335735A1/en not_active Withdrawn
-
2010
- 2010-12-13 BR BR112012014190A patent/BR112012014190B8/pt active IP Right Grant
- 2010-12-13 PL PL10790775T patent/PL2512515T3/pl unknown
- 2010-12-13 JP JP2012542577A patent/JP5663595B2/ja active Active
- 2010-12-13 ES ES10790775.0T patent/ES2449308T3/es active Active
- 2010-12-13 WO PCT/EP2010/069495 patent/WO2011073134A1/en not_active Ceased
- 2010-12-13 KR KR1020167023214A patent/KR101722039B1/ko active Active
- 2010-12-13 DK DK10790775.0T patent/DK2512515T3/en active
- 2010-12-13 IN IN3128DEN2012 patent/IN2012DN03128A/en unknown
- 2010-12-13 BR BR122017018955-7A patent/BR122017018955B1/pt active IP Right Grant
- 2010-12-13 CA CA2776860A patent/CA2776860C/en active Active
- 2010-12-13 EP EP10790775.0A patent/EP2512515B1/en active Active
- 2010-12-13 PT PT107907750T patent/PT2512515E/pt unknown
- 2010-12-13 AU AU2010333039A patent/AU2010333039B2/en active Active
- 2010-12-13 CA CA2941956A patent/CA2941956C/en active Active
- 2010-12-13 US US13/513,886 patent/US8614178B2/en active Active
- 2010-12-13 KR KR1020127018066A patent/KR101652714B1/ko active Active
- 2010-12-13 CN CN201080055507.7A patent/CN102652022B/zh active Active
- 2010-12-13 MX MX2012006720A patent/MX2012006720A/es active IP Right Grant
- 2010-12-13 BR BR122020020872-4A patent/BR122020020872B1/pt active IP Right Grant
-
2014
- 2014-10-01 JP JP2014203406A patent/JP6096731B2/ja active Active
-
2016
- 2016-12-22 JP JP2016248533A patent/JP6397472B2/ja active Active
-
2018
- 2018-08-31 JP JP2018163569A patent/JP2019006803A/ja active Pending
- 2018-12-28 JP JP2018248700A patent/JP6731039B2/ja active Active
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