JP2013513586A - ドライアイ症候群の治療のための医薬組成物 - Google Patents
ドライアイ症候群の治療のための医薬組成物 Download PDFInfo
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- JP2013513586A JP2013513586A JP2012542577A JP2012542577A JP2013513586A JP 2013513586 A JP2013513586 A JP 2013513586A JP 2012542577 A JP2012542577 A JP 2012542577A JP 2012542577 A JP2012542577 A JP 2012542577A JP 2013513586 A JP2013513586 A JP 2013513586A
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- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
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- 239000001993 wax Substances 0.000 description 1
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- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
実施例
Claims (15)
- (a)乾性角結膜炎またはそれに関連する症状の予防または治療において有用なマクロライド系免疫抑制剤の群から選択される有効成分の治療有効量;および
(b)半フッ素化アルカンを含む液体ビヒクル
を含有する医薬組成物。 - 有効成分が、室温および中性pHで測定した場合、約1mg/ml未満の水溶解度を示す、請求項1に記載の組成物。
- 有効成分がシクロスポリンAである、請求項2に記載の組成物。
- シクロスポリンAの濃度が約0.01重量%〜約0.5重量%である、請求項3に記載の組成物。
- 半フッ素化アルカンが、式:
RFRH
または式:
RFRHRF
[式中、RFは、20個またはそれ以下の炭素原子を有する過フッ素化炭化水素部分であり、および
RHは、3〜20個の炭素原子を有する非フッ素化炭化水素部分である]
の化合物である、請求項1〜4のいずれか一項に記載の組成物。 - 半フッ素化アルカンが、式:
RFRH
[式中、RFは、3〜10個の炭素原子を有する直鎖状過フッ素化炭化水素部分であり、および
RHは、3〜10個の炭素原子を有する直鎖状アルキル基である]
の化合物である、請求項5に記載の組成物。 - 半フッ素化アルカンが、F4H5、F4H6、F6H6およびF6H8から選択される、請求項6に記載の組成物。
- 溶液として製剤される、請求項1〜7のいずれか一項に記載の組成物。
- 水を実質的に含まない、請求項1〜8のいずれか一項に記載の組成物。
- 有機共溶媒をさらに含む、請求項1〜9のいずれか一項に記載の組成物。
- 有機共溶媒がエタノールである、請求項10に記載の組成物。
- 約1重量%またはそれ以下の濃度のエタノールを含む、請求項11に記載の組成物。
- 乾性角結膜炎またはそれに関連する症状の予防または治療のための、請求項1〜12のいずれか一項に記載の医薬組成物の使用。
- 組成物が患者の眼への局所投与に適する、請求項13に記載の使用。
- 請求項1〜12のいずれか一項に記載の組成物および組成物を保持する容器を含み、容器が、組成物を患者の眼に局所投与するのに適した投薬手段を備える、医薬キット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09015423A EP2335735A1 (en) | 2009-12-14 | 2009-12-14 | Pharmaceutical composition for treatment of dry eye syndrome |
EP09015423.8 | 2009-12-14 | ||
PCT/EP2010/069495 WO2011073134A1 (en) | 2009-12-14 | 2010-12-13 | Pharmaceutical composition for treatment of dry eye syndrome |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2014203406A Division JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
Publications (3)
Publication Number | Publication Date |
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JP2013513586A true JP2013513586A (ja) | 2013-04-22 |
JP2013513586A5 JP2013513586A5 (ja) | 2014-01-09 |
JP5663595B2 JP5663595B2 (ja) | 2015-02-04 |
Family
ID=41731659
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Application Number | Title | Priority Date | Filing Date |
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JP2012542577A Active JP5663595B2 (ja) | 2009-12-14 | 2010-12-13 | ドライアイ症候群の治療のための医薬組成物 |
JP2014203406A Active JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
JP2016248533A Active JP6397472B2 (ja) | 2009-12-14 | 2016-12-22 | ドライアイ症候群の治療のための医薬組成物 |
JP2018163569A Pending JP2019006803A (ja) | 2009-12-14 | 2018-08-31 | ドライアイ症候群の治療のための医薬組成物 |
JP2018248700A Active JP6731039B2 (ja) | 2009-12-14 | 2018-12-28 | ドライアイ症候群の治療のための医薬組成物 |
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Application Number | Title | Priority Date | Filing Date |
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JP2014203406A Active JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
JP2016248533A Active JP6397472B2 (ja) | 2009-12-14 | 2016-12-22 | ドライアイ症候群の治療のための医薬組成物 |
JP2018163569A Pending JP2019006803A (ja) | 2009-12-14 | 2018-08-31 | ドライアイ症候群の治療のための医薬組成物 |
JP2018248700A Active JP6731039B2 (ja) | 2009-12-14 | 2018-12-28 | ドライアイ症候群の治療のための医薬組成物 |
Country Status (16)
Country | Link |
---|---|
US (1) | US8614178B2 (ja) |
EP (2) | EP2335735A1 (ja) |
JP (5) | JP5663595B2 (ja) |
KR (2) | KR101652714B1 (ja) |
CN (1) | CN102652022B (ja) |
AU (1) | AU2010333039B2 (ja) |
BR (3) | BR122020020872B1 (ja) |
CA (2) | CA2941956C (ja) |
DK (1) | DK2512515T3 (ja) |
ES (1) | ES2449308T3 (ja) |
HK (1) | HK1172269A1 (ja) |
IN (1) | IN2012DN03128A (ja) |
MX (1) | MX2012006720A (ja) |
PL (1) | PL2512515T3 (ja) |
PT (1) | PT2512515E (ja) |
WO (1) | WO2011073134A1 (ja) |
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JP2017501111A (ja) * | 2013-10-15 | 2017-01-12 | フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. | 粘液を増加または減少させる製剤および方法 |
JP2018531233A (ja) * | 2015-09-30 | 2018-10-25 | ノバリック ゲーエムベーハー | 半フッ素化化合物およびその組成物 |
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-
2009
- 2009-12-14 EP EP09015423A patent/EP2335735A1/en not_active Withdrawn
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- 2010-12-13 CA CA2776860A patent/CA2776860C/en active Active
- 2010-12-13 PT PT107907750T patent/PT2512515E/pt unknown
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