JP6397472B2 - ドライアイ症候群の治療のための医薬組成物 - Google Patents
ドライアイ症候群の治療のための医薬組成物 Download PDFInfo
- Publication number
- JP6397472B2 JP6397472B2 JP2016248533A JP2016248533A JP6397472B2 JP 6397472 B2 JP6397472 B2 JP 6397472B2 JP 2016248533 A JP2016248533 A JP 2016248533A JP 2016248533 A JP2016248533 A JP 2016248533A JP 6397472 B2 JP6397472 B2 JP 6397472B2
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- JP
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- Prior art keywords
- eye
- composition
- sfa
- treatment
- ethanol
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Description
実施例
Claims (5)
- F4H5またはF6H8ならびに1重量%またはそれ以下の濃度のエタノール、のみからなる、角膜損傷を治療するための眼への局所投与用医薬組成物。
- 溶液として製剤される、請求項1に記載の組成物。
- 乾性角結膜炎またはそれに関連する症状の予防または治療のために用いられる、請求項1または2のいずれか一項に記載の医薬組成物。
- 角膜損傷を有する眼の治療用医薬を製造するための、請求項1〜3のいずれか一項に記載された医薬組成物の使用
- 請求項1〜3のいずれか一項に記載の組成物および組成物を保持する容器を含み、容器が、組成物を患者の眼に局所投与するのに適した投薬手段を備える、医薬キット。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09015423A EP2335735A1 (en) | 2009-12-14 | 2009-12-14 | Pharmaceutical composition for treatment of dry eye syndrome |
EP09015423.8 | 2009-12-14 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014203406A Division JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018163569A Division JP2019006803A (ja) | 2009-12-14 | 2018-08-31 | ドライアイ症候群の治療のための医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017078086A JP2017078086A (ja) | 2017-04-27 |
JP6397472B2 true JP6397472B2 (ja) | 2018-09-26 |
Family
ID=41731659
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012542577A Active JP5663595B2 (ja) | 2009-12-14 | 2010-12-13 | ドライアイ症候群の治療のための医薬組成物 |
JP2014203406A Active JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
JP2016248533A Active JP6397472B2 (ja) | 2009-12-14 | 2016-12-22 | ドライアイ症候群の治療のための医薬組成物 |
JP2018163569A Pending JP2019006803A (ja) | 2009-12-14 | 2018-08-31 | ドライアイ症候群の治療のための医薬組成物 |
JP2018248700A Active JP6731039B2 (ja) | 2009-12-14 | 2018-12-28 | ドライアイ症候群の治療のための医薬組成物 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012542577A Active JP5663595B2 (ja) | 2009-12-14 | 2010-12-13 | ドライアイ症候群の治療のための医薬組成物 |
JP2014203406A Active JP6096731B2 (ja) | 2009-12-14 | 2014-10-01 | ドライアイ症候群の治療のための医薬組成物 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018163569A Pending JP2019006803A (ja) | 2009-12-14 | 2018-08-31 | ドライアイ症候群の治療のための医薬組成物 |
JP2018248700A Active JP6731039B2 (ja) | 2009-12-14 | 2018-12-28 | ドライアイ症候群の治療のための医薬組成物 |
Country Status (16)
Country | Link |
---|---|
US (1) | US8614178B2 (ja) |
EP (2) | EP2335735A1 (ja) |
JP (5) | JP5663595B2 (ja) |
KR (2) | KR101652714B1 (ja) |
CN (1) | CN102652022B (ja) |
AU (1) | AU2010333039B2 (ja) |
BR (3) | BR112012014190B8 (ja) |
CA (2) | CA2776860C (ja) |
DK (1) | DK2512515T3 (ja) |
ES (1) | ES2449308T3 (ja) |
HK (1) | HK1172269A1 (ja) |
IN (1) | IN2012DN03128A (ja) |
MX (1) | MX2012006720A (ja) |
PL (1) | PL2512515T3 (ja) |
PT (1) | PT2512515E (ja) |
WO (1) | WO2011073134A1 (ja) |
Families Citing this family (42)
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JP5695035B2 (ja) | 2009-06-03 | 2015-04-01 | フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. | 前眼部薬物供給 |
US10045996B2 (en) | 2010-03-17 | 2018-08-14 | Novaliq Gmbh | Pharmaceutical composition for treatment of increased intraocular pressure |
EP2444063A1 (en) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
ES2617968T3 (es) | 2011-05-25 | 2017-06-20 | Novaliq Gmbh | Composición farmacéutica para la administración a uñas |
DK2714010T3 (en) | 2011-05-25 | 2017-06-12 | Novaliq Gmbh | TOPICAL PHARMACEUTICAL COMPOSITION BASED ON SEMIFLUORED ALKANES |
AU2013211645B2 (en) | 2012-01-23 | 2017-06-15 | Novaliq Gmbh | Stabilised protein compositions based on semifluorinated alkanes |
TR201812013T4 (tr) | 2012-09-12 | 2018-09-21 | Novaliq Gmbh | Göz yikama bi̇leşi̇mleri̇. |
CA3142049C (en) | 2012-09-12 | 2023-08-29 | Novaliq Gmbh | Semifluorinated alkane compositions |
CA2997744C (en) * | 2012-09-12 | 2019-12-31 | Novaliq Gmbh | Compositions comprising mixtures of semifluorinated alkanes |
EP2730291A1 (en) * | 2012-11-09 | 2014-05-14 | Fluoron Gmbh | Internal Tamponade Composition |
EP2948134B1 (en) | 2013-01-24 | 2020-03-04 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mtor inhibitors |
JP6304475B2 (ja) * | 2013-01-31 | 2018-04-04 | ロート製薬株式会社 | 点眼剤 |
TWI656874B (zh) * | 2013-03-13 | 2019-04-21 | 日商參天製藥股份有限公司 | 西羅莫司或其藥學上可容許的鹽之用途 |
CN105555311B (zh) * | 2013-07-23 | 2021-10-08 | 诺瓦利克有限责任公司 | 稳定的抗体组合物 |
JP2017501111A (ja) * | 2013-10-15 | 2017-01-12 | フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. | 粘液を増加または減少させる製剤および方法 |
US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
WO2016168141A1 (en) | 2015-04-13 | 2016-10-20 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
US11013403B2 (en) * | 2015-09-29 | 2021-05-25 | The Regents Of The University Of California | Methods of diagnosing diseases of mucosal surfaces |
ES2803248T3 (es) | 2015-09-30 | 2021-01-25 | Novaliq Gmbh | 2-perfluorohexil octano para administración oftálmica |
CN110403923B (zh) * | 2015-09-30 | 2021-09-21 | 诺瓦利克有限责任公司 | 半氟化化合物和其组合物 |
PT3442480T (pt) | 2016-06-23 | 2019-12-23 | Novaliq Gmbh | Método de administração tópica |
US11684589B2 (en) | 2016-09-22 | 2023-06-27 | Novaliq Gmbh | Pharmaceutical compositions for use in the therapy of blepharitis |
AU2017329983B2 (en) * | 2016-09-23 | 2022-05-05 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
JP2019534867A (ja) * | 2016-09-28 | 2019-12-05 | ノバリック ゲーエムベーハー | カンナビノイド受容体結合リガンドを含む組成物 |
CA3045733C (en) * | 2016-12-22 | 2024-01-16 | Novaliq Gmbh | Compositions comprising tacrolimus for the treatment of intraocular inflammatory eye diseases |
AU2017384650B2 (en) * | 2016-12-23 | 2021-02-18 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
CA3049402A1 (en) | 2017-01-06 | 2018-07-12 | Palvella Therapeutics Llc | Anhydrous compositions of mtor inhibitors and methods of use |
AU2018253944B2 (en) * | 2017-04-21 | 2022-09-15 | Dermaliq Therapeutics, Inc. | Iodine compositions |
EP3619186B1 (en) | 2017-05-05 | 2021-02-17 | Novaliq GmbH | Process for the production of semifluorinated alkanes |
CN110650734A (zh) * | 2017-05-12 | 2020-01-03 | 诺瓦利克有限责任公司 | 治疗与隐形眼镜有关病症的包含半氟化烷烃的药物组合物 |
MX2020003534A (es) | 2017-09-27 | 2020-07-29 | Novaliq Gmbh | Composiciones oftalmicas que comprenden latanoprost para usarse en el tratamiento de las enfermedades oculares. |
WO2019068763A1 (en) | 2017-10-04 | 2019-04-11 | Novaliq Gmbh | OPHTHALMIC COMPOSITIONS COMPRISING F6H8 |
AU2019228119A1 (en) | 2018-03-02 | 2020-09-10 | Novaliq Gmbh | Pharmaceutical compositions comprising nebivolol |
US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
AU2019342426A1 (en) | 2018-09-22 | 2021-05-20 | Novaliq Gmbh | Ophthalmic compositions for treatment of ocular surface damage and symptoms of dryness |
WO2020074697A1 (en) | 2018-10-12 | 2020-04-16 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
US20220226426A1 (en) | 2019-05-24 | 2022-07-21 | Novaliq Gmbh | Ophthalmic composition for the treatment of ocular allergy |
US20230181679A1 (en) | 2019-09-06 | 2023-06-15 | Novaliq Gmbh | Ophthalmic composition for the treatment of uveitis |
WO2021048803A1 (en) | 2019-09-13 | 2021-03-18 | Minas Coroneo | Eye drop dispenser |
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CA2372448A1 (en) * | 1999-04-30 | 2000-11-09 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
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2009
- 2009-12-14 EP EP09015423A patent/EP2335735A1/en not_active Withdrawn
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2010
- 2010-12-13 ES ES10790775.0T patent/ES2449308T3/es active Active
- 2010-12-13 CA CA2776860A patent/CA2776860C/en active Active
- 2010-12-13 BR BR112012014190A patent/BR112012014190B8/pt active IP Right Grant
- 2010-12-13 JP JP2012542577A patent/JP5663595B2/ja active Active
- 2010-12-13 BR BR122017018955-7A patent/BR122017018955B1/pt active IP Right Grant
- 2010-12-13 PL PL10790775T patent/PL2512515T3/pl unknown
- 2010-12-13 KR KR1020127018066A patent/KR101652714B1/ko active IP Right Grant
- 2010-12-13 BR BR122020020872-4A patent/BR122020020872B1/pt active IP Right Grant
- 2010-12-13 EP EP10790775.0A patent/EP2512515B1/en active Active
- 2010-12-13 PT PT107907750T patent/PT2512515E/pt unknown
- 2010-12-13 DK DK10790775.0T patent/DK2512515T3/en active
- 2010-12-13 IN IN3128DEN2012 patent/IN2012DN03128A/en unknown
- 2010-12-13 KR KR1020167023214A patent/KR101722039B1/ko active IP Right Review Request
- 2010-12-13 WO PCT/EP2010/069495 patent/WO2011073134A1/en active Application Filing
- 2010-12-13 US US13/513,886 patent/US8614178B2/en active Active
- 2010-12-13 CN CN201080055507.7A patent/CN102652022B/zh active Active
- 2010-12-13 CA CA2941956A patent/CA2941956C/en active Active
- 2010-12-13 MX MX2012006720A patent/MX2012006720A/es active IP Right Grant
- 2010-12-13 AU AU2010333039A patent/AU2010333039B2/en active Active
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2012
- 2012-12-20 HK HK12113225.6A patent/HK1172269A1/xx unknown
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2014
- 2014-10-01 JP JP2014203406A patent/JP6096731B2/ja active Active
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2016
- 2016-12-22 JP JP2016248533A patent/JP6397472B2/ja active Active
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2018
- 2018-08-31 JP JP2018163569A patent/JP2019006803A/ja active Pending
- 2018-12-28 JP JP2018248700A patent/JP6731039B2/ja active Active
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