BR0312111A - Formulação estável, lìquida, parenteral de parecoxib - Google Patents
Formulação estável, lìquida, parenteral de parecoxibInfo
- Publication number
- BR0312111A BR0312111A BR0312111-9A BR0312111A BR0312111A BR 0312111 A BR0312111 A BR 0312111A BR 0312111 A BR0312111 A BR 0312111A BR 0312111 A BR0312111 A BR 0312111A
- Authority
- BR
- Brazil
- Prior art keywords
- parecoxib
- stable
- liquid
- parenteral formulation
- conversion
- Prior art date
Links
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 4
- 229960004662 parecoxib Drugs 0.000 title abstract 4
- 239000007788 liquid Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 1
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 abstract 1
- 238000003916 acid precipitation Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 229960002004 valdecoxib Drugs 0.000 abstract 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39171402P | 2002-06-26 | 2002-06-26 | |
| PCT/US2003/021028 WO2004002533A1 (en) | 2002-06-26 | 2003-06-18 | Stable liquid parenteral parecoxib formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312111A true BR0312111A (pt) | 2005-03-29 |
Family
ID=30000741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312111-9A BR0312111A (pt) | 2002-06-26 | 2003-06-18 | Formulação estável, lìquida, parenteral de parecoxib |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040127537A1 (enExample) |
| EP (1) | EP1524997A1 (enExample) |
| JP (1) | JP2005535644A (enExample) |
| AR (1) | AR039747A1 (enExample) |
| AU (1) | AU2003247793A1 (enExample) |
| BR (1) | BR0312111A (enExample) |
| CA (1) | CA2488526A1 (enExample) |
| MX (1) | MXPA05000011A (enExample) |
| PA (1) | PA8576601A1 (enExample) |
| PE (1) | PE20040303A1 (enExample) |
| TW (1) | TW200409645A (enExample) |
| WO (1) | WO2004002533A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003303591A1 (en) * | 2002-12-30 | 2004-07-29 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| CA2551523A1 (en) * | 2003-12-24 | 2005-07-21 | Pharmacia Corporation | Metal salts of parecoxib as prodrugs of the cox-2 inhibitor valdecoxib for the treatment of inflammation, pain and/or fever |
| EA201101085A1 (ru) | 2005-12-22 | 2012-05-30 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Феноксиуксусные кислоты в качестве активаторов ppar дельта |
| GB0612749D0 (en) * | 2006-06-27 | 2006-08-09 | Univ College London Hospitals | Treatment and/or prevention of pain |
| DE102014115951A1 (de) * | 2014-11-03 | 2016-05-04 | Merlion Pharmaceuticals Pte Ltd. | Zusammensetzungen, die Finafloxacin und Tris enthalten |
| CN104965041B (zh) * | 2015-06-11 | 2016-06-29 | 成都克莱蒙医药科技有限公司 | 一种帕瑞昔布钠异构体的高效液相色谱检测方法 |
| CN109568277B (zh) * | 2019-01-30 | 2022-06-21 | 成都欣捷高新技术开发股份有限公司 | 枸橼酸在制备帕瑞昔布钠冻干制剂组合物中的应用及其组合物和制备方法 |
| CN112409283A (zh) * | 2020-11-24 | 2021-02-26 | 苏州璞正医药有限公司 | 一种帕瑞昔布衍生物及其制备方法和应用 |
| WO2023214433A1 (en) * | 2022-05-05 | 2023-11-09 | Inventia Healthcare Limited | Stable parenteral compositions of parecoxib |
| CN117003769B (zh) * | 2023-07-11 | 2024-11-22 | 中国科学院宁波材料技术与工程研究所 | 氯诺昔康复合物、氯诺昔康-小檗碱共晶及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430057A (en) * | 1993-09-30 | 1995-07-04 | Board Of Regents, The University Of Texas System | Parenteral busulfan for treatment of malignant disease |
| SE9501189D0 (sv) * | 1995-03-31 | 1995-03-31 | Pharmacia Ab | Protein formulation |
| CZ293747B6 (cs) * | 1995-12-21 | 2004-07-14 | Pfizer Inc. | Vodný farmaceutický roztok vhodný pro injekční podávání hostiteli a jeho použití |
| GEP20032998B (en) * | 1996-04-12 | 2003-06-25 | Searle & Co | Substituted Benzenesulfonamide Derivatives as Prodrugs of Cox-2 Inhibitors |
| US6413965B1 (en) * | 1999-06-30 | 2002-07-02 | Pfizer Inc. | Compositions and treatment for diabetic complications |
| HRP20010582A2 (en) * | 1999-12-08 | 2002-08-31 | Pharmacia Corp | Valdecoxib compositions |
| JP2003523958A (ja) * | 1999-12-23 | 2003-08-12 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法 |
| GB0002336D0 (en) * | 2000-02-01 | 2000-03-22 | Glaxo Group Ltd | Medicaments |
| CA2415697A1 (en) * | 2000-07-13 | 2002-01-24 | James C. Forbes | Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain |
| US20030105144A1 (en) * | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
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2003
- 2003-06-18 EP EP03762337A patent/EP1524997A1/en not_active Withdrawn
- 2003-06-18 CA CA002488526A patent/CA2488526A1/en not_active Abandoned
- 2003-06-18 WO PCT/US2003/021028 patent/WO2004002533A1/en not_active Ceased
- 2003-06-18 US US10/464,015 patent/US20040127537A1/en not_active Abandoned
- 2003-06-18 JP JP2004518239A patent/JP2005535644A/ja not_active Withdrawn
- 2003-06-18 BR BR0312111-9A patent/BR0312111A/pt not_active IP Right Cessation
- 2003-06-18 AU AU2003247793A patent/AU2003247793A1/en not_active Abandoned
- 2003-06-18 MX MXPA05000011A patent/MXPA05000011A/es not_active Application Discontinuation
- 2003-06-25 PE PE2003000637A patent/PE20040303A1/es not_active Application Discontinuation
- 2003-06-25 AR ARP030102282A patent/AR039747A1/es unknown
- 2003-06-26 PA PA20038576601A patent/PA8576601A1/es unknown
- 2003-06-26 TW TW092117433A patent/TW200409645A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005535644A (ja) | 2005-11-24 |
| CA2488526A1 (en) | 2004-01-08 |
| EP1524997A1 (en) | 2005-04-27 |
| US20040127537A1 (en) | 2004-07-01 |
| WO2004002533A1 (en) | 2004-01-08 |
| TW200409645A (en) | 2004-06-16 |
| PE20040303A1 (es) | 2004-08-13 |
| AR039747A1 (es) | 2005-03-09 |
| PA8576601A1 (es) | 2005-03-28 |
| AU2003247793A1 (en) | 2004-01-19 |
| MXPA05000011A (es) | 2005-04-08 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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