JP5019923B2 - プラノプロフェン含有医薬組成物 - Google Patents
プラノプロフェン含有医薬組成物 Download PDFInfo
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- JP5019923B2 JP5019923B2 JP2007082955A JP2007082955A JP5019923B2 JP 5019923 B2 JP5019923 B2 JP 5019923B2 JP 2007082955 A JP2007082955 A JP 2007082955A JP 2007082955 A JP2007082955 A JP 2007082955A JP 5019923 B2 JP5019923 B2 JP 5019923B2
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- pharmaceutical composition
- salt
- pranoprofen
- composition
- aqueous
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- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 claims description 8
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
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Description
項1-1. (A)プラノプロフェン及び/又はその塩、及び(B)アルギン酸及び/又はその塩を含有することを特徴とする、医薬組成物。
項1-2. (B)成分が、グルロン酸に対するマンヌロン酸の構成比が、0.4〜3.0であるアルギン酸、及び/又はその塩である、項1-1に記載の医薬組成物。
項1-3. 水性組成物である、項1-1又は1-2に記載の医薬組成物。
項1-4. 眼科用組成物である、項1-1乃至1-3のいずれかに記載の医薬組成物。
項2-1. プラノプロフェン及び/又はその塩を含有する水性医薬組成物の安定化方法であって、該水性医薬組成物に(B)アルギン酸及び/又はその塩を配合することを特徴とする、前記水性医薬組成物の安定化方法。
項2-2. (B)成分が、グルロン酸に対するマンヌロン酸の構成比が、0.4〜3.0であるアルギン酸、及び/又はその塩である、項2-1に記載の安定化方法。
項2-3. 水性医薬組成物が眼科用組成物である、項2-1又は2-2に記載の安定化方法。
項3-1. (A)プラノプロフェン及び/又はその塩、及び(B)アルギン酸及び/又はその塩を含有することを特徴とする、防腐剤組成物。
項3-2. (B)成分が、グルロン酸に対するマンヌロン酸の構成比が、0.4〜3.0であるアルギン酸、及び/又はその塩である、項3-1に記載の防腐剤組成物。
項3-3. (A)成分の総量1重量部に対して、(B)成分が総量で0.001〜50重量部の比率で含まれる項3-1又は3-2に記載の防腐剤組成物。
項3-4. 眼科用である、項3-1乃至3-3に記載の防腐剤組成物。
項4-1. プラノプロフェン及び/又はその塩を含有する医薬組成物に防腐作用を付与する方法であって、該医薬組成物に(B)アルギン酸及び/又はその塩を配合することを特徴とする、防腐作用の付与方法。
項4-2. (B)成分が、グルロン酸に対するマンヌロン酸の構成比が、0.4〜3.0であるアルギン酸、及び/又はその塩である、項4-1に記載の付与方法。
項4-3. 医薬組成物が眼科用組成物である、項4-1又は4-2に記載の付与方法。
本発明の医薬組成物は、プラノプロフェン及び/又はその塩(以下、単に(A)成分と表記することもある)を含有する。プラノプロフェンは、α−メチル−5H−[1]ベンゾピラノ[2,3-b]ピリジン−7−酢酸とも称される公知化合物であり、公知の方法により合成してもよく市販品として入手することもできる。
水性医薬組成物中に、プラノプロフェン及び/又はその塩が総量で0.0001〜2w/v%、好ましくは0.0005〜0.2w/v%、更に好ましくは0.001〜0.1w/v%;より具体的には、水性医薬組成物が点眼剤であれば、プラノプロフェン又はその塩が総量で、特に好ましくは0.01〜0.1w/v%、更に特に好ましくは0.01〜0.05w/v%;水性医薬組成物が洗眼剤であれば、プラノプロフェン又はその塩が総量で、特に好ましくは0.001〜0.01w/v%、更に特に好ましくは0.001〜0.005w/v%。
水性医薬組成物中に、アルギン酸及び/又はその塩が総量で0.001〜5w/v%、好ましくは0.002〜2w/v%、更に好ましくは0.005〜1w/v%;より具体的には、水性医薬組成物が点眼剤であれば、アルギン酸又はその塩が総量で、特に好ましくは0.001〜0.5w/v%、更に特に好ましくは0.005〜0.2w/v%;水性医薬組成物が洗眼剤であれば、アルギン酸又はその塩が総量で、特に好ましくは0.001〜0.2w/v%、更に特に好ましくは0.005〜0.1w/v%。
プラノプロフェン及び/又はその塩の総量1重量部に対して、アルギン酸及び/又はその塩が総量で0.001〜50重量部、好ましくは0.01〜30重量部、更に好ましくは0.1〜10重量部、特に好ましくは0.5〜5重量部、更に特に好ましくは0.5〜3重量部。
また、水性医薬組成物において上記比率を充足する場合、水性医薬組成物の澄明化をより顕著ならしめ、安定性を効果的に向上させることもできる。
前述するように、プラノプロフェン及び/又はその塩と、アルギン酸及び/又はその塩とを共存させることにより、Escherichia coli、Pseudomonas aeruginosa、Burkholderia cepacia等の雑菌の繁殖を防止して優れた防腐作用を示すので、本発明は、更に他の観点から、(A)プラノプロフェン及び/又はその塩、及び(B)アルギン酸及び/又はその塩を含有する防腐剤組成物を提供する。ここで、防腐剤組成物とは、防腐剤として、例えば、医薬組成物等の防腐対象となる組成物(以下、防腐対象組成物と表記する)に配合して使用される添加剤のことを意味する。当該防腐剤組成物において、上記(A)及び(B)成分の種類、及びこれら両成分の比率については、上記「(I)医薬組成物」の項に記載する内容と同様である。
前述するように、水性医薬組成物中で、プラノプロフェン及び/又はその塩と、アルギン酸及び/又はその塩とを共存させることにより、水性医薬組成物の澄明性を長期にわたり保持して、水性医薬組成物の安定性を向上させることが可能になる。故に、本発明は、別の観点から、プラノプロフェン及び/又はその塩を含有する水性医薬組成物に、(B)アルギン酸及び/又はその塩を配合することを特徴とする、プラノプロフェン及び/又はその塩を含有する水性医薬組成物の安定化方法を提供する。
前述するように、医薬組成物中で、プラノプロフェン及び/又はその塩と、アルギン酸及び/又はその塩とを共存させることにより、Escherichia coli、Pseudomonas aeruginosa、Burkholderia cepacia等の雑菌の繁殖を防止して優れた防腐作用を示す。従って、本発明は、更にプラノプロフェン及び/又はその塩を含有する医薬組成物に防腐作用を付与する方法であって、該医薬組成物に(B)アルギン酸及び/又はその塩を配合することを特徴とする、防腐作用の付与方法を提供する。当該防腐作用の付与方法は、プラノプロフェン及び/又はその塩を含む医薬組成物を防腐する方法と言い換えることもできる。
試験例1 防腐性の評価試験
表1に記載の処方に従い、各水性組成物を調製した(実施例1、比較例1及び2、コントロール)。
表2に記載の処方に従い、各水性組成物を調製し0.2μmフィルター(クラボウ株式会社製)で滅菌濾過して用いた(実施例2、比較例1及び3、コントロール)。また、別途、アラキドン酸ナトリウム(シグマアルドリッチジャパン株式会社製)を生理食塩水(日本薬局方 大塚生食注、大塚製薬株式会社製)に0.5w/v%となるように溶解した後に、0.2μmフィルター(クラボウ株式会社製)で濾過することにより、アラキドン酸溶液を調製した。
試験例3 プラノプロフェン含有水性組成物の安定性評価試験
表3に記載の処方に従い、プラノプロフェン含有水性組成物を調製した(実施例3及び比較例4)。これらのプラノプロフェン含有水性組成物を用いて、以下の試験を行い、光曝露条件下での安定性について評価した。
以下表4−7に記載の処方で、点眼剤(実施例4−14、26−33及び38−40)、及び洗眼剤(実施例15−25及び34−37)を調製した。なお、表4−6中、各配合成分の単位はg/100mLである。また、表4−7中、「アルギン酸1)」はM/G比の規格が1.0〜1.6、「アルギン酸ナトリウム2)」はM/G比の規格が0.4〜0.8、「アルギン酸ナトリウム3)」はM/G比の規格が2.0〜3.0、及び「アルギン酸ナトリウム4)」はM/G比の規格が1.0〜1.6のものを示す。
Claims (4)
- (A)プラノプロフェン及び/又はその塩、及び(B)アルギン酸及び/又はその塩を含有することを特徴とする、医薬組成物。
- (B)成分が、グルロン酸に対するマンヌロン酸の構成比が、0.4〜3.0であるアルギン酸、及び/又はその塩である、請求項1に記載の医薬組成物。
- 水性組成物である、請求項1又は2に記載の医薬組成物。
- 眼科用組成物である、請求項1乃至3に記載の医薬組成物。
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