JP2005533801A5 - - Google Patents
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- Publication number
- JP2005533801A5 JP2005533801A5 JP2004514874A JP2004514874A JP2005533801A5 JP 2005533801 A5 JP2005533801 A5 JP 2005533801A5 JP 2004514874 A JP2004514874 A JP 2004514874A JP 2004514874 A JP2004514874 A JP 2004514874A JP 2005533801 A5 JP2005533801 A5 JP 2005533801A5
- Authority
- JP
- Japan
- Prior art keywords
- indol
- carbonyl
- optionally
- halogen
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FBXWDVALKBNEJV-UHFFFAOYSA-N 1h-indol-3-yl(piperazin-1-yl)methanone Chemical class C=1NC2=CC=CC=C2C=1C(=O)N1CCNCC1 FBXWDVALKBNEJV-UHFFFAOYSA-N 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 150000002367 halogens Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- -1 R 2 is H Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NTIFEVGVXWYYHK-FQEVSTJZSA-N [(9as)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-[1-(cyclohexylmethyl)-7-methoxyindol-3-yl]methanone Chemical compound C1=2C(OC)=CC=CC=2C(C(=O)N2C[C@@H]3CCCCN3CC2)=CN1CC1CCCCC1 NTIFEVGVXWYYHK-FQEVSTJZSA-N 0.000 claims 1
- FSNJWYVUDGWBOO-UHFFFAOYSA-N [1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-(4-ethyl-3,5-dimethylpiperazin-1-yl)methanone Chemical compound C1C(C)N(CC)C(C)CN1C(=O)C(C1=CC=CC(OC)=C11)=CN1CC1CCCCC1 FSNJWYVUDGWBOO-UHFFFAOYSA-N 0.000 claims 1
- ONXJNAIZJKLJGA-KRWDZBQOSA-N [1-(cyclohexylmethyl)-7-methoxyindol-3-yl]-[(3s)-3,4-dimethylpiperazin-1-yl]methanone Chemical compound C1=2C(OC)=CC=CC=2C(C(=O)N2C[C@H](C)N(C)CC2)=CN1CC1CCCCC1 ONXJNAIZJKLJGA-KRWDZBQOSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- DMYGECJTVMCGEP-UHFFFAOYSA-N org 28312 Chemical compound C1=2C(OC)=CC=CC=2C(C(=O)N2CC(C)N(C)C(C)C2)=CN1CC1CCCCC1 DMYGECJTVMCGEP-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02077505 | 2002-06-21 | ||
| PCT/EP2003/050226 WO2004000832A1 (en) | 2002-06-21 | 2003-06-13 | 1-[(indol-3-yl)carbonyl] piperazine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005533801A JP2005533801A (ja) | 2005-11-10 |
| JP2005533801A5 true JP2005533801A5 (OSRAM) | 2006-07-13 |
| JP4408804B2 JP4408804B2 (ja) | 2010-02-03 |
Family
ID=29797228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004514874A Expired - Fee Related JP4408804B2 (ja) | 2002-06-21 | 2003-06-13 | １−［（インドル−３−イル）カルボニル］ピペラジン誘導体 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7304064B2 (OSRAM) |
| EP (1) | EP1549637B1 (OSRAM) |
| JP (1) | JP4408804B2 (OSRAM) |
| KR (1) | KR20050009755A (OSRAM) |
| CN (1) | CN1298716C (OSRAM) |
| AR (1) | AR040274A1 (OSRAM) |
| AT (1) | ATE361290T1 (OSRAM) |
| AU (1) | AU2003250245B2 (OSRAM) |
| BR (1) | BR0311960A (OSRAM) |
| CA (1) | CA2490141C (OSRAM) |
| CO (1) | CO5680419A2 (OSRAM) |
| CY (1) | CY1107677T1 (OSRAM) |
| DE (1) | DE60313640T2 (OSRAM) |
| DK (1) | DK1549637T3 (OSRAM) |
| EC (1) | ECSP045503A (OSRAM) |
| ES (1) | ES2285183T3 (OSRAM) |
| HR (1) | HRP20041186A2 (OSRAM) |
| IL (1) | IL165572A0 (OSRAM) |
| IS (1) | IS2443B (OSRAM) |
| MX (1) | MXPA04012856A (OSRAM) |
| NO (1) | NO20045351L (OSRAM) |
| NZ (1) | NZ537143A (OSRAM) |
| PE (1) | PE20040578A1 (OSRAM) |
| PL (1) | PL375152A1 (OSRAM) |
| PT (1) | PT1549637E (OSRAM) |
| RS (1) | RS111104A (OSRAM) |
| RU (1) | RU2318821C2 (OSRAM) |
| SI (1) | SI1549637T1 (OSRAM) |
| TW (1) | TW200402417A (OSRAM) |
| UA (1) | UA78317C2 (OSRAM) |
| WO (1) | WO2004000832A1 (OSRAM) |
| ZA (1) | ZA200410057B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI242015B (en) | 1999-11-29 | 2005-10-21 | Akzo Nobel Nv | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| ES2294330T3 (es) | 2002-08-02 | 2008-04-01 | MERCK & CO., INC. | Derivados de furo(2,3-b)piridina sustituidos. |
| DE10253426B4 (de) * | 2002-11-15 | 2005-09-22 | Elbion Ag | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
| ES2284076T3 (es) | 2003-12-17 | 2007-11-01 | N.V. Organon | Derivados triciclicos de 1-(indol-3-il)carbonil)piperazina como agonistas del receptor de cannabinoides cb1. |
| TWI330635B (en) | 2004-03-05 | 2010-09-21 | Organon Nv | (indol-3-yl)-heterocycle derivatives |
| JP2009500439A (ja) * | 2005-07-11 | 2009-01-08 | ナームローゼ・フエンノートチヤツプ・オルガノン | 疼痛の治療のための相乗的組み合わせ（カンナビノイド受容体アゴニスト及びオピオイド受容体アゴニスト） |
| KR101020351B1 (ko) * | 2005-07-29 | 2011-03-08 | 에프. 호프만-라 로슈 아게 | 인돌-3-일-카본일-피페리딘 및 피페라진 유도체 |
| TW200745096A (en) * | 2005-08-23 | 2007-12-16 | Organon Nv | Indole derivatives |
| US7763732B2 (en) | 2005-08-24 | 2010-07-27 | N.V. Organon | Indole derivatives |
| AU2006295130A1 (en) * | 2005-09-23 | 2007-04-05 | Janssen Pharmaceutica, N.V. | Tetrahydro-indazolyl cannabinoid modulators |
| TW200848417A (en) | 2007-02-22 | 2008-12-16 | Organon Nv | Indole derivatives |
| RU2387642C2 (ru) | 2007-10-31 | 2010-04-27 | Общество С Ограниченной Ответственностью "Бинатех" | Производные 5-замещенных индол-3-карбоновой кислоты, обладающие противовирусной активностью, способ их получения и применение |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| CN105829310B (zh) | 2013-12-20 | 2019-04-12 | 阿斯特克斯治疗有限公司 | 双环杂环化合物及其治疗用途 |
| CN111566105A (zh) | 2018-01-08 | 2020-08-21 | 豪夫迈·罗氏有限公司 | 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物 |
| CN108752342A (zh) * | 2018-08-17 | 2018-11-06 | 西安瑞联新材料股份有限公司 | 1-H-吡啶并[1,2-a]-6-氢吡嗪-1,4-二酮的制备方法 |
| CN111100063B (zh) * | 2018-10-25 | 2022-05-17 | 南京药石科技股份有限公司 | 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE142621T1 (de) * | 1989-12-28 | 1996-09-15 | Upjohn Co | Diaromatische substituierte verbindungen gegen den aids-virus |
| WO1998006715A1 (en) | 1996-08-09 | 1998-02-19 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
| AU1887401A (en) * | 1999-12-14 | 2001-06-25 | Nippon Shinyaku Co. Ltd. | Medicinal composition |
| EP1254115A2 (en) * | 2000-02-11 | 2002-11-06 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
-
2003
- 2003-06-11 TW TW092115888A patent/TW200402417A/zh unknown
- 2003-06-13 NZ NZ537143A patent/NZ537143A/en unknown
- 2003-06-13 HR HR20041186A patent/HRP20041186A2/xx not_active Application Discontinuation
- 2003-06-13 ES ES03760704T patent/ES2285183T3/es not_active Expired - Lifetime
- 2003-06-13 AT AT03760704T patent/ATE361290T1/de active
- 2003-06-13 US US10/518,279 patent/US7304064B2/en not_active Expired - Fee Related
- 2003-06-13 DK DK03760704T patent/DK1549637T3/da active
- 2003-06-13 RS YUP-1111/04A patent/RS111104A/sr unknown
- 2003-06-13 KR KR10-2004-7020734A patent/KR20050009755A/ko not_active Ceased
- 2003-06-13 SI SI200330855T patent/SI1549637T1/sl unknown
- 2003-06-13 JP JP2004514874A patent/JP4408804B2/ja not_active Expired - Fee Related
- 2003-06-13 CN CNB038170906A patent/CN1298716C/zh not_active Expired - Fee Related
- 2003-06-13 CA CA2490141A patent/CA2490141C/en not_active Expired - Fee Related
- 2003-06-13 RU RU2005101349/04A patent/RU2318821C2/ru not_active IP Right Cessation
- 2003-06-13 BR BR0311960-2A patent/BR0311960A/pt not_active IP Right Cessation
- 2003-06-13 EP EP03760704A patent/EP1549637B1/en not_active Expired - Lifetime
- 2003-06-13 PT PT03760704T patent/PT1549637E/pt unknown
- 2003-06-13 AU AU2003250245A patent/AU2003250245B2/en not_active Ceased
- 2003-06-13 DE DE60313640T patent/DE60313640T2/de not_active Expired - Lifetime
- 2003-06-13 UA UA20041210112A patent/UA78317C2/uk unknown
- 2003-06-13 WO PCT/EP2003/050226 patent/WO2004000832A1/en not_active Ceased
- 2003-06-13 PL PL03375152A patent/PL375152A1/xx not_active Application Discontinuation
- 2003-06-13 MX MXPA04012856A patent/MXPA04012856A/es active IP Right Grant
- 2003-06-18 PE PE2003000614A patent/PE20040578A1/es not_active Application Discontinuation
- 2003-06-19 AR ARP030102174A patent/AR040274A1/es unknown
-
2004
- 2004-12-06 IL IL16557204A patent/IL165572A0/xx unknown
- 2004-12-07 NO NO20045351A patent/NO20045351L/no not_active Application Discontinuation
- 2004-12-09 IS IS7590A patent/IS2443B/is unknown
- 2004-12-13 ZA ZA200410057A patent/ZA200410057B/en unknown
- 2004-12-21 EC EC2004005503A patent/ECSP045503A/es unknown
-
2005
- 2005-01-20 CO CO05004561A patent/CO5680419A2/es not_active Application Discontinuation
-
2007
- 2007-06-18 CY CY20071100804T patent/CY1107677T1/el unknown
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