JP2005532983A - Ｃ１７，２０リアーゼ阻害剤としての３‐ピリジルもしくは４‐イソキノリニルチアゾール - Google Patents

Ｃ１７，２０リアーゼ阻害剤としての３‐ピリジルもしくは４‐イソキノリニルチアゾール Download PDF

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JP2005532983A
JP2005532983A JP2003530675A JP2003530675A JP2005532983A JP 2005532983 A JP2005532983 A JP 2005532983A JP 2003530675 A JP2003530675 A JP 2003530675A JP 2003530675 A JP2003530675 A JP 2003530675A JP 2005532983 A JP2005532983 A JP 2005532983A
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Prior art keywords
alkyl
halogen
pyridyl
cycloalkyl
haloalkyl
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Japanese (ja)
Inventor
ドナルド・ビーラー
アンドレア・マックルアー
フ・ウェンラン
フラヒ・アチェベ
ゲータン・アッシュ・ラドゥスール
マイケル・ジェイ・バーク
チェン・ビ
バリー・ハート
ジャック・ドゥマ
ロバート・シブレー
ウィリアム・ジェイ・スコット
ジェフリー・ジョンソン
ダヴォード・アスガリ
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バイエル・フアーマシユーチカルズ・コーポレーシヨン
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2003530675A 2001-09-26 2002-09-26 Ｃ１７，２０リアーゼ阻害剤としての３‐ピリジルもしくは４‐イソキノリニルチアゾール Withdrawn JP2005532983A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32499301P 2001-09-26 2001-09-26
PCT/US2002/030483 WO2003027085A2 (en) 2001-09-26 2002-09-26 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors

Publications (1)

Publication Number Publication Date
JP2005532983A true JP2005532983A (ja) 2005-11-04

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Family Applications (2)

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JP2003530675A Withdrawn JP2005532983A (ja) 2001-09-26 2002-09-26 Ｃ１７，２０リアーゼ阻害剤としての３‐ピリジルもしくは４‐イソキノリニルチアゾール
JP2003530682A Withdrawn JP2005528325A (ja) 2001-09-26 2002-09-26 Ｃ１７，２０リアーゼ阻害剤としての置換３−ピリジルインドール類およびインダゾール類

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JP2003530682A Withdrawn JP2005528325A (ja) 2001-09-26 2002-09-26 Ｃ１７，２０リアーゼ阻害剤としての置換３−ピリジルインドール類およびインダゾール類

Country Status (5)

Country Link
EP (2) EP1432706A2 (enExample)
JP (2) JP2005532983A (enExample)
AU (2) AU2002340010A1 (enExample)
CA (2) CA2461360A1 (enExample)
WO (8) WO2003027094A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
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JP2002234843A (ja) * 2000-12-08 2002-08-23 Takeda Chem Ind Ltd ３−ピリジル基を有する置換チアゾール誘導体、その製造法および用途
WO2009099195A1 (ja) 2008-02-08 2009-08-13 Shiseido Company Ltd. 美白剤及び皮膚外用剤
JP2011524422A (ja) * 2008-06-16 2011-09-01 ユニバーシティ オブ テネシー リサーチ ファウンデーション 癌を処置するための化合物
JP2012500278A (ja) * 2008-08-20 2012-01-05 シェーリング コーポレイション 置換ピリジン誘導体および置換ピリミジン誘導体ならびにそれらのウイルス感染の治療における使用
JP2014512411A (ja) * 2011-04-28 2014-05-22 ノバルティス アーゲー １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
JP2018127451A (ja) * 2017-02-08 2018-08-16 国立大学法人岐阜大学 芳香族アミン化合物の製造方法と新規な芳香族アミン化合物および蛍光発光材料と紫外線吸収剤

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DE60136530D1 (de) * 2000-03-01 2008-12-24 Janssen Pharmaceutica Nv 2,4-disubstituierte thiazolyl derivate

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JP2002234843A (ja) * 2000-12-08 2002-08-23 Takeda Chem Ind Ltd ３−ピリジル基を有する置換チアゾール誘導体、その製造法および用途
WO2009099195A1 (ja) 2008-02-08 2009-08-13 Shiseido Company Ltd. 美白剤及び皮膚外用剤
JP2011524422A (ja) * 2008-06-16 2011-09-01 ユニバーシティ オブ テネシー リサーチ ファウンデーション 癌を処置するための化合物
JP2012162541A (ja) * 2008-06-16 2012-08-30 Univ Of Tennessee Research Foundation 癌を処置するための化合物
JP2012500278A (ja) * 2008-08-20 2012-01-05 シェーリング コーポレイション 置換ピリジン誘導体および置換ピリミジン誘導体ならびにそれらのウイルス感染の治療における使用
JP2014512411A (ja) * 2011-04-28 2014-05-22 ノバルティス アーゲー １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
JP2018127451A (ja) * 2017-02-08 2018-08-16 国立大学法人岐阜大学 芳香族アミン化合物の製造方法と新規な芳香族アミン化合物および蛍光発光材料と紫外線吸収剤
JP7193071B2 (ja) 2017-02-08 2022-12-20 国立大学法人東海国立大学機構 蛍光発光材料および紫外線吸収剤

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