JP2005532057A5 - - Google Patents
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- JP2005532057A5 JP2005532057A5 JP2004518745A JP2004518745A JP2005532057A5 JP 2005532057 A5 JP2005532057 A5 JP 2005532057A5 JP 2004518745 A JP2004518745 A JP 2004518745A JP 2004518745 A JP2004518745 A JP 2004518745A JP 2005532057 A5 JP2005532057 A5 JP 2005532057A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- hydrolyzate
- yeast
- concentration
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000010469 Glycine max Nutrition 0.000 claims description 60
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 59
- 241001465754 Metazoa Species 0.000 claims description 24
- 241000700605 Viruses Species 0.000 claims description 20
- 244000068988 Glycine max Species 0.000 claims description 12
- 235000021120 animal protein Nutrition 0.000 claims description 11
- 239000000427 antigen Substances 0.000 claims description 8
- 102000036639 antigens Human genes 0.000 claims description 8
- 108091007433 antigens Proteins 0.000 claims description 8
- 241000710831 Flavivirus Species 0.000 claims description 7
- 241000709664 Picornaviridae Species 0.000 claims description 7
- 239000000413 hydrolysate Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 241000711573 Coronaviridae Species 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 5
- 241001529453 unidentified herpesvirus Species 0.000 claims description 5
- 241000712461 unidentified influenza virus Species 0.000 claims description 4
- 230000003612 virological effect Effects 0.000 claims description 4
- 241000712891 Arenavirus Species 0.000 claims description 3
- 241000702263 Reovirus sp. Species 0.000 claims description 3
- 241000701161 unidentified adenovirus Species 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims 99
- 239000002609 medium Substances 0.000 claims 36
- 238000000034 method Methods 0.000 claims 33
- 239000006143 cell culture medium Substances 0.000 claims 12
- 230000007062 hydrolysis Effects 0.000 claims 9
- 238000006460 hydrolysis reaction Methods 0.000 claims 9
- 239000007857 degradation product Substances 0.000 claims 8
- 210000003292 kidney cell Anatomy 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 6
- 108010009736 Protein Hydrolysates Proteins 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 241000271566 Aves Species 0.000 claims 3
- 206010066919 Epidemic polyarthritis Diseases 0.000 claims 3
- 241000238631 Hexapoda Species 0.000 claims 3
- 241000710942 Ross River virus Species 0.000 claims 3
- 241000700618 Vaccinia virus Species 0.000 claims 3
- 210000004102 animal cell Anatomy 0.000 claims 3
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 210000003501 vero cell Anatomy 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000282465 Canis Species 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 241000699800 Cricetinae Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000712431 Influenza A virus Species 0.000 claims 1
- 241000713196 Influenza B virus Species 0.000 claims 1
- 241000713297 Influenza C virus Species 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39424302P | 2002-07-09 | 2002-07-09 | |
| PCT/EP2003/007341 WO2004005493A1 (en) | 2002-07-09 | 2003-07-08 | Animal protein free media for cultivation of cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010265835A Division JP5485863B2 (ja) | 2002-07-09 | 2010-11-29 | 細胞を培養するための動物性タンパク質非含有培地 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532057A JP2005532057A (ja) | 2005-10-27 |
| JP2005532057A5 true JP2005532057A5 (https=) | 2011-02-03 |
Family
ID=30115698
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004518745A Withdrawn JP2005532057A (ja) | 2002-07-09 | 2003-07-08 | 細胞を培養するための動物性タンパク質非含有培地 |
| JP2010265835A Expired - Lifetime JP5485863B2 (ja) | 2002-07-09 | 2010-11-29 | 細胞を培養するための動物性タンパク質非含有培地 |
| JP2011258106A Expired - Lifetime JP6084359B2 (ja) | 2002-07-09 | 2011-11-25 | 細胞を培養するための動物性タンパク質非含有培地 |
| JP2013100500A Expired - Lifetime JP6178109B2 (ja) | 2002-07-09 | 2013-05-10 | 細胞を培養するための動物性タンパク質非含有培地 |
| JP2014245252A Expired - Lifetime JP6244294B2 (ja) | 2002-07-09 | 2014-12-03 | 細胞を培養するための動物性タンパク質非含有培地 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010265835A Expired - Lifetime JP5485863B2 (ja) | 2002-07-09 | 2010-11-29 | 細胞を培養するための動物性タンパク質非含有培地 |
| JP2011258106A Expired - Lifetime JP6084359B2 (ja) | 2002-07-09 | 2011-11-25 | 細胞を培養するための動物性タンパク質非含有培地 |
| JP2013100500A Expired - Lifetime JP6178109B2 (ja) | 2002-07-09 | 2013-05-10 | 細胞を培養するための動物性タンパク質非含有培地 |
| JP2014245252A Expired - Lifetime JP6244294B2 (ja) | 2002-07-09 | 2014-12-03 | 細胞を培養するための動物性タンパク質非含有培地 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7955833B2 (https=) |
| EP (2) | EP2287288B1 (https=) |
| JP (5) | JP2005532057A (https=) |
| CN (2) | CN100591759C (https=) |
| AU (1) | AU2003249990B2 (https=) |
| CA (1) | CA2491992A1 (https=) |
| DK (2) | DK2287288T3 (https=) |
| ES (2) | ES2394085T3 (https=) |
| MX (1) | MXPA05000418A (https=) |
| NZ (1) | NZ538094A (https=) |
| PL (1) | PL214284B1 (https=) |
| PT (2) | PT2287288E (https=) |
| SI (1) | SI1520008T1 (https=) |
| WO (1) | WO2004005493A1 (https=) |
Families Citing this family (73)
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|---|---|---|---|---|
| US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| US7425437B2 (en) * | 1999-11-26 | 2008-09-16 | Crucell Holland B.V. | Vaccines against West Nile Virus |
| FR2836924B1 (fr) * | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| PT2287288E (pt) | 2002-07-09 | 2012-12-10 | Baxter Int | Meio isento de proteína animal para cultura de células |
| JP4713567B2 (ja) * | 2004-03-01 | 2011-06-29 | アレス トレーディング ソシエテ アノニム | 哺乳類細胞のｉｌ−１８ｂｐの産生のための無血清細胞培地の使用 |
| JP4650798B2 (ja) * | 2004-04-19 | 2011-03-16 | デンカ生研株式会社 | ウイルスの生産方法 |
| JP2008512443A (ja) * | 2004-09-09 | 2008-04-24 | カイロン ベーリング ゲーエムベーハー アンド カンパニー | インフルエンザワクチンに関連する潜在的医原性リスクの減少 |
| AU2011221414B2 (en) * | 2004-10-29 | 2012-09-20 | Takeda Pharmaceutical Company Limited | Animal Protein-Free Media for Cultivation of Cells |
| US20060094104A1 (en) * | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| KR100679112B1 (ko) | 2004-11-17 | 2007-02-07 | 삼성정밀화학 주식회사 | 동물세포 배양방법 |
| ATE547511T1 (de) | 2004-12-23 | 2012-03-15 | Medimmune Llc | Nichttumorbildende mdck-zellinie zur vermehrung von viren |
| WO2006095431A1 (ja) * | 2005-03-10 | 2006-09-14 | Kyoritsu Seiyaku Corporation | 動物由来の成分なしで培養可能である細胞株及びその作出方法、これを用いたウイルスの生産方法、及びワクチンの生産方法 |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| EP3088893B1 (en) * | 2005-04-13 | 2018-02-14 | Merial, Inc. | Assay for monitoring porcine circovirus production |
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| JP2007000077A (ja) * | 2005-06-23 | 2007-01-11 | Hitachi Medical Corp | 付着性動物細胞の無血清培養方法及び付着性動物細胞の無血清培養用培地 |
| EP3653699A1 (en) | 2006-01-04 | 2020-05-20 | Baxalta Incorporated | Oligopeptide-free cell culture media |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| CA2650676C (en) | 2006-04-28 | 2016-03-22 | Kyoritsu Seiyaku Corporation | Feline cell capable of being cultured without animal-derived protein, and method for producing virus and method for producing vaccine using thereof |
| WO2007141274A2 (en) * | 2006-06-06 | 2007-12-13 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
| EP2500417A1 (en) * | 2006-08-09 | 2012-09-19 | Vivalis | Method of production of transgenic avian using embryonic stem cells |
| WO2008105931A2 (en) * | 2006-09-15 | 2008-09-04 | Medimmune Vaccines, Inc. | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
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| EP1985305A1 (en) | 2007-04-24 | 2008-10-29 | Vivalis | Duck embryonic derived stem cell lines for the production of viral vaccines |
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| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| WO2009023562A2 (en) * | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| PL2235197T3 (pl) * | 2007-12-27 | 2018-01-31 | Baxalta GmbH | Sposoby hodowli komórek |
| ES2735173T3 (es) * | 2007-12-31 | 2019-12-16 | Baxalta GmbH | Furina recombinante sustancialmente libre de proteína animal y métodos para producir la misma |
| KR101220239B1 (ko) * | 2008-04-01 | 2013-01-09 | 바이오스펙트럼 주식회사 | 식물성 펩톤을 포함하는 줄기세포 증식 촉진용 조성물 |
| TW201012930A (en) | 2008-06-16 | 2010-04-01 | Intervet Int Bv | Method of replicating viruses in suspension |
| RU2547587C2 (ru) * | 2008-09-24 | 2015-04-10 | Медиммун, Ллк | Способы культивирования клеток, размножения и очистки вирусов |
| CA2769003C (en) * | 2009-07-23 | 2018-10-16 | Xcellerex, Inc. | Drain down and re-feed of microcarrier bioreactor |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| CN101988047B (zh) * | 2010-05-13 | 2013-07-03 | 维亚生物科技(上海)有限公司 | 一种低成本的昆虫细胞无血清培养基 |
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| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| CN105154389A (zh) * | 2015-10-15 | 2015-12-16 | 南京三生生物技术有限公司 | 一种适于pk-15细胞生长的低血清无蛋白培养基及其制备方法 |
| CA3014435C (en) | 2016-02-19 | 2023-04-18 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza b virus replication for vaccine development |
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| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| KR20210090632A (ko) | 2018-11-15 | 2021-07-20 | 알레프 팜스 리미티드 | 고품질 배양육, 이를 생산하기 위한 조성물 및 방법 |
| JP7625519B2 (ja) * | 2018-11-21 | 2025-02-03 | カリヴィル イムノセラピューティクス， インコーポレイテッド | ウイルスの製造 |
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| US11241492B2 (en) | 2019-01-23 | 2022-02-08 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to genes in influenza viruses |
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| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| KR102817858B1 (ko) | 2019-12-24 | 2025-06-10 | 주식회사 엘지화학 | 베로 세포 배양용 저혈청 배지 조성물 및 이의 이용 |
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| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| WO2022103252A1 (en) * | 2020-11-12 | 2022-05-19 | Imu Education Sdn Bhd | Culture medium for bacteria |
| KR102581772B1 (ko) * | 2021-03-30 | 2023-09-22 | 강원대학교 산학협력단 | 식물 및 곤충 단백질 가수 분해물을 이용한 배양육 제조를 위한 최적 배양 방법 및 그 응용 |
| CN119300846A (zh) * | 2022-06-03 | 2025-01-10 | 蓝岩治疗有限公司 | 细胞递送媒介物及其使用方法 |
| WO2025113718A1 (zh) * | 2024-05-27 | 2025-06-05 | 安琪酵母股份有限公司 | 一种以蛋白水解物为核心原料的干细胞培养基制备及其应用方法 |
| CN119162122B (zh) * | 2024-09-14 | 2025-10-03 | 江苏华诺泰生物医药科技有限公司 | 一种流感病毒维持液配方及其制备方法和应用 |
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-
2003
- 2003-07-08 PT PT100105840T patent/PT2287288E/pt unknown
- 2003-07-08 CA CA 2491992 patent/CA2491992A1/en not_active Abandoned
- 2003-07-08 DK DK10010584T patent/DK2287288T3/da active
- 2003-07-08 PT PT03762657T patent/PT1520008E/pt unknown
- 2003-07-08 US US10/614,037 patent/US7955833B2/en not_active Expired - Lifetime
- 2003-07-08 MX MXPA05000418A patent/MXPA05000418A/es active IP Right Grant
- 2003-07-08 ES ES03762657T patent/ES2394085T3/es not_active Expired - Lifetime
- 2003-07-08 NZ NZ538094A patent/NZ538094A/en not_active IP Right Cessation
- 2003-07-08 AU AU2003249990A patent/AU2003249990B2/en not_active Expired
- 2003-07-08 JP JP2004518745A patent/JP2005532057A/ja not_active Withdrawn
- 2003-07-08 DK DK03762657T patent/DK1520008T3/da active
- 2003-07-08 SI SI200332208T patent/SI1520008T1/sl unknown
- 2003-07-08 WO PCT/EP2003/007341 patent/WO2004005493A1/en not_active Ceased
- 2003-07-08 EP EP20100010584 patent/EP2287288B1/en not_active Expired - Lifetime
- 2003-07-08 EP EP20030762657 patent/EP1520008B1/en not_active Expired - Lifetime
- 2003-07-08 CN CN03821326A patent/CN100591759C/zh not_active Expired - Lifetime
- 2003-07-08 CN CN2007101019058A patent/CN101058800B/zh not_active Expired - Lifetime
- 2003-07-08 PL PL374782A patent/PL214284B1/pl unknown
- 2003-07-08 ES ES10010584T patent/ES2398706T3/es not_active Expired - Lifetime
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2010
- 2010-11-29 JP JP2010265835A patent/JP5485863B2/ja not_active Expired - Lifetime
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2011
- 2011-05-06 US US13/102,765 patent/US8524497B2/en not_active Expired - Fee Related
- 2011-11-25 JP JP2011258106A patent/JP6084359B2/ja not_active Expired - Lifetime
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2013
- 2013-05-10 JP JP2013100500A patent/JP6178109B2/ja not_active Expired - Lifetime
- 2013-08-06 US US13/960,481 patent/US9163211B2/en not_active Expired - Lifetime
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2014
- 2014-12-03 JP JP2014245252A patent/JP6244294B2/ja not_active Expired - Lifetime
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