JP2005530744A5 - - Google Patents
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- Publication number
- JP2005530744A5 JP2005530744A5 JP2004500775A JP2004500775A JP2005530744A5 JP 2005530744 A5 JP2005530744 A5 JP 2005530744A5 JP 2004500775 A JP2004500775 A JP 2004500775A JP 2004500775 A JP2004500775 A JP 2004500775A JP 2005530744 A5 JP2005530744 A5 JP 2005530744A5
- Authority
- JP
- Japan
- Prior art keywords
- amiodarone
- sae
- formulation
- independently
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IYIKLHRQXLHMJQ-UHFFFAOYSA-N amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 claims 59
- 229960005260 amiodarone Drugs 0.000 claims 59
- 239000012669 liquid formulation Substances 0.000 claims 40
- 239000000203 mixture Substances 0.000 claims 34
- 239000007788 liquid Substances 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 22
- 238000009472 formulation Methods 0.000 claims 21
- 239000007787 solid Substances 0.000 claims 21
- 238000000034 method Methods 0.000 claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 150000001768 cations Chemical class 0.000 claims 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 10
- 239000000872 buffer Substances 0.000 claims 7
- 238000004108 freeze drying Methods 0.000 claims 7
- 238000001556 precipitation Methods 0.000 claims 6
- 235000020354 squash Nutrition 0.000 claims 6
- 229920000858 Cyclodextrin Polymers 0.000 claims 5
- 238000010438 heat treatment Methods 0.000 claims 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 5
- 125000004964 sulfoalkyl group Chemical group 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 3
- 239000002535 acidifier Substances 0.000 claims 3
- 239000003429 antifungal agent Substances 0.000 claims 3
- 229940121375 antifungal agent Drugs 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 3
- 239000004067 bulking agent Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000008121 dextrose Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003792 electrolyte Substances 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- -1 lyophilization aid Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 239000003381 stabilizer Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical group 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 239000012296 anti-solvent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 230000000536 complexating effect Effects 0.000 claims 2
- 238000010668 complexation reaction Methods 0.000 claims 2
- 239000003599 detergent Substances 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 239000000344 soap Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 238000000935 solvent evaporation Methods 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 238000001694 spray drying Methods 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 229940095602 acidifiers Drugs 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 150000004982 aromatic amines Chemical group 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 239000004327 boric acid Substances 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 150000002085 enols Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 150000003141 primary amines Chemical class 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium group Chemical group [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/139,620 | 2002-05-04 | ||
| US10/139,620 US6869939B2 (en) | 2002-05-04 | 2002-05-04 | Formulations containing amiodarone and sulfoalkyl ether cyclodextrin |
| PCT/US2003/013250 WO2003092590A2 (en) | 2002-05-04 | 2003-04-29 | Formulations containing amiodarone and sulfoalkyl ether cyclodextrin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011048873A Division JP5656692B2 (ja) | 2002-05-04 | 2011-03-07 | アミオダロンおよびスルホアルキルエーテルシクロデキストリンを含む製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005530744A JP2005530744A (ja) | 2005-10-13 |
| JP2005530744A5 true JP2005530744A5 (enExample) | 2006-06-15 |
| JP4764004B2 JP4764004B2 (ja) | 2011-08-31 |
Family
ID=29399340
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004500775A Expired - Lifetime JP4764004B2 (ja) | 2002-05-04 | 2003-04-29 | アミオダロンおよびスルホアルキルエーテルシクロデキストリンを含む製剤 |
| JP2011048873A Expired - Lifetime JP5656692B2 (ja) | 2002-05-04 | 2011-03-07 | アミオダロンおよびスルホアルキルエーテルシクロデキストリンを含む製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011048873A Expired - Lifetime JP5656692B2 (ja) | 2002-05-04 | 2011-03-07 | アミオダロンおよびスルホアルキルエーテルシクロデキストリンを含む製剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6869939B2 (enExample) |
| EP (2) | EP2402008B1 (enExample) |
| JP (2) | JP4764004B2 (enExample) |
| KR (1) | KR100984197B1 (enExample) |
| AT (1) | ATE535239T1 (enExample) |
| AU (1) | AU2003234285B2 (enExample) |
| CA (1) | CA2483774C (enExample) |
| CY (1) | CY1112527T1 (enExample) |
| DK (2) | DK2402008T3 (enExample) |
| ES (2) | ES2567716T3 (enExample) |
| HU (1) | HUE027551T2 (enExample) |
| IL (2) | IL165022A0 (enExample) |
| MX (1) | MXPA04010925A (enExample) |
| PT (1) | PT1501496E (enExample) |
| SI (2) | SI2402008T1 (enExample) |
| WO (1) | WO2003092590A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1713504T (pt) | 2004-01-30 | 2017-08-29 | Zoetis Services Llc | Conservantes antimicrobianos para obter uma formulação multidose utilizando beta-ciclodextrinas para formas galénicas líquidas |
| CN101098678A (zh) | 2004-04-23 | 2008-01-02 | 锡德克斯公司 | 含有磺基烷基醚环糊精的dpi制剂 |
| US8092559B2 (en) | 2004-05-12 | 2012-01-10 | Luca Technologies, Inc. | Generation of hydrogen from hydrocarbon bearing materials |
| US7426960B2 (en) | 2005-05-03 | 2008-09-23 | Luca Technologies, Inc. | Biogenic fuel gas generation in geologic hydrocarbon deposits |
| US20100204178A1 (en) | 2006-10-02 | 2010-08-12 | James Cloyd | Novel parenteral carbamazepine formulation |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| US7416879B2 (en) | 2006-01-11 | 2008-08-26 | Luca Technologies, Inc. | Thermacetogenium phaeum consortium for the production of materials with enhanced hydrogen content |
| BRPI0709409A2 (pt) | 2006-03-28 | 2011-07-12 | Javelin Pharmaceuticals Inc | composição farmacêutica e método para tratar um mamìfero necessitando de analgesia |
| EP2003970A4 (en) | 2006-03-28 | 2012-07-11 | Javelin Pharmaceuticals Inc | FORMULATIONS OF LOW-DOSEED NON-STEROID INFLAMMATORY INHIBITORS AND BETA-CYCLODEXTRIN |
| US7977282B2 (en) | 2006-04-05 | 2011-07-12 | Luca Technologies, Inc. | Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material |
| US7696132B2 (en) | 2006-04-05 | 2010-04-13 | Luca Technologies, Inc. | Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material |
| US20090239942A1 (en) | 2006-09-15 | 2009-09-24 | Cloyd James C | Topiramate Compositions and Methods of Making and Using the Same |
| PT2061458E (pt) * | 2006-09-15 | 2015-03-11 | Univ Minnesota | Composições de topiramato e métodos para a sua utilização |
| US20090270496A1 (en) * | 2007-05-03 | 2009-10-29 | Courchesne William E | Antifungal compounds |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| US8479813B2 (en) | 2009-12-16 | 2013-07-09 | Luca Technologies, Inc. | Biogenic fuel gas generation in geologic hydrocarbon deposits |
| EP2335686A1 (en) | 2009-12-21 | 2011-06-22 | LEK Pharmaceuticals d.d. | An aqueous intravenous nanosuspension with reduced adverse effects |
| NL2004260C2 (en) * | 2010-02-18 | 2011-08-22 | Univ Amsterdam | Disinfectant composition and its use in dental treatment. |
| AU2011264919A1 (en) * | 2010-06-11 | 2013-01-10 | Baxter Healthcare S.A. | Formulations including amiodarone and salts thereof and methods of their manufacture and use |
| EP2734212B1 (en) | 2011-07-20 | 2017-09-06 | Hospira, Inc. | Compositions comprising diclofenac for the treatment of post-operative pain |
| SG11201401597TA (en) | 2011-11-29 | 2014-05-29 | Jurox Pty Ltd | Methods of preserving injectable pharmaceutical compositions comprising a cyclodextrin and a hydrophobic drug |
| EP3415153A1 (en) * | 2012-01-30 | 2018-12-19 | Baxalta GmbH | Non-anticoagulant sulfated or sulfonated polysaccharides |
| PL3702374T3 (pl) | 2012-02-15 | 2022-11-21 | Cydex Pharmaceuticals, Inc. | Sposób wytwarzania pochodnych cyklodekstryny |
| WO2013130666A1 (en) | 2012-02-28 | 2013-09-06 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| US9004162B2 (en) | 2012-03-23 | 2015-04-14 | Transworld Technologies Inc. | Methods of stimulating acetoclastic methanogenesis in subterranean deposits of carbonaceous material |
| CA2887057A1 (en) * | 2012-10-17 | 2014-04-24 | Sapiotec Gmbh | Anthocyanidin complex for the treatment of multiple myeloma |
| UA121095C2 (uk) | 2012-10-22 | 2020-04-10 | Сідекс Фармасьютікалс, Інк. | Композиції алкілованого циклодекстрину і способи їх одержання і застосування |
| CN104870001B (zh) * | 2012-11-15 | 2019-01-18 | 赛博尔泰克股份公司 | 用作消炎或免疫抑制有效成分的飞燕草素络合物 |
| EP2773033B1 (en) | 2013-02-28 | 2018-12-05 | Dialog Semiconductor GmbH | Divide by 2 and 3 charge pump methods |
| GB201312737D0 (en) | 2013-07-17 | 2013-08-28 | Univ Greenwich | Cyclodextrin |
| EP3183295B1 (en) | 2014-08-22 | 2023-08-02 | CyDex Pharmaceuticals, Inc. | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
| US10736891B2 (en) * | 2016-01-07 | 2020-08-11 | Roy MADIGAN | Composition and method for treating chagas disease |
| US11166911B2 (en) * | 2016-03-04 | 2021-11-09 | Sun Pharmaceutical Industries Limited | Parenteral dosage form of amiodarone |
| CN107753439A (zh) * | 2016-08-22 | 2018-03-06 | 黑龙江迪龙制药有限公司 | 一种注射用盐酸胺碘酮及其制备方法 |
| CA3043979A1 (en) | 2016-11-18 | 2018-05-24 | Aicuris Anti-Infective Cures Gmbh | Novel formulations of amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and acidifying agents, their preparation and use as antimicrobial pharmaceutical compositions |
| US12416024B2 (en) | 2018-03-29 | 2025-09-16 | Transworld Technologies Inc. | Biologically enhanced oil recovery methods |
| WO2020232274A1 (en) * | 2019-05-15 | 2020-11-19 | Bexson Biomedical, Inc. | Ketamine formulation for subcutaneous injection |
| CA3149914A1 (en) | 2019-08-06 | 2021-02-11 | L.E.A.F. Holdings Group Llc | Processes of preparing polyglutamated antifolates and uses of their compositions |
| JP2023551145A (ja) | 2020-11-18 | 2023-12-07 | ベクソン バイオメディカル，インク． | 医薬化合物の錯化剤塩製剤 |
| CN115969833A (zh) * | 2023-01-03 | 2023-04-18 | 上海上药第一生化药业有限公司 | 胺碘酮药物组合物、注射液及其制备方法及含其的注射器 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991004026A1 (en) | 1989-09-14 | 1991-04-04 | Australian Commercial Research & Development Limited | Drug delivery compositions |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| EP0518930A4 (en) | 1990-03-02 | 1993-09-15 | Australian Commercial Research & Development Limited | Cyclodextrin compositions and methods for pharmaceutical and industrial applications |
| US5234949A (en) | 1992-04-01 | 1993-08-10 | Academic Pharmaceuticals, Inc. | Parenteral solutions containing amiodarone in acetate buffer solution |
| FR2735978B1 (fr) * | 1995-06-30 | 1997-09-19 | Sanofi Sa | Composition pharmaceutique d'amiodarone pour administration parenterale |
| UA57734C2 (uk) * | 1996-05-07 | 2003-07-15 | Пфайзер Інк. | Комплекси включення арилгетероциклічних солей |
| US5916883A (en) | 1996-11-01 | 1999-06-29 | Poly-Med, Inc. | Acylated cyclodextrin derivatives |
| US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
| US6046177A (en) | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| EE200100382A (et) | 1999-01-21 | 2002-12-16 | Bristol-Myers Squibb Company | Ras-farnesüültransferaasi inhibiitori ja sulfobutüüleeter-7-ß-tsüklodekstriini või 2-hüdroksüpropüül-ß-tsüklodekstriini kompleks ja selle valmistamise meetod |
| US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| GB9921958D0 (en) * | 1999-09-16 | 1999-11-17 | Pharmacia & Upjohn Spa | Formulations for parenteral use of estramustine phosphate and sulfoalkylether-cyclodextrins |
| US6479541B1 (en) * | 2000-03-30 | 2002-11-12 | Baxter International | Amiodarone-containing parenteral administration |
-
2002
- 2002-05-04 US US10/139,620 patent/US6869939B2/en not_active Expired - Lifetime
-
2003
- 2003-04-29 SI SI200332474A patent/SI2402008T1/sl unknown
- 2003-04-29 AU AU2003234285A patent/AU2003234285B2/en not_active Expired
- 2003-04-29 AT AT03728598T patent/ATE535239T1/de active
- 2003-04-29 EP EP11182697.0A patent/EP2402008B1/en not_active Expired - Lifetime
- 2003-04-29 WO PCT/US2003/013250 patent/WO2003092590A2/en not_active Ceased
- 2003-04-29 EP EP03728598A patent/EP1501496B1/en not_active Expired - Lifetime
- 2003-04-29 IL IL16502203A patent/IL165022A0/xx unknown
- 2003-04-29 HU HUE11182697A patent/HUE027551T2/en unknown
- 2003-04-29 CA CA2483774A patent/CA2483774C/en not_active Expired - Lifetime
- 2003-04-29 DK DK11182697.0T patent/DK2402008T3/en active
- 2003-04-29 PT PT03728598T patent/PT1501496E/pt unknown
- 2003-04-29 JP JP2004500775A patent/JP4764004B2/ja not_active Expired - Lifetime
- 2003-04-29 SI SI200332113T patent/SI1501496T1/sl unknown
- 2003-04-29 KR KR1020047017639A patent/KR100984197B1/ko not_active Expired - Lifetime
- 2003-04-29 DK DK03728598.8T patent/DK1501496T3/da active
- 2003-04-29 MX MXPA04010925A patent/MXPA04010925A/es active IP Right Grant
- 2003-04-29 ES ES11182697.0T patent/ES2567716T3/es not_active Expired - Lifetime
- 2003-04-29 ES ES03728598T patent/ES2378306T3/es not_active Expired - Lifetime
-
2004
- 2004-11-04 IL IL165022A patent/IL165022A/en active IP Right Grant
-
2011
- 2011-03-07 JP JP2011048873A patent/JP5656692B2/ja not_active Expired - Lifetime
-
2012
- 2012-02-23 CY CY20121100190T patent/CY1112527T1/el unknown
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