SI1501496T1 - Formulacije, ki vsebujejo amiodaron in sulfoalkil eter ciklodekstrin - Google Patents

Formulacije, ki vsebujejo amiodaron in sulfoalkil eter ciklodekstrin

Info

Publication number
SI1501496T1
SI1501496T1 SI200332113T SI200332113T SI1501496T1 SI 1501496 T1 SI1501496 T1 SI 1501496T1 SI 200332113 T SI200332113 T SI 200332113T SI 200332113 T SI200332113 T SI 200332113T SI 1501496 T1 SI1501496 T1 SI 1501496T1
Authority
SI
Slovenia
Prior art keywords
formulations containing
sulfoalkyl ether
ether cyclodextrin
containing amiodarone
amiodarone
Prior art date
Application number
SI200332113T
Other languages
English (en)
Slovenian (sl)
Inventor
Gerold L Mosher
Karen T Johnson
Atef A Gayed
Original Assignee
Cydex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cydex Pharmaceuticals Inc filed Critical Cydex Pharmaceuticals Inc
Publication of SI1501496T1 publication Critical patent/SI1501496T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/724Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0006Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
SI200332113T 2002-05-04 2003-04-29 Formulacije, ki vsebujejo amiodaron in sulfoalkil eter ciklodekstrin SI1501496T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/139,620 US6869939B2 (en) 2002-05-04 2002-05-04 Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
EP03728598A EP1501496B1 (en) 2002-05-04 2003-04-29 Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
PCT/US2003/013250 WO2003092590A2 (en) 2002-05-04 2003-04-29 Formulations containing amiodarone and sulfoalkyl ether cyclodextrin

Publications (1)

Publication Number Publication Date
SI1501496T1 true SI1501496T1 (sl) 2012-04-30

Family

ID=29399340

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200332113T SI1501496T1 (sl) 2002-05-04 2003-04-29 Formulacije, ki vsebujejo amiodaron in sulfoalkil eter ciklodekstrin
SI200332474A SI2402008T1 (sl) 2002-05-04 2003-04-29 Formulacije, ki vsebujejo amiodaron in sulfoalkil eter ciklodekstrin

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200332474A SI2402008T1 (sl) 2002-05-04 2003-04-29 Formulacije, ki vsebujejo amiodaron in sulfoalkil eter ciklodekstrin

Country Status (16)

Country Link
US (1) US6869939B2 (enExample)
EP (2) EP1501496B1 (enExample)
JP (2) JP4764004B2 (enExample)
KR (1) KR100984197B1 (enExample)
AT (1) ATE535239T1 (enExample)
AU (1) AU2003234285B2 (enExample)
CA (1) CA2483774C (enExample)
CY (1) CY1112527T1 (enExample)
DK (2) DK2402008T3 (enExample)
ES (2) ES2378306T3 (enExample)
HU (1) HUE027551T2 (enExample)
IL (2) IL165022A0 (enExample)
MX (1) MXPA04010925A (enExample)
PT (1) PT1501496E (enExample)
SI (2) SI1501496T1 (enExample)
WO (1) WO2003092590A2 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1713504B1 (en) 2004-01-30 2017-06-07 Zoetis Services LLC Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms
BRPI0510119A (pt) 2004-04-23 2007-09-25 Cydex Inc formulação para dpi contendo sulfoaquil éter de ciclodextrina
EP1766037B1 (en) 2004-05-12 2015-07-01 Transworld Technologies Limited Generation of hydrogen from hydrocarbon-bearing materials
US7426960B2 (en) 2005-05-03 2008-09-23 Luca Technologies, Inc. Biogenic fuel gas generation in geologic hydrocarbon deposits
US20100204178A1 (en) 2006-10-02 2010-08-12 James Cloyd Novel parenteral carbamazepine formulation
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US7416879B2 (en) 2006-01-11 2008-08-26 Luca Technologies, Inc. Thermacetogenium phaeum consortium for the production of materials with enhanced hydrogen content
KR20160033796A (ko) 2006-03-28 2016-03-28 자블린 파머슈티칼스 인코포레이티드 저 복용량의 디클로페낙 및 베타-사이클로덱스트린 제형
KR20090010953A (ko) * 2006-03-28 2009-01-30 자블린 파머슈티칼스 인코포레이티드 저 복용량의 비-스테로이드성 항염증성 약물 및 베타-사이클로덱스트린 제형
US7977282B2 (en) 2006-04-05 2011-07-12 Luca Technologies, Inc. Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material
US7696132B2 (en) 2006-04-05 2010-04-13 Luca Technologies, Inc. Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material
DK2061458T3 (en) * 2006-09-15 2015-03-09 Univ Minnesota Topiramate compositions and methods for their use
US20090239942A1 (en) * 2006-09-15 2009-09-24 Cloyd James C Topiramate Compositions and Methods of Making and Using the Same
US20090270496A1 (en) * 2007-05-03 2009-10-29 Courchesne William E Antifungal compounds
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
US8479813B2 (en) 2009-12-16 2013-07-09 Luca Technologies, Inc. Biogenic fuel gas generation in geologic hydrocarbon deposits
EP2335686A1 (en) 2009-12-21 2011-06-22 LEK Pharmaceuticals d.d. An aqueous intravenous nanosuspension with reduced adverse effects
NL2004260C2 (en) * 2010-02-18 2011-08-22 Univ Amsterdam Disinfectant composition and its use in dental treatment.
PH12012502454A1 (en) * 2010-06-11 2013-02-18 Baxter Healthcare Sa Formulations including amiodarone and salts thereof and methods of their manufacture and use
ES2646226T3 (es) 2011-07-20 2017-12-12 Hospira, Inc. Composiciones que comprenden diclofenaco para el tratamiento del dolor posoperatorio
CA2852716C (en) 2011-11-29 2015-11-17 Jurox Pty Ltd Methods of preserving injectable pharmaceutical compositions comprising a cyclodextrin and a hydrophobic drug
CA2861077A1 (en) * 2012-01-30 2013-08-08 Baxter International Inc. Non-anticoagulant sulfated or sulfonated polysaccharides
PT3702374T (pt) 2012-02-15 2022-06-23 Cydex Pharmaceuticals Inc Processo de fabrico para derivados de ciclodextrina
CN110066351B (zh) 2012-02-28 2022-06-14 锡德克斯药物公司 烷基化环糊精组合物及其制备和使用方法
US9004162B2 (en) 2012-03-23 2015-04-14 Transworld Technologies Inc. Methods of stimulating acetoclastic methanogenesis in subterranean deposits of carbonaceous material
JP2015534970A (ja) * 2012-10-17 2015-12-07 ザピオテック・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングSAPIOTEC GmbH 多発性骨髄腫の治療のためのアントシアニジン複合体
JP6557144B2 (ja) 2012-10-22 2019-08-07 サイデックス・ファーマシューティカルズ・インコーポレイテッド アルキル化シクロデキストリン組成物ならびにその調製方法および使用方法
WO2014075935A1 (de) * 2012-11-15 2014-05-22 Sapiotec Gmbh Delphinidinkomplex als antiphlogistischer oder immunsuppressiver wirkstoff
EP2773033B1 (en) 2013-02-28 2018-12-05 Dialog Semiconductor GmbH Divide by 2 and 3 charge pump methods
GB201312737D0 (en) 2013-07-17 2013-08-28 Univ Greenwich Cyclodextrin
FI3183295T3 (fi) 2014-08-22 2023-09-25 Cydex Pharmaceuticals Inc Fraktioidut alkyloidut syklodekstriinikoostumukset ja menetelmät niiden valmistamiseksi ja käyttämiseksi
US10736891B2 (en) 2016-01-07 2020-08-11 Roy MADIGAN Composition and method for treating chagas disease
WO2017149552A1 (en) * 2016-03-04 2017-09-08 Sun Pharmaceutical Industries Ltd. Parenteral dosage form of amiodarone
CN107753439A (zh) * 2016-08-22 2018-03-06 黑龙江迪龙制药有限公司 一种注射用盐酸胺碘酮及其制备方法
TW201828938A (zh) 2016-11-18 2018-08-16 德商艾庫里斯抗感染治療有限公司 以改質的環糊精及酸化劑為基底之經脒取代之β-內醯胺化合物的新穎調配物,其製備方法及作為抗微生物醫藥組合物之用途
US12416024B2 (en) 2018-03-29 2025-09-16 Transworld Technologies Inc. Biologically enhanced oil recovery methods
US10973780B2 (en) * 2019-05-15 2021-04-13 Bexson Biomedical, Inc. Ketamine formulation for subcutaneous injection
EP4010031A1 (en) 2019-08-06 2022-06-15 L.E.A.F Holdings Group LLC Processes of preparing polyglutamated antifolates and uses of their compositions
JP2023551145A (ja) 2020-11-18 2023-12-07 ベクソン バイオメディカル,インク. 医薬化合物の錯化剤塩製剤
CN115969833A (zh) * 2023-01-03 2023-04-18 上海上药第一生化药业有限公司 胺碘酮药物组合物、注射液及其制备方法及含其的注射器

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0491812A4 (en) 1989-09-14 1992-11-04 Australian Commercial Research & Development Limited Drug delivery compositions
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
EP0518930A4 (en) 1990-03-02 1993-09-15 Australian Commercial Research & Development Limited Cyclodextrin compositions and methods for pharmaceutical and industrial applications
US5234949A (en) 1992-04-01 1993-08-10 Academic Pharmaceuticals, Inc. Parenteral solutions containing amiodarone in acetate buffer solution
FR2735978B1 (fr) 1995-06-30 1997-09-19 Sanofi Sa Composition pharmaceutique d'amiodarone pour administration parenterale
UA57734C2 (uk) * 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
US5916883A (en) 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives
US6046177A (en) 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
TR200102109T2 (tr) 1999-01-21 2001-12-21 Bristol-Myers Squibb Company Ras-farnesiltransferazı inhibitörü ve sülfobütileter-7-ß-siklodekstrin veya 2-hidroksipropil-ß-siklodekstrin kompleksi ve metod.
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
GB9921958D0 (en) * 1999-09-16 1999-11-17 Pharmacia & Upjohn Spa Formulations for parenteral use of estramustine phosphate and sulfoalkylether-cyclodextrins
US6479541B1 (en) * 2000-03-30 2002-11-12 Baxter International Amiodarone-containing parenteral administration

Also Published As

Publication number Publication date
AU2003234285A1 (en) 2003-11-17
ATE535239T1 (de) 2011-12-15
US6869939B2 (en) 2005-03-22
EP1501496B1 (en) 2011-11-30
DK1501496T3 (da) 2012-03-19
EP2402008B1 (en) 2016-01-27
CY1112527T1 (el) 2015-12-09
HUE027551T2 (en) 2016-10-28
IL165022A (en) 2011-08-31
JP2005530744A (ja) 2005-10-13
CA2483774A1 (en) 2003-11-13
EP2402008A1 (en) 2012-01-04
DK2402008T3 (en) 2016-05-02
US20030216353A1 (en) 2003-11-20
KR20040106452A (ko) 2004-12-17
JP2011116776A (ja) 2011-06-16
EP1501496A4 (en) 2006-05-31
ES2378306T3 (es) 2012-04-11
SI2402008T1 (sl) 2016-05-31
WO2003092590A3 (en) 2004-01-22
WO2003092590A2 (en) 2003-11-13
PT1501496E (pt) 2012-02-20
IL165022A0 (en) 2005-12-18
ES2567716T3 (es) 2016-04-26
AU2003234285B2 (en) 2007-01-04
EP1501496A2 (en) 2005-02-02
JP5656692B2 (ja) 2015-01-21
CA2483774C (en) 2011-07-19
KR100984197B1 (ko) 2010-09-28
MXPA04010925A (es) 2005-02-14
JP4764004B2 (ja) 2011-08-31

Similar Documents

Publication Publication Date Title
IL165022A0 (en) Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
AU2002325856A1 (en) Agent containing fat (oil), which contains onion extract, the production and use thereof for caring, preventing or treating damaged skin tissue, especially scarred tissue
WO2003028802A3 (en) Devices for treating atrial fibrilation
EP1465492A4 (en) LIQUID COMPOSITION FOR PROMOTING PLANT GROWTH CONTAINING NANOPARTICULAR TITANIUM DIOXIDE
PL1643833T3 (pl) Formulacje agrochemiczne
IL164533A0 (en) Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds
MXPA05013232A (es) Composicion en forma de pulverizador que comprende un activo farmaceutico, al menos una silicona volatil y una fase aceitosa no volatil.
WO2001078702A3 (en) Methods and compositions for modulating alpha adrenergic receptor activity
IL216579A0 (en) Aminocyclohexyl ether derivatives and pharmaceutical compositions containing the same
WO2001015715A3 (en) Composition for maintenance of bone or dental health or treatment of bone or dental disorders
CY1107942T1 (el) Ψεκασιμη συνθεση για τη χορηγηση παραγωγων της βιταμινης d
WO2000066528A3 (en) Quinones for treatment of diseases
TW200510367A (en) Novel lapachone compounds, their preparation, and the use thereof
WO2001078703A3 (en) Methods and compositions for modulating alpha adrenergic receptor activity
AU9543601A (en) Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
WO2002039997A3 (en) Ace-2 modulating compounds and use thereof
PL350917A1 (en) C16 unsaturated fp-selective prostaglandins analogs
WO2004098522A3 (en) Gemini vitamin d3 compounds and methods of use thereof
TW200513264A (en) Remedy and a therapeutic method for periodontal diseases and pulpal diseases
IL150527A0 (en) Use of vitamin d-derivatives in the treatment of osteoporosis and related bone disorders, as well as novel vitamin d3-derivatives
PT1406859E (pt) Derivados substituídos de 4-aminociclo-hexanol
EP1574507A3 (en) Furo- and pyrano-naphthoquinones and their use in the treatment of cancer
AU2001235706A1 (en) Cosmetic or medicinal composition containing sesquiterpene lactone or the like for treating hair-growth related disorders, and preparation method
WO2004052331A3 (fr) Utilisation d'un extrait de miellat de coton comme ingredient acitif
AU2003210554A1 (en) Methods and compositions for treating urological disorders using 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 or 6351 mo