JP2005526494A5 - - Google Patents
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- JP2005526494A5 JP2005526494A5 JP2003560177A JP2003560177A JP2005526494A5 JP 2005526494 A5 JP2005526494 A5 JP 2005526494A5 JP 2003560177 A JP2003560177 A JP 2003560177A JP 2003560177 A JP2003560177 A JP 2003560177A JP 2005526494 A5 JP2005526494 A5 JP 2005526494A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 77
- 229920001184 polypeptide Polymers 0.000 claims 74
- 102000004196 processed proteins & peptides Human genes 0.000 claims 74
- 125000000539 amino acid group Chemical group 0.000 claims 45
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 43
- 238000000034 method Methods 0.000 claims 42
- 239000012472 biological sample Substances 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 235000001014 amino acid Nutrition 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 210000001519 tissue Anatomy 0.000 claims 16
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 15
- 206010061218 Inflammation Diseases 0.000 claims 13
- 230000004054 inflammatory process Effects 0.000 claims 13
- 241000124008 Mammalia Species 0.000 claims 12
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 244000052769 pathogen Species 0.000 claims 11
- 230000001717 pathogenic effect Effects 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 230000002757 inflammatory effect Effects 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 210000002798 bone marrow cell Anatomy 0.000 claims 8
- 210000004976 peripheral blood cell Anatomy 0.000 claims 8
- 210000004698 lymphocyte Anatomy 0.000 claims 7
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 6
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 6
- 108010002350 Interleukin-2 Proteins 0.000 claims 6
- 108010002386 Interleukin-3 Proteins 0.000 claims 6
- 108090000978 Interleukin-4 Proteins 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 6
- 125000006850 spacer group Chemical group 0.000 claims 6
- 238000013518 transcription Methods 0.000 claims 6
- 230000035897 transcription Effects 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 230000028709 inflammatory response Effects 0.000 claims 4
- 239000003053 toxin Substances 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 102000003675 cytokine receptors Human genes 0.000 claims 3
- 108010057085 cytokine receptors Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000003394 haemopoietic effect Effects 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 239000006249 magnetic particle Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 230000000638 stimulation Effects 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 239000003981 vehicle Substances 0.000 claims 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000024245 cell differentiation Effects 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000002853 nucleic acid probe Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000037487 Endotoxemia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010044248 Toxic shock syndrome Diseases 0.000 claims 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35032502P | 2002-01-18 | 2002-01-18 | |
| US60/350,325 | 2002-01-18 | ||
| US37532302P | 2002-04-25 | 2002-04-25 | |
| US60/375,323 | 2002-04-25 | ||
| US43531502P | 2002-12-19 | 2002-12-19 | |
| US60/435,315 | 2002-12-19 | ||
| PCT/US2003/001984 WO2003060090A2 (en) | 2002-01-18 | 2003-01-21 | Novel cytokine zcytor17 ligand |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526494A JP2005526494A (ja) | 2005-09-08 |
| JP2005526494A5 true JP2005526494A5 (https=) | 2006-03-02 |
| JP4795641B2 JP4795641B2 (ja) | 2011-10-19 |
Family
ID=27407940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003560177A Expired - Fee Related JP4795641B2 (ja) | 2002-01-18 | 2003-01-21 | 新規サイトカインｚｃｙｔｏｒ１７リガンド |
Country Status (21)
| Country | Link |
|---|---|
| US (12) | US7064186B2 (https=) |
| EP (3) | EP1476541B1 (https=) |
| JP (1) | JP4795641B2 (https=) |
| KR (1) | KR101013401B1 (https=) |
| CN (2) | CN101843895A (https=) |
| AT (3) | ATE478944T1 (https=) |
| AU (2) | AU2003225525B2 (https=) |
| BR (1) | BR0306979A (https=) |
| CA (1) | CA2473686C (https=) |
| CY (1) | CY1112833T1 (https=) |
| DE (2) | DE60333963D1 (https=) |
| DK (3) | DK1961811T3 (https=) |
| ES (3) | ES2310660T3 (https=) |
| IL (3) | IL163066A (https=) |
| NO (1) | NO332266B1 (https=) |
| PL (1) | PL211833B1 (https=) |
| PT (1) | PT2230299E (https=) |
| RU (2) | RU2360923C2 (https=) |
| SI (1) | SI2230299T1 (https=) |
| WO (1) | WO2003060090A2 (https=) |
| ZA (1) | ZA200405695B (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2325316B8 (en) | 1999-06-02 | 2017-04-19 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, NR10 |
| AU7445900A (en) | 1999-09-27 | 2001-04-30 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, nr12 |
| US20030096339A1 (en) * | 2000-06-26 | 2003-05-22 | Sprecher Cindy A. | Cytokine receptor zcytor17 |
| DK1961811T3 (da) | 2002-01-18 | 2010-11-08 | Zymogenetics Inc | Cytokinligand til behandling af asthma og luftvejs-hyper-responsivitet |
| US9738700B2 (en) | 2002-01-18 | 2017-08-22 | Zymogenetics Inc. | ZCYTOR17 heterodimeric cytokine receptor |
| EP2840089A1 (en) * | 2002-01-18 | 2015-02-25 | ZymoGenetics, Inc. | Cytokine receptor zcytor17 multimers |
| WO2005040380A1 (ja) * | 2003-10-29 | 2005-05-06 | Bml, Inc. | げっ歯類動物の免疫応答調節蛋白質 |
| JP2007068402A (ja) * | 2003-12-26 | 2007-03-22 | Bml Inc | 免疫応答調節蛋白質 |
| CA2580084A1 (en) * | 2004-11-03 | 2006-05-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | T cell proteins and nucleotides encoding the same |
| JP2008528039A (ja) * | 2005-01-28 | 2008-07-31 | ザイモジェネティクス，インコーポレイティド | Ｉｌ−３１の均質調製物 |
| EP1858924A1 (en) * | 2005-02-14 | 2007-11-28 | ZymoGenetics, Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| AU2012202218B2 (en) * | 2005-02-14 | 2014-05-22 | National Jewish Medical And Research Center | Methods Of Treating Diseases Which Are Mediated By Cutaneous Lymphocyte Antigen Positive Cells |
| WO2006088955A2 (en) * | 2005-02-14 | 2006-08-24 | Zymogenetics, Inc. | Methods of treating diseases which are mediated by cutaneous lymphocyte antigen positive cells |
| CA2604852A1 (en) * | 2005-04-15 | 2006-10-26 | Oncomethylome Sciences, S.A. | Methylation markers for diagnosis and treatment of cancers |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| KR101443050B1 (ko) * | 2005-05-06 | 2014-09-22 | 지모제넥틱스, 인코포레이티드 | Ｉｌ-31 단클론성 항체 및 사용법 |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| EP2749571A3 (en) | 2006-01-10 | 2014-08-13 | ZymoGenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using IL-31RA and OSMRb antagonists |
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| ES2429407T3 (es) | 2006-06-08 | 2013-11-14 | Chugai Seiyaku Kabushiki Kaisha | Agente preventivo o remedio para enfermedades inflamatorias |
| ES2548714T3 (es) * | 2006-09-01 | 2015-10-20 | Zymogenetics, Inc. | Anticuerpos monoclonales IL-31 y procedimientos de uso |
| US8278056B2 (en) | 2008-06-13 | 2012-10-02 | Oncohealth Corp. | Detection of early stages and late stages HPV infection |
| JP2010515755A (ja) | 2007-01-10 | 2010-05-13 | ザイモジェネティクス， インコーポレイテッド | 気道過敏および喘息を処置するためのｉｌ−３１の使用法 |
| KR101680906B1 (ko) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| ES2595638T3 (es) * | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| WO2009052487A2 (en) * | 2007-10-18 | 2009-04-23 | University Of South Florida | Method of detecting oncogenesis of hematopoietic cells |
| TW201634479A (zh) | 2007-12-05 | 2016-10-01 | 中外製藥股份有限公司 | 抗ｎｒ１０抗體及其應用 |
| CA2708065C (en) * | 2007-12-05 | 2015-02-24 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for pruritus |
| ME03057B (me) | 2007-12-07 | 2019-01-20 | Zymogenetics Inc | Molekuli humanizovanih antitela specifični za il-31 |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| JP5588970B2 (ja) | 2008-05-27 | 2014-09-10 | ダコ・デンマーク・エー／エス | ハイブリダイゼーション組成物及び方法 |
| US9303287B2 (en) | 2009-02-26 | 2016-04-05 | Dako Denmark A/S | Compositions and methods for RNA hybridization applications |
| JP2010210772A (ja) | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
| EP2826789A1 (en) | 2009-03-19 | 2015-01-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| US8892184B2 (en) | 2010-10-18 | 2014-11-18 | Siemens Medical Solutions Usa, Inc. | Systems and methods for reducing interference in a dual modality imaging system |
| EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| EP2742127B1 (en) * | 2011-08-12 | 2019-10-09 | Mello Biotechnology, Inc. | Inducable expression from the eukaryotic pol-2 promoter in prokaryotes |
| US10662465B2 (en) | 2011-09-30 | 2020-05-26 | Agilent Technologies, Inc. | Hybridization compositions and methods using formamide |
| US11118226B2 (en) | 2011-10-21 | 2021-09-14 | Agilent Technologies, Inc. | Hybridization compositions and methods |
| US10196662B2 (en) * | 2012-08-10 | 2019-02-05 | Mello Biotechnology, Inc. | Composition for producing microRNA precursors as drugs for enhancing wound healing and production method of the microRNA precursors |
| HUE056580T2 (hu) | 2013-05-30 | 2022-02-28 | Kiniksa Pharmaceuticals Ltd | Onkosztatin-M-receptor antigénjét kötõ fehérjék |
| US10464982B2 (en) | 2014-04-23 | 2019-11-05 | Emory University | Compositions of GM-CSF and interleukin fusions for immune modulation and uses related thereto |
| EP3142692B1 (en) * | 2014-05-12 | 2019-05-01 | Technion Research & Development Foundation Limited | Compositions comprising il-31 and uses thereof |
| JP5954916B1 (ja) | 2015-04-14 | 2016-07-20 | 中外製薬株式会社 | Ｉｌ−３１アンタゴニストを有効成分として含有する、アトピー性皮膚炎の予防用及び／又は治療用医薬組成物 |
| CN104826100A (zh) * | 2015-04-16 | 2015-08-12 | 浙江海隆生物科技有限公司 | 一种猪瘟病毒重组亚单位疫苗的制备方法与应用 |
| DE102015215840B4 (de) * | 2015-08-19 | 2017-03-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Multiaperturabbildungsvorrichtung, Abbildungssystem und Verfahren zum Bereitstellen einer Multiaperturabbildungsvorrichtung |
| US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
| MX2022005654A (es) | 2019-11-20 | 2022-06-22 | Chugai Pharmaceutical Co Ltd | Preparacion que contiene anticuerpo. |
| CN111337666B (zh) * | 2020-02-12 | 2021-04-02 | 山东大学 | I-motif重组介导的FRET探针及其原位成像癌细胞表面蛋白质同源二聚化的应用 |
| TWI765431B (zh) * | 2020-11-25 | 2022-05-21 | 長庚大學 | 核酸放大系統及其方法 |
| EP4367226B1 (en) * | 2021-07-07 | 2026-02-11 | Vib Vzw | Crystal structures of alk and ltk receptor tyrosine kinases and their ligands |
| US12509510B2 (en) | 2024-04-23 | 2025-12-30 | Attovia Therapeutics, Inc. | IL31-binding polypeptides and uses thereof |
| WO2026055142A1 (en) | 2024-09-03 | 2026-03-12 | Attovia Therapeutics, Inc. | Il13 and il31 bispecific polypeptides and uses thereof |
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