JP2005526153A - 水中において改善された安定性を持つ修飾糖 - Google Patents

水中において改善された安定性を持つ修飾糖 Download PDF

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Publication number
JP2005526153A
JP2005526153A JP2003578430A JP2003578430A JP2005526153A JP 2005526153 A JP2005526153 A JP 2005526153A JP 2003578430 A JP2003578430 A JP 2003578430A JP 2003578430 A JP2003578430 A JP 2003578430A JP 2005526153 A JP2005526153 A JP 2005526153A
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Prior art keywords
modified
capsular saccharide
group
saccharide
groups
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JP2003578430A
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Japanese (ja)
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JP2005526153A5 (enExample
Inventor
パオロ コスタンティーノ,
フランチェスコ ベルティ,
フランチェスコ ノレーリ,
アントネーラ バルトローニ,
Original Assignee
カイロン ソチエタ ア レスポンサビリタ リミタータ
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Priority claimed from GB0207117A external-priority patent/GB0207117D0/en
Priority claimed from GB0220195A external-priority patent/GB0220195D0/en
Priority claimed from GB0229494A external-priority patent/GB0229494D0/en
Priority claimed from GB0230163A external-priority patent/GB0230163D0/en
Application filed by カイロン ソチエタ ア レスポンサビリタ リミタータ filed Critical カイロン ソチエタ ア レスポンサビリタ リミタータ
Publication of JP2005526153A publication Critical patent/JP2005526153A/ja
Publication of JP2005526153A5 publication Critical patent/JP2005526153A5/ja
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2003578430A 2002-03-26 2003-03-26 水中において改善された安定性を持つ修飾糖 Ceased JP2005526153A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0207117A GB0207117D0 (en) 2002-03-26 2002-03-26 Modified saccharides having improved stability in water
GB0220195A GB0220195D0 (en) 2002-08-30 2002-08-30 Modified saccharides having improved stability in water
GB0229494A GB0229494D0 (en) 2002-12-18 2002-12-18 Modified saccharides having improved stability in water
GB0230163A GB0230163D0 (en) 2002-12-24 2002-12-24 Modified saccharides having improved stability in water
PCT/IB2003/001436 WO2003080678A1 (en) 2002-03-26 2003-03-26 Modified saccharides having improved stability in water

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010044780A Division JP5361767B2 (ja) 2002-03-26 2010-03-01 水中において改善された安定性を持つ修飾糖

Publications (2)

Publication Number Publication Date
JP2005526153A true JP2005526153A (ja) 2005-09-02
JP2005526153A5 JP2005526153A5 (enExample) 2010-04-15

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Family Applications (2)

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JP2003578430A Ceased JP2005526153A (ja) 2002-03-26 2003-03-26 水中において改善された安定性を持つ修飾糖
JP2010044780A Expired - Fee Related JP5361767B2 (ja) 2002-03-26 2010-03-01 水中において改善された安定性を持つ修飾糖

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010044780A Expired - Fee Related JP5361767B2 (ja) 2002-03-26 2010-03-01 水中において改善された安定性を持つ修飾糖

Country Status (14)

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EP (2) EP1490409B1 (enExample)
JP (2) JP2005526153A (enExample)
AT (1) ATE419278T1 (enExample)
BR (1) BR0308768A (enExample)
CA (1) CA2480389C (enExample)
CY (2) CY1108911T1 (enExample)
DE (1) DE60325565D1 (enExample)
DK (2) DK1490409T3 (enExample)
ES (2) ES2616180T3 (enExample)
HU (1) HUE030532T2 (enExample)
MX (1) MXPA04009339A (enExample)
NZ (1) NZ535968A (enExample)
PT (2) PT1777236T (enExample)
WO (1) WO2003080678A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515718A (ja) * 2007-01-11 2010-05-13 ノバルティス アーゲー 修飾糖類
JP2013237693A (ja) * 2009-06-22 2013-11-28 Wyeth Llc 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法

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GB0220198D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Modified saccharides,conjugates thereof and their manufacture
HUE031886T2 (en) 2002-10-11 2017-08-28 Glaxosmithkline Biologicals Sa Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines
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EP2172213B1 (en) 2003-01-30 2013-04-03 Novartis AG Injectable vaccines against multiple meningococcal serogroups
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
NZ546430A (en) 2003-10-02 2009-04-30 Novartis Vaccines & Diagnostic Liquid vaccines for multiple meningococcal serogroups
GB0406013D0 (en) 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
NZ550533A (en) 2004-04-30 2010-02-26 Novartis Vaccines & Diagnostic Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
GB0409745D0 (en) 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
BRPI0511442A (pt) * 2004-05-20 2007-12-26 Chiron Srl análise de eluatos por cromatografia lìquida
GB0411387D0 (en) 2004-05-21 2004-06-23 Chiron Srl Analysis of saccharide length
KR20070101207A (ko) * 2004-08-30 2007-10-16 사노피 파스퇴르 인크 다가 수막구균 유도체화된 다당류-단백질 접합체 및 백신
MX2007003292A (es) * 2004-09-21 2007-09-07 Sanofi Pasteur Inc Conjugados y vacuna con proteinas de polisacarido derivadas meningococales multivalentes.
MX2007013881A (es) * 2005-05-06 2008-10-22 Novartis Vaccines & Diagnostic Inmunogenos para vacunas de meningitides-a.
PE20110072A1 (es) * 2005-06-27 2011-02-04 Glaxosmithkline Biolog Sa Composicion inmunogenica
GB0513071D0 (en) * 2005-06-27 2005-08-03 Glaxosmithkline Biolog Sa Immunogenic composition
CA2620416A1 (en) * 2005-08-24 2007-03-01 Novartis Vaccines And Diagnostics S.R.L. Zwitterionization of capsular saccharides
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
GB0605757D0 (en) 2006-03-22 2006-05-03 Chiron Srl Separation of conjugated and unconjugated components
PL2004225T3 (pl) 2006-03-22 2012-09-28 Novartis Ag Schematy immunizacji koniugatami meningokokowymi
GB0612854D0 (en) 2006-06-28 2006-08-09 Novartis Ag Saccharide analysis
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
AU2014200640B2 (en) * 2007-01-11 2016-06-16 Glaxosmithkline Biologicals Sa Modified saccharides
ES2555786T3 (es) 2007-06-04 2016-01-08 Glaxosmithkline Biologicals Sa Formulación de vacunas contra la meningitis
GB0713880D0 (en) 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
BR122016015627A2 (pt) 2007-10-19 2018-10-30 Novartis Ag kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica
CN102356089B (zh) 2008-02-21 2014-02-19 诺华股份有限公司 脑膜炎球菌fHBP多肽
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WO2010070453A2 (en) 2008-12-17 2010-06-24 Novartis Ag Meningococcal vaccines including hemoglobin receptor
EP3017826A1 (en) 2009-03-24 2016-05-11 Novartis AG Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates
EP2411048B1 (en) 2009-03-24 2020-05-06 GlaxoSmithKline Biologicals SA Adjuvanting meningococcal factor h binding protein
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US10407703B2 (en) * 2014-04-17 2019-09-10 Medizinische Hochschule Hannover Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity
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Citations (3)

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JPH05505392A (ja) * 1989-12-14 1993-08-12 ナシヨナル・リサーチ・カウンシル・カナダ 修飾メニンゴコツクス多糖複合ワクチン
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515718A (ja) * 2007-01-11 2010-05-13 ノバルティス アーゲー 修飾糖類
JP2013237693A (ja) * 2009-06-22 2013-11-28 Wyeth Llc 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法
JP2016053051A (ja) * 2009-06-22 2016-04-14 ワイス・エルエルシー 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法
JP2017179378A (ja) * 2009-06-22 2017-10-05 ワイス・エルエルシー 組成物および黄色ブドウ球菌(Staphylococcus aureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法

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Publication number Publication date
NZ535968A (en) 2006-08-31
ATE419278T1 (de) 2009-01-15
JP2010132925A (ja) 2010-06-17
EP1777236A1 (en) 2007-04-25
EP1490409B1 (en) 2008-12-31
HUE030532T2 (en) 2017-05-29
DE60325565D1 (de) 2009-02-12
CY1108911T1 (el) 2014-07-02
EP1777236B1 (en) 2016-11-30
EP1490409A1 (en) 2004-12-29
CY1118584T1 (el) 2017-07-12
JP5361767B2 (ja) 2013-12-04
PT1777236T (pt) 2017-02-13
CA2480389C (en) 2012-10-09
DK1777236T3 (en) 2017-02-27
PT1490409E (pt) 2009-04-03
BR0308768A (pt) 2005-02-15
DK1490409T3 (da) 2009-03-23
CA2480389A1 (en) 2003-10-02
AU2003216633A1 (en) 2003-10-08
ES2616180T3 (es) 2017-06-09
WO2003080678A1 (en) 2003-10-02
MXPA04009339A (es) 2005-01-25
ES2318117T3 (es) 2009-05-01
EP1777236B8 (en) 2017-02-22

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