JP2005526153A - 水中において改善された安定性を持つ修飾糖 - Google Patents

水中において改善された安定性を持つ修飾糖 Download PDF

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Publication number
JP2005526153A
JP2005526153A JP2003578430A JP2003578430A JP2005526153A JP 2005526153 A JP2005526153 A JP 2005526153A JP 2003578430 A JP2003578430 A JP 2003578430A JP 2003578430 A JP2003578430 A JP 2003578430A JP 2005526153 A JP2005526153 A JP 2005526153A
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modified
capsular saccharide
group
saccharide
groups
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Japanese (ja)
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JP2005526153A5 (enExample
Inventor
パオロ コスタンティーノ,
フランチェスコ ベルティ,
フランチェスコ ノレーリ,
アントネーラ バルトローニ,
Original Assignee
カイロン ソチエタ ア レスポンサビリタ リミタータ
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Priority claimed from GB0207117A external-priority patent/GB0207117D0/en
Priority claimed from GB0220195A external-priority patent/GB0220195D0/en
Priority claimed from GB0229494A external-priority patent/GB0229494D0/en
Priority claimed from GB0230163A external-priority patent/GB0230163D0/en
Application filed by カイロン ソチエタ ア レスポンサビリタ リミタータ filed Critical カイロン ソチエタ ア レスポンサビリタ リミタータ
Publication of JP2005526153A publication Critical patent/JP2005526153A/ja
Publication of JP2005526153A5 publication Critical patent/JP2005526153A5/ja
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2003578430A 2002-03-26 2003-03-26 水中において改善された安定性を持つ修飾糖 Ceased JP2005526153A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0207117A GB0207117D0 (en) 2002-03-26 2002-03-26 Modified saccharides having improved stability in water
GB0220195A GB0220195D0 (en) 2002-08-30 2002-08-30 Modified saccharides having improved stability in water
GB0229494A GB0229494D0 (en) 2002-12-18 2002-12-18 Modified saccharides having improved stability in water
GB0230163A GB0230163D0 (en) 2002-12-24 2002-12-24 Modified saccharides having improved stability in water
PCT/IB2003/001436 WO2003080678A1 (en) 2002-03-26 2003-03-26 Modified saccharides having improved stability in water

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010044780A Division JP5361767B2 (ja) 2002-03-26 2010-03-01 水中において改善された安定性を持つ修飾糖

Publications (2)

Publication Number Publication Date
JP2005526153A true JP2005526153A (ja) 2005-09-02
JP2005526153A5 JP2005526153A5 (enExample) 2010-04-15

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Family Applications (2)

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JP2003578430A Ceased JP2005526153A (ja) 2002-03-26 2003-03-26 水中において改善された安定性を持つ修飾糖
JP2010044780A Expired - Fee Related JP5361767B2 (ja) 2002-03-26 2010-03-01 水中において改善された安定性を持つ修飾糖

Family Applications After (1)

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JP2010044780A Expired - Fee Related JP5361767B2 (ja) 2002-03-26 2010-03-01 水中において改善された安定性を持つ修飾糖

Country Status (14)

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EP (2) EP1490409B1 (enExample)
JP (2) JP2005526153A (enExample)
AT (1) ATE419278T1 (enExample)
BR (1) BR0308768A (enExample)
CA (1) CA2480389C (enExample)
CY (2) CY1108911T1 (enExample)
DE (1) DE60325565D1 (enExample)
DK (2) DK1490409T3 (enExample)
ES (2) ES2616180T3 (enExample)
HU (1) HUE030532T2 (enExample)
MX (1) MXPA04009339A (enExample)
NZ (1) NZ535968A (enExample)
PT (2) PT1490409E (enExample)
WO (1) WO2003080678A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515718A (ja) * 2007-01-11 2010-05-13 ノバルティス アーゲー 修飾糖類
JP2013237693A (ja) * 2009-06-22 2013-11-28 Wyeth Llc 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法

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EP2351579B1 (en) 2002-10-11 2016-09-21 Novartis Vaccines and Diagnostics S.r.l. Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages
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DK1587537T3 (da) 2003-01-30 2012-07-16 Novartis Ag Injicerbare vacciner mod multiple meningococ-serogrupper
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GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
GB0406013D0 (en) 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
GB0409745D0 (en) 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
RU2379052C2 (ru) 2004-04-30 2010-01-20 Чирон С.Р.Л. Вакцинация менингококковыми конъюгатами
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
WO2005114171A2 (en) * 2004-05-20 2005-12-01 Chiron Srl Analysis of liquid chromatography eluates
GB0411387D0 (en) 2004-05-21 2004-06-23 Chiron Srl Analysis of saccharide length
CA2577920A1 (en) * 2004-08-30 2006-03-09 Sanofi Pasteur, Inc. Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine
AU2005286798A1 (en) * 2004-09-21 2006-03-30 Sanofi Pasteur, Inc. Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine
PL1885734T3 (pl) * 2005-05-06 2015-08-31 Novartis Ag Immunogeny dla szczepionek przeciwko Meningitidis-A
GB0513071D0 (en) * 2005-06-27 2005-08-03 Glaxosmithkline Biolog Sa Immunogenic composition
HUE045482T2 (hu) * 2005-06-27 2019-12-30 Glaxosmithkline Biologicals Sa Immunogén készítmény
WO2007023386A2 (en) * 2005-08-24 2007-03-01 Novartis Vaccines And Diagnostics Srl Zwitterionization of capsular saccharides
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
NZ572054A (en) 2006-03-22 2011-12-22 Novartis Ag Regimens for immunisation with meningococcal conjugates
GB0605757D0 (en) 2006-03-22 2006-05-03 Chiron Srl Separation of conjugated and unconjugated components
GB0612854D0 (en) 2006-06-28 2006-08-09 Novartis Ag Saccharide analysis
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
AU2014200640B2 (en) * 2007-01-11 2016-06-16 Glaxosmithkline Biologicals Sa Modified saccharides
IN2009KN04098A (enExample) 2007-06-04 2015-08-28 Novartis Ag
GB0713880D0 (en) 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
HRP20120433T1 (en) 2007-10-19 2012-07-31 Novartis@Ag Meningococcal vaccine formulations
AU2009215364B2 (en) 2008-02-21 2014-09-18 Glaxosmithkline Biologicals S.A. Meningococcal fHBP polypeptides
GB0822633D0 (en) 2008-12-11 2009-01-21 Novartis Ag Formulation
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
AU2009329193A1 (en) 2008-12-17 2011-07-14 Novartis Ag Meningococcal vaccines including hemoglobin receptor
EP3017826A1 (en) 2009-03-24 2016-05-11 Novartis AG Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates
CN104548082A (zh) 2009-03-24 2015-04-29 诺华股份有限公司 为脑膜炎球菌因子h结合蛋白添加佐剂
AU2010264538B2 (en) 2009-06-22 2013-10-03 Wyeth Llc Immunogenic compositions of Staphylococcus aureus antigens
WO2011024072A2 (en) 2009-08-27 2011-03-03 Novartis Ag Hybrid polypeptides including meningococcal fhbp sequences
CN102724988B (zh) 2009-09-30 2014-09-10 诺华股份有限公司 脑膜炎球菌fHBP多肽的表达
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JP7104027B2 (ja) 2016-09-02 2022-07-20 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 淋菌に対するワクチン
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JPH05505392A (ja) * 1989-12-14 1993-08-12 ナシヨナル・リサーチ・カウンシル・カナダ 修飾メニンゴコツクス多糖複合ワクチン
JP2001519817A (ja) * 1997-03-26 2001-10-23 ブリガム アンド ウイメンズ ホスピタル 糖断片生成法
JP2001526902A (ja) * 1997-12-23 2001-12-25 ノース・アメリカン・ヴァクシン・インコーポレーテッド ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法

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JP2001519817A (ja) * 1997-03-26 2001-10-23 ブリガム アンド ウイメンズ ホスピタル 糖断片生成法
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515718A (ja) * 2007-01-11 2010-05-13 ノバルティス アーゲー 修飾糖類
JP2013237693A (ja) * 2009-06-22 2013-11-28 Wyeth Llc 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法
JP2016053051A (ja) * 2009-06-22 2016-04-14 ワイス・エルエルシー 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法
JP2017179378A (ja) * 2009-06-22 2017-10-05 ワイス・エルエルシー 組成物および黄色ブドウ球菌(Staphylococcus aureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法

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Publication number Publication date
CA2480389C (en) 2012-10-09
NZ535968A (en) 2006-08-31
EP1777236A1 (en) 2007-04-25
MXPA04009339A (es) 2005-01-25
PT1490409E (pt) 2009-04-03
EP1777236B8 (en) 2017-02-22
ES2616180T3 (es) 2017-06-09
HUE030532T2 (en) 2017-05-29
CA2480389A1 (en) 2003-10-02
JP5361767B2 (ja) 2013-12-04
EP1490409B1 (en) 2008-12-31
JP2010132925A (ja) 2010-06-17
WO2003080678A1 (en) 2003-10-02
EP1777236B1 (en) 2016-11-30
DK1490409T3 (da) 2009-03-23
BR0308768A (pt) 2005-02-15
EP1490409A1 (en) 2004-12-29
DK1777236T3 (en) 2017-02-27
CY1118584T1 (el) 2017-07-12
ATE419278T1 (de) 2009-01-15
ES2318117T3 (es) 2009-05-01
CY1108911T1 (el) 2014-07-02
DE60325565D1 (de) 2009-02-12
AU2003216633A1 (en) 2003-10-08
PT1777236T (pt) 2017-02-13

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