CY1108911T1 - Τροποποιημενοι σακχαριτες με βελτιωμενη σταθεροτητα στο νερο - Google Patents
Τροποποιημενοι σακχαριτες με βελτιωμενη σταθεροτητα στο νεροInfo
- Publication number
- CY1108911T1 CY1108911T1 CY20091100322T CY091100322T CY1108911T1 CY 1108911 T1 CY1108911 T1 CY 1108911T1 CY 20091100322 T CY20091100322 T CY 20091100322T CY 091100322 T CY091100322 T CY 091100322T CY 1108911 T1 CY1108911 T1 CY 1108911T1
- Authority
- CY
- Cyprus
- Prior art keywords
- improved water
- modified sugars
- water stability
- modified
- polysaccharide
- Prior art date
Links
- 150000008163 sugars Chemical class 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 150000004676 glycans Chemical class 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Polymers & Plastics (AREA)
- Immunology (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207117A GB0207117D0 (en) | 2002-03-26 | 2002-03-26 | Modified saccharides having improved stability in water |
| GB0220195A GB0220195D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides having improved stability in water |
| GB0229494A GB0229494D0 (en) | 2002-12-18 | 2002-12-18 | Modified saccharides having improved stability in water |
| GB0230163A GB0230163D0 (en) | 2002-12-24 | 2002-12-24 | Modified saccharides having improved stability in water |
| EP03712543A EP1490409B1 (en) | 2002-03-26 | 2003-03-26 | Modified saccharides having improved stability in water |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108911T1 true CY1108911T1 (el) | 2014-07-02 |
Family
ID=28457825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100322T CY1108911T1 (el) | 2002-03-26 | 2009-03-23 | Τροποποιημενοι σακχαριτες με βελτιωμενη σταθεροτητα στο νερο |
| CY20171100115T CY1118584T1 (el) | 2002-03-26 | 2017-01-25 | Τροποποιημενα σακχαριδια με βελτιωμενη σταθεροτητα σε υδωρ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100115T CY1118584T1 (el) | 2002-03-26 | 2017-01-25 | Τροποποιημενα σακχαριδια με βελτιωμενη σταθεροτητα σε υδωρ |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP1490409B1 (enExample) |
| JP (2) | JP2005526153A (enExample) |
| AT (1) | ATE419278T1 (enExample) |
| BR (1) | BR0308768A (enExample) |
| CA (1) | CA2480389C (enExample) |
| CY (2) | CY1108911T1 (enExample) |
| DE (1) | DE60325565D1 (enExample) |
| DK (2) | DK1490409T3 (enExample) |
| ES (2) | ES2616180T3 (enExample) |
| HU (1) | HUE030532T2 (enExample) |
| MX (1) | MXPA04009339A (enExample) |
| NZ (1) | NZ535968A (enExample) |
| PT (2) | PT1490409E (enExample) |
| WO (1) | WO2003080678A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| DE60328481D1 (de) | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| EP2351579B1 (en) | 2002-10-11 | 2016-09-21 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| DK1587537T3 (da) | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
| ES2397923T3 (es) | 2003-10-02 | 2013-03-12 | Novartis Ag | Vacunas líquidas para múltiples serogrupos meningocócicos |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| RU2379052C2 (ru) | 2004-04-30 | 2010-01-20 | Чирон С.Р.Л. | Вакцинация менингококковыми конъюгатами |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| WO2005114171A2 (en) * | 2004-05-20 | 2005-12-01 | Chiron Srl | Analysis of liquid chromatography eluates |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| CA2577920A1 (en) * | 2004-08-30 | 2006-03-09 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| AU2005286798A1 (en) * | 2004-09-21 | 2006-03-30 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| PL1885734T3 (pl) * | 2005-05-06 | 2015-08-31 | Novartis Ag | Immunogeny dla szczepionek przeciwko Meningitidis-A |
| GB0513071D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| HUE045482T2 (hu) * | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| WO2007023386A2 (en) * | 2005-08-24 | 2007-03-01 | Novartis Vaccines And Diagnostics Srl | Zwitterionization of capsular saccharides |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| NZ572054A (en) | 2006-03-22 | 2011-12-22 | Novartis Ag | Regimens for immunisation with meningococcal conjugates |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| IN2009KN04098A (enExample) | 2007-06-04 | 2015-08-28 | Novartis Ag | |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| HRP20120433T1 (en) | 2007-10-19 | 2012-07-31 | Novartis@Ag | Meningococcal vaccine formulations |
| AU2009215364B2 (en) | 2008-02-21 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Meningococcal fHBP polypeptides |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| EP3017826A1 (en) | 2009-03-24 | 2016-05-11 | Novartis AG | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| CN104548082A (zh) | 2009-03-24 | 2015-04-29 | 诺华股份有限公司 | 为脑膜炎球菌因子h结合蛋白添加佐剂 |
| AU2010264538B2 (en) | 2009-06-22 | 2013-10-03 | Wyeth Llc | Immunogenic compositions of Staphylococcus aureus antigens |
| WO2011041003A2 (en) * | 2009-06-22 | 2011-04-07 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| WO2011024072A2 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| WO2011161653A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| CA2808975C (en) | 2010-08-23 | 2018-10-30 | Wyeth Llc | Stable formulations of neisseria meningitidis rlp2086 antigens |
| EP2612148B1 (en) | 2010-09-04 | 2019-06-12 | GlaxoSmithKline Biologicals SA | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
| KR101584871B1 (ko) | 2010-09-10 | 2016-01-22 | 와이어쓰 엘엘씨 | 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체 |
| CN103533954B (zh) | 2011-03-02 | 2015-09-09 | 诺华股份有限公司 | 含较低剂量的抗原和/或佐剂的联合疫苗 |
| CN103764171B (zh) | 2011-07-08 | 2016-08-17 | 诺华股份有限公司 | 酪氨酸连接方法 |
| RU2636350C2 (ru) | 2011-11-07 | 2017-11-22 | Новартис Аг | МОЛЕКУЛА, СОДЕРЖАЩАЯ SPR0096 и SPR2021 |
| EP2797624A1 (en) | 2011-12-29 | 2014-11-05 | Novartis AG | Adjuvanted combinations of meningococcal factor h binding proteins |
| EP2822584A1 (en) | 2012-03-08 | 2015-01-14 | Novartis AG | Combination vaccines with tlr4 agonists |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CA2865745C (en) | 2012-03-09 | 2018-01-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| BR112015005056A2 (pt) | 2012-09-06 | 2017-11-21 | Novartis Ag | vacinas de combinação com sorogrupo b meningococcus e d/t/p |
| JP2016502994A (ja) | 2012-12-18 | 2016-02-01 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ジフテリア及び/又は破傷風から防御するためのコンジュゲート |
| GB201300707D0 (en) | 2013-01-15 | 2013-02-27 | Novartis Ag | Compounds and processes |
| CA2903716C (en) | 2013-03-08 | 2019-04-09 | Pfizer Inc. | Immunogenic fusion polypeptides |
| KR20160040556A (ko) | 2013-07-11 | 2016-04-14 | 노파르티스 아게 | 미생물 트랜스글루타미나제를 사용한 리신-특이적 화학효소적 단백질 변형 |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| CN106661092B (zh) | 2014-02-28 | 2021-07-06 | 葛兰素史密丝克莱恩生物有限公司 | 修饰的脑膜炎球菌fHbp多肽 |
| US10407703B2 (en) * | 2014-04-17 | 2019-09-10 | Medizinische Hochschule Hannover | Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity |
| KR20190049940A (ko) | 2015-02-19 | 2019-05-09 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
| JP7104027B2 (ja) | 2016-09-02 | 2022-07-20 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 淋菌に対するワクチン |
| CN109890413B (zh) | 2016-09-02 | 2024-04-16 | 赛诺菲巴斯德股份有限公司 | 脑膜炎奈瑟氏菌疫苗 |
| SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| CA3155669A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| GB202208089D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| GB202208093D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB733459A (en) * | 1952-05-21 | 1955-07-13 | Wander A G A | Process for preparing stimulating agents for clinical use from bacterial polysaccharides |
| DE2748132A1 (de) * | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| RO111416B1 (ro) * | 1989-12-14 | 1996-10-31 | Ca Nat Research Council | Polizaharide modificate de neisseria meningitidis si e coli, combinatii antigenice si metoda de imunizare |
| FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
| DE69708318T3 (de) * | 1996-08-27 | 2006-11-16 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung |
| JP2001519817A (ja) * | 1997-03-26 | 2001-10-23 | ブリガム アンド ウイメンズ ホスピタル | 糖断片生成法 |
| JP4435413B2 (ja) * | 1997-12-23 | 2010-03-17 | バクスター・ヘルスケヤー・ソシエテ・アノニム | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
-
2003
- 2003-03-26 ES ES06076853.8T patent/ES2616180T3/es not_active Expired - Lifetime
- 2003-03-26 BR BR0308768-9A patent/BR0308768A/pt not_active IP Right Cessation
- 2003-03-26 CA CA2480389A patent/CA2480389C/en not_active Expired - Fee Related
- 2003-03-26 MX MXPA04009339A patent/MXPA04009339A/es active IP Right Grant
- 2003-03-26 EP EP03712543A patent/EP1490409B1/en not_active Expired - Lifetime
- 2003-03-26 DK DK03712543T patent/DK1490409T3/da active
- 2003-03-26 EP EP06076853.8A patent/EP1777236B8/en not_active Expired - Lifetime
- 2003-03-26 PT PT03712543T patent/PT1490409E/pt unknown
- 2003-03-26 AT AT03712543T patent/ATE419278T1/de active
- 2003-03-26 PT PT60768538T patent/PT1777236T/pt unknown
- 2003-03-26 DK DK06076853.8T patent/DK1777236T3/en active
- 2003-03-26 WO PCT/IB2003/001436 patent/WO2003080678A1/en not_active Ceased
- 2003-03-26 NZ NZ535968A patent/NZ535968A/en not_active IP Right Cessation
- 2003-03-26 ES ES03712543T patent/ES2318117T3/es not_active Expired - Lifetime
- 2003-03-26 HU HUE06076853A patent/HUE030532T2/en unknown
- 2003-03-26 JP JP2003578430A patent/JP2005526153A/ja not_active Ceased
- 2003-03-26 DE DE60325565T patent/DE60325565D1/de not_active Expired - Lifetime
-
2009
- 2009-03-23 CY CY20091100322T patent/CY1108911T1/el unknown
-
2010
- 2010-03-01 JP JP2010044780A patent/JP5361767B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-25 CY CY20171100115T patent/CY1118584T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2480389C (en) | 2012-10-09 |
| JP2005526153A (ja) | 2005-09-02 |
| NZ535968A (en) | 2006-08-31 |
| EP1777236A1 (en) | 2007-04-25 |
| MXPA04009339A (es) | 2005-01-25 |
| PT1490409E (pt) | 2009-04-03 |
| EP1777236B8 (en) | 2017-02-22 |
| ES2616180T3 (es) | 2017-06-09 |
| HUE030532T2 (en) | 2017-05-29 |
| CA2480389A1 (en) | 2003-10-02 |
| JP5361767B2 (ja) | 2013-12-04 |
| EP1490409B1 (en) | 2008-12-31 |
| JP2010132925A (ja) | 2010-06-17 |
| WO2003080678A1 (en) | 2003-10-02 |
| EP1777236B1 (en) | 2016-11-30 |
| DK1490409T3 (da) | 2009-03-23 |
| BR0308768A (pt) | 2005-02-15 |
| EP1490409A1 (en) | 2004-12-29 |
| DK1777236T3 (en) | 2017-02-27 |
| CY1118584T1 (el) | 2017-07-12 |
| ATE419278T1 (de) | 2009-01-15 |
| ES2318117T3 (es) | 2009-05-01 |
| DE60325565D1 (de) | 2009-02-12 |
| AU2003216633A1 (en) | 2003-10-08 |
| PT1777236T (pt) | 2017-02-13 |
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