JP2005523946A5 - - Google Patents
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- JP2005523946A5 JP2005523946A5 JP2004519536A JP2004519536A JP2005523946A5 JP 2005523946 A5 JP2005523946 A5 JP 2005523946A5 JP 2004519536 A JP2004519536 A JP 2004519536A JP 2004519536 A JP2004519536 A JP 2004519536A JP 2005523946 A5 JP2005523946 A5 JP 2005523946A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- binding site
- tnfα
- human
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 54
- 102000036639 antigens Human genes 0.000 claims 54
- 108091007433 antigens Proteins 0.000 claims 54
- 125000003275 alpha amino acid group Chemical group 0.000 claims 32
- 201000010099 disease Diseases 0.000 claims 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 31
- 239000003814 drug Substances 0.000 claims 30
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 19
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 19
- 102000057041 human TNF Human genes 0.000 claims 19
- 238000006467 substitution reaction Methods 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 14
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 13
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 13
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 13
- 229960004194 lidocaine Drugs 0.000 claims 13
- 239000000126 substance Substances 0.000 claims 13
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 12
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 12
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 12
- 229910052791 calcium Inorganic materials 0.000 claims 12
- 239000011575 calcium Substances 0.000 claims 12
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 12
- 229960000590 celecoxib Drugs 0.000 claims 12
- 229960000304 folic acid Drugs 0.000 claims 12
- 235000019152 folic acid Nutrition 0.000 claims 12
- 239000011724 folic acid Substances 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- -1 multivitamins Chemical compound 0.000 claims 12
- 229960005489 paracetamol Drugs 0.000 claims 12
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims 12
- 229960000371 rofecoxib Drugs 0.000 claims 12
- 229960004380 tramadol Drugs 0.000 claims 12
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 12
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 12
- 229960005294 triamcinolone Drugs 0.000 claims 12
- 241000712461 unidentified influenza virus Species 0.000 claims 12
- 229940031348 multivalent vaccine Drugs 0.000 claims 11
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 11
- 208000023275 Autoimmune disease Diseases 0.000 claims 10
- 230000001627 detrimental effect Effects 0.000 claims 10
- 230000000694 effects Effects 0.000 claims 10
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 claims 9
- 230000003013 cytotoxicity Effects 0.000 claims 9
- 231100000135 cytotoxicity Toxicity 0.000 claims 9
- 239000002988 disease modifying antirheumatic drug Substances 0.000 claims 9
- 235000004279 alanine Nutrition 0.000 claims 8
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 238000003556 assay Methods 0.000 claims 7
- 238000000338 in vitro Methods 0.000 claims 7
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 102000004889 Interleukin-6 Human genes 0.000 claims 6
- 108090001005 Interleukin-6 Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000003929 folic acid group Chemical group 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 208000030507 AIDS Diseases 0.000 claims 4
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
- 206010006895 Cachexia Diseases 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 206010037660 Pyrexia Diseases 0.000 claims 4
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 4
- 206010040047 Sepsis Diseases 0.000 claims 4
- 206010040070 Septic Shock Diseases 0.000 claims 4
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 238000010494 dissociation reaction Methods 0.000 claims 4
- 230000005593 dissociations Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 208000019622 heart disease Diseases 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 229940100601 interleukin-6 Drugs 0.000 claims 4
- 201000004792 malaria Diseases 0.000 claims 4
- 208000023504 respiratory system disease Diseases 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 230000004614 tumor growth Effects 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 238000002648 combination therapy Methods 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 2
- 208000003322 Coinfection Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 206010018634 Gouty Arthritis Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 206010019728 Hepatitis alcoholic Diseases 0.000 claims 2
- 206010019799 Hepatitis viral Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 208000001940 Massive Hepatic Necrosis Diseases 0.000 claims 2
- 201000009906 Meningitis Diseases 0.000 claims 2
- 206010027202 Meningitis bacterial Diseases 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 208000000112 Myalgia Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000019155 Radiation injury Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 201000010001 Silicosis Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000002353 alcoholic hepatitis Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- 201000004982 autoimmune uveitis Diseases 0.000 claims 2
- 201000009904 bacterial meningitis Diseases 0.000 claims 2
- 208000015294 blood coagulation disease Diseases 0.000 claims 2
- 208000019664 bone resorption disease Diseases 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 2
- 229940076085 gold Drugs 0.000 claims 2
- 239000010931 gold Substances 0.000 claims 2
- 229910052737 gold Inorganic materials 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 208000011379 keloid formation Diseases 0.000 claims 2
- 230000036210 malignancy Effects 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 208000028169 periodontal disease Diseases 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
- 201000003651 pulmonary sarcoidosis Diseases 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 230000036303 septic shock Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 230000009772 tissue formation Effects 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 201000001862 viral hepatitis Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims 1
- 229960004171 hydroxychloroquine Drugs 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 1
- 229960000681 leflunomide Drugs 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims 1
- 229960001940 sulfasalazine Drugs 0.000 claims 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/133,715 US20030206898A1 (en) | 2002-04-26 | 2002-04-26 | Use of anti-TNFalpha antibodies and another drug |
| PCT/US2003/012976 WO2004004633A2 (en) | 2002-04-26 | 2003-04-24 | Use of tnfalpha antibodies and another drug |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010118647A Division JP2010248199A (ja) | 2002-04-26 | 2010-05-24 | ＴＮＦα抗体および他の薬剤の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005523946A JP2005523946A (ja) | 2005-08-11 |
| JP2005523946A5 true JP2005523946A5 (https=) | 2006-12-07 |
Family
ID=29268783
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004519536A Withdrawn JP2005523946A (ja) | 2002-04-26 | 2003-04-24 | ＴＮＦα抗体および他の薬剤の使用 |
| JP2010118647A Pending JP2010248199A (ja) | 2002-04-26 | 2010-05-24 | ＴＮＦα抗体および他の薬剤の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010118647A Pending JP2010248199A (ja) | 2002-04-26 | 2010-05-24 | ＴＮＦα抗体および他の薬剤の使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20030206898A1 (https=) |
| EP (3) | EP2196218A3 (https=) |
| JP (2) | JP2005523946A (https=) |
| KR (1) | KR20100106631A (https=) |
| CN (3) | CN101890163A (https=) |
| AR (2) | AR039656A1 (https=) |
| AU (2) | AU2003278692B2 (https=) |
| BR (1) | BR0306444A (https=) |
| CA (1) | CA2385777A1 (https=) |
| IL (2) | IL164759A0 (https=) |
| MX (1) | MXPA04010498A (https=) |
| NZ (1) | NZ560793A (https=) |
| PE (1) | PE20040474A1 (https=) |
| PL (1) | PL373333A1 (https=) |
| TW (2) | TWI353851B (https=) |
| UY (1) | UY27780A1 (https=) |
| WO (1) | WO2004004633A2 (https=) |
| ZA (1) | ZA200408509B (https=) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| DK0929578T3 (da) * | 1996-02-09 | 2003-08-25 | Abbott Lab Bermuda Ltd | Humane antistoffer, der binder human TNFalfa |
| US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
| US20040219142A1 (en) * | 2002-07-19 | 2004-11-04 | Abbott Laboratories S.A. | Treatment of skin and nail disorders using TNFalpha inhibitors |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| TWI439284B (zh) | 2004-04-09 | 2014-06-01 | 艾伯維生物技術有限責任公司 | 用於治療ＴＮＦα相關失調症之多重可變劑量療法 |
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| PL1799230T3 (pl) * | 2004-08-27 | 2013-05-31 | Cyclacel Ltd | Purynowe i pirymidynowe inhibitory CDK i ich zastosowanie do leczenia chorób autoimmunologicznych |
| US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
| CN102961746B (zh) | 2005-05-16 | 2016-06-15 | 艾伯维生物技术有限公司 | TNFα抑制剂治疗腐蚀性多关节炎的用途 |
| MX2007015476A (es) | 2005-06-14 | 2008-02-25 | Amgen Inc | Formulaciones de proteina autoamortiguadoras. |
| NZ567286A (en) * | 2005-11-01 | 2012-03-30 | Abbott Biotechnolgy Ltd | Methods and compositions for diagnosing ankylosing spondylitis using biomarkers |
| KR20140071452A (ko) * | 2006-04-05 | 2014-06-11 | 애브비 바이오테크놀로지 리미티드 | 항체 정제 |
| US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
| US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| EP2012586A4 (en) | 2006-04-10 | 2010-08-18 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF ANKYLOSANTE SPONDYLARTHRITIS |
| EP2007426A4 (en) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | COMPOSITIONS FOR THE TREATMENT OF PSORIASTIC POLYARTHRITIS AND THEIR APPLICATIONS |
| US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
| US20100021451A1 (en) | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
| KR101396797B1 (ko) | 2006-06-30 | 2014-05-26 | 애브비 바이오테크놀로지 리미티드 | 자동 주사 장치 |
| WO2008057240A2 (en) * | 2006-10-27 | 2008-05-15 | Abbott Biotechnology Ltd. | Crystalline anti-htnfalpha antibodies |
| EP2679996A1 (en) * | 2007-05-31 | 2014-01-01 | AbbVie Inc. | Biomarkers predictive of the responsiveness to TNF-alfa inhibitors in autoimmune disorders |
| WO2008150490A2 (en) * | 2007-06-01 | 2008-12-11 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of psoriasis and crohn's disease |
| EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
| US20090110679A1 (en) * | 2007-07-13 | 2009-04-30 | Luk-Chiu Li | Methods and compositions for pulmonary administration of a TNFa inhibitor |
| EP2185201A4 (en) | 2007-08-08 | 2011-11-30 | Abbott Lab | COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODIES |
| TWI543768B (zh) | 2007-11-30 | 2016-08-01 | 艾伯維生物技術有限責任公司 | 蛋白質調配物及製造其之方法 |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| EP3524619A1 (en) | 2007-12-06 | 2019-08-14 | Dana-Farber Cancer Institute, Inc. | Antibodies against influenza virus and methods of use thereof |
| US20090271164A1 (en) * | 2008-01-03 | 2009-10-29 | Peng Joanna Z | Predicting long-term efficacy of a compound in the treatment of psoriasis |
| WO2009090189A1 (en) | 2008-01-15 | 2009-07-23 | Abbott Gmbh & Co.Kg | Powdered protein compositions and methods of making same |
| BRPI0910482A2 (pt) | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
| PE20100092A1 (es) | 2008-06-03 | 2010-03-12 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
| BRPI0913366A8 (pt) | 2008-06-03 | 2017-07-11 | Abbott Lab | Imunoglobulinas de domínio variável duplo e seus usos |
| NZ603698A (en) | 2008-07-08 | 2014-03-28 | Abbvie Inc | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
| US20100016265A1 (en) * | 2008-07-16 | 2010-01-21 | Qaiser Yusuf | Anti-inflammatory composition and method for preparation |
| US8722860B2 (en) | 2009-04-16 | 2014-05-13 | Abbvie Biotherapeutics Inc. | Anti-TNF-α antibodies and their uses |
| KR101721906B1 (ko) | 2009-04-29 | 2017-03-31 | 애브비 바이오테크놀로지 리미티드 | 자동 주입 장치 |
| KR20120060877A (ko) * | 2009-09-01 | 2012-06-12 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| AU2010306677B2 (en) * | 2009-10-15 | 2013-05-23 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| NZ627052A (en) | 2009-12-15 | 2015-12-24 | Abbvie Biotechnology Ltd | Improved firing button for automatic injection device |
| WO2011127141A1 (en) * | 2010-04-07 | 2011-10-13 | Abbott Laboratories | TNF-α BINDING PROTEINS |
| HRP20181598T1 (hr) | 2010-06-03 | 2018-11-30 | Abbvie Biotechnology Ltd | Uporaba i pripravci za liječenje hidradenitis suppurativa (hs) |
| US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| PE20140229A1 (es) | 2010-08-26 | 2014-03-27 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
| SG190069A1 (en) | 2010-11-11 | 2013-06-28 | Abbvie Biotechnology Ltd | IMPROVED HIGH CONCENTRATION ANTI-TNFa ANTIBODY LIQUID FORMULATIONS |
| MX360402B (es) | 2011-01-24 | 2018-10-31 | Abbvie Biotechnology Ltd | Dispositivos de inyeccion automaticos que tienen superficies de agarre sobremoldeadas. |
| CN102675460B (zh) * | 2011-02-28 | 2015-08-19 | 珠海市丽珠单抗生物技术有限公司 | 抗肿瘤坏死因子α的人源化抗体 |
| WO2012121403A1 (en) * | 2011-03-07 | 2012-09-13 | The University Of Tokushima | The method of treating amyotrophic lateral sclerosis |
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- 2003-04-24 AU AU2003278692A patent/AU2003278692B2/en not_active Ceased
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- 2003-04-24 CN CN2010101480474A patent/CN101890163A/zh active Pending
- 2003-04-24 KR KR1020107021349A patent/KR20100106631A/ko not_active Ceased
- 2003-04-24 MX MXPA04010498A patent/MXPA04010498A/es unknown
- 2003-04-24 EP EP03762970A patent/EP1501545A4/en not_active Withdrawn
- 2003-04-24 BR BR0306444-1A patent/BR0306444A/pt not_active IP Right Cessation
- 2003-04-24 CN CNA2007101692298A patent/CN101229371A/zh active Pending
- 2003-04-24 AR ARP030101417A patent/AR039656A1/es not_active Application Discontinuation
- 2003-04-24 WO PCT/US2003/012976 patent/WO2004004633A2/en not_active Ceased
- 2003-04-24 CN CNA038094371A patent/CN1649624A/zh active Pending
- 2003-04-25 TW TW092109743A patent/TWI353851B/zh not_active IP Right Cessation
- 2003-04-25 PE PE2003000417A patent/PE20040474A1/es not_active Application Discontinuation
- 2003-04-25 UY UY27780A patent/UY27780A1/es not_active Application Discontinuation
- 2003-04-25 TW TW100124823A patent/TW201138826A/zh unknown
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- 2004-10-21 IL IL16475904A patent/IL164759A0/xx unknown
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