JP2005523698A - インフルエンザウイルスの生産用多重プラスミドシステム - Google Patents

インフルエンザウイルスの生産用多重プラスミドシステム Download PDF

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JP2005523698A
JP2005523698A JP2003587937A JP2003587937A JP2005523698A JP 2005523698 A JP2005523698 A JP 2005523698A JP 2003587937 A JP2003587937 A JP 2003587937A JP 2003587937 A JP2003587937 A JP 2003587937A JP 2005523698 A JP2005523698 A JP 2005523698A
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influenza
virus
amino acid
cells
group
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JP2005523698A5 (fr
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エリッヒ・ホフマン
ホン・ジン
ビン・ルー
グレッグ・デューク
ジョージ・ウィリアム・ケンブル
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メディミューン・ヴァクシンズ・インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16162—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16241—Use of virus, viral particle or viral elements as a vector
    • C12N2760/16243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16261—Methods of inactivation or attenuation
    • C12N2760/16262—Methods of inactivation or attenuation by genetic engineering
JP2003587937A 2002-04-26 2003-04-25 インフルエンザウイルスの生産用多重プラスミドシステム Withdrawn JP2005523698A (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US37567502P 2002-04-26 2002-04-26
US39498302P 2002-07-09 2002-07-09
US41057602P 2002-09-12 2002-09-12
US41980202P 2002-10-18 2002-10-18
US42070802P 2002-10-23 2002-10-23
US45769903P 2003-03-24 2003-03-24
US46236103P 2003-04-10 2003-04-10
PCT/US2003/012728 WO2003091401A2 (fr) 2002-04-26 2003-04-25 Systeme multiplasmide de production de virus influenza

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JP2011103852A Division JP5303603B2 (ja) 2002-04-26 2011-05-06 インフルエンザウイルスの生産用多重プラスミドシステム

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JP2005523698A true JP2005523698A (ja) 2005-08-11
JP2005523698A5 JP2005523698A5 (fr) 2006-06-01

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JP2003587937A Withdrawn JP2005523698A (ja) 2002-04-26 2003-04-25 インフルエンザウイルスの生産用多重プラスミドシステム
JP2011103852A Expired - Lifetime JP5303603B2 (ja) 2002-04-26 2011-05-06 インフルエンザウイルスの生産用多重プラスミドシステム
JP2013089445A Pending JP2013179943A (ja) 2002-04-26 2013-04-22 インフルエンザウイルスの生産用多重プラスミドシステム
JP2013131951A Pending JP2013230156A (ja) 2002-04-26 2013-06-24 インフルエンザウイルスの生産用多重プラスミドシステム

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JP2013089445A Pending JP2013179943A (ja) 2002-04-26 2013-04-22 インフルエンザウイルスの生産用多重プラスミドシステム
JP2013131951A Pending JP2013230156A (ja) 2002-04-26 2013-06-24 インフルエンザウイルスの生産用多重プラスミドシステム

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US (3) US8012736B2 (fr)
EP (2) EP2497826A1 (fr)
JP (4) JP2005523698A (fr)
KR (2) KR101169468B1 (fr)
CN (4) CN1678345B (fr)
AR (2) AR039465A1 (fr)
AU (2) AU2003231083A1 (fr)
CA (1) CA2482946C (fr)
DK (1) DK1499348T3 (fr)
ES (1) ES2526191T3 (fr)
HK (1) HK1082422A1 (fr)
TW (2) TWI347363B (fr)
WO (1) WO2003091401A2 (fr)

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JP2009532352A (ja) * 2006-03-31 2009-09-10 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション ワクチンのための高力価組み換えインフルエンザ・ウィルス
JP2009534039A (ja) * 2006-04-19 2009-09-24 メディミューン，エルエルシー イヌ細胞中でマイナス鎖ウイルスｒｎａを発現させるための方法および組成物
US8278433B2 (en) 2005-06-21 2012-10-02 Medimmune, Llc Methods and compositions for expressing negative-sense viral RNA in canine cells
JP2013507952A (ja) * 2009-10-20 2013-03-07 ノバルティス アーゲー ウイルスレスキューのための改善された逆遺伝学
JP2016185988A (ja) * 2005-11-01 2016-10-27 ノバルティス アーゲー β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
US10119124B2 (en) 2007-06-18 2018-11-06 Wisconsin Alumni Research Foundation (Warf) Influenza M2 protein mutant viruses as live influenza attenuated vaccines
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
US10808229B2 (en) 2009-10-26 2020-10-20 Wisconsin Alumni Research Foundation (“WARF”) High titer recombinant influenza viruses with enhanced replication in vero cells
US11197925B2 (en) 2016-02-19 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Influenza B virus replication for vaccine development
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
US11851648B2 (en) 2019-02-08 2023-12-26 Wisconsin Alumni Research Foundation (Warf) Humanized cell line

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KR101169468B1 (ko) 2002-04-26 2012-08-01 메디뮨 엘엘씨 인플루엔자 바이러스의 생산을 위한 다중 플라스미드시스템
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
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KR101190932B1 (ko) 2003-02-25 2012-10-16 메디뮨 엘엘씨 인플루엔자 백신 조성물의 제조 방법
KR20060026854A (ko) * 2003-05-28 2006-03-24 위스콘신 얼럼나이 리서어치 화운데이션 ＰｏｌⅡ 프로모터 및 리보자임을 갖는 재조합 인플루엔자벡터
WO2005018539A2 (fr) * 2003-06-16 2005-03-03 Medimmune Vaccines, Inc. Hemagglutinine du virus de la grippe et variantes de la neuraminidase
CA2551489C (fr) 2003-12-23 2013-09-03 Gregory Duke Systeme a plasmides multiples pour la production du virus de la grippe
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EP1797189A4 (fr) * 2004-09-02 2010-05-19 Qun Chen Systeme d'encapsidation pour la production de particules de types virus de recombinaison
ES2386272T3 (es) * 2004-09-09 2012-08-16 Novartis Vaccines And Diagnostics Gmbh Reducción de riesgos iatrogénicos potenciales asociados a las vacunas antigripales
NZ555118A (en) 2004-11-11 2009-09-25 Solvay Biologicals Bv Defective influenza virus particles incapable of producing functional polymerase
KR20070086344A (ko) 2004-11-19 2007-08-27 위스콘신 얼럼나이 리서어치 화운데이션 탠덤 전사 유닛을 갖는 재조합 인플루엔자 벡터
EP2573186A1 (fr) 2004-12-08 2013-03-27 MedImmune, LLC Procédés de production de compositions de vaccin contre la grippe
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BRPI0518568A2 (pt) * 2004-12-24 2008-11-25 Solvay Pharm Bv mÉtodo para produzir uma partÍcula do vÍrus da influenza replicativo sem o uso de vÍrus auxiliar, partÍcula de vÍrus da influenza replicativo, cÉlula, composiÇço, uso de uma composiÇço, mÉtodo para gerar proteÇço imunolàgica contra infecÇço de um indivÍduo com um vÍrus da influenza, e, Ácido nuclÉico
EP1856271A4 (fr) 2005-03-08 2009-11-18 Medimmune Vaccines Inc Variants d'hemagglutinine et de neuraminidase du virus influenza
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JP5349049B2 (ja) 2005-10-17 2013-11-20 メディミューン，エルエルシー インフルエンザウイルス製造用マルチプラスミド系
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EP2615167A1 (fr) 2006-09-15 2013-07-17 MedImmune, LLC Méthode d'élimination de contaminants d'ADN des préparations de virus
CA2690196A1 (fr) * 2007-06-18 2008-12-24 Medimmune, Llc Virus b de la grippe presentant des modifications du polypeptide de l'hemagglutinine
EP2045323A1 (fr) * 2007-10-05 2009-04-08 Avir Green Hills Biotechnology Research Development Trade Ag Constructions linéaires d'expression pour la production de particules de virus influenza
AU2008331673B2 (en) * 2007-11-12 2014-12-11 The Trustees Of The University Of Pennsylvania Novel vaccines against multiple subtypes of influenza virus
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