JP2005521676A5 - - Google Patents
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- Publication number
- JP2005521676A5 JP2005521676A5 JP2003565474A JP2003565474A JP2005521676A5 JP 2005521676 A5 JP2005521676 A5 JP 2005521676A5 JP 2003565474 A JP2003565474 A JP 2003565474A JP 2003565474 A JP2003565474 A JP 2003565474A JP 2005521676 A5 JP2005521676 A5 JP 2005521676A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- cycloalkyl
- aryl
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 85
- 125000000217 alkyl group Chemical group 0.000 claims 53
- 125000000753 cycloalkyl group Chemical group 0.000 claims 51
- 125000003118 aryl group Chemical group 0.000 claims 30
- -1 NR c R d Chemical group 0.000 claims 29
- 125000004423 acyloxy group Chemical group 0.000 claims 19
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 19
- 125000001589 carboacyl group Chemical group 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000005843 halogen group Chemical group 0.000 claims 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000005505 thiomorpholino group Chemical group 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 4
- 125000001401 1,2,4-triazol-4-yl group Chemical group N=1N=C([H])N([*])C=1[H] 0.000 claims 3
- 102000003840 Opioid Receptors Human genes 0.000 claims 3
- 108090000137 Opioid Receptors Proteins 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- LFWAVNRDCVJWNS-UHFFFAOYSA-N 3-(3-tert-butylphenyl)-4-(3-methoxyphenyl)-1,2,4-triazole Chemical compound COC1=CC=CC(N2C(=NN=C2)C=2C=C(C=CC=2)C(C)(C)C)=C1 LFWAVNRDCVJWNS-UHFFFAOYSA-N 0.000 claims 1
- XAUBIRVVXYSHLW-UHFFFAOYSA-N 3-(4-tert-butylphenyl)-4-(3-methoxyphenyl)-1,2,4-triazole Chemical compound COC1=CC=CC(N2C(=NN=C2)C=2C=CC(=CC=2)C(C)(C)C)=C1 XAUBIRVVXYSHLW-UHFFFAOYSA-N 0.000 claims 1
- LXPRIRPPEBBCBL-UHFFFAOYSA-N 3-(5-tert-butyl-2-methoxyphenyl)-4-(3-methoxyphenyl)-1,2,4-triazole Chemical compound COC1=CC=CC(N2C(=NN=C2)C=2C(=CC=C(C=2)C(C)(C)C)OC)=C1 LXPRIRPPEBBCBL-UHFFFAOYSA-N 0.000 claims 1
- KMHZSWOKFAORBT-UHFFFAOYSA-N 5-(4-tert-butylphenyl)-4-(3-methoxyphenyl)-n,n-dimethyl-1,2,4-triazol-3-amine Chemical compound COC1=CC=CC(N2C(=NN=C2N(C)C)C=2C=CC(=CC=2)C(C)(C)C)=C1 KMHZSWOKFAORBT-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 238000013160 medical therapy Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 *C(Nc1cc(*)ccc1)=N* Chemical compound *C(Nc1cc(*)ccc1)=N* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35499002P | 2002-02-07 | 2002-02-07 | |
| PCT/US2003/003746 WO2003066050A1 (en) | 2002-02-07 | 2003-02-07 | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005521676A JP2005521676A (ja) | 2005-07-21 |
| JP2005521676A5 true JP2005521676A5 (enExample) | 2006-02-02 |
Family
ID=27734448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565474A Pending JP2005521676A (ja) | 2002-02-07 | 2003-02-07 | オピオイドレセプター作動性４−（３−ヒドロキシフェニル）または４−（３−アルコキシフェニル）−１，２，４−トリアゾール化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7045520B2 (enExample) |
| EP (1) | EP1485088B1 (enExample) |
| JP (1) | JP2005521676A (enExample) |
| AT (1) | ATE403426T1 (enExample) |
| AU (1) | AU2003210916B9 (enExample) |
| CA (1) | CA2475767A1 (enExample) |
| DE (1) | DE60322680D1 (enExample) |
| ES (1) | ES2311711T3 (enExample) |
| MX (1) | MXPA04007719A (enExample) |
| WO (1) | WO2003066050A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003210916B9 (en) * | 2002-02-07 | 2008-12-18 | The Curators Of The University Of Missouri | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
| ES2594874T3 (es) | 2004-11-18 | 2016-12-23 | Synta Pharmaceuticals Corp. | Compuestos de triazol que modulan la actividad de HSP90 |
| WO2006124687A1 (en) * | 2005-05-12 | 2006-11-23 | University Of Medicine And Dentistry Of New Jersey | Opioid receptor subtype-selective agents |
| WO2008064310A2 (en) * | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Mixed opioid receptor active compounds |
| EP2509961B1 (en) | 2009-12-11 | 2016-03-09 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
| KR101862375B1 (ko) | 2010-12-06 | 2018-05-29 | 오티포니 세라피틱스 리미티드 | Kv3 억제제로서 유용한 하이단토인 유도체 |
| ES2716865T3 (es) | 2011-02-18 | 2019-06-17 | Scripps Research Inst | Diferenciación dirigida de células precursoras de oligodendrocitos a un destino celular mielinizante |
| US9193704B2 (en) | 2011-06-07 | 2015-11-24 | Autifony Therapeutics Limited | Hydantoin derivatives as KV3 inhibitors |
| EP2757881A4 (en) | 2011-09-15 | 2014-11-12 | Univ Kansas | KAPPA OPIATE RECEPTOR EFFECTORS AND USES THEREOF |
| EP2613277A1 (en) * | 2012-01-06 | 2013-07-10 | MathPharm GmbH | Method and system for indentifying compounds that bind and preferably activate a target opioid receptor in a pH-dependent manner |
| WO2013134562A1 (en) | 2012-03-09 | 2013-09-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| JP2015517563A (ja) | 2012-05-22 | 2015-06-22 | アウトイフオンイ トヘラペウトイクス リミテッド | Ｋｖ３阻害剤としてのヒダントイン誘導体 |
| CN104334547B (zh) | 2012-05-22 | 2017-06-06 | 奥蒂福尼疗法有限公司 | 作为kv3抑制剂的三唑类 |
| MX376108B (es) | 2012-12-20 | 2025-03-07 | Tempest Therapeutics Inc | Compuestos de triazolona y usos de los mismos. |
| PT2953942T (pt) | 2013-02-06 | 2018-01-17 | Bayer Cropscience Ag | Derivados de pirazol substituídos com halogéneo como agentes pesticidas |
| AU2014315151A1 (en) | 2013-09-06 | 2016-03-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| WO2015101622A1 (de) | 2014-01-03 | 2015-07-09 | Bayer Cropscience Ag | Neue pyrazolyl-heteroarylamide als schädlingsbekämpfungsmittel |
| AU2016231174B2 (en) | 2015-03-10 | 2020-09-10 | Bayer Animal Health Gmbh | Pyrazolyl-derivatives as pest control agents |
| CA2996281C (en) * | 2015-08-31 | 2022-03-08 | Regents Of The University Of Minnesota | Opioid receptor modulators and use thereof |
| CN111574368B (zh) * | 2020-05-15 | 2023-03-28 | 西安瑞联新材料股份有限公司 | 一种5-叔丁基-2-羟基苯甲酸甲酯的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2269938A2 (en) * | 1974-05-08 | 1975-12-05 | Delalande Sa | 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc. |
| FR2488891A1 (fr) * | 1980-08-22 | 1982-02-26 | Roussel Uclaf | Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicament |
| US4481360A (en) * | 1983-08-26 | 1984-11-06 | The Upjohn Company | 4H-1,2,4-Triazol-3-yl compounds |
| US5108486A (en) * | 1990-02-09 | 1992-04-28 | Kanagawa Chemical Laboratory, Ltd. | Herbicidal substituted-phenyl-1,2,4-triazol-5(1H)-thiones and -ones |
| US5310724A (en) * | 1990-02-09 | 1994-05-10 | Fmc Corporation | Herbicidal substituted phenyl-1,2,4-triazol-5(1H)-thiones |
| WO1999014204A1 (en) | 1997-09-16 | 1999-03-25 | G.D. Searle & Co. | Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity |
| JP2000063363A (ja) | 1998-08-12 | 2000-02-29 | Yamanouchi Pharmaceut Co Ltd | 新規なトリアゾール誘導体 |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| AU2003210916B9 (en) * | 2002-02-07 | 2008-12-18 | The Curators Of The University Of Missouri | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
-
2003
- 2003-02-07 AU AU2003210916A patent/AU2003210916B9/en not_active Ceased
- 2003-02-07 US US10/360,602 patent/US7045520B2/en not_active Expired - Fee Related
- 2003-02-07 AT AT03737705T patent/ATE403426T1/de not_active IP Right Cessation
- 2003-02-07 JP JP2003565474A patent/JP2005521676A/ja active Pending
- 2003-02-07 ES ES03737705T patent/ES2311711T3/es not_active Expired - Lifetime
- 2003-02-07 DE DE60322680T patent/DE60322680D1/de not_active Expired - Fee Related
- 2003-02-07 MX MXPA04007719A patent/MXPA04007719A/es active IP Right Grant
- 2003-02-07 WO PCT/US2003/003746 patent/WO2003066050A1/en not_active Ceased
- 2003-02-07 EP EP03737705A patent/EP1485088B1/en not_active Expired - Lifetime
- 2003-02-07 CA CA002475767A patent/CA2475767A1/en not_active Abandoned
-
2006
- 2006-01-23 US US11/337,366 patent/US7294720B2/en not_active Expired - Fee Related
-
2007
- 2007-09-18 US US11/857,193 patent/US7776898B2/en not_active Expired - Fee Related
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