MXPA04007719A - Compuestos 4-(3hidroxifenil) o 4-(3-alcoxifenil)-1,2,4-triazol activos del receptor opioide. - Google Patents
Compuestos 4-(3hidroxifenil) o 4-(3-alcoxifenil)-1,2,4-triazol activos del receptor opioide.Info
- Publication number
- MXPA04007719A MXPA04007719A MXPA04007719A MXPA04007719A MXPA04007719A MX PA04007719 A MXPA04007719 A MX PA04007719A MX PA04007719 A MXPA04007719 A MX PA04007719A MX PA04007719 A MXPA04007719 A MX PA04007719A MX PA04007719 A MXPA04007719 A MX PA04007719A
- Authority
- MX
- Mexico
- Prior art keywords
- compound according
- alkyl
- cycloalkyl
- compound
- butyl
- Prior art date
Links
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- 150000001875 compounds Chemical class 0.000 claims abstract description 236
- 238000000034 method Methods 0.000 claims abstract description 33
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- 125000000217 alkyl group Chemical group 0.000 claims description 95
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- 125000003118 aryl group Chemical group 0.000 claims description 61
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- 125000004423 acyloxy group Chemical group 0.000 claims description 35
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 34
- 125000004429 atom Chemical group 0.000 claims description 30
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 27
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- 125000001424 substituent group Chemical group 0.000 claims description 22
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 21
- 125000001401 1,2,4-triazol-4-yl group Chemical group N=1N=C([H])N([*])C=1[H] 0.000 claims description 18
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- CPRRHERYRRXBRZ-SRVKXCTJSA-N methyl n-[(2s)-1-[[(2s)-1-hydroxy-3-[(3s)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate Chemical compound COC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CO)C[C@@H]1CCNC1=O CPRRHERYRRXBRZ-SRVKXCTJSA-N 0.000 claims description 18
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- 230000000694 effects Effects 0.000 claims description 16
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- 125000005505 thiomorpholino group Chemical group 0.000 claims description 14
- DBTDEFJAFBUGPP-UHFFFAOYSA-N Methanethial Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 claims description 13
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- LFWAVNRDCVJWNS-UHFFFAOYSA-N 3-(3-tert-butylphenyl)-4-(3-methoxyphenyl)-1,2,4-triazole Chemical compound COC1=CC=CC(N2C(=NN=C2)C=2C=C(C=CC=2)C(C)(C)C)=C1 LFWAVNRDCVJWNS-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
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- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35499002P | 2002-02-07 | 2002-02-07 | |
| PCT/US2003/003746 WO2003066050A1 (en) | 2002-02-07 | 2003-02-07 | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04007719A true MXPA04007719A (es) | 2005-09-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04007719A MXPA04007719A (es) | 2002-02-07 | 2003-02-07 | Compuestos 4-(3hidroxifenil) o 4-(3-alcoxifenil)-1,2,4-triazol activos del receptor opioide. |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7045520B2 (enExample) |
| EP (1) | EP1485088B1 (enExample) |
| JP (1) | JP2005521676A (enExample) |
| AT (1) | ATE403426T1 (enExample) |
| AU (1) | AU2003210916B9 (enExample) |
| CA (1) | CA2475767A1 (enExample) |
| DE (1) | DE60322680D1 (enExample) |
| ES (1) | ES2311711T3 (enExample) |
| MX (1) | MXPA04007719A (enExample) |
| WO (1) | WO2003066050A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1485088B1 (en) * | 2002-02-07 | 2008-08-06 | The Curators Of The University Of Missouri | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
| CN101072759B (zh) | 2004-11-18 | 2013-06-19 | Synta医药公司 | 调节hsp90活性的三唑化合物 |
| WO2006124687A1 (en) * | 2005-05-12 | 2006-11-23 | University Of Medicine And Dentistry Of New Jersey | Opioid receptor subtype-selective agents |
| WO2008064310A2 (en) * | 2006-11-22 | 2008-05-29 | University Of Medicine And Dentistry Of New Jersey | Mixed opioid receptor active compounds |
| KR101735675B1 (ko) | 2009-12-11 | 2017-05-15 | 오티포니 세라피틱스 리미티드 | 이미다졸리딘디온 유도체 |
| US9346790B2 (en) | 2010-12-06 | 2016-05-24 | Autifony Therapeutics Limited | Hydantoin derivatives useful as Kv3 inhibitors |
| JP6133790B2 (ja) | 2011-02-18 | 2017-05-24 | ザ スクリプス リサーチ インスティテュート | ミエリン形成細胞運命へのオリゴデンドロサイト前駆細胞の定方向分化 |
| EP2718285B1 (en) | 2011-06-07 | 2016-03-16 | Autifony Therapeutics Limited | Hydantoin derivatives as kv3 inhibitors |
| EP2757881A4 (en) | 2011-09-15 | 2014-11-12 | Univ Kansas | KAPPA OPIATE RECEPTOR EFFECTORS AND USES THEREOF |
| EP2613277A1 (en) * | 2012-01-06 | 2013-07-10 | MathPharm GmbH | Method and system for indentifying compounds that bind and preferably activate a target opioid receptor in a pH-dependent manner |
| WO2013134562A1 (en) | 2012-03-09 | 2013-09-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| BR112014028991A2 (pt) | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | triazóis como inibidores de kv3 |
| WO2013175211A1 (en) | 2012-05-22 | 2013-11-28 | Autifony Therapeutics Limited | Hydantoin derivatives as kv3 inhibitors |
| JP6404230B2 (ja) | 2012-12-20 | 2018-10-10 | インセプション ２、 インコーポレイテッド | トリアゾロン化合物およびその使用 |
| EA028858B9 (ru) | 2013-02-06 | 2018-06-29 | Байер Кропсайенс Акциенгезельшафт | Галогензамещенные производные пиразола в качестве средств борьбы с вредителями |
| EA201690230A1 (ru) | 2013-09-06 | 2016-07-29 | Инсепшн 2, Инк. | Соединения триазолона и их применения |
| RU2016131792A (ru) | 2014-01-03 | 2018-02-06 | Байер Энимэл Хельс ГмбХ | Новые пиразолил-гетероариламиды в качестве средств для борьбы с вредителями |
| US10202351B2 (en) | 2015-03-10 | 2019-02-12 | Bayer Animal Health Gmbh | Pyrazolyl derivatives as pest control agents |
| EP3344997B1 (en) * | 2015-08-31 | 2020-11-18 | Regents of the University of Minnesota | Opioid receptor modulators and use thereof |
| CN111574368B (zh) * | 2020-05-15 | 2023-03-28 | 西安瑞联新材料股份有限公司 | 一种5-叔丁基-2-羟基苯甲酸甲酯的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2269938A2 (en) | 1974-05-08 | 1975-12-05 | Delalande Sa | 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc. |
| FR2488891A1 (fr) * | 1980-08-22 | 1982-02-26 | Roussel Uclaf | Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicament |
| US4481360A (en) | 1983-08-26 | 1984-11-06 | The Upjohn Company | 4H-1,2,4-Triazol-3-yl compounds |
| US5108486A (en) * | 1990-02-09 | 1992-04-28 | Kanagawa Chemical Laboratory, Ltd. | Herbicidal substituted-phenyl-1,2,4-triazol-5(1H)-thiones and -ones |
| US5310724A (en) * | 1990-02-09 | 1994-05-10 | Fmc Corporation | Herbicidal substituted phenyl-1,2,4-triazol-5(1H)-thiones |
| AU9297798A (en) | 1997-09-16 | 1999-04-05 | G.D. Searle & Co. | Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity |
| JP2000063363A (ja) | 1998-08-12 | 2000-02-29 | Yamanouchi Pharmaceut Co Ltd | 新規なトリアゾール誘導体 |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| EP1485088B1 (en) * | 2002-02-07 | 2008-08-06 | The Curators Of The University Of Missouri | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
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2003
- 2003-02-07 EP EP03737705A patent/EP1485088B1/en not_active Expired - Lifetime
- 2003-02-07 AU AU2003210916A patent/AU2003210916B9/en not_active Ceased
- 2003-02-07 MX MXPA04007719A patent/MXPA04007719A/es active IP Right Grant
- 2003-02-07 US US10/360,602 patent/US7045520B2/en not_active Expired - Fee Related
- 2003-02-07 DE DE60322680T patent/DE60322680D1/de not_active Expired - Fee Related
- 2003-02-07 CA CA002475767A patent/CA2475767A1/en not_active Abandoned
- 2003-02-07 JP JP2003565474A patent/JP2005521676A/ja active Pending
- 2003-02-07 WO PCT/US2003/003746 patent/WO2003066050A1/en not_active Ceased
- 2003-02-07 ES ES03737705T patent/ES2311711T3/es not_active Expired - Lifetime
- 2003-02-07 AT AT03737705T patent/ATE403426T1/de not_active IP Right Cessation
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2006
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2007
- 2007-09-18 US US11/857,193 patent/US7776898B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003066050A1 (en) | 2003-08-14 |
| AU2003210916A1 (en) | 2003-09-02 |
| AU2003210916B2 (en) | 2008-10-23 |
| EP1485088A1 (en) | 2004-12-15 |
| ES2311711T3 (es) | 2009-02-16 |
| US20030225072A1 (en) | 2003-12-04 |
| US20060128776A1 (en) | 2006-06-15 |
| US7776898B2 (en) | 2010-08-17 |
| EP1485088B1 (en) | 2008-08-06 |
| US7045520B2 (en) | 2006-05-16 |
| US7294720B2 (en) | 2007-11-13 |
| DE60322680D1 (de) | 2008-09-18 |
| US20080070964A1 (en) | 2008-03-20 |
| ATE403426T1 (de) | 2008-08-15 |
| JP2005521676A (ja) | 2005-07-21 |
| AU2003210916B9 (en) | 2008-12-18 |
| CA2475767A1 (en) | 2003-08-14 |
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