JP2005518403A - アンドロゲンレセプターをブロックする化合物 - Google Patents
アンドロゲンレセプターをブロックする化合物 Download PDFInfo
- Publication number
- JP2005518403A JP2005518403A JP2003559448A JP2003559448A JP2005518403A JP 2005518403 A JP2005518403 A JP 2005518403A JP 2003559448 A JP2003559448 A JP 2003559448A JP 2003559448 A JP2003559448 A JP 2003559448A JP 2005518403 A JP2005518403 A JP 2005518403A
- Authority
- JP
- Japan
- Prior art keywords
- compounds
- cyclohexenone
- composition
- administered
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/603—Unsaturated compounds containing a keto groups being part of a ring of a six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
本発明は、患者において非必須アンドロゲンレセプターをブロックすることにより媒介される症状を処置するために有用である化合物に関する。
アンドロゲンは、挫瘡および雄性パターン禿のような種々の症状を引き起こすことで顕著な役割を演じていることが周知である。アンドロゲンに関係すると考えられているその他の症状には、ケロイド、接着、エラスチン合成、皺影響、および変形性関節症が含まれる。
本発明は、患者においてアンドロゲンレセプターをブロックするために用いられ得るシクロヘキセノン化合物に関する。この化合物は室温で安定であり、そして局所適用、経口、または内部投与のための種々の組成物で用いられ得る。
アンドロゲンレセプター部位をブロックするために用いられるいくつかの化合物は、ペンダントアルキル部分をもつ環式および二環式アルカノン環を利用している。これら化合物のいくつかでは、アルキル部分および環式の環は、炭素−炭素二重結合によって分離されている。代表的には、これらの化合物は、調製が困難で、そして室温および光に曝されるとき不安定である。これらの性質は、それらを、市販組成物および処置方法のための所望されない候補にしている。
Claims (10)
- RがCH3である、請求項1に記載の化合物。
- 哺乳動物においてアンドロゲンレセプター部位をブロックする方法であって、哺乳動物に有効用量の3−(5−メトキシヘプチル)−2−シクロヘキセノンを含む組成物を投与する工程を包含する、方法。
- 前記組成物が局所投与のために適合されており、そして局所的に投与される、請求項3に記載の方法。
- 前記組成物が経口的に投与される、請求項3に記載の方法。
- 前記組成物が内部に投与される、請求項3に記載の方法。
- 前記組成物が挫瘡に罹患した哺乳動物に投与される、請求項3に記載の方法。
- 前記組成物がケロイドに罹患した哺乳動物に投与される、請求項3に記載の方法。
- 前記組成物が雄性パターン禿に影響された哺乳動物に投与される、請求項3に記載の方法。
- 3−(5−メトキシヘプチル)−2−シクロヘキセノンを含む、哺乳動物に投与される組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34654502P | 2002-01-09 | 2002-01-09 | |
PCT/US2003/000534 WO2003059283A2 (en) | 2002-01-09 | 2003-01-09 | Compounds for blocking androgen receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005518403A true JP2005518403A (ja) | 2005-06-23 |
JP2005518403A5 JP2005518403A5 (ja) | 2006-03-02 |
Family
ID=23359898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003559448A Pending JP2005518403A (ja) | 2002-01-09 | 2003-01-09 | アンドロゲンレセプターをブロックする化合物 |
Country Status (9)
Country | Link |
---|---|
US (2) | US6768026B2 (ja) |
EP (1) | EP1474122A4 (ja) |
JP (1) | JP2005518403A (ja) |
KR (1) | KR20040086262A (ja) |
CN (1) | CN1273121C (ja) |
AU (1) | AU2003235672A1 (ja) |
CA (1) | CA2473908A1 (ja) |
IL (1) | IL162849A0 (ja) |
WO (1) | WO2003059283A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009507016A (ja) * | 2005-09-01 | 2009-02-19 | バイオフィジカ インコーポレイテッド | 新規なスキンケア組成物 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003235672A1 (en) * | 2002-01-09 | 2003-07-30 | Trident Sciences Llc | Compounds for blocking androgen receptors |
US20060263452A1 (en) * | 2005-05-17 | 2006-11-23 | Alwyn Dowell | Topical composition containing essential oils |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135849A (en) | 1986-04-17 | 1992-08-04 | Trustees Of Tufts College | In-vitro methods for identifying compositions which are agonists and antagonists of androgens |
US5808139A (en) * | 1992-04-21 | 1998-09-15 | Ligand Pharmaceuticals Incorporated | Non-steroid progesterone receptor agonist and antagonist and compounds and methods |
US5264619B1 (en) * | 1993-01-15 | 1996-05-14 | Cosmos Pharm Corp | Anti-androgenic cyclo and bicyclo alkenes |
CA2299308C (en) | 1997-08-13 | 2008-03-25 | Meiji Milk Products Co., Ltd. | Cyclohexenone long-chain alcohol and medicament containing same |
US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
AU2003235672A1 (en) * | 2002-01-09 | 2003-07-30 | Trident Sciences Llc | Compounds for blocking androgen receptors |
-
2003
- 2003-01-09 AU AU2003235672A patent/AU2003235672A1/en not_active Abandoned
- 2003-01-09 EP EP03729598A patent/EP1474122A4/en not_active Withdrawn
- 2003-01-09 CA CA002473908A patent/CA2473908A1/en not_active Abandoned
- 2003-01-09 WO PCT/US2003/000534 patent/WO2003059283A2/en not_active Application Discontinuation
- 2003-01-09 CN CNB038020432A patent/CN1273121C/zh not_active Expired - Fee Related
- 2003-01-09 US US10/338,889 patent/US6768026B2/en not_active Expired - Fee Related
- 2003-01-09 KR KR10-2004-7010712A patent/KR20040086262A/ko not_active Application Discontinuation
- 2003-01-09 IL IL16284903A patent/IL162849A0/xx unknown
- 2003-01-09 JP JP2003559448A patent/JP2005518403A/ja active Pending
-
2004
- 2004-07-12 US US10/888,544 patent/US7211604B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009507016A (ja) * | 2005-09-01 | 2009-02-19 | バイオフィジカ インコーポレイテッド | 新規なスキンケア組成物 |
Also Published As
Publication number | Publication date |
---|---|
WO2003059283A3 (en) | 2003-09-18 |
US20040266884A1 (en) | 2004-12-30 |
US20030153627A1 (en) | 2003-08-14 |
EP1474122A2 (en) | 2004-11-10 |
CN1620286A (zh) | 2005-05-25 |
EP1474122A4 (en) | 2006-04-19 |
US7211604B2 (en) | 2007-05-01 |
WO2003059283A2 (en) | 2003-07-24 |
CN1273121C (zh) | 2006-09-06 |
CA2473908A1 (en) | 2003-07-24 |
US6768026B2 (en) | 2004-07-27 |
AU2003235672A1 (en) | 2003-07-30 |
KR20040086262A (ko) | 2004-10-08 |
IL162849A0 (en) | 2005-11-20 |
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